BPC157, TB-500 5mg (ngwakọta)

▎ TB-500

TB-500, ihe nrụpụta sịntetik nke Thymosin Beta-4 (Tβ4), bụ molekul polypeptide. Isi usoro ya na-enweta ụkpụrụ dị ike site na ịchịkwa nguzozi n'etiti mgbakọ na mwepụ nke actin n'ime cytoskeleton. Mkpụrụ ndụ a nwere ike ịkwalite ikike ịkwaga cell, mmụba, na ọdịiche dị iche iche, si otú a na-ekere òkè dị mkpa na nhazi nhazi na nhazi nke anụ ahụ. N'ebe a na-edozi ọnyá akpụkpọ ahụ, TB-500 nwere ike ime ka usoro mmechi ahụ dịkwuo ngwa ngwa, kwalite ntinye nke collagen n'usoro, ma gbochie mgbasawanye nke anụ ahụ na-adịghị mma; maka ọrịa metabolic, ọ nwere ike belata usoro pathological nke mbufụt, dị ka ọrịa imeju abụba na-adịghị egbu egbu na fibrosis pulmonary, site na igbochi mwepụta nke cytokines pro-inflammatory; N'ihe banyere nchebe obi, n'oge nnukwu ọrịa myocardial infarction, TB-500 nwere ike ichebe cardiomyocytes dị ndụ, mee ka usoro angiogenesis nke endogenous rụọ ọrụ, na-ebuli netwọk microcirculation myocardial, ma na-emecha welie arụmọrụ nke obi.

Okwesiri iburu n'uche na TB-500 na-egosiputa bioavailability dị elu, mmetụta synergistic multi-target, yana ezigbo biocompatibility. Ngwongwo ya pụrụ iche nke na-eche anụ ahụ na-enyere ya aka ime ya kpọmkwem na microenvironment nke anụ ahụ mebiri emebi, na-ebelata ihe ize ndụ nke ikpughe usoro ahụ mgbe ọ na-enweta ọgwụgwọ ezubere iche. Usoro ihe omimi a na-adabere na nhazi nke actin dynamics ọ bụghị nanị na-enye usoro ọgwụgwọ ọhụrụ maka ọgwụgwọ anụ ahụ na-emegharị ahụ kamakwa na-etinye ntọala siri ike nke usoro ihe ọmụma na nkwado siri ike maka ngwa nsụgharị ụlọ ọgwụ. Site n'otu oge na-arụ ọrụ ọtụtụ ụzọ nke angiogenesis, mgbochi mbufụt, na cytoprotection, TB-500 na-egosi atụmanya ngwa ngwa n'ịkwado homeostasis anụ ahụ na nrụzi arụ ọrụ.

▎ Nchịkọta

Ejikọtara ọnụ nke BPC 157 na TB500 na-egosipụta mmetụta synergistic dị ịrịba ama n'ọtụtụ mpaghara dị ka nrụzi anụ ahụ, mgbochi mbufụt, na angiogenesis. Nke a synergistic mmetụta ọ bụghị nanị enhances ọgwụgwọ mmetụta nke otu molekul kamakwa gbasaa ya ngwa akporo, na-enye ọhụrụ ohere maka ọgwụgwọ nke ọrịa dị iche iche.

Mmezi anụ ahụ na mmụgharị

BPC 157 na-eme ngwa ngwa nrụzi anụ ahụ site n'ịkwalite njikọ nke collagen, mmụba na mbugharị nke fibroblasts, na ịkwalite angiogenesis. TB500 na-akwalite ịkwaga cell na ọdịiche dị iche iche site na ịhazi nguzozi ike nke actin, na-enye nkwado nhazi maka nrụzi anụ ahụ. Mgbe ejiri ya mee ihe, BPC 157 na TB500 na-eme synergistically na ọkwa cellular, na-eme ka ikike nke imegharị anụ ahụ dịkwuo elu. Dịka ọmụmaatụ, na nrụzi ọnya akpụkpọ ahụ, BPC 157 na-eme ka mmechi ọnya dịkwuo ngwa ngwa, ebe TB500 na-akwalite ntinye nke collagen n'usoro, na-ejikọta ọnụ na-egbochi hyperplasia na-adịghị mma nke anụ ahụ na-egbu egbu. Na mmerụ ahụ akwara na akwara, BPC 157 na-akwalite angiogenesis, na-enye nkwado nri maka nrụzi, ebe TB500 na-akwalite ịkwaga cell na saịtị mmerụ ahụ site n'ịhazi cytoskeleton, na-eme ka anụ ahụ dịkwuo elu.

Mgbochi mbufụt na mgbochi mgbochi

BPC 157 nwere mmetụta mgbochi mkpali dị ịrịba ama, nke nwere ike ibelata ntọhapụ nke ihe ndị na-emepụta ihe dị ka TNF-α na IL-6, ma n'otu oge ahụ na-eme ka nkwupụta nke ihe mgbochi dị ka IL-10. TB500 na-ebelata mbufụt site na igbochi nzaghachi mgbochi metụtara mbufụt. Mgbe ejiri ya mee ihe, BPC 157 na TB500 na-emepụta mmetụta synergistic na igbochi nzaghachi mkpali, nke na-enweghị ike iwepụ nnukwu mbufụt ngwa ngwa kamakwa ịchịkwa mmepe nke mbufụt na-adịghị ala ala. Nke a synergistic mmetụta dị ịrịba ama karịsịa na mbufụt metụtara ọrịa ndị dị ka ndị na-abụghị mmanya na-aba n'anya abụba ọrịa imeju na pulmonary fibrosis, nke nwere ike budata mma pathological usoro na-akwalite mgbake nke anụ ahụ ọrụ.

Angiogenesis na nnyefe nri

Ma BPC 157 na TB500 nwere ike ịkwalite angiogenesis ma melite nnyefe ọbara na anụ ahụ mebiri emebi. BPC 157 na-akwalite angiogenesis site n'ịkwalite mmụba, mbugharị, na ike ịmepụta lumen nke mkpụrụ ndụ endothelial, na-enye nri dị mkpa na oxygen maka ịrụzi anụ ahụ. TB500 na-akwalite ịkwaga na ọdịiche nke sel endothelial vaskụla site na ịhazi actin dynamics, na-eme ka nhazi nke netwọkụ vaskụla dịkwuo mma. Mgbe ejiri ya mee ihe, BPC 157 na TB500 na-etolite usoro nkwado na usoro nke angiogenesis. BPC 157 na-enye nkwado ndabere maka angiogenesis, ebe TB500 na-eme ka nhazi na ọrụ nke arịa ọbara dịkwuo mma, si otú a na-emeziwanye arụmọrụ na ịdị mma nke nrụzi anụ ahụ.

Mee mgbake na mgbochi ike ọgwụgwụ

N'ihe gbasara mgbake mgbatị ahụ, ijikọ BPC 157 na TB500 nwere ike belata oge mgbake nke mmerụ ahụ kpatara mmega ahụ. BPC 157 na-ebelata ahụ mgbu na mbufụt site n'ịkwalite nrụzi anụ ahụ na mmetụta mgbochi mkpali, ebe TB500 na-eme ka nrụzi na nweghachi ike nke mkpụrụ ndụ akwara site na ịhazi cytoskeleton. Mgbe ejikọtara ọnụ, BPC 157 na TB500 na-etolite mmetụta synergistic na nrụzi mmerụ ahụ, nke nwere ike ọ bụghị naanị belata mgbu ahụ ngwa ngwa kamakwa kwalite ike na ntachi obi ike, na-eme ka mgbake nke arụmọrụ egwuregwu dị ngwa ngwa.

Mgbochi ịka nká

Ngwakọta ejikọtara ọnụ nke BPC 157 na TB500 na-egosi ikike mgbochi ịka nká na ịdị ogologo ndụ site n'ịkwalite nrụzi cell na mmeghari na ịkwado ahụike nke sistemu obi na akwara. BPC 157 na-echebe mkpụrụ ndụ pụọ na mmebi radical free site na mgbochi mkpali na mmetụta antioxidant, ebe TB500 na-ejigide ọrụ nkịtị na nhazi nke mkpụrụ ndụ site na ịhazi cytoskeleton. Mgbe ejiri ya mee ihe, BPC 157 na TB500 na-etolite usoro nchebe synergistic na ọkwa cellular, nke nwere ike ọ bụghị naanị igbu oge ịka nká kamakwa mee ka ikike ịmaliteghachi nke mkpụrụ ndụ, si otú ahụ na-eme ka ọnọdụ ahụike zuru oke nke ahụ dịkwuo mma ma na-egbu oge usoro ịka nká.

Mgbake mgbe arụchara arụ ọrụ yana njikwa ọrịa na-adịghị ala ala

Na mgbake mgbe arụchara ọrụ na njikwa ọrịa na-adịghị ala ala, ijikọ BPC 157 na TB500 nwere ike ime ka mmezi anụ ahụ dịkwuo ngwa ngwa ma melite ọnọdụ ahụike zuru oke. BPC 157 na-ebelata ihe mgbagwoju anya mgbe ọ gasịrị site n'ịkwalite nrụzi anụ ahụ na mmetụta mgbochi mkpali, ebe TB500 na-eme ka ike nweghachi anụ ahụ site na ịhazi cytoskeleton. Mgbe ejiri ya na ngwakọta, BPC 157 na TB500 na-etolite mmetụta synergistic na mgbake postoperative, nke nwere ike ọ bụghị naanị mee ka ọgwụgwọ ọnya dị ngwa ngwa kamakwa melite mgbake ọrụ mgbe ịwachara ahụ ma welie ndụ ndị ọrịa.

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