Kolotugudaw ye kolotugudaw kɛnɛya kunba ye. A bɛ kolotugudaw sɔgɔ ani ka u sɛgɛn bali. Nka a seko danma bɛ a la ka segin a cogo kɔrɔ la.Pepitiri minnu bɛ kolotugudaw kɛrɛnkɛrɛnnenw na, olu bɛ kolotugudaw laɲini, o bɛ dɛmɛ don ka kolotugudaw dilan ani ka a lasegin. U bɛ layidu ta jɛ-ka-baara kɛnɛyako la.
Nin barokun in kɔnɔ, an bɛna o kow sɛgɛsɛgɛ cogo min na pepitiriw bɛ baara kɛ ani u nafa. Aw ye a dɔn u bɛ dɛmɛ don cogo min na kolotugudaw furakɛli la ani ka taama ɲɛ.Aw ye kunnafoni caman sɔrɔ an ka furaw kan Cocer Peptides la ani u bɛ kolotugudaw kɛnɛya dɛmɛ cogo min na.
Cartilage peptides ye asidi aminiki cakɛda surunw ye minnu bɛ kɛ biyoregulateurs ye cartilage cellules la. U bɛ bɔ pepitiriw la minnu bɛ sɔrɔ u yɛrɛ la, wa u dabɔra ka kolotugudaw labɛn kokura ani ka u dilan. O pepitiriw bɛ ɲɔgɔn sɔrɔ ni kondrositɛriw ye, olu minnu bɛ kɛ sababu ye ka kolotugudaw dafalen mara. Pepitidi minnu bɛ kɛ ni kolotugudaw ye, olu bɛ selilɛriw ka ɲɛnamaya sabati, ka kolajɛni sɔrɔli sabati, ani ka dɛmɛ don farikolo kɔkanna matirili (ECM) labɛnni na min bɛ kolotugudaw di a jɔcogo ma.
Pepitiri suguya caman bɛ yen minnu bɛ kɛ ni kolotugudaw kɛrɛnkɛrɛnnenw ye, u kelen-kelen bɛɛ ka jogo ni u kɛcogo tɛ kelen ye. Pepitiri minnu bɛ kɛ ka caya kolotugudaw labɛnni na, olu dɔw ye Cartalax, BPC-157 ani TB-500 ye. O pepitiriw tɛ kelen ye u ka asidi aminiki hakɛ la ani u nɔfɛkow la kolotugudaw la. Misali la, karitalasi dilannen don kɛrɛnkɛrɛnnenya la walasa ka kolotugudaw laɲini, k’a sɔrɔ BPC-157 bɛ se ka fɛnw lasegin u cogo kɔrɔ la, minnu bɛ taa fo senkɔniw, sɔgɔsɔgɔninjɛw ani farikolo yɔrɔw la ka fara kolotugudaw kan.
Pepitiridi (péptide). |
Laɲini Tissue (Tissue) ye |
Nafa jɔnjɔnw |
A kɛcogo furakɛli la |
Cartalax (Kɔrɔtalan) ye |
Cartilage (Kɔnɔbara) (cartilage). |
A bɛ kolajɛ kɛcogo ɲɛ, a bɛ kondrositɛriw ka baara sabati |
Kolotugudaw, kolotugudaw tiɲɛni |
BPC-157 ye |
Kartilage, Tendons, Ligaments (Kɔnɔbara) |
A bɛ farikolo yɔrɔw labɛncogo kura sabati, ka funu dɔgɔya |
Jogindaw joginniw, senkɔniw dilancogo |
TB-500 ye |
Cartilage, Fasa |
A bɛ funu dɔgɔya, a bɛ kɛnɛyali teliya |
Farikolo kɛnɛyali, kolotugudaw seginni |
Pepitiriw ka baara kɛcogo fɔlɔ ye u ka se ka don kondrositɛriw ka selilɛri kɔnɔ ani ka nɔ bila jeninida jirali la. Ni o pepitiriw bɛ jɛnɛya kɛrɛnkɛrɛnnenw ka baara sɛmɛntiya, u bɛ se ka kolajɛ ni protéoglycan (poroteyogilikan) sɔrɔli sabati, olu minnu ye kolotuguda matirizi yɔrɔ nafama fila ye. U bɛ anzimuw fana labɛn minnu bɛ matiriyali tiɲɛ, o b’a to balansi bɛ to kolotugudaw tiɲɛni ni a lasegincogo cɛ. Ka fara o kan, kolotugudaw pepitiriw bɛ dɛmɛ ka funu ni oksidan degun dɔgɔya, olu minnu ye kolotugudaw tiɲɛni sababuba ye.
Kɔndrositɛriw ye farikolokisɛ fɔlɔw ye minnu bɛ kolotugudaw jɔcogo sabati. U bɛ selilu kɔkanna matirili (matrix extracellular matrix) Bɔ, o min bɛ farikolo yɔrɔ in fanga ni a ka sɔgɔsɔgɔninjɛ Di. Pepitiriw minnu bɛ kolotugudaw la, olu bɛ dɛmɛ don ka kolosinsinnanw ka baara dɛmɛ ni u bɛ kolajɛ ni protéoglycanw dilanni lawuli, olu minnu nafa ka bon kosɛbɛ kolotugudaw dilancogo la. U bɛ kondrositɛri apoptose (selilu saya) fana bali, o b’a to kolotugudaw bɛ balo ani ka to baara la farikolo yɔrɔw dilancogo ni u lasegin waati.
Kolajeni ye farikolojɔlifɛn nafamaba ye min bɛ farikolojɔli ni fanga di kolotugudaw ma. Kɔnɔbara pepitiriw, i n’a fɔ Cartalax, olu bɛ kolajɛ fiyɛw sɔrɔli sabati kolotuguda matirili kɔnɔ, o bɛ a to farikolo yɔrɔ barika ka to ani ka baara kɛ. O nafa ka bon kɛrɛnkɛrɛnnenya la kolotugudaw walima kolotugudaw tiɲɛni bɛ mɔgɔ minnu na, barisa kolotugudaw la kolajɛni fiyɛw bɛ barika dɔgɔya ani u tɛ baara kɛ kosɛbɛ waati tɛmɛnen kɔfɛ.
Extracellular matrix (ECM) ye farikolojɔlifɛnw ka rezo gɛlɛn ye, kolajɛ ni protéoglycans fana bɛ minnu na, minnu bɛ kolotugudaw jɔcogo dɛmɛ. Cartilage peptides bɛ dɛmɛ ka ECM yɔrɔw jiginni labɛn, o b’a to balansi bɛ to matiriyali sintezi ni tiɲɛni cɛ. Nin sariya in nafa ka bon kosɛbɛ walasa ka kolotugudaw tiɲɛ kojugu, o min bɛ na ni kolotugudaw dimi ni baarakɛbaliya ye. Ni ECM seginni sabatili ye, kolotugudaw pepitiriw bɛ kolotugudaw ka kɛnɛya ni u dafalen dɛmɛ waatijan kɔnɔ.
Kolotugudaw (OA) ye kolotugudaw bana ye min ka ca ni tɔw bɛɛ ye, a bɛ mɔgɔ miliyɔn caman minɛ diɲɛ kɔnɔ. A bɛ kɛ ni kolotugudaw ka kolotugudaw tiɲɛna, o bɛ na ni dimi ye, ka gɛlɛya, ani ka dɔ bɔ a lamagacogo la. OA bɛ sɔrɔ fɔlɔ balanbaliya fɛ kolotugudaw tiɲɛni ni a dilancogo cɛ, o bɛ juguya ni mɔgɔ kɔrɔbayara ani ni masinw ka degun ye. Kɔnɔbara pepitiriw i n’a fɔ Cartalax ye layidu belebele jira ka ɲɛsin kolotugudaw tiɲɛni sumaya ma walima hali k’a kɔsegin OA banabagatɔw la.
Ni kolotugudaw lasegincogo ni kolajɛni sɔrɔli lawuli, kolotuguda pepitiriw bɛ dɛmɛ don ka kolotuguda min tununna kolotugudaw la kolotugudaw la, o lasegin a cogo kɔrɔ la. Kɛrɛnkɛrɛnnenya la, a jirala ko karɔti bɛ se ka poroteyogilikanw ni kolajɛni sɔrɔli ɲɛ, olu minnu ye kolotuguda yɔrɔ nafama fila ye. O bɛ farikolo yɔrɔw dilancogo sabati ani ka dɛmɛ don ka OA taabolo sumaya ni a bɛ kolotugudaw jɔcogo dafalen mara. Ka fara o kan, kolotugudaw pepitiriw bɛ dɛmɛ ka funu dɔgɔya, o min ye sababuba ye ka OA ka taa ɲɛ.
Pepitiri minnu bɛ kolotugudaw la, olu tɛ se ka farikolo yɔrɔw labɛn kokura dɔrɔn, nka u bɛ dimi nɔgɔya fana ani ka kolotugudaw lamagacogo ɲɛ. U bɛ dɔ bɔ funubana sitokiniw bɔli la ani ka kolotugudaw tiɲɛni bali, o bɛ dɔ bɔ kolotugudaw dimi ni funu na. O nafa ka bon kɛrɛnkɛrɛnnenya la mɔgɔ kelen-kelen bɛɛ ma minnu bɛ OA la, barisa a bɛ u ka ɲɛnamaya kɛcogo ɲɛ, a kɛtɔ k’u bila ka taa u yɛrɛ ma dimi tɛ minnu na.
Pepitiridi (péptide). |
A bɛ nɔ bila Cartilage la |
A bɛ se ka kɛ kolotugudaw la |
Nafa wɛrɛw bɛ sɔrɔ a la |
Cartalax (Kɔrɔtalan) ye |
A bɛ kolajɛ bɔli lawuli, ka matiriyali seginni ɲɛ |
A bɛ OA taabolo sumaya, ka dimi ni funu dɔgɔya |
A bɛ kolotugudaw lamagacogo ɲɛ, a bɛ kolotugudaw lakana |
BPC-157 ye |
A bɛ farikolo yɔrɔw dilancogo ɲɛ ani ka kolajɛ tiɲɛni dɔgɔya |
A bɛ kɛnɛya sabati OA daminɛ na |
A bɛ funu kɛlɛ, a bɛ opereli kɔfɛ kɛnɛya sabatili dɛmɛ |
TB-500 ye |
A bɛ kolotugudaw kɛnɛyali sabati ani ka fiɲɛ bilali dɔgɔya |
A bɛ dɛmɛ ka kolotugudaw tiɲɛni wɛrɛw bali |
A bɛ farikolo yɔrɔw labɛncogo kura ni u kɛnɛyali teliya |
Jogindaw, i n’a fɔ kirinni, kirinni, ani kolotugudaw ɲɛji bɛ se ka kɛ dimi ni baarakɛbaliya ye min bɛ mɛn sen na ni u ma furakɛ ka ɲɛ. Kolotuguda pepitiriw, i n’a fɔ Cartalax, olu bɛ se ka dɛmɛ don ka kɛnɛya ni ka segin a cogo kɔrɔ la kolotuguda min bananen don. Ni o pepitiriw bɛ kolosinsinnanw ka baara ni kolajɛni sɔrɔli lawuli, u bɛ farikolo yɔrɔw dilan teliya, ka funu dɔgɔya, ka kolotugudaw baara kokura. Baganw ka misaliw la, kolotuguda pepitiriw y’a jira ko u bɛ se ka kɛnɛya teliya kolotuguda jogin kɔfɛ.
Pepitiriw minnu bɛ kolotugudaw la, olu tɛ farikolo yɔrɔ tiɲɛnenw dilan dɔrɔn, nka u bɛ kolotuguda kura kɛnɛmanw fana dɛmɛ. U bɛ kondrositɛriw falenni ni u caya lawuli, ka dilancogo bɛɛ lajɛlen ɲɛ. O nafa ka bon kosɛbɛ mɔgɔ kelen-kelen bɛɛ ma minnu bɛ kɛnɛya ka bɔ kolotugudaw joginw na, barisa o bɛ a to farikolo yɔrɔ ka kɛnɛya joona ani ka ɲɛ, o bɛ dɔ bɔ kɛnɛya waati la.
Ni joginda caya kojugu kolotugudaw jogin kɔfɛ, o bɛ se ka kolotugudaw baara tiɲɛ ani ka dimi bila mɔgɔ la waati jan kɔnɔ. Cartilage peptides bɛ fibroblaste baara ɲɛnabɔ, ka kolajɛ ni sɔgɔsɔgɔninjɛ yɔrɔ wɛrɛw bali ka caya kojugu. O bɛ a to kolotugudaw ka kɛnɛya ka ɲɛ ka sɔrɔ a ma kɛ ni jolida tɛmɛnenw ye, o bɛ se ka kolotugudaw lamagacogo ni u ka wulicogo tiɲɛ.
Ni an bɛ kɔrɔbaya, an kolotugudaw kɔnɔ kolotugudaw tɛ se ka muɲu kosɛbɛ, wa a ka teli ka tiɲɛ. O bɛ na ni kolotugudaw dimi ye, ka u gɛlɛya, ani ka dɔ bɔ u lamagacogo la, kɛrɛnkɛrɛnnenya la kolotugudaw la minnu bɛ girinya ta i n’a fɔ gɛnɛgɛnɛw, kɔkiliw ani kɔkolo. Kɔnɔbara pepitiriw bɛ dɛmɛ ka kolotugudaw sɛgɛnni sumaya min bɛ sɔrɔ kɔrɔya fɛ, u kɛtɔ ka kolajɛ bɔli lawuli, ka oksidan degun dɔgɔya, ani ka kolotugudaw labɛn kokura.
Kɔnɔbara pepitiriw, i n’a fɔ Cartalax, olu bɛ kolotugudaw lasegincogo dɛmɛ, o bɛ dɛmɛ don ka kolotugudaw tiɲɛni bali min bɛ kɛ ni kɔrɔya ye. U bɛ farikolo kɔkanna matiriyali jɔcogo dafalen mara ani ka a to kolotuguda ka to baara la, hali mɔgɔkɔrɔbaw la. O nafa ka bon kosɛbɛ kolotugudaw ka kɛnɛya sabatili la ani ka taa-ka-segin kɛ ni an bɛ kɔrɔbaya.
Cartilage peptides bɛ ni geroprotective property ye, o kɔrɔ ye ko u bɛ dɛmɛ ka cartilage cellules lakana ka bɔ kɔrɔya nɔw na. U bɛ kondrositɛriw ka seko segin u cogo kɔrɔ la, ka selilɛriw ka ɲɛnamaya sabati ani ka farikolo yɔrɔw dilancogo ɲɛ. O bɛ dɛmɛ ka kolotugudaw kɔrɔyacogo dafalen sumaya, ka kolotugudaw kɛnɛya sabati ka mɛn.
A ka ca a la farikoloɲɛnajɛlamɔgɔw bɛ joginw sɔrɔ kolotugudaw la minnu bɛ se ka kolotugudaw tiɲɛ. Cartilage peptides, i n’a fɔ Cartalax, nafa ka bon kɛrɛnkɛrɛnnenya la farikoloɲɛnajɛla minnu ka kan ka kɛnɛya joona ani ka baara kɛcogo ɲuman sabati. O pepitiriw bɛ farikolo yɔrɔw dilancogo ni u lasegincogo teliya, o bɛ farikoloɲɛnajɛlamɔgɔw dɛmɛ u ka kɛnɛya ka bɔ kolotugudaw joginw na ani ka segin u ka farikoloɲɛnajɛw la joona.
Pepitidi minnu bɛ kɛ ni kolotugudaw ye, olu tɛ kɛnɛya dɔrɔn dɛmɛ, nka u bɛ kɛ farikoloɲɛnajɛla fana kunbɛncogo ye. Ni o pepitiriw bɛ kolotugudaw kɛnɛman mara ani k’a lasegin a cogo kɔrɔ la, o bɛ dɛmɛ ka dɔ bɔ joginw na minnu bɛ kɛ sababu ye ka kolotugudaw tiɲɛ. O nafa ka bon kɛrɛnkɛrɛnnenya la farikoloɲɛnajɛla minnu bɛ degunba don u kolotugudaw la degeliw ni ɲɔgɔndan waatiw la.
Pepitiri minnu bɛ kolotugudaw la, olu bɛ se ka kolotugudaw baara ɲɛ farikoloɲɛnajɛ gɛlɛn kɔfɛ, u kɛtɔ ka funu dɔgɔya, ka kolotugudaw tanga kolotugudaw sɛgɛnni ma, ani ka kɛnɛya sabati. O bɛ farikoloɲɛnajɛlamɔgɔw dɛmɛ u ka seko ni dɔnko hakɛ mara ka sɔrɔ ka kolotugudaw tiɲɛni kuntaalajan farati dɔgɔya.
Waleyali |
Nafa min bɛ sɔrɔ Cartilage Peptides la |
Misali la, Peptides (Péptides) minnu bɛ kɛ |
Jogin kɔfɛ kɛnɛyako |
A bɛ farikolo yɔrɔw dilan teliya, ka kolotugudaw baara lasegin |
Cartalax, BPC-157 (BPC-157) ye |
Kɔnɔbara tiɲɛni kunbɛnni |
A bɛ kolotugudaw kɛnɛya sabati, a bɛ dɔ bɔ joginni farati la |
Cartalax, TB-500 ye, o ye TB-500 ye |
Ɲɛtaa sɔrɔli jɛkuluw ka taamacogo la |
A bɛ funu dɔgɔya, a bɛ kɛnɛya sabati |
Cartalax, BPC-157 (BPC-157) ye |
Sɛgɛsɛgɛli minnu kɛra baganw ka misaliw kan, olu ye ɲɛtaa ɲuman jira ka ɲɛsin kolotugudaw pepitiriw ma. Nin ɲinini ninnu y’a jira ko kolotugudaw seginni ka ɲɛ, ka funu dɔgɔya, ani ka kolotugudaw baara caya, o b’a jira ko kolotugudaw pepitiriw bɛ se ka kɛ kolotugudaw banaw furakɛcogo ɲuman ye i n’a fɔ kolotugudaw.
Kɛnɛyaso sɛgɛsɛgɛliw bɛ senna walasa ka kolotugudaw pepitiriw nɔw sɛgɛsɛgɛ hadamaden banabagatɔw la. Kalan fɔlɔw y’a jira ko ɲɛtaa kɛra kolotugudaw lamagacogo la, dimi dɔgɔyali la, ani kolotugudaw seginni na. Nin kɔrɔbɔli ninnu nafa ka bon walasa ka kolotugudaw pepitiriw lakanani ni u nafa dɔn waatijan kɔnɔ hadamadenw na.
Pepitiliw ka siniɲɛsigi bɛ i n’a fɔ layidu talen don, ɲininiw ni kɛnɛyaso sɛgɛsɛgɛliw minnu bɛ senna, olu b’a jira k’u bɛ se ka kɛ fura ye min bɛ se ka fɛn caman sɛmɛntiya kolotugudaw tiɲɛni na. Ni dalilu caman bɛ ka bɔ kɛnɛ kan, kolotugudaw pepitiriw bɛ se ka kɛ furakɛlicogo jɔnjɔn ye furakɛli la min bɛ mɔgɔ lasegin farikolo la ani baarakɛminɛn jɔnjɔn ye kolotugudaw kɛnɛyako ɲɛnabɔli la.
Kolotuguda pepitiriw, i n’a fɔ Cartalax, olu ye fura ye min bɛ layidu ta walasa ka kolotugudaw kɛnɛya segin a cogo kɔrɔ la ani ka kolotugudaw tiɲɛni bali. O pepitiriw bɛ kolotugudaw labɛn kokura, ka funu dɔgɔya, ka kolajɛni sɔrɔli sabati. U nafa ka bon kolotugudaw kɛnɛyali la, kɔrɔya kunbɛnni na, ani joginni kɔfɛ kɛnɛyali la. Ni ɲininiw bɛ ka taa ɲɛ, kolotugudaw pepitiriw bɛ se ka kɛ kolotugudaw furakɛli jɔnjɔn ye ani fura minnu bɛ mɔgɔ lasegin u cogo kɔrɔ la.
Fɛ Cocer Peptides , an bɛ fɛnw dilan minnu bɛ kolotugudaw kɛnɛya sabati ani ka kolotugudaw baara kuntaalajan ɲɛ, ka taamacogo ɲuman ni kɛnɛya sabati.
A: Kɔnɔbara pepitiriw, i n’a fɔ Cartalax, olu ye asidi aminiki cakɛda surunw ye minnu bɛ kolotugudaw seliluw laɲini. U bɛ segin-ka-bɔnye sabati, ka funu dɔgɔya, ka kolajɛni sɔrɔli dɛmɛ walasa ka kolotugudaw kɛnɛya sabati.
A: Kolotugudaw pepitiriw bɛ dɛmɛ ni kolotugudaw labɛnni ye, ka funu dɔgɔya, ani ka kolotugudaw taabolo sumaya, o bɛ kolotugudaw baara ɲɛ ani ka dimi dɔgɔya.
A: Ɔwɔ, kolotugudaw pepitiriw bɛ farikolo yɔrɔw dilan teliya, ka kolajɛni sɔrɔli sabati, ani ka kolotugudaw lamagacogo segin, o b’a to u bɛ se ka kɛnɛya jogin kɔfɛ.
A: Kɔrɔya pepitiriw bɛ kolotugudaw tiɲɛni sumaya min bɛ sɔrɔ kɔrɔya fɛ, u kɛtɔ ka kolotugudaw labɛn kokura, ka kolotugudaw baara lakana, ani ka fɛn caman sɛgɛsɛgɛ, o la, u bɛ kɔrɔya kɛnɛman dɛmɛ.
