Semax miligaramu 10

▎ Semax ka sigicogo

▎ Semax Sɛgɛsɛgɛli

Semax ye mun ye?

Semax ye pepitiri sintetiki ye, wa a bɛ nootropic suguya dɔ la. A yɔrɔba ye thyrotropin-releasing hormone (TRH) ɲɔgɔnna ye, min ni asidi aminiki wɛrɛw (i n’a fɔ valine ni leucine) faralen don ɲɔgɔn kan. Semax bɛ se ka hakililabaara ɲɛ ka taa a fɛ ni a bɛ farikolojidɛsɛbanakisɛw (i n’a fɔ dopamine ni norepinephrine) labɛn farikolo cɛmancɛ la, o la, a bɛ hakilijagabɔ bonya, ka hakilijagabɔ kɛcogo ɲɛ, ani ka kalan kɛ.

Semax ka ɲininiw kɛcogo ye mun ye?

Yiriwali min sinsinnen bɛ ACTH yɔrɔw kan: 

Semax bɛ Kɛ ni ACTH (4 - 7) yɔrɔ ye ani tripeptide Pro - Gly - Pro (PGP). ACTH, n’o ye adrénocorticotrope hormone ye, o ye ɔrimɔni ye min bɛ bɔ ɲɛgɛnɛsira ɲɛfɛla fɛ, wa a jɔyɔrɔ ka bon sugunɛbaralabana baara ɲɛnabɔli la. Ɲininikalaw ye ACTH jɔcogo sɛgɛsɛgɛ, ka yɔrɔ kɛrɛnkɛrɛnnen dɔ (4 - 7) bɔ a la, k’a fara ɲɔgɔn kan ni tripeptide PGP ye walasa ka Semax dilan. Nin sinsincogo in b’a to Semax bɛ se ka ACTH ka baara yɔrɔ dɔ mara ani fana ka ɲɛnamaya kɛcogo kɛrɛnkɛrɛnnenw sɔrɔ ^{[1] .}.

Kunfilanitu furakɛli ɲinini: 

Epilepsie ye kunsɛmɛ baara gɛlɛya ye min bɛ sɔrɔ ni senfagabana depolarize (depolarisation) ye min tɛ cogo la. Kɔnɔboli ye kɔnɔboli taamasiɲɛba ye, a ka ca a la a bɛ sɔrɔ kunsɛmɛ joginni fɛ. Hali ni sisan fura minnu bɛ kɛ ka kɔnɔboli furakɛ, olu bɛ nɔ dɔw bila kɛnɛya la, u bɛ nɔ jugu dɔw fana bila kɛnɛyako la. O cogo la, ɲininikɛlaw y’a daminɛ ka furakɛli fɛɛrɛ kuraw ɲini. I n’a fɔ neuropeptide, Semax peptide bɛ baara kɛ ka ɲɛsin farikolo cɛmancɛ ma, wa a tɛ baara kɛ ni ɔrimɔni ye, o la a tɛna nɔ jugu bila kɛnɛyako la. O bɛ fɛɛrɛ kuraw di sɔgɔsɔgɔninjɛ furakɛli ma ^{[2] .}.

Ischemie (Ischemie) furakɛcogo: 

Ischemic stroke ye bana juguba ye, wa k’a sababu kɛ a sɔrɔli ka ca ani a ka seko dɛsɛ, a kɛra furakɛli ɲininiw ɲɛsinnen ye tuma bɛɛ. Semax peptide, ka da a ka farikolo tangacogo ni farikolo tangacogo kan, o bɛ kɛ ka sɔgɔsɔgɔninjɛ furakɛ. Kɔlɔsiliw y’a jira ko Semax bɛ se ka funubanakisɛw jirali bali ani ka farikolojidɛsɛbanakisɛw jirali baara, o la, a bɛ farikolo lakanani nɔ bila sɛbɛnni ni farikolojɔlifɛnw hakɛ la ^[3,.

Ladilikan kura min bɛ kɛ ka ɲɛsin degun furakɛli ma: 

Selective serotonin reuptake inhibitors (SSRI) ye furaw ye minnu bɛ kɛ ka caya degun furakɛli la kɔnɔmaya waati, nka SSRI bɛ se ka denso tigɛ ani u bɛ se ka nɔ bila den kunsɛmɛ kɔgɔli la. I n’a fɔ ACTH (4-10) analozi sintetiki, Semax bɛ ni nootropic ni neuroprotective baara jɛlenw ye. Sɛgɛsɛgɛliw y’a jira ko Semax bɛ se ka dɔ bɔ sosow ka kɛwalew ni u hakililata caman yeli minnu bɛ sɔrɔ fluvoxamine tali fɛ joona, o bɛ hakilina kura di degun furakɛli ma^la .

Nafa minnu bɛ pepitiri fɛnw na: 

Semax ye pepitiri fɛn dilannen ye min ka baarakɛcogo ɲɔgɔn tɛ. A bɛ se ka baara kɛ farikolo cɛmancɛ la, ka farikolojɔli dumuni dɔw labɛn kunsɛmɛ na, ka farikolo tangalanw kɛ. Misali la, sosow ka sɔgɔsɔgɔninjɛ modɛli la, Semax pepitiri bɛ se ka MDA hakɛ dɔgɔya ani ka farikolojɔlifɛn saba dilan minnu tɛ sɔrɔ sosow la minnu bɛ sɔgɔsɔgɔ ^[2]..

I n’a fɔ pepitiri min bɛ sariyasunba la, Semax ɲinini tariku bɛ se ka sɔrɔ kabini waati jan. Kɔlɔsiliw y’a jira ko Semax bɛ se ka baara kɛ ni hakilijagabɔ ye, hakili baara kɛcogo ɲuman dɔgɔyali, ani COVID kɔfɛ banaw, ka fara somatoform ni psychosomatic banaw ^kan.

Yɛlɛma minnu bɛ kɛ pJNK ni pCREB furakisɛw hakɛ la ischemie ni Semax furakɛli senfɛ sosow ka ɲɛgɛnɛsiraw ni u ɲɛda ɲɛfɛla la lɛrɛ 24 kɔnɔ tMCAO kɔfɛ.

Soso:PubMed ^{[4] Ɲɛjirali dɔw.}

Semax ka baarakɛcogo min bɛ kɛ ka sɔgɔsɔgɔninjɛ furakɛ, o bɛ nɔ bila kɛrɛnkɛrɛnnenya la sugunɛ baara la cogo di?

Antioxydant (banakisɛfagalan) nɔ

Semax bɛ ni farikolo tangalanw ye. A ka ca a la, sɔgɔsɔgɔninjɛ bɛ na ni dɔ fara oksidan degun kan kunsɛmɛ na, wa Semax bɛ se ka dɔ bɔ tiɲɛni na min bɛ sɔrɔ oksidan degun fɛ. Oksizɛni degun bɛna kɛ sababu ye ka oksizɛni suguya minnu bɛ se ka kɛ ka caya kojugu, i n’a fɔ malondialdehyde (MDA). Kɔlɔsiliw y’a jira ko Semax bɛ se ka MDA hakɛ dɔgɔya sɔgɔsɔgɔninjɛbanatɔw kunkolo la fo ka se 40,46% ma ^[2] . Ni Semax ye MDA hakɛ dɔgɔya, a bɛ se ka oksidan degun tiɲɛni nɔgɔya senfagabana na, o la, a bɛ hakili baara lakana.

Sugunɛ furakisɛw dilanni

Semax bɛ se ka farikolojɔlifɛn dɔw labɛn hakili la. Sɔgɔsɔgɔninjɛbanatɔw ka sɛgɛsɛgɛli la, furakɛli kɔfɛ ni Semax ye, farikolojɔlifɛn saba minnu ma sɔrɔ sɔgɔsɔgɔninjɛbanatɔw la, olu kɛra. O farikolojɔlifɛn ninnu girinya ye 93,54kDa, 66,76kDa ani 59,66kDa ye ^[2] . U bɛ se ka jɔyɔrɔba ta hakili ka baara kɛcogo ɲuman sabatili la ani ka senfagabana tiɲɛnenw dilan.

A bɛ nɔ bila hakili-la-minɛnw ka rezo la

Lafiɲɛbɔ waati baarakɛcogo magɛnni rezɔn (resting-state FMRI) sɛgɛsɛgɛliw sababu fɛ, a jirala ko Semax bɛ nɔ bila kunsɛmɛnasumaya rezo la. Kɛnɛyabaarakɛlaw ka sɛgɛsɛgɛli la, ni i ye a suma ni kɔrɔsili kulu ye, rostral (intermediate anterior cortex) sub-component of the default mode network hakɛ cayalenba sɔrɔla Semax ^kulu kɔnɔ O b’a jira ko Semax bɛ se ka hakili baara ɲɛ ka taa a fɛ ni a bɛ kunsɛmɛnasumaya rezow ka jɛɲɔgɔnyaw ni u ka baarakɛcogo ɲɛnabɔ.

Ni Semax pikiri kɛra don o don wuluw la minnu ka teli ka mɛnni sɔrɔ, k’a ta u ka ɲɛnamaya tile 7nan na ka se u ka tile 11nan ma, a jirala ko wuluw ka tulolabanaw kɛcogo bɛ Changé ni u si bɛ kalo 1 la, wa fura fila bɛɛ bɛ se ka farikolojidɛsɛ sabati hippocampal dentate gyrus kɔnɔ. Neurogenesis bɛ se ka kɛ ni hakili kalan, hakilijagabɔ ani dilan baarakɛcogo ye, wa Semax bɛ se ka hakili baara ɲɛ ka taa a fɛ ni hakilijagabɔ sabatili ye.

Ni Semax pikiri kɛra den kuraw ka soso suguya duuru la minnu bɔra ɲɔgɔn na (k’a ta u si tile 2nan na ka se u si tile ), o ye dɔ bɔ kosɛbɛ kirinni sɔrɔli la DBA / 2J sogow dɔrɔn na minnu si bɛ kalo 1 ^{7nan ma} la O fana b’a jira ko Semax bɛ se ka nɔ bila hakili baara la fɛɛrɛ dɔw fɛ ani ka dɔ bɔ sɔgɔsɔgɔninjɛ sɔrɔli la.

Ɔrimɔni baara dɛsɛ

Semax ye neuropeptide ye min bɛ baara kɛ farikolo cɛmancɛ la, wa a tɛ baara kɛ ni ɔrimɔni ye, o la a tɛna nɔ jugu bila kɛnɛyako la (Puspita R, 2018). O bɛ nafa dɔw di Semax ma sɔgɔsɔgɔninjɛ furakɛli la, ka a yɛrɛ tanga tubabufura kɔrɔlenw kɔlɔlɔw ma minnu bɛ se ka kɛ.

Semax bɛ farikolo tangacogo ɲɛnabɔ fɛɛrɛ kɛrɛnkɛrɛnnen jumɛn fɛ?

Banakisɛfagalanw ka taamasiɲɛw siraw bonya minnu bɛ tali kɛ farikolo tangalanw na: 

Semax bɛ se ka antijeni jiracogo taamasiɲɛw sira bonya. Antijeni jirali ye fɛɛrɛ jɔnjɔn ye farikolo tangalanw fɛ walasa ka jamana wɛrɛw ka antijeniw dɔn ani k’u baara. Ni Semax ye nin taamasiɲɛ sira in bonya, a bɛ se ka farikolo tangalanw dɔnni ni u ka jaabi sabati dunanw na i n’a fɔ banakisɛw ^[1] . Ka fara o kan, Semax bɛ se fana ka fanga di ischemie nɔ ma interferon taamasiɲɛ sira kan. Interféron jɔyɔrɔ ka bon farikolo tangacogo ɲɛnabɔli la, i n’a fɔ banakisɛfagalanw, tumuw kɛlɛli, ani farikolo tangalanw ka baara ɲɛnabɔli. Interferon taamasiɲɛ sira barika bonya Semax fɛ, o bɛ dɛmɛ ka farikolo tangalanw ka baara bɛɛ lajɛlen ɲɛ ^{[1] .}.

Ka nɔ bila immunoglobuline (immunoglobuline) sɔrɔli taabolo la: 

Semax bɛ dɔ fara kosɛbɛ jamu minnu bɛ farikolo tangalanw ka cakɛda girinmanw kofɔ, olu jirali kan. Immunoglobulines jɔyɔrɔ ka bon humoral immunité la, wa u bɛ se ka siri kɛrɛnkɛrɛnnenya la antigènes la, o la, u bɛ dunan fɛnw bɔ yen i n’a fɔ banakisɛw. Semax bɛ farikolo tangalanw dilanni sabati, o bɛ dɛmɛ ka farikolo ka farikolo tangalanw baara ɲɛ ^{[1] .}.

Banakisɛfagalanw ka baara labɛnni: 

Semax bɛ nɔba bila jɛnɛya la minnu bɛ sitokiniw kofɔ, degun jaabiw, ani ribosomali poroteyini. Sitokiniw jɔyɔrɔ ka bon farikolo tangacogo la, wa u bɛ se ka farikolo tangalanw caya, u danfara ani u ka baara ɲɛnabɔ. Semax bɛ farikolo tangalanw ka baara ɲɛnabɔ ni a bɛ nɔ bila nin jamu ninnu jirali la, o la a bɛ farikolo tangalanw ka baara ɲɛnabɔ ^{[1] .}.

Seamx ka baarakɛcogo ye mun ye?

Ɲɛgɛnɛsiraw furakɛli

A bɛ nɔ bila senfagabana na: 

Epilepsie ye kunsɛmɛ baara gɛlɛya ye min bɛ sɔrɔ ni senfagabana depolarize (depolarisation) ye min tɛ cogo la. Semax peptide ye neuropeptide ye min bɛ baara kɛ farikolo cɛmancɛ la, wa a tɛ kɛ ni ɔrimɔni baara ye, o la a tɛna nɔ jugu bila kɛnɛya la. Semax bɛ se ka MDA hakɛ dɔgɔya sɔgɔsɔgɔninjɛbanatɔw kunkolo la. MDA ye lipid peroxidation taamasiɲɛ ye, wa MDA hakɛ caman bɛ tali kɛ oksidan degun ni selilɛri tiɲɛni na. Semax bɛ se ka MDA hakɛ dɔgɔya kunsɛmɛ na fo ka se 40,46% ma ^{[9] .}.

Protéines (banakisɛfagalanw) dilanni: 

Semax bɛ se fana ka farikolojɔli dumuni dɔw labɛn kunsɛmɛnasumaya wuluw hakili la. Kɔlɔsiliw y’a jira ko Semax bɛ se ka farikolojɔlifɛn saba dilan minnu tun ma dilan fɔlɔ sɔgɔsɔgɔninjɛ bɛ wulu minnu na, wa o farikolojɔlifɛnw girinya ye 93,54 kDa, 66,76 kDa ani 59,66 kDa ^ye.

Ischemic stroke furakɛli

Neurotrophine sɛbɛnni fanga bonya: 

Semax (MET-GLU - amino acid - phenylalanine - proline - glycine - proline) peptide ye melanocortin bɔlen ye min dilannen don ni a bɛ kɛ ka jolida furakɛli kɛ. Kɔlɔsiliw y’a jira ko Semax bɛ se ka neurotrophines ni u minɛbagaw sɛbɛnni bonya ani ka jeninida minnu sen bɛ farikolo tangacogo jaabi la, olu jiracogo sɛmɛntiya. ARN bɛɛ lajɛlen ka ARN sinsinni sɛgɛsɛgɛli y’a jira ko cɛmancɛ kunsɛmɛsira datugucogo tɛmɛnen (tMCAO) misali la sosow la, Semax bɛ funubanakisɛw jirali bali ani ka farikolojidɛsɛbanakisɛw jirali baara ^kɛ.

Protéines (poroteyini kolomaw) jiracogo labɛnni: 

Lɛrɛ 24 tMCAO kɔfɛ, CREB baarakɛta jiginni kɔlɔsira kɔkolo jukɔrɔla yɔrɔw la, o la, joginda ischemique sinsinnan fana sen bɛ o la; MMP - 9 ni c - fos tun bɛ jigin ɲɛda ɲɛfɛla kɛrɛfɛ; Semax ka wale kɔrɔ, JNK baarakɛta fana jiginna nin farikolo yɔrɔ fila in na. Baarakɛcogo balili ni a seginni funu ni selilɛri saya taabolo la, o bɛ se ka kɛ sababu ye ka Semax ka farikolo lakanani nɔ bila sɛbɛnnikɛlan ni farikolojɔlifɛnw hakɛ ^la.

Degun jugumanw lajɔli

Dimi dɔgɔyali: 

Degun jugumanba misali la, Semax bɛ nɔ dɔ bila sosow ka kɛwalew ni u ka dimi dɔnni na. Senna-sɔgɔsɔgɔli degun min tɛ se ka bɔ waati ni waati ani ji nɛnɛba jagoya degun misaliw la, Semax ni opioid minɛbaga nalokɔni fila bɛɛ bɛ se ka dimimada min bɛ sɔrɔ degun fɛ (SIA) senna-sɔgɔli degun modɛli la min tɛ se ka boli, nka u tɛ nɔ bila dimi hakɛ la ji nɛnɛ fanga-ji-sɔgɔli degun misali ^la.

A tɛ nɔ bila kɛwale caman yeli la: 

Semax ni naloxone fila bɛɛ tɛ nɔ bila sosow ka kɛwalew la sanfɛ degun jugumanba misaliw la ^{[10] .}.

Ka hakilijagabɔ ni hakilijagabɔ kɛcogo ɲɛ: 

Semax bɛ se ka baganw ni hadamadenw ka baarakɛ hakili ni u hakili lawuli, ka dɔ fara oksizɛni dɔgɔyali kunbɛnni kan, ani ka kunsɛmɛ joli bolicogo ɲɛ. Semax bɛ mɔgɔ kɛnɛmanw hakilijagabɔ ni u ka jateminɛ kɛcogo ɲɛ kosɛbɛ farikoloɲɛnajɛ jugumanba la. Ka fara o kan, Semax kɛra ka ɲɛ sisan walasa ka banabagatɔw furakɛ minnu ka bana suguya wɛrɛw bɛ u farikolo cɛmancɛ la. A ka ca a la, nin pepitiri in bɛ nɔ ɲumanw jira ka sɔrɔ a ma kɔlɔlɔ juguw walima gɛlɛyaw lase a tali ma ^[11]..

Kuncɛli la, i n’a fɔ pepitiri sintetiki fɛnɲɛnamafagalan, Semax bɛ furakɛli nɔba jira sɔgɔsɔgɔninjɛ, sɔgɔsɔgɔninjɛ, degun jugumanba, ani hakiliɲagami siratigɛ la, fɛɛrɛ caman fɛ i n’a fɔ ka neurotrophines (i n’a fɔ BDNF) ani u minɛbagaw (TrkB) jiracogo ɲɛnabɔ, ka funu jaabi bali, ka oksidan degun kɛlɛ, ani ka farikolo tangacogo sɛgɛsɛgɛli kɛ. A bɛ se fana ka farikolojidɛsɛ furakɛcogo ɲɛ, ka dɔ bɔ hakili tiɲɛni na, ani ka hakilijagabɔ ni hakilijagabɔ sabati.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Sudarkina OY ye ɲininikɛla ye min ni jamana ka ɲininikɛyɔrɔ - Kurchatov ka lakɔliso ani Risi dɔnniyakalanso cɛsirilen don. A ka ɲininiw ɲɛsinnen bɛ dɔnniya caman ma, i n’a fɔ Biochemistry & Molecular Biology, Genetics & Heredity, ani Chemistry. A ye dɛmɛba don Biotechnologie, Molecular Breeding ani Molecular Plant Pathology baarabolow la. A ka baara ɲɛsinnen bɛ jamu fɛɛrɛw kalanni ma, molekiyɔmuw ka jɛɲɔgɔnyaw, ani biyokimiki taabolo minnu bɛ fɛnɲɛnamaw ka ko suguya caman sinsin. A ka ɲininiw sababu fɛ, a b’a ɲini k’an ka faamuyali yiriwa nin sigida gɛlɛn ninnu kan, ka fɛɛrɛ kuraw labɛn walasa ka baara kɛ ni u ye sɛnɛko, furakɛli ani izini wɛrɛw la. Sudarkina OY tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [4].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Medvedeva E. V., Dmitrieva V. G., Limborska S. A., ani a ɲɔgɔnnaw. Semax, min ye ACTH(4-7) ɲɔgɔnna ye, o bɛ farikolo tangalanw jiracogo ɲɛnabɔ sosow ka kunsɛmɛ joginni waati la[J]. Molekuli jenɛtiki ni jamu, 2017,292(3):635-653.DOI:10.1007/s00438-017-1297-1.

[2] Puspita R, Pratamasuti D, Safitri A, ani a ɲɔgɔnnaw. Semax Peptide furakɛli fanga ka ɲɛsin MDA hakɛ ma ani farikolojɔlifɛnw ma Epilepsie wuluw la (Rattus norvegicus), 2018[C]. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew

[3] Dergunova L. V., Dmitrieva V. G., Filippenkov I. B., ani mɔgɔ wɛrɛw. Peptide fura ACTH(4-7)PGP (Semax) bɛ mRNA sɛbɛnniw bali minnu bɛ proinflammatory mediators kodeli kɛ minnu bɛ sɔrɔ sosow ka kunsɛmɛ ischemie reversible fɛ[J]. Biologie moléculaire, 2021,55(3):346-353.DOI:10.1134/S0026893321010040. Ɲɛgɛnɛsiraw ani mɔgɔ dogoyɔrɔw.

[4] Sudarkina O. Y., Filippenkov I. B., Stavchansky V. V., ani a ɲɔgɔnnaw. Sugunɛbilenni furakisɛw jiracogo ɲɛfɔli bɛ ACTH(4-7)PGP Peptide (Semax) ka lakanani nɔ jira, ka kɛɲɛ ni sosow ka misali ye, min bɛ kɛ ka ɲɛgɛnɛsiralabanaw (Serebral Ischemia-Reperfusion) kɛ[J]. Duniya kɔnɔ, 2021,22(12).DOI:10.3390/ijms22126179.

[5] Glazova N. Y., Manchenko D. M., Volodina M. A., ani a ɲɔgɔnnaw. Semax, min ye ACTH(4-10) analozi sintetiki ye, o bɛ kɛwalew ni hakiliɲagami caman yeli dɔgɔya fluvoxamine tali kɔfɛ soso finmanw na u ka ɲɛnamaya daminɛ na[J]. Neuropeptides, 2021,86.DOI:10.1016/j.npep.2020.102114. Ɲɛgɛnɛsiraw ani mɔgɔ dogoyɔrɔw.

[6] Hadarceva K, Belyaeva E. Semax-application prospect (kumasen surun cikan).[J]. Dɔgɔtɔrɔso furakɛli ni furakɛli, 2021.DOI:https://api.semanticscholar.org/CorpusID:245468513.

[7] Lebedeva I. S., Panikratova Y. R., Sokolov O. Y., ani mɔgɔ wɛrɛw. Semax nɔ minnu bɛ sɔrɔ Default Mode Network of the Brain kan[J]. Bulletin de biologie expérimentale et médecine, 2018,165(5):653-656.DOI:10.1007/s10517-018-4234-3.

[8] Boyarshinova O. S., Perepelkina O. V., Markina N. V., ani a ɲɔgɔnnaw. Odiogenic Epilepsy in soso denmisɛnninw na minnu suguya tɛ kelen ye den bangenenw ka semax furakɛli kɔfɛ[J]. Bulletin de biologie expérimentale et médecine, 2008,146(1):86-88.DOI:10.1007/s10517-008-0212-5.

[9] Puspita R. Semax ka ɲɛsin sɔgɔsɔgɔninjɛ furakɛli ma[M]. 2020.DOI:10.31219/osf.io/hcn3g, Bamako, Mali.

[10] Glazova NY, Manchenko D. M., Vilensky D. A., ani a ɲɔgɔnnaw. Semax nɔ minnu bɛ sɔrɔ degun jugumanba ka sosow ka misaliw la[J]. Biochimie et physiologie évolutionnaire gafe, 2023,59(1):200-212.DOI:10.1134/S0022093023010179.

[11] Ashmarin I. P., Nezavibatko V. N., Myasoedov N. F., ani a ɲɔgɔnnaw. Adrénocorticotropin 4-10-semax analogue nootropic (a dilanni ni sɛgɛsɛgɛli kɛcogo san 15 kɔnɔ)[J]. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I. P. Pavlova, 1997,47(2):420-430. https://pubmed.ncbi.nlm.nih.gov/9173745/ Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.