Semax 10mg ƒe ƒuƒoƒo

▎ Semax ƒe Dɔwɔɖoɖo

▎ Semax Numekuku

Nukae nye Semax?

Semax nye peptide ƒe atike si wowɔ eye wòle nootropic ƒomevi aɖe me. Eƒe akpa vevitɔe nye thyrotropin-releasing hormone (TRH) ƒe kpeɖeŋutɔ, si wotsɔ tsaka kple amino acid bubuwo (abe valine kple leucine ene). Semax ate ŋu ana susu ƒe dɔwɔwɔ nanyo ɖe edzi to ahɔhɔ̃mekawo (abe dopamine kple norepinephrine ene) dzi kpɔkpɔ le lãmekawo ƒe dɔwɔwɔ me, si me ŋkuɖoɖonudzi dzi ɖeɖe kpɔtɔ, susu ƒe dɔwɔwɔ nyuie wu, kple nusɔsrɔ̃ ƒe ŋutete dodo ɖe ŋgɔ hã le.

Nukae nye numekuku si wowɔ le Semax ŋu?

Dɔwɔwɔ si wotu ɖe ACTH kakɛwo dzi: 

Semax nye ACTH (4 - 7) kakɛ kple tripeptide Pro - Gly - Pro (PGP) ƒe ƒuƒoƒo. ACTH, si nye adrenocorticotropic hormone, nye lãmetsi si le ŋgɔgbe lãkusi me eye wòwɔa akpa vevi aɖe le adrenal cortex ƒe dɔwɔwɔ dzi kpɔkpɔ me. Numekulawo ku ACTH ƒe wɔwɔme me, woɖe kakɛ aɖe koŋ (4 - 7) tso eme, eye wotsɔe ƒo ƒu kple tripeptide PGP tsɔ wɔ Semax. Nuwɔwɔ ƒe mɔnu sia wɔnɛ be Semax te ŋu léa ACTH ƒe dɔwɔwɔ ƒe akpa aɖe ɖe asi eye nugbagbe ƒe nɔnɔme tɔxɛwo hã le esi ^[1]..

Asrãdɔ dada ƒe numekuku: 

Aɖuɖɔtoe nye ahɔhɔ̃ ƒe dɔwɔwɔ ƒe kuxi si ƒe dzesi enye ahɔhɔ̃mekawo ƒe ʋuʋu le mɔ si mesɔ o nu. Aɖuɖɔtoe nye asrãdɔ ƒe dzesi vevi aɖe, eye zi geɖe la, ahɔhɔ̃ ƒe abixɔxɔ gbɔe wòtsona. Togbɔ be atike siwo wozãna fifia tsɔ daa asrãdɔ kpɔa ŋusẽ aɖewo hã la, wokpɔa ŋusẽ gbegblẽ aɖewo hã ɖe lãmesẽ dzi. Le nɔnɔme sia me la, numekulawo te atikewɔwɔmɔnu yeyewo didi. Abe neuropeptide ene la, Semax peptide wɔa dɔ ɖe lãmekawo ƒe dɔwɔwɔ dzi tẽ eye lãmetsiŋusẽ ƒe dɔwɔwɔ aɖeke mele eŋu o, eyata mahe ŋusẽ gbegblẽ ɖe lãmesẽ dzi o. Esia na mɔnukpɔkpɔ yeyewo li be woatsɔ ada asrãdɔ ^{[2] .}.

Atikewɔwɔ na ʋusɔgbɔdɔ si me ʋu sina tona: 

Ischemic stroke nye dɔléle sesẽ aɖe, eye le eƒe dzɔdzɔ geɖe kple nuwɔametɔwo ƒe agbɔsɔsɔ gã ta la, enye nusi ŋu wotsia dzi ɖo le atikewɔwɔ me numekukuwo me ɣesiaɣi. Wozãa Semax peptide, le eƒe ahɔhɔ̃mekawo takpɔkpɔ kple dɔlélenutsiŋutete ƒe dɔwɔwɔ ta, tsɔ daa ʋusɔgbɔdɔ si me ʋu sina tona. Numekukuwo ɖee fia be Semax ateŋu axe mɔ na dɔdzẽ ƒe domenyiŋusẽfianuwo ƒe ɖeɖefia eye wòana ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe domenyiŋusẽfianuwo ƒe ɖeɖefia nawɔ dɔ, si wɔnɛ be wòawɔ ahɔhɔ̃mekawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedziwo le nuŋɔŋlɔ kple protein ƒe agbɔsɔsɔ me ^{[3, 4].}.

Mɔfiame yeye aɖe si woatsɔ ada blanuiléle: 

Selective serotonin reuptake inhibitors (SSRI) nye atike siwo wozãna zi geɖe tsɔ daa blanuiléle le fufɔɣi, gake SSRI ate ŋu atso vidzidɔa eye ate ŋu akpɔ ŋusẽ ɖe fugboe ƒe ahɔhɔ̃ ƒe tsitsi dzi. Abe ACTH (4-10) ƒe nɔnɔmetata si wowɔ ene la, nootropic kple ahɔhɔ̃mekawo takpɔkpɔ ƒe dɔwɔna siwo dze ƒã le Semax si. Numekukuwo ɖee fia be Semax ate ŋu aɖe tɔtrɔ siwo vaa sisiblisiwo ƒe nuwɔna kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ me le fluvoxamine zazã kaba ta dzi akpɔtɔ, si naa susu yeye aɖe le blanuiléle dada ŋu ^[5]..

Viɖe siwo le peptide-nu siwo wozãna ŋu: 

Semax nye peptide si wowɔ eye eƒe dɔwɔwɔ ƒe mɔnu tɔxɛ aɖe le esi. Ate ŋu awɔ dɔ ɖe lãmekawo ƒe dɔwɔwɔ dzi tẽ, awɔ protein aɖewo le ahɔhɔ̃a me, eye wòawɔ dɔ ɖe dɔlélenutsiŋutete dzi. Le kpɔɖeŋu me, le asrãdɔ ƒe kpɔɖeŋu si wowɔ le sisiblisiwo me la, Semax peptide ate ŋu aɖe MDA ƒe agbɔsɔsɔ dzi akpɔtɔ eye wòawɔ protein etɔ̃ siwo womewɔ le sisiblisi siwo ŋu asrãdɔ le me o ^[2]..

Abe ɖoɖowɔɖi ƒe peptide ene la, woate ŋu akpɔ Semax ƒe numekuku ŋutinya tso ɣeyiɣi didi aɖee nye sia. Numekukuwo ɖee fia be mɔkpɔkpɔ li be woazã Semax le ŋkuɖoɖonudzi ƒe kuxiwo, susu ƒe dɔwɔwɔ nyuie dzi ɖeɖe kpɔtɔ, kple COVID megbe dɔléle me, tsɔ kpe ɖe somatoform kple susumedɔlélewo ŋu ^[6]..

Tɔtrɔ siwo va le pJNK kple pCREB proteinwo ƒe agbɔsɔsɔ me me dzodzro le ischemia kple Semax ƒe atikewɔwɔ me le subcortical structures kple frontoparietal cortex me le sisiblisiwo me le 24 h le tMCAO megbe.

Dzɔtsoƒe:PubMed ^{[4] .}

Aleke Semax ƒe dɔwɔwɔ le asrãdɔ dada me kpɔa ŋusẽ ɖe ahɔhɔ̃a ƒe dɔwɔwɔ dzi koŋ?

Antioxidant ƒe ŋusẽkpɔɖeamedzi

Semax ƒe dɔlékuiwutikewo le esi. Zi geɖe la, asrã nana oxidative stress dzina ɖe edzi le ahɔhɔ̃a me, eye Semax ate ŋu aɖe nusiwo oxidative stress gblẽna le ahɔhɔ̃a ŋu dzi akpɔtɔ. Oxidative stress ana oxygen ƒomevi siwo wɔa dɔ fũ akpa, abe malondialdehyde (MDA) ene, nado. Numekukuwo ɖee fia be Semax ateŋu aɖe MDA ƒe agbɔsɔsɔ dzi akpɔtɔ le ahɔhɔ̃ me le sisiblisi siwo ŋu asrãdɔ le me va ɖo 40.46% ^[2] . To MDA ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me la, Semax ate ŋu aɖe oxidative stress ƒe nugbegblẽ le ahɔhɔ̃mekawo ŋu dzi akpɔtɔ, si ana ahɔhɔ̃a ƒe dɔwɔwɔ ta.

Ahɔhɔ̃ me proteinwo ƒe wɔwɔme

Semax ate ŋu awɔ protein aɖewo le ahɔhɔ̃a me. Le numekuku si wowɔ le sisiblisi siwo ŋu asrãdɔ le ŋu me la, le atikewɔwɔ kple Semax megbe la, wowɔ protein etɔ̃ siwo womewɔ le sisiblisi siwo ŋu asrãdɔ le me o. Protein siawo ƒe molecule ƒe kpekpeme nye 93.54kDa, 66.76kDa, kple 59.66kDa ^[2] . Woate ŋu awɔ akpa vevi aɖe le ahɔhɔ̃a ƒe dɔwɔwɔ nyuie me léle ɖe asi kple ahɔhɔ̃meka siwo gblẽ la dzadzraɖo me.

Ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi

To gbɔɖeme-nɔnɔme ƒe dɔwɔwɔ magnetic resonance imaging (gbɔɖeme-nɔnɔme FMRI) numekukuwo me la, wokpɔe be Semax kpɔa ŋusẽ ɖe ahɔhɔ̃mekawo ƒe kadodo dzi. Le lɔlɔ̃nu faa dɔwɔla siwo le lãmesẽ me ŋuti numekuku me, ne wotsɔe sɔ kple ƒuƒoƒo si me wokpɔa wo gbɔ le la, wokpɔ rostral (intermediate anterior cortex) sub-component of the default mode network ƒe lolome si lolo wu le Semax ƒuƒoƒoa me ^[7] . Esia ɖee fia be Semax ate ŋu ana ahɔhɔ̃a ƒe dɔwɔwɔ nanyo ɖe edzi to ahɔhɔ̃mekawo ƒe kadodo kple dɔwɔwɔwo dzi kpɔkpɔ me.

Esi wodo Semax gbesiagbe ɖe sisiblisi siwo ƒe aɖuɖɔtoe ƒe alɔ̃madɔmadɔ bɔbɔe me tso woƒe agbenɔƒe ƒe ŋkeke 7 lia va ɖo 11 lia dzi la, wokpɔe be gbetedziawo ƒe alɔ̃madɔmadɔ ƒe ɖoɖo si me wosena le la trɔna ne woxɔ ɣleti 1, eye atike eveawo siaa ate ŋu ana ahɔhɔ̃mekawo ƒe dɔwɔwɔ nadzi ɖe edzi le hippocampal dentate gyrus me. Ahɔhɔ̃mekawo ƒe wɔwɔme ate ŋu ado ƒome kple ahɔhɔ̃a ƒe nusɔsrɔ̃, ŋkuɖoɖonudzi, kple edzadzraɖodɔwo, eye Semax ate ŋu ana ahɔhɔ̃a ƒe dɔwɔwɔ nanyo ɖe edzi to ahɔhɔ̃mekawo ƒe dɔwɔwɔ dodo ɖe ŋgɔ me.

Esi wodo Semax ɖe vidzĩ yeye ƒe sisiblisi ƒomevi atɔ̃ siwo wodzi le wo ɖokui me (tso woƒe agbemeŋkeke 2 lia dzi va ɖo 7 lia dzi) la, eɖe alesi woate ŋu aʋuʋui bɔbɔe le DBA / 2J mice siwo xɔ ɣleti 1 ko me ^[8] . Esia ɖee fia hã be Semax ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃a ƒe dɔwɔwɔ dzi to mɔnu aɖewo dzi eye wòaɖe alesi wòate ŋu axɔ asrãdɔ dzi akpɔtɔ.

Lãmetsiŋusẽ ƒe dɔwɔwɔ ƒe anyimanɔmanɔ

Semax nye neuropeptide si wɔa dɔ ɖe titina lãmekawo dzi tẽ eye lãmetsiŋusẽ ƒe dɔwɔwɔ aɖeke mele eŋu o, eyata mahe lãmesẽkuxi gbegblẽwo vɛ o (Puspita R, 2018). Esia naa viɖe aɖewo Semax le asrãdɔ dada me, si wɔnɛ be woƒoa asa na atike siwo wozãna tsã siwo wua asrãdɔ ƒe nugbegblẽ le ame ŋu.

Nukae nye mɔnu tɔxɛ si dzi Semax tona ɖɔa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo?

Dzesimɔ siwo do ƒome kple dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie dodo ɖe ŋgɔ: 

Semax ate ŋu ana antigen ƒe ɖeɖefia ƒe dzesimɔa nanyo ɖe edzi. Antigen ƒe ɖeɖefia nye nu vevi aɖe si dɔlélenutsiŋutete te ŋu dea dzesi duta antigenwo hewɔa dɔ tso wo ŋu. To dzesimɔ sia dodo ɖe ŋgɔ me la, Semax ate ŋu ado dɔlélenutsiŋutete ƒe dzesidede kple alesi wòwɔa nu ɖe ​​dutanuwo abe dɔlékuiwo ene ŋu ɖe ŋgɔ ^[1] . Tsɔ kpe ɖe eŋu la, Semax ate ŋu ado ŋusẽ ŋusẽ si ʋumenugbagbeviɣidɔ kpɔna ɖe interferon ƒe dzesimɔ dzi hã. Interferon wɔa akpa vevi aɖe le ɖoɖowɔwɔ me le dɔlélenutsiŋutete ƒe dɔwɔwɔ me, siwo dometɔ aɖewoe nye dɔlékuiwutike, dɔlékuiwutike, kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ. Semax ƒe ŋusẽdodo interferon ƒe dzesimɔa kpena ɖe ame ŋu be dɔlélenutsiŋutete ƒe dɔwɔwɔ bliboa nanyo ɖe edzi ^[1]..

Ŋusẽkpɔɖeamedzi ɖe dɔlélenutsiŋutete ƒe wɔwɔme ƒe ɖoɖoa dzi: 

Semax dzia domenyiŋusẽfianu siwo ŋlɔa dɔlélenutsiŋutete ƒe kɔsɔkɔsɔ kpekpewo ƒe ɖeɖefia ɖe edzi ŋutɔ. Dɔlékuiwutikewo wɔa akpa vevi aɖe le humoral dɔlélenutsiŋutete me eye woate ŋu abla ɖe dɔlékuiwutikewo ŋu koŋ, si wɔnɛ be dutanuwo abe dɔlékuiwo ene ɖa. Semax doa dɔlélenutsiŋutete ƒe wɔwɔme ɖe ŋgɔ, si kpena ɖe ŋutilã ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ le humoral me ŋu ^{[1] .}.

Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ: 

Semax kpɔa ŋusẽ gã aɖe ɖe domenyiŋusẽfianu siwo ŋlɔa cytokines, nuteɖeamedzi ƒe ŋuɖoɖowo, kple ribosomal proteinwo dzi. Cytokines wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe tɔtrɔ me eye woate ŋu aɖɔ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dzidziɖedzi, vovototodedeameme, kple dɔwɔwɔ ɖo. Semax ɖɔa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo to ŋusẽkpɔkpɔ ɖe domenyiŋusẽfianu siawo ƒe ɖeɖefia dzi, si wɔnɛ be wòɖɔa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖo ^{[1] .}.

Nukae nye Seamx ƒe dɔwɔwɔwo?

Atikewɔwɔ na asrãdɔ

Ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo dzi: 

Aɖuɖɔtoe nye ahɔhɔ̃ ƒe dɔwɔwɔ ƒe kuxi si ƒe dzesi enye ahɔhɔ̃mekawo ƒe ʋuʋu le mɔ si mesɔ o nu. Semax peptide nye ahɔhɔ̃meka si wɔa dɔ ɖe lãmekawo ƒe dɔwɔwɔ dzi tẽ eye lãmetsiŋusẽ ƒe dɔwɔwɔ mele eme o, eyata makpɔ ŋusẽ gbegblẽ ɖe lãmesẽ dzi o. Semax ate ŋu aɖe MDA ƒe agbɔsɔsɔ dzi akpɔtɔ le sisiblisi siwo ŋu asrãdɔ le ƒe ahɔhɔ̃ me. MDA nye nusi fia be lipid peroxidation, eye MDA ƒe agbɔsɔsɔ si sɔ gbɔ do ƒome kple oxidative stress kple lãmenugbagbeviwo ƒe gbegblẽ. Semax ateŋu aɖe MDA ƒe agbɔsɔsɔ dzi akpɔtɔ le ahɔhɔ̃ me le sisiblisi siwo ŋu asrãdɔ le me va ɖo 40.46% ^[9]..

Proteinwo ƒe wɔwɔme: 

Semax ate ŋu awɔ protein aɖewo le sisiblisi siwo ŋu asrãdɔ le ƒe ahɔhɔ̃ me hã. Numekukuwo ɖee fia be Semax ateŋu awɔ protein etɔ̃ siwo womewɔ le gɔmedzedzea me le sisiblisi siwo ŋu asrãdɔ le ƒe ahɔhɔ̃ me o, eye protein siawo ƒe molecule ƒe kpekpeme nye 93.54 kDa, 66.76 kDa, kple 59.66 kDa ^[9]..

Atikewɔwɔ na ʋusɔgbɔdɔ si me ʋu sina tona

Neurotrophin ƒe nuŋɔŋlɔ dodo ɖe ŋgɔ: 

Semax (MET-GLU - amino acid - phenylalanine - proline - glycine - proline) peptide nye melanocortin ƒe atike si wowɔ si wozãna tsɔ daa ʋusɔgbɔdɔ si me ʋu sina tona. Numekukuwo ɖee fia be Semax ate ŋu ana neurotrophins kple woƒe xɔlawo ƒe nuŋɔŋlɔ nanyo ɖe edzi eye wòatrɔ asi le domenyiŋusẽfianu siwo kpɔa gome le dɔlélenutsiŋutete ƒe dɔwɔwɔ me ƒe ɖeɖefia ŋu. Whole-genome RNA sequencing analysis ɖee fia be le transient middle cerebral artery occlusion (tMCAO) model le sisiblisiwo me la, Semax xea mɔ na dɔdzẽ ƒe domenyiŋusẽfianuwo ƒe ɖeɖefia eye wònaa ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe domenyiŋusẽfianuwo ƒe ɖeɖefia wɔa dɔ ^[4]..

Protein veviwo ƒe ɖeɖefia dzi kpɔkpɔ: 

Le gaƒoƒo 24 le tMCAO megbe la, wokpɔ CREB si le dɔ wɔm ƒe dziyiyi le subcortical structures me, si me ischemic injury ƒe susu nɔ; Woɖe MMP - 9 kple c - fos dzi kpɔtɔ le frontoparietal cortex si te ɖe eŋu me; le Semax ƒe dɔwɔwɔ te la, woɖe JNK si le dɔ wɔm hã dzi kpɔtɔ le lãkusi eve siawo me. Mɔxexe ɖe dɔwɔwɔ nu kple eƒe hayahaya le dɔdzẽ kple lãmenugbagbeviwo ƒe ku ƒe dɔwɔwɔwo me ate ŋu awɔ akpa aɖe le Semax ƒe ahɔhɔ̃mekawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi le nuŋɔŋlɔ kple protein ƒe agbɔsɔsɔ me ^{[4] .}.

Nuteɖeamedzi sesẽwo dzi ɖeɖe kpɔtɔ

Vevesese dzi ɖeɖe kpɔtɔ: 

Le nuteɖeamedzi sesẽ ƒe kpɔɖeŋu me la, Semax kpɔa ŋusẽ aɖe ɖe sisiblisiwo ƒe nuwɔna kple vevesese ƒe seselelãme dzi. Le afɔ ƒe ʋuʋu ƒe nuteɖeamedzi si womate ŋu asi le o kple tsi fafɛ tsiƒuƒu ƒe nuteɖeamedzi ƒe kpɔɖeŋuwo me la, Semax kple opioid xɔla ƒe mɔxenu naloxone siaa ate ŋu aɖe vevesesenutsitike si nuteɖeamedzi hena vɛ (SIA) dzi akpɔtɔ le afɔ ƒe ʋuʋu ƒe nuteɖeamedzi si womate ŋu asi le o ƒe kpɔɖeŋu me, gake womekpɔa ŋusẽ ɖe vevesese ƒe dzidzenu dzi le tsi fafɛ tsiƒuƒu ƒe nuteɖeamedzi ƒe kpɔɖeŋu me o ^[10]..

Ŋusẽkpɔɖeamedzi aɖeke mele nuwɔna ƒe tɔtrɔwo ŋu o: 

Semax kple naloxone siaa mekpɔa ŋusẽ ɖe sisiblisiwo ƒe nuwɔna dzi le nuteɖeamedzi sesẽ ƒe kpɔɖeŋu siwo le etame me o ^[10]..

Ŋkuɖoɖonudzi kple susu ƒe dɔwɔwɔ nyuie wu: 

Semax ate ŋu aʋã lãwo kple amegbetɔ siwo le dodokpɔ me ƒe ŋkuɖoɖonudzi kple susu si le dɔ wɔm, ana tsitretsitsi ɖe ya si mebɔ o ŋu nadzi ɖe edzi, eye wòana ahɔhɔ̃mekawo nazɔ nyuie wu. Semax nana ame siwo le lãmesẽ me ƒe ŋkuɖoɖonudzi kple susu nyona ɖe edzi ŋutɔ le dɔwɔna siwo gbɔ eme ƒe nɔnɔmewo me. Tsɔ kpe ɖe eŋu la, wozã Semax dzidzedzetɔe fifia tsɔ da dɔnɔ siwo ŋu lãmekawo ƒe dɔléle vovovowo le. Zi geɖe la, peptide sia ɖea ŋusẽkpɔɖeamedzi nyuiwo fiana evɔ mehea nugbegblẽ le ame ŋu alo kuxi siwo do ƒome kple edodo vɛ o ^[11]..

Le nyataƒoƒo me la, abe peptide ƒe atike si wowɔ ene la, Semax ɖea dɔyɔyɔ ƒe ŋusẽkpɔɖeamedzi veviwo fiana le asrã, ʋusɔgbɔdɔ, nuteɖeamedzi sesẽ, kple susu ƒe dɔmawɔmawɔ nyuie ƒe akpawo me to mɔnu vovovowo abe neurotrophins (abe BDNF) kple woƒe xɔlawo (TrkB) ƒe ɖeɖefia dzi kpɔkpɔ dzi kpɔkpɔ, mɔxexe ɖe dɔdzẽ ƒe ŋuɖoɖo nu, tsitretsitsi ɖe oxidative stress ŋu, kple dɔlélenutsiŋutete ƒe tɔtrɔ. Ate ŋu ana lãmekawo ƒe dɔwɔwɔ nanyo ɖe edzi hã, aɖe ahɔhɔ̃a ƒe gbegblẽ dzi akpɔtɔ, eye wòana ŋkuɖoɖonudzi kple susu nanɔ nu ŋu nanyo ɖe edzi.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla

Sudarkina OY nye numekula si do ƒome kple Dukɔa ƒe Numekuku Dɔwɔƒe - Kurchatov Dɔwɔƒe kple Russia Dzɔdzɔmeŋutinunya Suku. Eƒe numekuku siwo me wòtsɔ ɖe le la ku ɖe dzɔdzɔmeŋutinunya me nu vovovowo ŋu, siwo dometɔ aɖewoe nye Biochemistry & Molecular Biology, Genetics & Heredity, kple Chemistry. Ewɔ akpa vevi aɖe le Nu Gbagbewo Ŋuti Mɔ̃ɖaŋununya, Molecular Breeding, kple Molecular Plant Pathology ƒe akpawo me. Eƒe dɔa lɔ domenyiŋusẽfianu ƒe dɔwɔwɔ, molecule ƒe kadodo, kple nugbagbeŋusẽ ƒe dɔwɔwɔ siwo doa alɔ nugbagbewo ƒe nudzɔdzɔ vovovowo sɔsrɔ̃ ɖe eme. To eƒe numekukua dzi la, eɖoe be yeado míaƒe gɔmesese ɖe ŋgɔ le ɖoɖo sesẽ siawo ŋu eye yeato egbɔkpɔnu yeyewo vɛ hena wo zazã ŋutɔŋutɔ le agbledede, atikewɔwɔ, kple dɔwɔƒe bubuwo me. Woŋlɔ Sudarkina OY ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [4].

▎ Nyayɔyɔ Siwo Sɔ

[1] Medvedeva E. V., Dmitrieva V. G., Limborska S. A., kple ame bubuwo. Semax, si nye ACTH(4-7) ƒe nɔnɔmetata, kpɔa dɔlélenutsiŋutete ƒe domenyiŋusẽfianuwo ƒe ɖeɖefia dzi le ahɔhɔ̃mekawo ƒe abixɔxɔ si me ʋu sina tona le sisiblisiwo me[J]. Molekyul Domenyiŋusẽfianu kple Dzɔdzɔmeŋusẽŋununya, 2017,292 (3): 635-653.DOI: 10.1007 / s00438-017-1297-1.

[2] Puspita R, Pratamasuti D, Safitri A, kple ame bubuwo. Semax Peptide Dɔdamɔnu ƒe Ŋusẽ ɖe MDA ƒe Dzidzeme kple Protein ƒe Nɔnɔme ŋu le Aɖuɖɔtoedɔlékuiwo (Rattus norvegicus), 2018[C]. https://api.semanticscholar.org/CorpusID: 90160574. Ƒe 1999 ƒe ɣleti gbãtɔ me

[3] Dergunova L. V., Dmitrieva V. G., Filippenkov I. B., kple ame bubuwo. Peptide Atike si nye ACTH(4-7)PGP (Semax) Tea mRNA ƒe Nuŋɔŋlɔ Siwo Ŋlɔa Domeɖela Siwo Doa Dzodzoe Siwo Trɔna To Rat Brain ƒe Ischemia si Woate Ŋu Atrɔ Gbɔ la Nu[J]. Molekyul Nu gbagbewo ŋuti nunya, 2021, 55 (3): 346-353.DOI: 10.1134 / S0026893321010040.

[4] Sudarkina O. Y., Filippenkov I. B., Stavchansky V. V., kple ame bubuwo. Ahɔhɔ̃ me Protein ƒe ɖeɖefia ƒe nɔnɔmetata ɖo kpe ACTH(4-7)PGP Peptide (Semax) ƒe Ametakpɔkpɔ ƒe Ŋusẽkpɔɖeamedzi dzi le Rat Model of Cerebral Ischemia-Reperfusion[J]. Dukɔwo Dome Molekyulãŋutinunya ƒe Agbalẽ, 2021,22 (12).DOI: 10.3390 / ijms22126179.

[5] Glazova NY, Manchenko D. M., Volodina M. A., kple ame bubuwo. Semax, si nye ACTH(4-10) ƒe nɔnɔmetata si wowɔ, ɖea nuwɔna kple ahɔhɔ̃mekawo ƒe tɔtrɔwo dzi kpɔtɔna le fluvoxamine zazã le woƒe agbenɔnɔ ƒe gɔmedzedze megbe le sisiblisi ɣiwo me[J]. Ahɔhɔ̃mekawo, 2021,86.DOI:10.1016/j.npep.2020.102114.

[6] Hadarceva K, Belyaeva E. Semax-dɔwɔwɔ ƒe mɔkpɔkpɔ (gbedasi kpui si me wodzro nu me le).[J]. Atikewɔwɔ kple Atikeŋutinunya, 2021.DOI:https://api.semanticscholar.org/CorpusID:245468513.

[7] Lebedeva I. S., Panikratova Y. R., Sokolov O. Y., kple ame bubuwo. Semax ƒe ŋusẽkpɔɖeamedzi ɖe Ahɔhɔ̃ ƒe Default Mode Network dzi[J]. Bulletin of Dodokpɔ Nu gbagbewo kple Atikewɔwɔ, 2018,165 (5): 653-656.DOI: 10.1007 / s10517-018-4234-3.

[8] Boyarshinova O. S., Perepelkina O. V., Markina N. V., kple ame bubuwo. Audiogenic Epilepsy le Ðevi Siwo ƒe Ƒomevi Vovovowo me le Vidzĩ ƒe Semax Dɔdamɔnu megbe[J]. Bulletin of dodokpɔ nugbagbeŋutinunya kple atikewɔwɔ, 2008, 146 (1): 86-88.DOI: 10.1007 / s10517-008-0212-5.

[9] Puspita R. Semax na Aɖuɖɔtoedɔdada[M]. 2020.DOI: 10.31219 / osf.io / hcn3g.

[10] Glazova NY, Manchenko D. M., Vilensky D. A., kple ame bubuwo. Semax ƒe ŋusẽkpɔɖeamedzi le Rat Models of Acute Stress me[J]. Journal of Nɔnɔmetɔtrɔ ƒe Nu gbagbewo ƒe Dzɔdzɔmeŋusẽŋununya kple Dzɔdzɔmeŋusẽŋununya, 2023,59 (1): 200-212.DOI: 10.1134 / S0022093023010179.

[11] Ashmarin I. P., Nezavibatko V. N., Myasoedov N. F., kple ame bubuwo. Nootropic analogue of adrenocorticotropin 4-10-semax (nuteƒekpɔkpɔ le aɖaŋuwɔwɔ kple numekuku me le ƒe 15 me)[J]. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I. P. Pavlova, 1997, 47 (2): 420-430. https://pubmed.ncbi.nlm.nih.gov/9173745/ Ƒe 1999 ƒe ɣleti gbãtɔ me.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO KAKAKA KPLEE NUFIAFIA ƑE TAÐOÐOWO KO TA.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.