CJC1295,Ipa 5/5 (Tsatsaka) .

▎ Ipa ƒe nya

Ipa nye pentapeptide ƒe atike si wowɔ. Esi wònye tsitsime lãmetsiŋusẽ ƒe ʋuʋu ƒe ƒomea me tɔ vevi aɖe ta la, eƒe molecule ƒe wɔwɔme na ŋutetee be wòaɖɔ tsitsime lãmetsi ƒe ʋuʋu ƒe axis ɖo pɛpɛpɛ. Atike sia blana ɖe tsitsi ƒe lãmetsiŋusẽ ƒe ʋuʋu ƒe xɔla (GHS-R) ŋu le lɔlɔ̃ me vevie, si wɔnɛ be dzesimɔ si le anyime la wɔa dɔ, si wɔnɛ be tsitsi ƒe lãmetsi (GH) ƒe dodo le ʋuʋudedi me nyuie eye wòdoa domenyiŋusẽfianu ƒe ɖeɖefia kple protein ƒe wɔwɔme si le abe insulin-like growth factor-1 (IGF-1) ɖe ŋgɔ le ɣeyiɣi ɖeka me. Menye ɖeko dɔwɔwɔ ƒe mɔnu eve sia ɖɔa ŋusẽ ƒe asitɔtrɔ ƒe ɖoɖoa ɖo (siwo dometɔ aɖewoe nye amino acid ƒe xɔxlɔ̃ dodo ɖe ŋgɔ, protein ƒe wɔwɔ kabakaba, kple ami ƒe asitɔtrɔ nyuie wu), ke ewɔa ɖoɖo nyui aɖe hã le lãmenugbagbeviwo ɖɔɖɔɖo kple tsitsi me to lãmenugbagbeviwo ƒe dzidziɖedzi ƒe dzesi dodo ɖe ŋgɔ me.

Le dɔdamɔnu zazã ŋuti numekuku me la, Ipa ɖe ɖoɖo vovovowo ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi fia: eƒe ŋusẽkpɔɖeamedzi ɖe dɔgbo ƒe ʋuʋu ƒe nyonyo dzi dzena abe dɔgbo ƒe ƒuƒlu ƒe agbɔsɔsɔ si dzi ɖe edzi kabakaba ene. Vevietɔ le dɔléle ƒe nɔnɔme si me ileus le le dɔwɔwɔ vɔ megbe me la, ate ŋu aɖe dɔgboa ƒe ʋuʋu ƒe kuxiwo dzi akpɔtɔ nyuie to dɔgbo ƒe lãmeka siwo le gbadzaa ƒe peristaltic frequency kple contraction intensity dodo ɖe ŋgɔ me; le vevesese dzi kpɔkpɔ gome la, atike sia ɖɔa nociceptive signal ƒe kaka to titina kple gota mɔwo siaa dzi, si ɖea ŋusẽ gã aɖe si ɖea gbɔdzɔe fiana ɖe vevesese si menye dɔdzẽ o kple ŋutilã me vevesese dzi. Eƒe dɔwɔwɔ ƒe mɔnu ate ŋu anye endogenous opioid peptide system ƒe dɔwɔwɔ kple ion channel ƒe dɔwɔwɔ dzi kpɔkpɔ.

Ne wotsɔe sɔ kple tsitsime lãmetsiŋusẽ ƒe ʋuʋudedi siwo wozãna tsã la, viɖe vevi si le Ipa ŋue nye eƒe tiatiawɔwɔ gã na tsitsimeŋusẽ ƒe dodo - togbɔ be eʋãa GH ƒe dodo nyuie hã la, mekpɔa ŋusẽ gã aɖeke ɖe pituitary-adrenal axis lãmetsi bubuwo abe adrenocorticotropic hormone (ACTH) kple cortisol ƒe dodo dzi o, si wɔnɛ be wòɖea afɔku si le nu gbegblẽ siwo lãmetsiŋusẽ ƒe dɔlélewo hena vɛ ŋu dzi kpɔtɔna. Atikeŋutinunya ƒe nɔnɔme sia naa ŋutetee be wòade nu tsitsi ƒe lãmetsiŋusẽ ƒe anyimanɔmanɔ ƒe atikewɔwɔ teƒe pɛpɛpɛ me, eye le ɣeyiɣi ma ke me la, ena atike yeye si woatsɔ awɔ numekuku le dɔgbo ƒe ʋuʋu ƒe dɔlélewo ƒe dɔléle dzɔdzɔ kple vevesese didi kple edada ƒe ɖoɖowo ƒe nyonyome ŋu. Fifia, le eƒe dɔwɔwɔ ƒe mɔnu tɔxɛ kple dedienɔnɔ ƒe nɔnɔmewo nu la, Ipa ƒe gbegɔmeɖeɖe zazã ŋuti numekuku le lãmenugbagbeviwo ƒe dɔlélewo, nuɖuɖumeŋusẽ ƒe dɔlélewo, kple vevesesenutsitike ƒe akpawo me le goglom ɖe edzi ɣesiaɣi, si ɖe mɔkpɔkpɔ gbadza siwo li be woazãe le atikewɔnyawo me fia.

▎ Kpuie ko la

Lãmetsiwo ƒe Tsitsi Kple Wo Dzadzraɖo Dodo Ðe Ŋgɔ:

CJC1295 No DAC kple Ipa zazã ɖekae ate ŋu ana lãmeka me proteinwo ƒe wɔwɔme nadzi ɖe edzi ŋutɔ eye wòana lãmekawo ƒe lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ kabakaba. Alesi wòwɔa dɔe ate ŋu anye be tsitsiŋusẽ ƒe lãmetsiŋusẽ naʋã lãmekawo tẽ, eye wòado lãmekawo ƒe tsitsi ɖe ŋgɔ le mɔ si mele tẽ o nu to tsitsinu bubuwo kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔnuwo dzi kpɔkpɔ me. Le kamedefefewo ƒe atikewɔwɔ gome la, asixɔxɔ vevi aɖe le peptide-nu eve siawo zazã ɖekae ŋu. Le kamedede lɔ̃lawo gome la, ate ŋu ana lãmekawo nahaya le kamedede megbe, ana lãmekawo ƒe ŋusẽ kple gbeɖiɖi nanyo ɖe edzi, eye wòana hehexɔxɔ ƒe ŋusẽkpɔɖeamedziwo nanyo ɖe edzi. Numekukuwo ɖee fia be tsitsi ƒe lãmetsi ate ŋu ana lãmekawo ƒe lãmenugbagbeviwo nawɔ dɔ, si ana woƒe dzidziɖedzi kple vovototodedeameme nazu lãmeka ƒe lãmenugbagbevi tsitsiwo, si wɔnɛ be lãmekawo ɖɔɖɔɖo kabakaba.

Ami ƒe Dɔwɔnawo ƒe Dɔwɔwɔ Nyuie Wu:

Ipa kple CJC1295 No DAC zazã ɖekae ate ŋu ana tsitsi ƒe lãmetsi ƒe agbɔsɔsɔ nadzi ɖe edzi, si ana ami ƒe gbegblẽ kple eƒe oxidation nado ŋgɔ. Tsitsi ƒe lãmetsi ate ŋu ana ami ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nadzi ɖe edzi, si ana ami ƒe gbegblẽ nazu ami siwo me ami mele o kple glycerol be wòana ŋusẽ ŋutilãa. Le ɣeyiɣi ma ke me la, ate ŋu ana ami zazã nyuie hã nanyo ɖe edzi, aɖe ami siwo le ŋutilã me ƒe dzadzraɖo dzi akpɔtɔ, eye wòana ŋutilã ƒe wɔwɔme nanyo ɖe edzi. Esia le vevie ŋutɔ na ami ƒe ɖiɖi kple ŋutilã ƒe nɔnɔme, vevietɔ na amesiwo di be yewoaɖe yewoƒe ŋutilã me ami ƒe alafa memamã dzi akpɔtɔ eye yewoana yewoƒe ŋutilã ƒe fliwo nanyo ɖe edzi.

Ŋusẽ ƒe Agbɔsɔsɔ Kple Kamedefefewɔlawo ƒe Dɔwɔwɔ Dzi Ðeɖe Akpɔtɔ:

Tsitsi ƒe lãmetsi ƒe dzidziɖedzi ate ŋu ana basal metabolic rate nadzi ɖe edzi eye wòana ŋusẽ wɔwɔ kple eŋudɔwɔwɔ nanyo ɖe edzi. Basal metabolic rate ƒe dzidziɖedzi fia be ŋutilãa ate ŋu aɖu ŋusẽ geɖe le ɖiɖiɖemeɣi gɔ̃ hã, si kpena ɖe ŋutilãa ƒe ŋusẽ ƒe dadasɔ ŋu. Esia wɔnɛ be ezãlawo te ŋu kpɔa ŋusẽ geɖe wu le gbesiagbedɔwo kple kamedede me, kekea kamedede ƒe dzidodo ɖe enu, eye wònaa kamedefefewo ƒe ŋutete nyona ɖe edzi.

Alɔ̃dɔdɔ ƒe Nyonyome ƒe Nyonyome:

Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le alɔ̃dɔdɔ ƒe tsatsam kple eƒe nyonyome dzi kpɔkpɔ me. Ipa kple CJC1295 No DAC zazã ɖekae ate ŋu ana alɔ̃dɔdɔ ƒe wɔwɔme nanyo ɖe edzi eye wòana alɔ̃dɔdɔ deto ƒe ɣeyiɣi nadzi ɖe edzi. Alɔ̃dɔdɔ deto le vevie ŋutɔ na ŋutilãa ƒe hayahaya kple eƒe dzadzraɖo. Ate ŋu ado tsitsi ƒe lãmetsi ƒe dodo ɖe ŋgɔ, ana dɔlélenutsiŋutete ƒe dɔwɔwɔ nanyo ɖe edzi, eye wòana ahɔhɔ̃a ƒe susuŋutete nanyo ɖe edzi.

Dɔlélenutsiŋutete ƒe Dɔwɔwɔ Dodo Ðe Ŋgɔ:

Tsitsi ƒe lãmetsi doa alɔ dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie. Ate ŋu ana dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔwɔwɔ nanyo ɖe edzi, ana ŋutilã ƒe dɔlélenutsiŋutete nanyo ɖe edzi, eye wòakpe ɖe ame ŋu wòatsi dɔlélewo nu. To tsitsi ƒe lãmetsi ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me la, Ipa kple CJC1295 No DAC zazã ɖekae ate ŋu ana dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ŋutete nadzi ɖe edzi, ado dɔlékuiwutikewo wɔwɔ ɖe ŋgɔ, eye wòana ŋutilãa nate ŋu anɔ te ɖe dɔlékuiwo nu nyuie wu.

2. Dɔwɔwɔ ƒe Agblewo

Atike si Tsi Tre Ðe tsitsi Ŋu:

Ne ame tsi la, tsitsi ƒe lãmetsi si le amegbetɔ ƒe ŋutilã me dzi ɖena kpɔtɔna vivivi, si wɔnɛ be tsitsi ƒe nudzɔdzɔwo abe lãmekawo ƒe tsɔtsɔ, ami ƒe dzidziɖedzi, kple ŋutigbalẽ ƒe ɖiɖiɖeme ene vɛ. Ipa kple CJC1295 No DAC zazã ɖekae ate ŋu ana tsitsi ƒe lãmetsi ƒe agbɔsɔsɔ nadzi ɖe edzi eye ate ŋu atsi tsitsi nu. Numekulawo le peptide-nu eve siawo zazã le tsitsi hehe ɖe megbe kple ame tsitsiwo ƒe agbenɔnɔ ƒe nyonyome me dzrom. Le kpɔɖeŋu me, woate ŋu azã wo atsɔ axe mɔ ɖe tsitsi ƒe dɔlélewo abe tsitsi ƒe lãmekawo ƒe tsɔtsɔ, ƒumeŋuɖui, kple dzitodzito me dɔlélewo ene nu ahada wo.

Kamedefefewo ƒe Atikewɔwɔ:

Le kamedefefewo me la, CJC1295 No DAC kple Ipa zazã ɖekae ate ŋu ado lãmekawo ƒe tsitsi kple wo ɖɔɖɔɖo ɖe ŋgɔ, ana kamedefefewo nawɔ dɔ nyuie wu, eye wòaɖe abixɔxɔ le kamedefefewo me dzi akpɔtɔ. Lãmesẽfefewɔlawo ate ŋu azã peptide-nu eve siawo abe kpeɖeŋutɔ ene atsɔ ana hehexɔxɔ ƒe ŋusẽkpɔɖeamedziwo nanyo ɖe edzi eye wòana hayahaya ƒe ɖoɖoa nawɔ kabakaba.

Lãmetsiŋusẽdɔlélewo Dada:

Le lãmenugbagbeviwo ƒe dɔlélewo abe tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ kple idiopathic short stature gome la, Ipa kple CJC1295 No DAC zazã ɖekae naa susu yeyewo kple mɔnu yeyewo hena atikewɔwɔ. To tsitsi ƒe lãmetsi ƒe dodo dzi wɔwɔ nyuie me la, ekpena ɖe dɔnɔwo ƒe dzesiwo ŋu wònyona ɖe edzi eye wòdoa ŋutilãa ƒe tsitsi kple tsitsi nyuie ɖe ŋgɔ.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.