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Bronchogen: Ninakili kɛnɛya kɔlɔsilikɛla dɔ

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Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.

Daminɛ kuma

Kalan caman cɛma ninakili kɛnɛya sabatili kan, Bronchogen y’a jira ko a bɛ se ka kɛ ni a nafa ye ninakili kɛnɛyako siratigɛ la. Nin barokun in bɛna Bronchogen nɔ ɲumanw sɛgɛsɛgɛ ninakili kɛnɛya la ani a kɛcogo ɲuman na ka da ɲininiw kan minnu kɛra.

Jaa 1 Bronchogen ka kemikaliya sigicogo.

Bronchogène nɔ min bɛ ADN sabatili la

1. Jɛɲɔgɔnya min bɛ se ka kɛ ADN sabatili ni ninakili kɛnɛya cɛ

Kɔnɔnatumuw ka baara kɛcogo ɲuman bɛ bɔ ADN jɔcogo sabatilen na. Ninakiliyɔrɔ la, sigida fɛn suguya caman i n’a fɔ nɔgɔw ni banakisɛw bɛ se ka selilɛriw ka ADN tiɲɛ, o la, u bɛ nɔ bila ninakilila farikolo baarakɛcogo la, ka na ni ninakilibana caman ye. ADN sabatili sabatili nafa ka bon kosɛbɛ walasa ka ninakilibanakisɛw ka farikoloɲɛnajɛ, u caya ani u farikolo tangacogo baarakɛcogo ɲuman sabati.

2. Bronchogène i n’a fɔ ADN sabatilikɛlan

Ni a hakɛ tɛ kelen ye, Bronchogen bɛ se ka nɔ bila ADN ka thermodynamique paramètres la. Ni ADN sɛgɛsɛgɛra ni diferential scanning microcalorimetry ye, a jirala ko Bronchogen bɛ se ka kɛ ADN sabatilifɛn ye. Ni Bronchogène bɛ ɲɔgɔn sɔrɔ ni ADN ye min bɛ bɔ misiw ka timu ni soso sugunɛ na, r hakɛ danmadɔ kɔnɔ (r ye Bronchogen ni ADN basigilen fila-fila ka molari hakɛ ye, 0,01–0,055), o bɛ se ka dɔ fara ADN denaturation funteni kan ni 3,1°C ye. O b’a jira ko Bronchogen bɛ ADN sabatili sabati, ka ADN tiɲɛni farati dɔgɔya min bɛ sɔrɔ kɛnɛmafɛnw fɛ, wa o bɛ dɛmɛ don ka kunnafonidi jamu ni selilɛriw ka baara kɛcogo ɲuman sabati ninakiliyɔrɔw la.

3. Sigicogo ni sabatili fɛɛrɛ

Kalan wɛrɛw y’a jira ko Bronchogen tɛ adenine-thymine kɛrɛnkɛrɛnnen walima guanine-cytosine kɛrɛnkɛrɛnnen ligandi ye. A sirili suguya bɛ jate barikama ye ani k’a kɛ k’a sɔrɔ a ma kɛ cogo si la, wa a bɛ siri ADN sɛrɛkili fila bɛɛ la (kɛrɛnkɛrɛnnenya la, azote basiw la). r hakɛw kɔnɔ, k’a ta 0,01 na ka se 1,0 ma, o fɛnɲɛnɛma in ka sɛnɛfɛnw wulicogo (ΔH(melt)) bɛ to a cogo la, o bɛ Bronchogen ka baarakɛcogo kɛrɛnkɛrɛnnen jira ka t’a fɛ ADN sabatili la ani ka hakilinata basigilen barikama di a jɔyɔrɔ ma jamu sabatili sabatili la ninakili seliluw kɔnɔ.

Bronchogène bɛ se ka kɛ ninakilibana furakɛli la

1. Banaw kunbɛnni ka da ADN sabatili kan

Ikomi Bronchogène bɛ se ka ADN jɔcogo sabati, a jɔyɔrɔ ka bon ninakilibana dɔw kunbɛnni na minnu bɛ sɔrɔ ADN tiɲɛni fɛ. Jamanaden minnu bɛ fiɲɛ nɔgɔli kuntaalajan sɔrɔ, olu farati ka bon ninakilibanaw la i n’a fɔ fogonfogon kansɛri ani fogonfogonlabana basigilen (COPD) ka da ADN tiɲɛni kan ninakiliyɔrɔw la. Bronchogène bɛ se ka dɔ bɔ o farati la ni ADN sabatili sabatili ye, ka banakunbɛn fɛɛrɛ dɔ di o jamana suguw ma.

2. Furakɛli dɛmɛnanw ninakilidegunw na

Ninakili funu waati, funu cɛmancɛlafɛnw minnu bɛ bɔ funubanakisɛw fɛ, olu bɛ se ka ninakilibanakisɛw ka ADN tiɲɛ. Bronchogène ka ADN sabatili seko bɛ se ka o tiɲɛni suguw nɔgɔya fo ka se hakɛ dɔ ma, ka dɛmɛ don farikolokisɛ tiɲɛnenw dilancogo n’u baarakɛcogo la. Ni aw ye jamu kunnafoniw cicogo ɲuman mara farikolokisɛw kɔnɔ, o fana bɛ se ka nɔ ɲuman bila jamu jiracogo labɛnni na min bɛ tali kɛ funu jaabiw la, o la, a bɛ dɛmɛ don ninakili funu furakɛli la.

Kuncɛli

Hali ni ɲinini minnu kɛra sisan Bronchogen kan ninakili kɛnɛyako la, olu bɛ a daminɛ na hali bi, sɔrɔ minnu bɛ sen na, olu b’a seko jira. K’a ta a nɔfɛkow la ADN sabatili la ka se a waleyali ma ninakilibanaw kunbɛnni n’u furakɛli la, Bronchogen bɛ sira kura da mɔgɔw ɲɛ ninakili kɛnɛyako ɲininiw kama.

Bununda

[1] Monaselidze JR, Khavinson V, Gɔrgoshidze MZ, ani mɔgɔ wɛrɛw. Pepitiri sɔgɔsɔgɔninjɛ (Ala-Asp-Glu-Leu) nɔ min bɛ ADN funteni sabatili la[J]. Bulletin de biologie expérimentale et médecine, 2011,150(3):375-377.DOI:10.1007/s10517-011-1146-x.

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