▎ Prostamax Numekuku
Nukae nye numekuku si wowɔ le Prostamax ŋu?
Esi amewo ƒe agbenɔnɔ le nyonyom ɖe edzi eye amewo ƒe tsitsi le dzidzim ɖe edzi ta la, dɔléle siwo tsoa ʋuka me ƒe dzɔdzɔ le dzidzim ɖe edzi ƒe sia ƒe, si le ŋusẽ kpɔm ɖe ŋutsuwo ƒe lãmesẽ dzi vevie. Eyata mɔnu nyuiwo didi hena ʋumenugbagbeviɣidɔ ƒe lãmesẽnyawo gbɔ kpɔkpɔ kple edada va zu nyati vevi aɖe le atikewɔwɔ ŋuti numekukuwo me.
Le numekuku deto si wowɔ tso ʋuka ƒe dɔwɔwɔ le ŋutilã me kple alesi ʋuka me dɔlélewo dzɔna ŋu me la, dzɔdzɔmeŋutinunyalawo kpɔe be ʋuka ŋutɔ ate ŋu aɖe nu vovovo siwo wɔa dɔ le ʋuka me, siwo wɔa akpa vevi aɖe le ʋuka ƒe dɔwɔwɔ nyuie me léle ɖe asi kple dɔlélewo ƒe dzɔdzɔ kple woƒe dzɔdzɔ me. To numekuku le ʋumenugbagbeviɣi ƒe akpa siwo le ʋuka me kple eƒe dɔwɔwɔ ŋuti numekuku me la, numekulawo ɖoe kplikpaa be yewoake ɖe nusi ate ŋu ana ʋuka ƒe lãmesẽ nanyo ɖe edzi koŋ ŋu. Woke ɖe Prostamax ŋu eye wosrɔ̃ nu tso eŋu le nya sia me. Wobua eŋu be enye nugbagbewo ƒe ɖoɖowɔwɔ ƒe peptide si si ɖoɖowɔɖi ƒe dɔ veviwo le le ʋuka me, eye numekuku siwo wowɔ tso eƒe dzɔtsoƒe ŋu na mɔfiame kple mɔnu yeye aɖe si dzi woato aku nu me yi ŋgɔe le mɔxexe ɖe ʋuka me dɔlélewo nu kple wo dada kpakple ŋutsuwo ƒe lãmesẽ me léle ɖe asi ŋu.
Nukae nye Prostamax ƒe dɔwɔwɔ ƒe mɔnu?
Mɔnu si wɔa dɔ le abacterial prostatitis si nɔa anyi didi dada me
Dɔdzẽ ƒe dzesiwo dzi ɖeɖe kpɔtɔ: Numekukuwo ɖee fia be Prostamax ate ŋu aɖe dɔdzẽ si nɔa anyi didi ƒe dzesiwo dzi akpɔtɔ, abe abi, ʋukawo ƒe ʋuʋu, kple ʋukawo ƒe gege ɖe lãme na ame dzi ɖeɖe kpɔtɔ ene, le dodokpɔ ƒe abacterial prostatitis si nɔa anyi didi kple eƒe kuxiwo dada me [1] . Woate ŋu awɔ esia to dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi kpɔkpɔ le ʋuka me lãkusiwo me me, eye egahiã kokoko be woagasrɔ̃ nu tso dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ ƒe mɔnu tɔxɛwo ŋu.
Mɔxexe ɖe ƒunukpeƒetetedɔ kple atrophy ƒe dɔwɔwɔ nu: Prostamax ate ŋu axe mɔ na sclerosis kple atrophy ƒe dɔwɔwɔwo ƒe tsitsi le ʋuka me lãkusiwo me. Alesi wòwɔa dɔe ate ŋu abia be wòawɔ ɖoɖo ɖe ʋumenugbagbevi dzĩwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu eye wòaxe mɔ ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ siwo hea lãmenugbagbeviwo ƒe ʋuʋu kple woƒe tsɔtsɔ vɛ nu.
Ne wotsɔe sɔ kple ʋumenugbagbeviɣitike bubuwo: Prostamax ƒe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi sɔ gbɔ wu ʋumenugbagbeviɣitike aɖewo siwo wozãna le afisiafi siwo woɖe tso saw palmetto extract kple lãwo ƒe ʋumenugbagbeviɣidɔ me tɔ. Esia tso eƒe atikewo ƒe wɔwɔme tɔxɛ kple dɔwɔwɔ ƒe mɔnu gbɔ, si wɔnɛ be wòte ŋu wɔa dɔ nyuie wu ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ siwo le abacterial prostatitis si nɔa anyi didi me dzi [1]..
Mɔnu si wɔa dɔ ɖe amegbetɔ ƒe ʋumenugbagbevi dzĩwo ƒe heterochromatin dzi
Dzoxɔxɔ ƒe gbugbɔmamã kple dzoxɔxɔ ƒe tɔtrɔ: Prostamax ateŋu ana chromatin ƒe dzoxɔxɔ gbugbɔmamã le amegbetɔ ƒe ʋumenugbagbeviɣiwo me eye wòatrɔ dzoxɔxɔ eve siwo trɔna le dzɔdzɔme nu (TdVII kple TdVIII) yi dzoxɔxɔ si bɔbɔ ɖe anyi wu 2.9 kple 1.0°C [2] . Dzoxɔxɔ ƒe gbugbɔmamã sia ate ŋu atso ka si ƒe titrime nye nanometer 30 ƒe akpa aɖe ƒe ɖiɖi va zu ka si ƒe titrime nye nanometer 10, si fia be Prostamax ate ŋu awɔ eƒe ŋusẽkpɔɖeamedzi to ŋusẽkpɔkpɔ ɖe chromatin ƒe wɔwɔme dzi me.
Tɔtrɔ siwo va le nucleosome ƒe ɖoɖowɔwɔ me: Lãmenugbagbevi siwo wotsɔ Prostamax da dɔe ƒe TdVII kple TdVIII bɔbɔ vie wu lãmenugbagbevi siwo womewɔ atike na o tɔ, si do ƒome kple ka siwo ƒe titrime nye nanometer 10 kple 30 ƒe nucleosome ƒe ɖoɖowɔwɔ ƒe wɔwɔme ƒe tɔtrɔ suewo [2]..
Nukae nye Prostamax zazã?
1. Prostate ƒe lãmesẽ dodo ɖe ŋgɔ
Prostatic hyperplasia si me dɔlékui aɖeke mele o ƒe dzesiwo dzi ɖeɖe kpɔtɔ: Benign prostatic hyperplasia nye dɔléle siwo bɔ siwo ɖea fu na ŋutsu tsitsiwo dometɔ ɖeka. Ne ame tsi la, ʋuka siwo me ʋu sina tona la dzina ɖe edzi vivivi, si tea tsinyegoea eye wòhea dzesiwo abe aɖuɖɔtoe enuenu, aɖuɖɔtoe kpata, kple aɖuɖɔtoe sesẽ vɛ. Prostamax ate ŋu ado prostate lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie ɖe ŋgɔ. To lãmenugbagbeviwo ƒe dɔwɔwɔ kple dzesiwo ƒe tɔtrɔmɔwo dzi kpɔkpɔ me la, eɖea dzesi siwo prostatic hyperplasia hena vɛ dzi kpɔtɔna. Ate ŋu awɔ dɔ ɖe lãmenugbagbeviwo ƒe tsitsinu, lãmenugbagbevi siwo xɔa dɔlékuiwo, kple enzymewo dzi, axe mɔ na lãmenugbagbeviwo ƒe dzidziɖedzi fũ, eye wòado lãmenugbagbeviwo ƒe vovototodedeameme kple woƒe tsɔtsrɔ̃ ƒe dadasɔ ɖe ŋgɔ, si ana wòaɖe nyaƒoɖeamenu si le ʋumenugbagbevi dzĩwo dzi dzi akpɔtɔ eye wòana aɖuɖɔtoe ƒe nɔnɔmea nanyo ɖe edzi [3]..
Prostate tissue ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ: Prostate tissue ƒe gbugbɔgadzɔ le vevie ŋutɔ be prostate ƒe wɔwɔme si le lãmesẽ me nanɔ anyi. Nuwo abe tsitsi, dɔlélewo, kple abixɔxɔ ate ŋu ana tɔtrɔ siwo gblẽa nu le ʋuka siwo me ʋu sina tona ŋu, si akpɔ ŋusẽ ɖe eƒe dɔwɔwɔ nyuie dzi. Prostamax kpena ɖe ame ŋu wòdoa alɔ ʋumenugbagbevi dzĩwo ƒe gbugbɔgadzɔ, ɖewohĩ to lãmenugbagbeviwo ɖɔɖɔɖo kple gbugbɔgadzɔ ƒe mɔnuwo dodo ɖe ŋgɔ me. Le kpɔɖeŋu me, ate ŋu ana lãmenugbagbeviwo nadzi ɖe edzi eye woato vovo, ana lãmenugbagbeviwo nadzi ɖe edzi le ʋumenugbagbeviɣidɔa me, eye wòato esia me ado lãmenugbagbevi siwo gblẽ la dzadzraɖo ɖe ŋgɔ. Tsɔ kpe ɖe eŋu la, Prostamax ate ŋu aɖɔ lãmenugbagbeviwo godo ƒe wɔwɔme kple eƒe gbegblẽ hã ɖo be wòalé ʋumenugbagbeviɣi ƒe wɔwɔme ƒe blibonyenye me ɖe asi [2, 4]..
2. Dɔlékuiwutike ƒe ŋusẽkpɔɖeamedzi
Prostate ƒe dɔdzẽ dzi ɖeɖe kpɔtɔ: Prostate dɔléle siwo xɔa abi abe prostatitis si nɔa anyi didi ene hea vevesese gã aɖe vɛ na dɔnɔwo. Dɔdzẽ ƒe ŋuɖoɖoa ana dzesiwo abe vuvu, ʋukawo ƒe ʋuʋu, kple ʋumenugbagbevi dzĩwo ƒe gege ɖe ʋuka me, si ana vevesese kple vevesese nadze ame dzi. Prostamax ate ŋu awɔ dɔ ɖe dɔlélenutsiŋutete dzi to dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ kple dɔdzẽ ƒe domenɔlawo wɔwɔ me be woaɖe prostate ƒe dɔdzẽ dzi akpɔtɔ. Ate ŋu axe mɔ na lãmenugbagbevi siwo naa dɔdzẽ ƒe dɔwɔwɔ kple woƒe ʋuʋu eye wòaɖe dɔdzẽ ƒe nusiwo dona ɖa, abe tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), kple interleukin-6 (IL-6) ene ƒe dodo dzi akpɔtɔ. Tsɔ kpe ɖe eŋu la, Prostamax ate ŋu ado cytokines siwo tsia dzodzodzoetsitsi nu, abe interleukin-10 (IL-10) ene, wɔwɔ hã ɖe ŋgɔ, si ana dɔdzẽ ƒe ŋuɖoɖo ƒe dadasɔ nanɔ anyi eye wòaɖe dɔdzẽ ƒe dzesiwo dzi akpɔtɔ [3]..
3. Ŋusẽkpɔɖeamedzi si tsi tre ɖe tsitsi ŋu
Lãmenugbagbeviwo ƒe tsitsi hehe ɖe megbe: Lãmenugbagbeviwo ƒe tsitsi do ƒome kplikplikpli kple dɔléle vovovowo ƒe dzɔdzɔ kple woƒe tsitsi. Prostamax ate ŋu akpɔ ŋusẽ ɖe chromatin ƒe wɔwɔme dzi, aɖe DNA ƒe ƒoƒo dzi akpɔtɔ, eye wòana lãmenugbagbeviwo nanɔ ɖekakpui me. Tɔtrɔ siwo vaa chromatin ƒe wɔwɔme me ate ŋu akpɔ ŋusẽ ɖe domenyiŋusẽfianu ƒe ɖeɖefia kple edziwɔwɔ dzi, si ana wòakpɔ ŋusẽ ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ kple woƒe agbenɔƒe dzi. Prostamax ate ŋu aɖɔ chromatin remodeling enzymes ƒe dɔwɔwɔ ɖo, atrɔ chromatin ƒe compactness, eye wòado domenyiŋusẽfianu ƒe nuŋɔŋlɔ kple eɖeɖe ɖe ŋgɔ. Esia kpena ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ kple ŋusẽ si sɔ ŋu eye wòhea lãmenugbagbeviwo ƒe tsitsi ɖe megbe. Tsɔ kpe ɖe eŋu la, Prostamax ate ŋu aɖe free radicals ƒe wɔwɔ kple nugbegblẽ hã dzi akpɔtɔ to eƒe antioxidant ŋusẽkpɔɖeamedzi me, si agakpɔ lãmenugbagbeviwo ta tso tsitsi ƒe ŋusẽkpɔɖeamedziwo me [2] ..
4. Dodo ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi
Dɔlélenutsiŋutete wɔa akpa vevi aɖe le amegbetɔ ƒe lãmesẽ me léle ɖe asi me. Prostamax ate ŋu akpɔ ŋusẽ nyui ɖe dɔlélenutsiŋutete dzi, ana ʋumenugbagbevi dzĩwo nawɔ dɔ nyuie wu, eye wòana ŋutilãa ƒe dɔlélenutsiŋutete nawɔ dɔ nyuie wu. Lãmenugbagbeviwo nye dɔlélenutsiŋutete ƒe akpa vevi aɖe, si ate ŋu ade dzesi dɔlékuiwo ahadze wo dzi eye woakpɔ ŋutilã ta tso dɔlékuiwo me. Prostamax ate ŋu ana ʋumenugbagbevi dzĩwo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ nanyo ɖe edzi to woƒe dzidziɖedzi, vovototodedeameme, kple dɔwɔwɔ dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu ana ʋumenugbagbevi dzĩwo nawɔ cytokines kple dɔlékuiwutikewo, si ana woƒe ŋutete be woawu dɔlékuiwo nadzi ɖe edzi. Tsɔ kpe ɖe eŋu la, Prostamax ate ŋu aɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbevi bubuwo abe macrophages kple dzɔdzɔme lãmenugbagbevi siwo wua ame ene ƒe dɔwɔwɔ hã ɖo, si awɔ ɖeka ana ŋutilã ƒe dɔlélenutsiŋutete ƒe ametakpɔkpɔ ŋutete nanyo ɖe edzi [5]..
5. Lãmetsiŋusẽ ƒe dadasɔ nyuie
Lãmetsiŋusẽ ƒe agbɔsɔsɔ abe testosterone kple dihydrotestosterone ene ƒe dadasɔ le vevie ŋutɔ na prostate ƒe lãmesẽ kple ŋutsuwo ƒe lãmesẽ bliboa me léle ɖe asi. Lãmetsiŋusẽ ƒe masɔmasɔ ate ŋu ana dɔlélewo abe ʋumenugbagbeviɣidɔ kple ʋumenugbagbeviɣidɔ ene nadze ame dzi. Prostamax kpena ɖe lãmetsiŋusẽ siawo ƒe agbɔsɔsɔ ŋu wòɖɔa ŋu ɖo, ɖewohĩ to ŋusẽkpɔkpɔ ɖe lãmetsiŋusẽwo ƒe wɔwɔme, woƒe lãmenugbagbeviwo ƒe dɔwɔwɔ, kple woƒe xɔlawo ƒe ɖeɖefia dzi. Le kpɔɖeŋu me, ate ŋu aɖɔ testosterone ƒe wɔwɔme kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe enzymewo ƒe dɔwɔwɔ ɖo, si akpɔ ŋusẽ ɖe testosterone ƒe wɔwɔ kple eƒe tɔtrɔ dzi. Tsɔ kpe ɖe eŋu la, Prostamax ate ŋu aɖɔ dihydrotestosterone xɔlawo ƒe ɖeɖefia hã ɖo, si atrɔ ŋusẽ si dihydrotestosterone kpɔna ɖe prostate lãmenugbagbeviwo dzi. To lãmetsiŋusẽ ƒe dadasɔ nyuie me la, Prostamax ate ŋu alé ʋumenugbagbeviɣidɔ ƒe dɔwɔwɔ nyuie ɖe te eye wòaxe mɔ ɖe ʋumenugbagbeviɣidɔ nu ahada wo [3] ..
Le nyataƒoƒo me la, abe nugbagbewo ƒe ɖoɖowɔwɔ ƒe peptide si woɖe tso ʋuka me ene la, Prostamax kpɔa ŋusẽ ɖedzesi aɖe le ʋumenugbagbeviɣi ƒe lãmesẽ nyonyo me. Menye ɖeko wòate ŋu aɖe prostatic hyperplasia si me dɔlékui aɖeke mele o ƒe dzesiwo dzi akpɔtɔ eye wòado prostate lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ ko o, ke ate ŋu aɖe prostate ƒe dɔdzẽ hã dzi akpɔtɔ eye wòahe lãmenugbagbeviwo ƒe tsitsi ɖe megbe. Ewɔa akpa nyui aɖe hã le dɔlélenutsiŋutete ƒe dɔwɔwɔ kple lãmetsiŋusẽ ƒe dadasɔ dzi kpɔkpɔ me, enaa kpekpeɖeŋu sesẽ na ŋutsuwo ƒe ʋuka ƒe lãmesẽ kple lãmesẽ bliboa me léle ɖe asi, eye asixɔxɔ vevi kple vevienyenye le eŋudɔwɔwɔ ŋu le lãmesẽnya siwo do ƒome kplii me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Karthaus WR nye numekula xɔŋkɔ aɖe le kansa kple lãmenugbagbeviwo ŋuti nunya me. Exɔ ɖoƒewo le dɔwɔƒe bubu geɖe siwo ŋu wodea bubui, siwo dometɔ aɖewoe nye Switzerland ƒe Dɔdzẽ Ŋuti Numekuku Dɔwɔƒe (ISREC) kple École Polytechnique Fédérale de Lausanne (EPFL) . Karthaus do ƒome kple Memorial Sloan Kettering Kansa Dɔwɔƒe hã, afisi wòkpe asi ɖe kansa ŋuti numekuku ŋu le . Eƒe sukudede ƒe mɔzɔzɔa dometɔ aɖewoe nye kadodo kple Utrecht Yunivɛsiti ƒe Atikewɔƒe kple Hubrecht Dɔwɔƒe (KNAW) le Netherlands . Tsɔ kpe ɖe eŋu la, kadodo le eya kple Johns Hopkins Yunivɛsiti dome .
Karthaus ƒe numekuku siwo me wòtsɔ ɖe le la ku ɖe kansaŋutinunya, lãmenugbagbeviwo ŋuti nunya, nugbagbeŋutinunya, molecule biology, kple dodokpɔ ƒe atikewɔwɔ ŋu. Zi geɖe la, eƒe dɔa lɔ ŋutinu siwo dzi steroid hormone kpɔa ŋusẽ ɖo, abe ʋuka, no me lãkusi, kple vidzidɔ ene, sɔsrɔ̃ ɖe eme. Ezãa mɔnu si me wozãa nu vovovowo le, eye wòƒoa organoid dekɔnuwo, sisiblisi ƒe kpɔɖeŋuwo, domenyiŋusẽfianu ŋuti nunya, kple lãmenugbagbevi ɖeka ƒe mɔnuwo nu ƒu tsɔ kpɔa nugbagbeŋutinunya ƒe nyabiase sesẽwo gbɔ . Eƒe dodokpɔxɔa léa fɔ ɖe nusiwo ʋãa dɔdzẽ ƒe gɔmedzedze, eƒe ŋgɔyiyi, kple atikewo ƒe dɔlélenutsiŋutete le kansa siwo nɔa te ɖe steroid lãmetsiŋusẽ dzi me gɔmesese ŋu . Woŋlɔ Karthaus WR ɖe nyayɔyɔ ƒe numekugbalẽ me [4].
