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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Cɛɲa ni farikolo ladonni siratigɛ la, kurukuruw kɛlɛli furakɛli ye barokun ye min ka di kosɛbɛ. Snap-8 ni botulinum toxin ye fɛn fila ye minnu bɛ kɛ ka kurukuruni kɛlɛ, u kelen-kelen bɛɛ ka baarakɛcogo ni u kɛcogo ɲɔgɔn tɛ.
1. Baarakɛcogo
Snap-8 ka baara kɛcogo : Snap-8 ye pepitiri kɛrɛnkɛrɛnnen ye min ka baarakɛcogo bɛ tali kɛ SNARE complexe (sɔgɔsɔgɔninjɛ) jɔli la. Ni Snap-8 bɛ SNARE complexe (sɔgɔsɔgɔninjɛ) sɔrɔli bali, a bɛ dɔ bɔ farikolo-ɲɛnajɛ-fɛnw bɔli la, o la, a bɛ farikolo-ɲɛnajɛ bali ani ka se ka kurukuruw dɔgɔyali nɔ sɔrɔ. Kɔnɔnatumuw ta fan fɛ, ni sɔgɔsɔgɔninjɛ taamasiɲɛw bɛ ci farikolokisɛw ma, u bɛ farikolo-ɲɛnajɛ jaabi caman lawuli, ni SNARE-komplekisi ka lajɛcogo bɛnnen ye, o ye senna-tɛgɛrɛ-minɛnw bɔli ye fɛɛrɛ kɔrɔba ye. Snap-8 sɔrɔli bɛ SNARE complexe (sɔgɔsɔgɔninjɛ) sɔrɔli bali, o bɛ na ni neurotransmetteurs (sɔgɔsɔgɔninjɛlanw) sebaliya ye ka bɔ synaptic cleft kɔnɔ. O de kosɔn, farikolokisɛw tɛ sɔgɔsɔgɔninjɛ taamasiɲɛw sɔrɔ, o bɛ dɔ bɔ farikolo sɔgɔsɔgɔli caya ni a fanga la. A tali kuntaalajan bɛ se ka dɔ bɔ kurukuruw juguya la dɔɔni dɔɔni.
Botulinum baga ka baara kɛcogo : Botulinum baga min bɛ bɔ Clostridium botulinum fɛ, o ye farikolojidɛsɛbanakisɛ ye. A bɛ baara kɛ fɔlɔ farikolo-ɲɛnajɛ-yɔrɔ la, a kɛtɔ ka farikolojɔlifɛnw tigɛ kɛrɛnkɛrɛnnenya la minnu bɛ tali kɛ farikolo-ɲɛnajɛ-minɛnw bɔli la, i n’a fɔ SNAP-25, o la, a bɛ farikolo-ɲɛnajɛ-minɛn asetilikolini bɔli bali. Asetilkolini ye farikolojidɛsɛ fura jɔnjɔn ye min bɛ farikoloɲɛnajɛ taamasiɲɛw lase farikolo ma ani ka farikolojidɛsɛ bila mɔgɔ la. Ni asetilikolini bɔli balila, farikolo yɔrɔw tɛ se ka sɔgɔsɔgɔninjɛ taamasiɲɛw sɔrɔ, o bɛ na ni farikolo lafiyali ye. Ɲɛda ɲɛda cogoya fasaw la, botulinum baga bɛ farikolojidɛsɛ fanga dɔgɔya ɲɛda ɲɛda cogoya la, o la, a bɛ dɔ bɔ kurukuruw la minnu bɛ sɔrɔ farikolojidɛsɛ segin-segin fɛ, i n’a fɔ kɔnɔbara senw ani ɲɛgɛnɛsiraw.
2. Baarakɛcogo minnu bɛ kɛ
A kɛli farilajidɛsɛ furaw la - Snap-8 : Snap-8 bɛ kɛ farilajidɛsɛ fura suguya caman na, i n’a fɔ kiribi ni serum. A nafa ye ko a ye kurukuruni fura ye min ka nɔgɔn kosɛbɛ, min bɛnnen don fari suguya fanba ma. Ni aw bɛ to ka farikoloɲɛnajɛ furaw kɛ minnu kɔnɔ Snap-8 bɛ sɔrɔ don o don, fari kurukuruw bɛ se ka ɲɛ dɔɔni dɔɔni. Ikomi a bɛ sɔrɔ farilajidɛsɛ fura cogo la, a tali ka nɔgɔn, wa a tɛ dɔgɔtɔrɔ ŋanaw wajibiya ka a di, o bɛ a tali balilan dɔgɔya.
A kɛli cɛɲa ni farilajidɛsɛ furaw la - Botulini baga : Botulini baga bɛ kɛ fɔlɔ cɛɲa yɔrɔ la pikiri fɛ. Nin fɛɛrɛ in bɛ fɛnɲɛnamafagalan lase farikolo yɔrɔ kɛrɛnkɛrɛnnenw ma, ka kurukuru koɲɛw laɲini. A ka ca a la, a bɛ kɛ ka kurukuruw furakɛ minnu ka dun minnu bɛ jɔ ani minnu bɛ se ka wuli, i n’a fɔ ɲɛdawolo ni kɔnɔbara senw. Nka, Botox pikiriw bɛ dɔgɔtɔrɔ ŋanaw de wajibiya u ka u kɛ, ni sariya gɛlɛnw ye u tata hakɛ, pikiri kɛyɔrɔw ani layɛrɛw kan. Ni u bɛ ɲɛda kurukuruw dɔgɔyali kɛ, dɔgɔtɔrɔw ka kan ka Botox hakɛ jateminɛ ani k’a kɔlɔsi ka kɛɲɛ ni banabagatɔ ka kurukuru cogoya ye ani ɲɛda fasaw tilatilali ye walasa ka kurukuruw kɛlɛli nɔ ɲumanw sɔrɔ ka sɔrɔ ka u yɛrɛ tanga nɔ juguw ma i n’a fɔ ɲɛda fasaw gɛlɛya.
Baarakɛcogo furakɛli siratigɛ la - Snap-8 : Sisan, ɲinini caman tɛ kɛ Snap-8 baarakɛcogo kan furakɛli siratigɛ la. Nka, ka da a kɛcogo kan, a bɛ se ka kɛ ko nafa bɛ a la i n’a fɔ furakɛli faralen bana nɔgɔman dɔw walima taamasiɲɛ dɔw la minnu bɛ tali kɛ farikolojidɛsɛ kojugu la. Ni ɲɛda dimi dɔɔni walima farikolojidɛsɛ min bɛ sɔrɔ farikolojidɛsɛ fɛ, fura minnu bɛ kɛ fari la, Snap-8 bɛ minnu na, olu bɛ se ka lafiya dɔ di.
Furakɛcogo - Botulin baga : Botulin baga bɛ kɛ ka caya furakɛli siratigɛ la. Ka fara ɲɛgɛnɛsiralabanaw dɔgɔyali kan, a bɛ kɛ ka farikolo bana suguya caman furakɛ. Sɔgɔsɔgɔninjɛ la, a bɛ kɛ ka distoniya furakɛ, i n’a fɔ kunsɛmɛnasumaya, kɔnɔbara basigilen, ani senkɔniw distoniya. Ni botulinum baga pikirila farikolo yɔrɔw la minnu tɔɔrɔla distoni fɛ, o bɛ kɛ sababu ye ka farikolo yɔrɔw lamini, min bɛ kunbɛn, o bɛ farikolojidɛsɛ jugumanba nɔgɔya ani ka bana taamasiɲɛw ɲɛ. Otolaryngologie la, botulinum toxin bɛ se ka kɛ ka banaw furakɛ i n’a fɔ Lucia Frey ka bana, sɔgɔsɔgɔninjɛ, sɔgɔsɔgɔninjɛ kojugu, ɲɛda tɔntɔnni, kan yɛrɛyɛrɛ, kanbaralabana, sinkinɛsi ɲɛda nɛrɛmuguma kɔfɛ, dumunikɛbaliya, ani sɔgɔsɔgɔninjɛ min tɛ se ka furakɛ. Ka fara o kan, ɲɛdimi na, a bɛ se ka kɛ ka ɲɛkisɛw ka bana dɔw furakɛ, i n’a fɔ ɲɛdimi.
Sosow (Sɔrɔyɔrɔw).
[1] Wee SY, Park E S. Botulin baga farikolo tangacogo[J]. Archives de opereli plastiki-Aps, 2022,49(1):12-18.DOI:10.5999/aps.2021.00766.
[2] Dołomisiewicz D, Lipiec M, Mielniczek K, ani a ɲɔgɔnnaw. Botulinum toxin - a kɛcogo lajɛlen ye tulolabanaw la[J].Polski Przegląd Otorynolaryngologiczny, 2022. https://api.semanticscholar.org/CorpusID:254297988
