Tesamoreli,Ipamorelini 5/5(Blend) Bamako, Mali.

▎ Ipamɔrilini (Ipamorelin) ye

I n’a fɔ pentapɛtidi fɛnɲɛnamafagalan dilannen, Ipamɔrilini, n’o ye bonya hormone secretagogue denbaya kɔnɔmɔgɔ nafama ye, o bɛ se ka bonya hormone bɔli yɔrɔ labɛnni tigitigi sɔrɔ a ka molekiyɔmu jɔcogo kɛrɛnkɛrɛnnen sababu fɛ. Nin fɛnɲɛnamafagalan in bɛ siri ni ɲɔgɔndɛmɛba ye ni bonyali hormone secretagogue receptor (GHS-R) ye, ka jiginɛ taamasiɲɛw sira baara, ka bonya hormone (GH) bɔli daminɛ ni wulikan ye ka ɲɛ, ani ka waati kelen na, a bɛ inisɔndiya-like growth factor-1 (IGF-1) ka jeninida jirali ni farikolojɔlifɛnw dilanni sabati. Nin walekɛcogo fila in tɛ fanga sukarodunbana taabolo ɲɛnabɔ dɔrɔn (o la, asidi aminikiw tali sabatili, farikolojɔlifɛnw sɔrɔli teliya, ani tulumafɛnw sɛnɛcogo ɲuman) nka a bɛ jɔyɔrɔ ɲuman fana ta ɲɛnabɔli la farikolo yɔrɔw dilancogo n’u bonya la, a kɛtɔ ka selilɛriw caya taamasiɲɛ bonya.

Kɛnɛyaso ka sɛgɛsɛgɛliw la, Ipamorelin ye a jira ko a bɛ se ka kɛ sababu ye ka sigida caman ɲɛnabɔ. A nɔ min bɛ kɔnɔbara lamagacogo ɲɛ, o bɛ ye ni kɔnɔbara lankolonya teliya ye. Kɛrɛnkɛrɛnnenya la opereli kɔfɛ ileus cogoya la, ni a bɛ kɔnɔbara basigilenw ka peristaltic frequency (peristaltic frequency) ni u ka sɔgɔsɔgɔli fanga sabati, a bɛ banakɔtaa motɛri baarakɛbaliya lajɔ kosɛbɛ. Dimi madali siratigɛ la, nin furakisɛ in bɛ dimi taamasiɲɛw cili ɲɛnabɔ cɛmancɛ ni a lamini siraw fɛ ani ka lajɔli nɔba jira kɔnɔbara dimi na min tɛ funu ye ani farikolo dimi. A kɛcogo bɛ se ka kɛ opioïde pepitiri sitɛmu kɔnɔnatumu baarakɛli ye ani ion kanal baarakɛcogo labɛnni ye.

Ni an y’a suma ni laadala bonya hormone secretagogues ye, Ipamorelin nafaba bɛ sɔrɔ a ka sugandili caman na ka ɲɛsin growth hormone bɔli ma. Hali ni a bɛ GH bɔli lawuli ka ɲɛ, nin furakisɛ in tɛ nɔba bila pituitaire-adrénale axis hormones wɛrɛw bɔli la i n’a fɔ adrénocorticotrope hormone (ACTH) ani cortisol, o la, a bɛ dɔ bɔ kɔlɔlɔw la minnu bɛ sɔrɔ ɔrimɔni banaw fɛ. Nin furakɛlicogo in b’a to a bɛ se ka sen don tigitigi bonya hormone dɛsɛ furakɛli nɔ na, ​​wa o waati kelen na, a bɛ fura laɲini kura di ɲininiw ma minnu bɛ kɛ kɔnɔbara basigilenw banakisɛw sɔrɔcogo kan ani dimi sɛgɛsɛgɛli ni furakɛli porogaramuw ɲɛnabɔli.

▎ Kuma surun

1. Bonya hormone (banakisɛfagalanw) labɛnni

Sinerji ka fɛɛrɛ:

Tesamoreli bɛ bonya hormone (GH) bɔli lawuli ka bɔ ɲɛgɛnɛsira ɲɛfɛla la ni a bɛ bonya hormone-releasing hormone (GHRH) minɛbaga baara, ka sɔrɔ Ipamorelin bɛ GH bɔli wuli ni wulikan ye ni a bɛ bonya hormone secretagogue receptor (GHSR) baara ka sugandi.

Ni u fila faralen don ɲɔgɔn kan, u bɛ se ka GH bɔli bonya ka bɔ sira wɛrɛw la, ka kɛ sababu ye ka jɛɲɔgɔnya kɛ, o la, ka dɔ fara GH hakɛ kan kosɛbɛ farikolo la.

GH bɔli balansi ni a kɔlɔsili:

Ipamorelini bɛ a yɛrɛ tanga GH lawulili kojugu farati ma ni a bɛ GH bɔli kɛcogo ladege, ka sɔrɔ Tesamoreli bɛ basigi sabatilen di GH bɔli ma GHRH sira fɛ. O baara faralen ɲɔgɔn kan, o bɛ se ka GH hakɛ mara ka sɔrɔ a bɔli ka fɔcogo n’a balansi sabatili.

2. Fɛnɲɛnɛmafagalanw ka ɲɛtaa

Sukarodunbana min bɛ sɔrɔ tulumafɛnw na:

Tesamoreli bɛ farikolo tulu dɔgɔya ni a bɛ tulumafɛnw tiɲɛni caya ani ka tulumafɛnw sukarodunbana ɲɛ, ka sɔrɔ Ipamorelini bɛ tulumafɛnw teliya ka taa a fɛ ni asidi fatɔw ka oksidan sɔrɔli ye. Ni u fila faralen don ɲɔgɔn kan, u bɛ se ka sukarodunbana kɛ ka ɲɛ, ka tulu dalajɛli dɔgɔya min bɛ sɔrɔ kɔrɔya fɛ, ani ka inisɔndiya kɛcogo ɲɛ.

Sukarodunbana min bɛ sɔrɔ sukaro la:

Tesamoreli bɛ farikolojɔli banaw farati dɔgɔya ni a bɛ sukaro tali kɛcogo ɲɛ, ka sɔrɔ Ipamorelini bɛ farikolo yɔrɔw lakana ani ka fanga bɔnɛ bali a ka kataboliki kɛlɛli fanga fɛ.

Nin jɛɲɔgɔnya nɔ in bɛ dɛmɛ ka farikoloɲɛnajɛ balansi sabati ani ka kɔrɔya kɛnɛman dɛmɛ.

3. Tissue dɛmɛni ni a dilancogo

Protéines synthèse et cellules kurayali:

Tesamoreli bɛ farikolo yɔrɔw dilancogo ni u lasegincogo sabati ni a bɛ farikolojɔli dumuniw dilanni ni farikolokisɛw kurayali lawuli, ka sɔrɔ Ipamorelini bɛ farikolo yɔrɔw tiɲɛni bali ni a bɛ farikolo yɔrɔw lakana minnu bɛ yen. Ni u fila faralen don ɲɔgɔn kan, u bɛ se ka farikolo yɔrɔw dɛmɛ kosɛbɛ, o fila bɛɛ bɛ farikolo yɔrɔ tiɲɛnenw dilancogo sabati ani ka farikolo yɔrɔ minnu bɛ yen, olu lakana walasa u kana tiɲɛ.

Kɔrɔya kɛlɛli nɔ:

GH hakɛ cayalenba ni kɔrɔya kɛlɛli nɔ bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Tesamoreli ni Ipamorelin tali faralen ɲɔgɔn kan, o bɛ se ka farikolokisɛw kɔrɔya bila kɔfɛ, ka fari lamagacogo ɲɛ, ka kurukuruw dɔgɔya, ka kolo kɛnɛya sabati.

4. Kɔrɔya kɛlɛli ni hakililata nafaw

Hakilila lakanani ani hakililabaara:

GH jɔyɔrɔ ka bon hakili baara la ani hakili lakanani na. Nin pepitiri fila ninnu tali faralen ɲɔgɔn kan, o bɛ se ka hakili baara ɲɛ ani ka dɔ bɔ hakililata dɔgɔyali la min bɛ tali kɛ si hakɛ la, ni GH hakɛ labɛnni ye.

Sistɛmu ka seko ni dɔnko:

Ni GH bɔli bɛ bɛn ɲɔgɔn ma ani ka sukarodunbana furakɛ ka ɲɛ, a tali faralen ɲɔgɔn kan, o bɛ se ka farikolo ka seko ni dɔnko sabati sigida la ani ka kɛnɛya ni baarakɛcogo kuntaalajan dɛmɛ.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

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Fɛn minnu olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.