Chonluten bɛ mun kɛ?

Konlutɛni ye jateminɛ sɔrɔ ka taa a fɛ i n’a fɔ ninakilila biyoregulatɛri pepitiri barikama —nka tigitigi , a bɛ baara kɛ cogo di, ani jɔn bɛ se ka nafa sɔrɔ a la? a bɛ mun kɛ

Nin gafe in kɔnɔ, aw ka kan ka fɛn o fɛn dɔn Chonluten kan, o bɛɛ ɲɛfɔ, i n’a fɔ a kɛcogo, a nafa, a dɔnniya sɔrɔcogo, a tata hakɛ kɛcogo, ani a kɛcogo bi kɛnɛyako ni ɲininiw na.

I mana kɛ Chonluten ɲinini na ninakili dɛmɛni , funu dɔgɔyali , dumunikɛcogo kɛnɛya , walima kɔrɔya kɛlɛli kunw , nin barokun bɛ ja dafalen di.

Chonluten ye mun ye?

Kɔnlutɛni ye tripeptide sintetiki surun ye min dilannen don ni:

• Asidi glutamiki (Glu) .

• Asidi aspartitiki (Asp) .

• Glycine (Glycine) (Glycine) .

Tuma caman na, a bɛ fɔ a ma ko EDG tripeptide , a daminɛ na a tun bɛ bɔ fogonfogon (fogonfogon) farikolo la , wa a bɛ laɲini fɔlɔ:

• Ninakilidegecogo ​

• Fogonfogon ni fogonfogon ɲɛgɛnɛsira

• Kɔnɔbara basigilen

Kɔnlutɛni bɛ don kulu kɔnɔ pepitiri biyoregulatɛriw —amino-asidi surunw sigiyɔrɔma minnu bɛ se ka kɛ sababu ye ka selilɛriw ka baara dɛmɛ, ka farikolo yɔrɔw labɛn kokura, ka jeninida labɛn ani ka funu balansi.

A tɛ ɔrimɔni ye , a bɛ baara kɛ joona, wa a bɛ ɲɛnamaya kɛcogo dafalenw dɛmɛ sanni ka fɛn dilannenw wajibiya.

Chonluten bɛ mun kɛ farikolo la?

Chonluten nafa bɛ taa ninakili, dumunikɛcogo ani selilɛri kɛnɛya bɛɛ la. Pepitiri bɛ dɔn ni min ye, o filɛ nin ye:

1. Kɔnlutɛni bɛ fogonfogonw dilancogo dɛmɛ

Kɔnlutɛni bɛ dɛmɛ ka fogonfogon ni fogonfogonw ka ɲɛgɛnɛsira nɔgɔlenw segin u cogo kɔrɔ la ani k’u lakana.
Sɛgɛsɛgɛliw y’a jira ko a bɛ dɛmɛ don:

• Fogonfogonw lasegincogo kura

• Fogonfogonlabanaw dilancogo

• A kɛnɛyali funu walima sigida laminiko kɔfɛ

O b’a to a nafa ka bon mɔgɔ o mɔgɔ ma min bɛ ninakilidegun basigilen walima min bɛ segin-ka-bɔ.

2. A bɛ dɔ bɔ funu na ninakiliyɔrɔ la

Kɔnɔnatumuw ka misaliw la, a jirala ko pepitiri bɛ dɛmɛ ka funubana sitokiniw dɔgɔya i n’a fɔ TNF-α ani IL-6 , o bɛ dɛmɛ ka fogonfogon diminnenw lafiya.

O bɛ se ka kɛ sababu ye ka:

• Fiɲɛbɔyɔrɔw ka dimi ka dɔgɔn

• Ninakilicogo ɲuman

• Taamasiɲɛw dɔgɔyali fiɲɛbana waati

3. Kɔnlutɛni bɛ ninakili lafiya ni fogonfogon baara ɲɛ

Baarakɛlaw ka teli ka ɲɛtaa dɔw fɔ i n’a fɔ:

• Ninakili ka nɔgɔn

• Fogonfogon seko ka bon

• A kɛnɛyali teliya la cɛsiri kɔfɛ

• Farikoloɲɛnajɛ muɲuni ka ɲɛ

Fɛnɲɛnɛmakɛlaw ni ninakilidegun bɛ mɔgɔ minnu na, olu ka teli ka nafa sɔrɔ.

4. A bɛ farikolo lafasali sabati sigida tiɲɛniw ma

Kɔnlutɛni bɛ fogonfogon dɛmɛ ka ɲɛsin ninnu ma:

• Fiɲɛ nɔgɔlenw

• Sisi

• Alɛrijini (alrégènes).

• Kemisɛnniw tali

• Oksidan degun

Ni a bɛ epiteliyali farikolo yɔrɔw barika bonya, a bɛ se ka ninakilicogo bɛɛ lajɛlen ɲɛ.

5. Chonluten bɛ dumunikɛcogo kɛnɛya dɛmɛ

Hali ni a lakodɔnnen don kosɛbɛ fogonfogon dɛmɛni na, Chonluten bɛ baara kɛ kɔnɔbara basigilen fana na , o b’a to a bɛ dɛmɛ don banaw la i n’a fɔ:

• Kɔnɔboli

• Kurukuruw (Ulcers).

• Dumunikɛcogo ŋɛɲɛ

A ka teli ka kɛ kɛnɛya waati la banakisɛfagalanw, chimiothérapie , walima dumuni jugu dunni kɔfɛ.

6. A bɛ selilɛriw ka ɲɛnamaya kuntaalajan & ɲɛnamaya jan sabati

Chonluten jate bɛ kɛ geroprotector ye , o kɔrɔ ye ko a bɛ kɔrɔya kɛnɛman dɛmɛ selilɛri ta fan fɛ.
A nɔ minnu bɛ sɔrɔ:

• jeninida ɲɛnabɔli

• balansi oksidantali

• farikolo yɔrɔw dafalenya

k’a kɛ nafa ye kɔrɔya kɛlɛli kɛnɛya sabatili fɛɛrɛw la.

Chonluten bɛ baara kɛ cogo di? (Fɛɛrɛ minnu ɲɛfɔra)

Hali n’a y’a sɔrɔ ɲininiw bɛ senna, fɛɛrɛ damadɔw Sɔrɔla walima k’u Labɛn.

1. Jɛnɛya jiracogo sɛgɛsɛgɛli ('Promoteur Docking') .

Pepitiri surunw i n’a fɔ Chonluten bɛ se ka siri ADN promotɛri yɔrɔw la, ka jamu jiracogo Changer minnu sen bɛ ninnu na:

• funu kunbɛnni

• farikolo tangalanw ye minnu bɛ farikolo tanga

• selilɛriw dilancogo

O bɛ farikolo yɔrɔw dɛmɛ u ka balansi mara ani ka u yɛrɛ sɔrɔ degunw na.

2. Epijenitiki ni kolosinsinnanw ka jɛɲɔgɔnya

Kalan dɔw b’a jira ko Chonluten bɛ se ka dɛmɛ don:

• ADN metilasi cogoyaw

• Histone bεε bεε bε bεn

• Kromatini sɔrɔli

O epijenitiki nɔ ninnu bɛ se k’a nafa caman ɲɛfɔ sigida la.

3. Redox Modulation (Antioxydants dɛmɛni) .

Konlutɛni bɛ se ka farikolo tangalanw wuli ka taa a fɛ i n’a fɔ:

• Superoxide dismutase (SOD) ye .

• Glutathione siraw

O bɛ dɛmɛ ka oksidan tiɲɛni dɔgɔya fogonfogon ni kɔnɔbara la.

4. Funu–banakisɛw cayacogo ɲɛnabɔli

Ni a bɛ funu siraw sɛmɛntiya i n’a fɔ:

• NF-κB ye

• AP-1 ye

• MAPK (KARTA) ye

Kɔnlutɛni bɛ se ka farikolo yɔrɔw dɛmɛ u ka to cogo la min bɛ bɛn funu ni u dilancogo ma.

Chonluten bɛ se ka dɛmɛ don bana jumɛnw na?

Kɔnlutɛni bɛ kɛ ninakili ni dumunikɛcogo caman na. Aplikasi minnu kofɔlen bɛ
kɔnɔ article.txt olu dɔw ye:

• Fogonfogonlabana basigilen

• Fogonfogon funu

• Sɔgɔsɔgɔninjɛ min bɛ sɔrɔ fogonfogon la

• Tonsilɛti bana

• Fogonfogonlabana basigilen

• Ninakilidegun

• Kɔnɔbara basigilenw

• Kɔnɔnatumuw ka banaw

• A kɛnɛyali sɔgɔsɔgɔninjɛ kɔfɛ

• Fiɲɛbɔlan kuntaalajan dɛmɛni kɛnɛyali

• Ninakilidegun

• Fogonfogon la sɔgɔsɔgɔninjɛ (a bɛ yafa) .

• Disi joginni kɛnɛyali

• Fogonfogon joginw minnu bɛ sɔrɔ baga fɛ

• Sisi walima gazi monoksidi tali

• Farikoloɲɛnajɛ dege kosɛbɛ

Ikomi Chonluten bɛ baara kɛ funu, ɲɛgɛnɛsira dafalen, ani farikolo yɔrɔw dilancogo kan, a bɛ dɛmɛ don kɛnɛya suguya caman na.

Bi ɲininiw kɛcogo minnu bɛ kɛ ni Chonluten ye

Mɔgɔ yɛrɛ ka kɛnɛya kɔfɛ, Chonluten bɛ baara kɛ kosɛbɛ fana dɔnniya ɲininiw na.

1. Ninakilidegunw ka misali kɛcogo

• Fogonfogon la organoïdes

• Ninakilila epiteliyali cultures

• Mucus ni tight-junction proteines kalanni

2. Oksidan degun ani Redox Biologi

A bɛ kɛ ka farikolo tangalanw ka jɛnɛya baarakɛcogo sɛgɛsɛgɛ cogoyaw la i n’a fɔ:

• perokisidi idɔrɔzi (hydrogène peroxyde) sɔrɔli

• degun min bɛ i n’a fɔ nɔgɔ

• ROS-sɛnɛyɔrɔw

3. Funu sira sɛgɛsɛgɛli

Ɲininikalaw bɛ Chonluten don modeliw kɔnɔ minnu lawulilen don ni:

• TNF-α (TNF-α) ye

• IL-1β (IL-1β) ye

• LPS ye

walasa ka fɛn caman suman fɛn caman Changements dans la cascades inflammatoires.

4. Jɛnɛya sabatili sɛgɛsɛgɛli

Kɔnlutɛni bɛ kɛ tuma caman na kunnafonidilaw ka sɛgɛsɛgɛliw la walasa ka pepitiri jaabi jamu siraw dɔn.

5. Tissue (Tissue Engineering) ka baara

A ka seko ni dɔnko lasegincogo b’a to a bɛ tali kɛ ninnu na:

• fogonfogonw sɔgɔsɔgɔninjɛ

• ɲɛgɛnɛsiralabanaw (mucosal patches).

• fiɲɛbɔyɔrɔw dilancogo misaliw

Chonluten ka baara kɛcogo caman b’a kɛ biyokimiki baarakɛminɛn nafama ye.

Jɔn bɛ se ka nafa caman sɔrɔ Chonluten na?

Kandida ɲumanw ye mɔgɔw ye minnu bɛ:

• Aw bɛ ninakilidegun basigilen sɔrɔ

• Sɔgɔsɔgɔninjɛ, Ɲɛgɛnɛsiraw walima sɔgɔsɔgɔninjɛ bɛ a la

• Aw bɛ ka kɛnɛya ka bɔ sɔgɔsɔgɔninjɛ walima ninakilidegunw na

• Aw b’a fɛ ka fogonfogon kɛnɛya dɛmɛ ni u kɔrɔla

• U bɛ kɛ nɔgɔw walima sisi la

• Aw ye aw sen don muɲuli farikoloɲɛnajɛ gɛlɛnw na

• Aw mago bɛ dɛmɛ na kɔnɔbara basigilen kɛnɛyali la

Kɔnlutɛni fana bɛ mɔgɔ kelen-kelen bɛɛ ɲɛnajɛ minnu bɛ fɛɛrɛ ɲini min bɛ kɛ ni farikolo yɔrɔw dilancogo ye ani ka funu dɔgɔya.

Chonluten tacogo (A tata hakɛ ni a furakɛcogo) .

Kapisilɛri hakɛ (i n’a fɔ a sɛbɛnnen bɛ cogo min na article.txt kɔnɔ) .

• 1–2 furakisɛ , siɲɛ 1–2 tile kɔnɔ

• Aw bɛ ta sani aw ka dumuni kɛ miniti 30

• Kalansen: Kalo 1

• Aw bɛ segin o kan kalo 4–6 o kalo 4

Furakɛli kuntaalajan min bɛ kɛ kalo 1–3 kɔnɔ, o bɛ se ka fɔ ka kɛɲɛ ni bana taamasiɲɛw fanga ye.

Sɛgɛsɛgɛli dɔrɔn de bɛ kɛ peptide protocole (sɔgɔsɔgɔninjɛ) .

O dosiye in fana bɛ kalan kɛ fura tata hakɛ la pepitiri furaw labɛncogo kura kan—o nafa ka bon laboratuwari dɔrɔn sigidaw la.

O dɔw ye ninnu ye:

• mililitiri 3 bɛ kɛ ka a labɛn kokura

• ~6,67 mg/mL hakɛ

• A ka ca a la, a hakɛ bɛ se miligaramu 1000–4000 ma don o don
  (Sɛgɛsɛgɛli kɛcogo dɔrɔn—a tɛ kɛ dumuni dafalanw na.)

Yala Chonluten ye farati ye wa?

Lakanali Lajɛba

Konlutɛni bɛ jate:

• min tɛ baga ye

• min tɛ ɔrimɔni ye

• bɛ muɲu kosɛbɛ kalan minnu bɛ sɔrɔ

• min bɛ bɛn furakisɛ wɛrɛw ma walima fura wɛrɛw ma

Kɔnɔnatumuw kɔlɔlɔw

Kɔnɔnatumu nafama si ma fɔ kunnafonisɛbɛnw kɔnɔ.
I n’a fɔ a bɛ kɛ cogo min na fɛnɲɛnamafagalan suguya bɛɛ la, kɔlɔsili bɛ kɛ hali bi.

Bɛnbaliya

Kɔnlutɛni bɛ se ka fara ɲɔgɔn kan ni:

• furakisɛ minnu bɛ banakisɛw kɛlɛ

• ninakili dɛmɛni fɛɛrɛw

• laadala furakɛli fɛɛrɛw

A ka fɛɛrɛ nɔgɔlen bɛ sira Di bɛnkanba ma.

Ɲininkali minnu bɛ kɛ tuma caman na Chonluten kan

Chonluten bɛ waati joli ta ka baara kɛ?

Baarakɛla caman bɛ ɲɛtaa ye dɔgɔkun 2–4 kɔnɔ , ni a nɔ jugumanba bɛ sɔrɔ kalo 1–3 kɔnɔ.

Yala Chonluten ka ɲi sɔgɔsɔgɔninjɛ walima Ɲɛgɛnɛsiraw ma wa?

A bɛ se ka funu dɔgɔyali dɛmɛ ani ka ninakili lafiya, o b’a to a nafa ka bon ninakilidegun basigilenw na.

Yala Chonluten bɛ fogonfogonw ka baga bɔ wa?

A tɛ 'detox' kɛ laadala kɔrɔ la nka a bɛ ɲɛgɛnɛsira dilancogo ni selilɛriw ka se ka muɲu ɲɛ.

Yala Chonluten farati tɛ a tali la waati jan kɔnɔ wa?

Sikilila tali (kalo 1–3 kalansen kelen kɔnɔ) ka ca, wa a bɛ bɛn pepitiri ɲinini kɛcogo ma.

Yala farikoloɲɛnajɛla bɛ se ka nafa sɔrɔ Chonluten na wa?

Ɔwɔ—fogonfogon baarakɛcogo ɲuman ni ninakili kɛnɛya teliya ye farikoloɲɛnajɛla bɛ baara kɛ ni a ye kun dɔw ye.

Miirili labanw: Chonluten bɛ mun kɛ tiɲɛ na?

Kɔnlutɛni ye pepitiri biyoregulatɛri ye min bɛ se ka kɛ fɛn caman na, a bɛ dɛmɛ don:

• Fogonfogon yɔrɔw dilancogo

• Funu dɔgɔyali

• Ninakili dusu saalo

• Dumunikɛminɛnw kɛnɛya

• Selulɛriw ka se ka muɲu ani u si jan

A nafa caman bɛ bɔ a seko la ka fɛn caman sɛmɛntiya:

• jeninida jiracogo

• balansi oksidantali

• funu taamasiɲɛw

• farikolo yɔrɔw labɛnni kokura

A kɛra mɔgɔ yɛrɛ ka kɛnɛyako ye wo, a kɛra ɲinini ɲɛtaa kama wo, Chonluten bɛ bɔ kɛnɛ kan i n’a fɔ baarakɛminɛn barikama min bɛ ninakili ni selilɛri kɛnɛya dɛmɛ.