Ðe nènya nu suesuesuewoa peptidewo abe Dihexa ene ate ŋu atrɔ ahɔhɔ̃a ƒe lãmesẽa? Dihexa, si woɖe tso angiotensin IV me la ɖe ŋugbedodo fia le ahɔhɔ̃a ƒe asitɔtrɔ le lãme na ame ŋu kple ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ me. Nyati sia ku alesi Dihexa wɔa dɔe kple ŋutete si le esi be wòakpɔ susu ƒe dɔmawɔmawɔ nyuie gbɔ.
Àsrɔ̃ nu tso Dihexa ƒe dɔwɔwɔ, viɖe siwo wòkpɔna, kple ŋusẽ si wòkpɔna ɖe ahɔhɔ̃a ƒe lãmesẽ dzi ŋu. Kpɔ alesi wòate ŋu akpe ɖe ame ŋu le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me ɖa.
Srɔ̃ nu geɖe tso míaƒe adzɔnuwo ŋu le Cocer Peptides.
Dihexa nye hexapeptide, si nye amino acid ade ƒe kɔsɔkɔsɔ kpui aɖe si wowɔ tso angiotensin IV, si nye peptide si le dzɔdzɔme nu me. To vovo na peptide bubu geɖe la, wotrɔ asi le Dihexa ŋu koŋ be wòage ɖe ʋu kple ahɔhɔ̃ ƒe mɔxenu (BBB) me nyuie wu. Esia wɔnɛ be wòkpɔa ŋusẽ ɖe ahɔhɔ̃a dzi tẽ, si le vevie ŋutɔ na eƒe zazã le susu ƒe dɔwɔwɔ nyuie kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie dada me. To dzɔdzɔme tsitsi ƒe dzesiwo sɔsrɔ̃ me la, Dihexa na mɔnu tɔxɛ aɖe si dzi woato ana ahɔhɔ̃a nawɔ dɔ nyuie wu.
Dihexa ƒe aɖaŋua tsɔ ami ƒe kɔsɔkɔsɔ (hexanoic acid) kple amino acid ƒe tɔtrɔ tɔxɛ aɖe si nye homophenylalanine de eme. Tɔtrɔ siawo siwo wowɔ le eƒe wɔwɔme ŋu nana Dihexa lɔ̃a ami wu, si wɔnɛ be ŋutete si le esi be wòatso BBB la eye wòanɔ ʋukawo me la dzina ɖe edzi. Aɖaŋu sia na Dihexa te ŋu gblɔa eƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ nyuie wu edzilawo ƒe molecule, angiotensin IV. Eƒe lolome sue si ade Da 500 kpena ɖe eŋu wòtoa nugbagbeviwo ƒe lãkusiwo me, siwo dome BBB hã le, be wòaɖo ahɔhɔ̃mekawo gbɔ eye wòawɔ eƒe ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo dzi.
Le eƒe taɖodzinu vevitɔ me la, Dihexa trɔa asi le ahɔhɔ̃mekawo ƒe dɔwɔwɔ ŋu—si nye ŋutete si le ahɔhɔ̃a si be wòawɔ ahɔhɔ̃mekawo ƒe kadodo siwo le ahɔhɔ̃mekawo dome ahagbugbɔ aɖo wo ɖe ɖoɖo nu. To tsitsimɔ veviwo abe HGF/c-Met ene ƒe dɔwɔwɔ me la, Dihexa ɖe ŋugbedodo fia le lãmeka yeyewo ƒe wɔwɔme dodo ɖe ŋgɔ kple ahɔhɔ̃mekawo ƒe tsitsi dodo ɖe ŋgɔ me. Esia le vevie ŋutɔ le ahɔhɔ̃a ƒe akpa siwo kpɔa gome le ŋkuɖoɖonudzi kple nusɔsrɔ̃ me, abe hippocampus ene.
Mɔnu vevitɔ si dzi Dihexa tona wɔa dɔe nye eƒe kadodo kple aklã me lãmenugbagbeviwo ƒe tsitsi ƒe akpa (HGF) kple c-Met xɔla. Zi geɖe la, HGF blana ɖe c-Met ŋu be wòaʋã dzesi gbogbo aɖewo siwo doa lãmenugbagbeviwo ƒe tsitsi, vovototodedeameme, kple agbetsitsi ɖe ŋgɔ. Dihexa, to kadodo kple HGF me la, edoa eƒe dɔwɔwɔ ɖe ŋgɔ le c-Met xɔla, si doa ŋusẽ eƒe ŋusẽkpɔɖeamedziwo. Dɔwɔwɔ sia hea dzesi siwo le anyime siwo kplɔ wo nɔewo ɖo siwo doa lãmenugbagbeviwo ƒe wɔwɔme kple ahɔhɔ̃mekawo ƒe kadodo ɖe ŋgɔ la vɛ.
Afɔɖeɖe le HGF/c-Met Mɔa dzi |
Afɔɖeɖe si Dihexa wɔ |
Ŋusẽkpɔɖeamedzi ɖe Ahɔhɔ̃a me Lãmenugbagbeviwo Dzi |
HGF ƒe Babla ɖe c-Met ŋu |
Dihexa doa ŋusẽ HGF ƒe kadodo ɖe c-Met xɔla ŋu |
Edzea lãmenugbagbeviwo ƒe agbenɔnɔ kple tsitsi ƒe dzesiwo gɔme |
c-Met Dɔwɔwɔ |
Dihexa doa ŋusẽ c-Met xɔla ƒe dɔwɔwɔ |
Enaa synapse ƒe wɔwɔme kple dendritic ƒe tsitsi dzina ɖe edzi |
Dzesi Siwo Wotsɔna Ðea Anyie |
PI3K/Akt kple MAPK/ERK mɔwo ƒe dɔwɔwɔ |
Edoa ahɔhɔ̃mekawo ƒe agbetsitsi kple synaptic plasticity ɖe ŋgɔ |
Dihexa ƒe HGF/c-Met mɔa ƒe dɔwɔwɔ hã doa alɔ ahɔhɔ̃mekawo ƒe dzɔdzɔ—si nye ahɔhɔ̃meka yeyewo ƒe wɔwɔ. Numekukuwo ɖee fia be Dihexa dzia dendritic spine density ɖe edzi le ahɔhɔ̃mekawo dzi, si nye synaptic kadodo yeyewo ƒe dzesi. Menye ɖeko akɔta siawo sɔ gbɔ wu ko o, ke wotsi wu hã, si fia be menye ɖeko Dihexa doa ŋusẽ ƒunukpeƒetetedɔ ƒe tsitsi ko o, ke edoa ŋusẽ wo hã hena kadodo si nyo wu le ahɔhɔ̃mekawo dome. Esia le vevie ŋutɔ na nusɔsrɔ̃, ŋkuɖoɖonudzi, kple susu ƒe dɔwɔwɔ bliboa.
Tsɔ kpe ɖe synaptic plasticity kple neurogenesis dodo ɖe ŋgɔ ŋu la, Dihexa naa ahɔhɔ̃mekawo takpɔkpɔ hã. Ekpena ɖe ahɔhɔ̃mekawo ŋu wotsia agbe le oxidative stress, aɖi ƒe agbɔsɔsɔ, kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe gbegblẽ me. To PI3K/Akt kple ERK/MAPK mɔwo ƒe dɔwɔwɔ me la, Dihexa naa lãmenugbagbeviwo ƒe agbenɔnɔ kple ŋusẽ wɔwɔ nyona ɖe edzi, si xea mɔ na lãmenugbagbeviwo ƒe gbegblẽ kple apoptosis (lãmenugbagbeviwo ƒe ku). Ametakpɔnu sia le vevie ŋutɔ be ahɔhɔ̃a ƒe lãmesẽ nanɔ anyi eye wòaxe mɔ ɖe susu ƒe dɔwɔwɔ ƒe toɖeɖe nu, vevietɔ le ahɔhɔ̃mekawo ƒe dɔléle siwo gblẽa nu le ame ŋu me.
Numekuku siwo wowɔ do ŋgɔ na dɔdamɔnua ku ɖe Dihexa ƒe ŋusẽkpɔɖeamedzi le lãwo ƒe kpɔɖeŋuwo me ŋu koŋ, eye emetsonu nyuiwo do tso eme. Le numekuku siwo wowɔ le lãklewo ŋu me la, wokpɔe be Dihexa naa nusɔsrɔ̃ kple ŋkuɖoɖonudzi nyona ɖe edzi le lã siwo ƒe susu mewɔa dɔ nyuie o me. Le kpɔɖeŋu me, sisiblisi siwo wotsɔ Dihexa da dɔe te ŋu wɔ dɔ nyuie wu le maze dodokpɔwo kple nusiwo wotsɔ dea dzesi nu ƒe dɔwo me ne wotsɔe sɔ kple sisiblisi siwo womewɔ atike na o siwo ƒe susu ƒe dɔwɔwɔ gblẽ. Nusiwo do tso eme siawo ɖee fia be ŋutete le Dihexa ŋu be wòatrɔ susu ƒe dɔmawɔmawɔ nyuie, si nye ahɔhɔ̃mekawo ƒe dɔléle geɖe ƒe dzesi.
Tsɔ kpe ɖe susu ƒe dɔmawɔmawɔ nyuie ŋu la, wole numekuku wɔm le Dihexa ƒe ŋutete be wòado hayahaya ɖe ŋgɔ le ahɔhɔ̃ ƒe abixɔxɔ ƒe kpɔɖeŋuwo me ŋu. Lãwo ŋuti numekukuwo ɖee fia be Dihexa ate ŋu akpe ɖe ahɔhɔ̃mekawo ƒe nutome siwo gblẽ la dzadzraɖo ŋu, ado axonal sprouting ɖe ŋgɔ, eye wòana synaptic reconstruction nanyo ɖe edzi le ahɔhɔ̃mekawo ƒe abixɔxɔ ƒe kpɔɖeŋuwo me. Esia fia be Dihexa ate ŋu aɖe vi le nɔnɔmewo abe ahɔhɔ̃mekawo ƒe abixɔxɔ si nu sẽ (TBI) kple ʋusɔgbɔdɔ ene, afisi ahɔhɔ̃mekawo ƒe gbegblẽ gblẽa nu le ahɔhɔ̃a ƒe dɔwɔwɔ nyuie ŋu le.
Gawu la, wole nu srɔ̃m tso Dihexa ŋu le akpa si wòate ŋu awɔ le ahɔhɔ̃mekawo ƒe dɔlélewo abe Alzheimer kple Parkinson ene me ŋu. Lãwo ƒe kpɔɖeŋu siwo wowɔ le Alzheimer ƒe dɔlélea ŋu ɖee fia be Dihexa zazã nana be ŋkuɖoɖonudzi nyona ɖe edzi eye ahɔhɔ̃a ƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzina ɖe edzi. Esia ɖe dzesi ŋutɔ elabena ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe bu nye nu vevi aɖe le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me. To synaptogenesis dodo ɖe ŋgɔ me la, Dihexa ate ŋu akpe ɖe ame ŋu wòagbugbɔ susu ƒe dɔwɔwɔ aɖo anyi eye wòana dɔléle siawo ƒe ŋgɔyiyi nagbɔdzɔ.
Le dodokpɔ siwo wowɔ le nudokpɔƒe me la, wokpɔe hã be Dihexa dzia synaptic plasticity ɖe edzi le hippocampal neurons me. Esia nye nu vevi aɖe le nusɔsrɔ̃ kple ŋkuɖoɖonudzi me, elabena synaptic plasticity ye doa alɔ ŋutete si le ame si be wòawɔ ŋkuɖodzinuwo ahalé wo ɖe te. Hippocampal ƒe dɔwɔwɔ ƒe nyonyo to Dihexa dzi ate ŋu ana lãwo ƒe susu ƒe dɔwɔwɔ nanyo ɖe edzi, si ana gɔmeɖoanyi na numekuku bubuwo le eƒe atikewɔwɔ ƒe ŋutete na amegbetɔ ƒe susu ƒe dɔmawɔmawɔ nyuie ŋu.
Nusɔsrɔ̃ Ƒomevi |
Emetsonu si Wokpɔ |
Nyanuwuwuw |
Sidzedze ƒe Dɔmawɔmawɔ nyuie ƒe Kpɔɖeŋu |
Nusɔsrɔ̃ si nyo ɖe edzi le maze dodokpɔwo kple nusiwo wotsɔ dea dzesi nu me |
Dihexa trɔ susu ƒe dɔmawɔmawɔ nyuie le sisiblisi siwo ƒe ŋkuɖoɖonudzi mesẽ o ŋu |
Ahɔhɔ̃mekawo ƒe Dɔléle ƒe Kpɔɖeŋu |
Synaptic density ƒe dzidziɖedzi le Alzheimer ƒe dɔléle ƒe kpɔɖeŋuwo me |
Dihexa ate ŋu akpe ɖe ame ŋu be lãmenugbagbeviwo ƒe kadodowo nagaɖo anyi le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ƒe nɔnɔmewo me |
Ahɔhɔ̃ ƒe Nuveviwɔame ƒe Kpɔɖeŋu |
Axonal sprouting kple synaptic gbugbɔgatu si wodo ɖe ŋgɔ |
Dihexa ɖe ŋugbedodo fia be yeaɖɔ ahɔhɔ̃mekawo ƒe gbegblẽ le ahɔhɔ̃ ƒe abixɔxɔ me ɖo |
Dihexa ƒe ŋugbedodotɔwo dometɔ ɖeka dɔwɔwɔwo le Alzheimer-dɔléle kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ƒe nɔnɔme bubuwo dada me. Numekukuwo ɖee fia be Dihexa ate ŋu akpe ɖe ame ŋu wòaɖe susu ƒe dɔwɔwɔ dzi akpɔtɔ alo atrɔe gɔ̃ hã to lãmenugbagbeviwo ƒe tsitsi dodo ɖe ŋgɔ kple ahɔhɔ̃mekawo ƒe kadodowo dodo ɖe ŋgɔ me. To HGF/c-Met mɔa dodo ɖe ŋgɔ me la, Dihexa ate ŋu ado alɔ ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ eye wòana ŋkuɖoɖonudzi ƒe dɔwɔwɔ nanyo ɖe edzi le dɔnɔ siwo ŋu Alzheimer ƒe dɔlélea le me.
Dihexa ƒe ahɔhɔ̃mekawo takpɔkpɔ ƒe ŋutetewo xɔ asi ŋutɔ na ame ɖekaɖeka siwo ŋu ɖeɖiteameŋu le susu ƒe dɔwɔwɔ me, ahɔhɔ̃ me fuɖename, kple susu ƒe dɔmawɔmawɔ nyuie ƒe dzesi bubuwo le fu ɖem na. To ahɔhɔ̃mekawo ƒe tsitsi dodo ɖe ŋgɔ kple synaptic plasticity dodo ɖe ŋgɔ me la, Dihexa ate ŋu ana ŋkuléle ɖe nu ŋu, ŋkuɖoɖonudzi, kple susu ƒe dɔwɔwɔ bliboa nanyo ɖe edzi. Tsɔ kpe ɖe eŋu la, ŋutete si le esi be wòakpɔ ahɔhɔ̃mekawo ta tso nusiwo gblẽ me na wònye tiatia si hea ame hena ahɔhɔ̃mekawo ƒe abi siwo nuveviwɔame alo ʋusɔgbɔdɔ hena vɛ dada.
Le eƒe ahɔhɔ̃mekawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedziwo godo la, ŋutete le Dihexa ŋu be wòana ŋkuɖoɖonudzi kple nusɔsrɔ̃ nanyo ɖe edzi. Le lãwo ŋuti numekukuwo me la, wokpɔe be Dihexa naa nusɔsrɔ̃ ƒe ŋutetewo nyona ɖe edzi le dɔwo abe maze navigation kple nuwo ƒe dzesidede me. Anɔ eme be ŋutete si le Dihexa si be wòana ahɔhɔ̃mekawo ƒe dɔwɔwɔ nadzi ɖe edzi eye wòdoa ahɔhɔ̃mekawo ƒe dɔwɔwɔ ɖe ŋgɔ gbɔ, eye esia evea siaa le vevie ŋutɔ na susu ƒe dɔwɔwɔ.
Togbɔ be Dihexa nye peptide si ŋugbe wodo na ahɔhɔ̃ ƒe lãmesẽ hã la, menye eya koe nye atike si le hatsotso sia me o. Wole nu srɔ̃m tso peptide bubuwo abe Sema ene hã ŋu le woƒe ahɔhɔ̃mekawo kple susuŋudɔwɔwɔ ƒe ŋutetewo ŋu. To vovo na Dihexa, si koŋ naa HGF/c-Met mɔa wɔa dɔ la, Sema wɔa dɔ to ahɔhɔ̃mekawo ƒe dɔwɔwɔ (BDNF), si nye protein si doa alɔ ahɔhɔ̃mekawo ƒe wɔwɔme kple ahɔhɔ̃mekawo ƒe tsitsi dzi ɖeɖe kpɔtɔ me. Peptide eveawo siaa ɖe ŋugbedodo fia, gake woƒe dɔwɔwɔ ƒe mɔnuwo to vovo, eye numekuku bubuwo ana woanya esi wɔa dɔ wu na susu ƒe nɔnɔme tɔxɛwo.
Dihexa ƒe ŋutete be wòado lãmenugbagbeviwo ƒe dɔwɔwɔ kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ ɖe ŋgɔ na wònye dɔwɔnu sẽŋu aɖe na susuŋudɔwɔwɔ ƒe atikewɔwɔ. To HGF/c-Met mɔa dzi dzedze me la, Dihexa naa mɔnu si le tẽ wu si dzi woato aʋã ahɔhɔ̃a ƒe ɖɔɖɔɖo eye wòana susu ƒe dɔwɔwɔ nanyo ɖe edzi. Afɔɖeɖe sia si woɖo taɖodzinu na ate ŋu ana Dihexa nawɔ dɔ wu peptide bubuwo le dɔwɔwɔ aɖewo me, vevietɔ le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie kple ahɔhɔ̃ ƒe abi dada me.
Peptide si woyɔna be peptide |
Dɔwɔwɔ ƒe Mɔnu |
Taɖodzinu ƒe Mɔ |
Viɖe Siwo Ate Ŋu Akpɔ |
Dihexa ƒe ŋkɔ |
Edoa HGF/c-Met ƒe dzesiwo ɖe ŋgɔ, edoa synaptogenesis kple neurogenesis ɖe ŋgɔ |
HGF/c-Met ƒe dɔwɔwɔ |
Sidzedze ƒe ŋgɔyiyi, ahɔhɔ̃mekawo ƒe wɔwɔme, synapse ƒe wɔwɔme |
Sema |
Dzia BDNF ɖe edzi, doa ŋusẽ serotonergic kple dopaminergic ɖoɖowo |
BDNF/Serotonergic & Dopaminergic Dɔwɔɖoɖowo |
Ŋkuɖodzinu ƒe nyonyo, nuteɖeamedzi dzi ɖeɖe kpɔtɔ, seselelãme ƒe ɖoɖowɔwɔ |
Togbɔ be Dihexa ɖe ŋugbedodo fia le numekuku siwo wowɔ do ŋgɔ na dɔdamɔnu me hã la, mege ɖe amegbetɔwo ƒe dodokpɔ gãwo me haɖe o. Trɔtrɔ tso lãwo ƒe kpɔɖeŋuwo dzi yi amegbetɔwo ŋuti numekukuwo dzi hea kuxi geɖe vɛ, siwo dometɔ aɖewoe nye agbɔsɔsɔme si sɔ nyuie, dedienɔnɔ si anɔ anyi ɣeyiɣi didi, kple eƒe nugbegblẽ le ame ŋu si ate ŋu ado tso eme la nyanya. Le fifia nu la, Dihexa gakpɔtɔ nye dodokpɔ ƒe atike, eye numekuku geɖe hiã be woatsɔ akpɔ eƒe dedienɔnɔ kple dɔwɔwɔ le amegbetɔwo me.
Togbɔ be womedo amegbetɔwo kpɔ o hã la, wole Dihexa zãm xoxo le atikewɔƒewo, vevietɔ le atikewɔwɔ si wɔa dɔ kple esi gbugbɔa nu gbugbɔna me. Ŋutete si le esi be wòana susu ƒe dɔwɔwɔ nanyo ɖe edzi eye wòado ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ ɖe ŋgɔ na wònye dɔwɔnu vevi aɖe si woatsɔ ada dɔnɔ siwo ƒe susu mewɔ dɔ nyuie o, ahɔhɔ̃ me abi, kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ƒe dɔlélewo. Ne numekukua le edzi yim la, ŋutete si le Dihexa si le atikewɔnyawo me la me adze ƒã wu.
Numekuku siwo yi edzi le ŋusẽ si Dihexa kpɔna ɖe ahɔhɔ̃ ƒe lãmesẽ kple susu ƒe dɔwɔwɔ dzi ŋu la do ŋugbe. Anɔ eme be numekuku siwo woawɔ le etsɔme aƒo nu tso ŋutete si le esi le nɔnɔmewo abe Parkinson ƒe dɔléle, Alzheimer ƒe dɔléle, kple susu ƒe dɔmawɔmawɔ nyuie si do ƒome kple tsitsi ene dada me ŋu. Numekulawo le Dihexa ƒe ŋutete hã me dzrom be wòado alɔ hayahaya tso ahɔhɔ̃ me abi kple ʋusɔgbɔdɔ sesẽwo me.
Dihexa ƒe ŋutete be wòaɖɔ ahɔhɔ̃mekawo ƒe kadodowo ɖo ahado ahɔhɔ̃a ƒe plasticity ɖe ŋgɔ la na wòzu akpa vevi aɖe le etsɔme atikewɔwɔwo me na susu ƒe lãmesẽ. Esi numekukuwo le edzi yim la, Dihexa ate ŋu ava zu atikewɔwɔ siwo ƒe taɖodzinue nye be woagbugbɔ ahɔhɔ̃a awɔ dɔ nyuie, ana ŋkuɖoɖonudzi nanyo ɖe edzi, eye woaxe mɔ ɖe ame tsitsiwo ƒe susu ƒe ɖiɖi nu ƒe akpa vevi aɖe.
Dihexa nye dodokpɔ peptide si ɖe ŋutete gã aɖe fia le tɔtrɔ gã aɖe le susu ƒe lãmesẽ kple ahɔhɔ̃ ƒe gbugbɔgadzɔ ŋu. To ahɔhɔ̃mekawo ƒe tsitsi, ahɔhɔ̃mekawo ƒe dzɔdzɔ, kple ahɔhɔ̃mekawo ƒe agbetsitsi dodo ɖe ŋgɔ me la, edo ŋugbe na ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, ahɔhɔ̃ ƒe abixɔxɔ, kple susu ƒe dɔmawɔmawɔ nyuie dada. Togbɔ be numekukua ƒe akpa gãtɔ gakpɔtɔ le afɔɖeɖe siwo do ŋgɔ na dɔdamɔnua me hã la, nusiwo ŋu woke ɖo vaseɖe fifia do ŋugbe. Ne woyi numekuku kple dɔdamɔnu dodokpɔwo dzi la, Dihexa ate ŋu awɔ akpa vevi aɖe le ahɔhɔ̃a ƒe lãmesẽ dodo ɖe ŋgɔ me.
Le Cocer Peptides , míetsɔa atike deŋgɔ siwo naa kpekpeɖeŋu xɔasi aɖe na susu ƒe lãmesẽ, si kpena ɖe ame ŋu be wòaʋu mɔ na etsɔme nyui aɖe le ahɔhɔ̃ŋutinunya me.
A: Dihexa peptide nye nusi wowɔ tso angiotensin IV me, si wowɔ be wòado ahɔhɔ̃a ƒe plasticity kple ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ ɖe ŋgɔ. Ewɔa dɔ to HGF/c-Met mɔa ƒe dɔwɔwɔ me, si doa ŋusẽ lãmenugbagbeviwo ƒe tsitsi, ahɔhɔ̃mekawo ƒe dzɔdzɔ, kple ahɔhɔ̃mekawo ƒe agbetsitsi.
A: Dihexa peptide kpena ɖe ame ŋu be ŋkuɖoɖonudzi kple nusɔsrɔ̃ dzina ɖe edzi to lãmenugbagbeviwo ƒe wɔwɔme dodo ɖe ŋgɔ kple ahɔhɔ̃mekawo takpɔkpɔ me, si naa atikewɔwɔ si ate ŋu anɔ nɔnɔmewo abe Alzheimer kple susu ƒe dɔmawɔmawɔ nyuie ene.
A: Dihexa peptide gakpɔtɔ nye dodokpɔ ƒe atike, si wodo kpɔ fifia le lãwo ƒe kpɔɖeŋuwo me ko. Wogale eƒe dedienɔnɔ kple eƒe dɔwɔwɔ nyuie le amegbetɔwo ŋu me kum to numekuku siwo le edzi yim me.
A: Dihexa peptide doa lãmenugbagbeviwo ƒe tsitsi kple ahɔhɔ̃mekawo ƒe dzɔdzɔ ɖe ŋgɔ tẽ, si naa viɖe siwo woɖo taɖodzinu na wu esiwo wozãna tsɔ doa ŋusẽ susu ƒe dɔwɔwɔ zi geɖe. Ekpɔa ahɔhɔ̃mekawo ta hã, si doa alɔ ahɔhɔ̃ ƒe lãmesẽ le ɣeyiɣi didi me.
