▎ Gịnị bụ TB-500?
TB-500 (Thymosin Beta-4) bụ peptide endogenous mejupụtara amino asịd 43, nke sitere na mpaghara na-arụ ọrụ nke thymosin β4 nke mmadụ. Ọ na-egosipụta ọmarịcha mmiri solubility na nkwụsi ike nhazi, na-emekarị na anụ ahụ dị ka ọbara, akwara, na akpụkpọ ahụ, enwere ike nweta ya site na usoro sịntetik. Tụnyere thymosin β4 na-emebibeghị, TB-500 na-ejigide ọrụ ndu ebe anụ ahụ na-etinye ya ngwa ngwa site na ịgba ọgwụ. Ọ na-arụ ọrụ na-achọghị mgbanwe mgbagwoju anya, na-eme ka ọ bụrụ otu n'ime ụmụ irighiri ihe peptide kacha mụọ n'ọhịa nrụzi anụ ahụ.
TB-500 na-akwalite mbugharị cell na mmeghari anụ ahụ site n'ịkwalite ikike ịkwaga nke mkpụrụ ndụ metụtara nrụzi dị ka mkpụrụ ndụ endothelial na fibroblasts. Ọ na-eme ka angiogenesis na ntinye collagen dịkwuo elu, na-enyere aka n'ịrụzi mmerụ anụ ahụ na-ejikọta na mọzụlụ, akwara, ligaments, na akpụkpọ ahụ. N'otu oge ahụ, ọ na-ahazi itule matrix extracellular iji belata nguzobe oke ọnya. Ọ na-egosipụta mmetụta mgbochi mkpali na cytoprotective site na igbochi ntọhapụ nke ihe ndị na-emepụta ihe dị ka TNF-a na IL-1β, si otú ahụ na-ebelata nsị anụ ahụ na edema. Ọzọkwa, ọ na-eme ka nguzogide nrụgide antioxidant cellular, na-ebelata mmebi sitere na ischemia na toxins, ma na-arụ ọrụ dị mkpa n'ịkwụsị microenvironment nke anụ ahụ merụrụ ahụ.
A na-eji ya dị ka ihe mgbakwunye ọgwụgwọ maka mmerụ ahụ metụtara egwuregwu dị ka ụbụrụ muscle, tendinitis, na anya mmiri ligament, na-ebelata usoro ọgwụgwọ na inye aka na mweghachi nke egwuregwu. N'ọgwụgwọ ọnya, ọ na-eme ka mmechi nke ọnya na-adịghị agwọ ọrịa na-adịghị ala ala (dịka ọmụmaatụ, ọnya ụkwụ na-arịa ọrịa shuga) yana mmerụ ahụ ọkụ site na ịkwalite uto anụ ahụ granulation na mbugharị cell epithelial. N'ime mmebi nke anụ ahụ, ọ na-egosipụtakwa ịdị irè na mmerụ ahụ akwara (dịka ọmụmaatụ, nhụsianya akwara dị n'akụkụ) yana ọmụmụ nrụzi post-myocardial ischemia.
Mmechi
Ngwakọta BPC-157/TB-500 bụ usoro ihe mejupụtara nke nwere peptides abụọ nwere ike ịrụzi anụ ahụ. BPC-157, ewepụtara na protein mucosal afọ mmadụ, nwere amino acid 15, ebe TB-500 bụ iberibe thymosin β4 na-arụ ọrụ, nke nwere amino acid 43. Mgbe ejikọtara ha, ha na-enwe mmetụta synergistic. BPC-157 na-akwalite mgbasa nke fibroblast, na-eme ka iguzosi ike n'ezi ihe na-egbochi mucosal, ma na-egbochi ntọhapụ pro-inflammatory, ebe TB-500 na-achịkwa actin polymerization, na-eme ka ịkwaga cell dịkwuo elu, na-akpali angiogenesis. N'otu aka, ha na-eme ka anụ ahụ dị ọhụrụ na ịrụzi ọrụ nke ọma, na-enwekwu mmetụta mgbochi mkpali, nchebe akụkụ visceral, na mmelite nke microenvironment cellular. Nchọpụta ngwa ugbu a na-elekwasị anya na mgbake mmerụ egwuregwu (dịka ọmụmaatụ, tendinitis, eriri anụ ahụ, mmerụ ahụ ligament); nchebe mucosal eriri afọ (dịka ọmụmaatụ, ọnya afọ, ọrịa eriri afọ mkpali na-enye aka); na ọtụtụ anụ ahụ na-emebi mweghachi synergistic (dịka ọmụmaatụ, ọnya anụ ahụ, obere mmerụ ahụ visceral). Usoro mgbakwunye a na-ebelata okirikiri nrụzi, na-ebelata nzaghachi mkpali, ma na-eme ka itinye aka n'ihe metụtara mmebi anụ ahụ.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
