1kits (10Ibikoresho)
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▎ BPC 157
BPC 157 ni peptide ya syntetique igizwe na acide amine cumi nagatanu, kandi izina ryayo ryuzuye ni umubiri urinda umubiri 157. Ubushakashatsi bwerekanye ko BPC 157 ifite imirimo myinshi yibinyabuzima, harimo kwihutisha gusana ingirabuzimafatizo, neuroprotection, anti-ibisebe, anti-inflammatory, na antioxydeant. Mu rwego rwo gusana ingirangingo, BPC 157 irashobora guteza imbere cyane kuvugurura ingingo zihuza nkuruhu, imitsi, na ligaments, kandi byagaragaje imbaraga zidasanzwe cyane cyane mugukiza ibikomere byahiye. Uburyo bwibikorwa bukubiyemo kongera ubwiyongere, kwimuka, hamwe nubushobozi bwo gukora ingirabuzimafatizo ya endoteliyale, bityo bigatera angiogenezi no kuvugurura ingirabuzima fatizo.
Ku bijyanye na neuroprotection, BPC 157 igira ingaruka nziza kuri sisitemu yo hagati yo hagati igenga urwego rwa neurotransmitter nka serotonine na dopamine, kandi irashobora guteza imbere ibibazo nko kutarya, kuribwa nabi, no gukingira indwara. Byongeye kandi, BPC 157 yerekana ibintu bikomeye birwanya ibisebe na anti-inflammatory, bishobora gukomeza ubusugire bwa mucosa gastrointestinal kandi bikarinda indwara ziterwa nuburozi gutera amara. Mu rwego rwo kurinda umwijima, iyi molekile irinda cyane imikorere yumwijima ibuza ikwirakwizwa ry’uturemangingo rudasanzwe, kugumana ubusugire bw’imiterere ya hepatocytes, guhagarika ibimenyetso byerekana imisemburo, kugabanya urwego rwibintu bitera umuriro, no guhagarika fiboside yumwijima.
Ugereranije n’ibindi biyobyabwenge, ibyiza bya BPC 157 biri muburozi bwayo buke no kutagira ingaruka zikomeye, byerekana umutekano mwiza no kwihanganira muburyo butandukanye bwinyamaswa. Kugeza ubu, BPC 157 ntabwo ifite ingaruka zidasanzwe zo kuvura mu kuvura indwara zo mu gifu ahubwo inerekana indangagaciro zishobora gukoreshwa mu guteza imbere ingirabuzimafatizo, kunoza imikorere ya sisitemu yo hagati y’imitsi, ndetse no mu rwego rwo kurwanya gusaza.
▎ TB4
TB4, ikomoka kuri synthique ya Thymosine Beta-4 (Tβ4), ni molekile ya polypeptide. Uburyo bwibanze bugera kumabwiriza agenga kugenzura neza uburinganire hagati yinteko no gusenya actin muri cytoskeleton. Iyi molekile irashobora kuzamura cyane ubushobozi bwimuka ryimuka, gukwirakwizwa, no gutandukana, bityo bikagira uruhare runini mugutegeka mugikorwa cyo gusana no kuvugurura. Mu rwego rwo gusana ibikomere byuruhu, TB4 irashobora kwihutisha gahunda yo gufunga ibikomere, guteza imbere kolagen igenda neza, kandi ikabuza ikwirakwizwa ridasanzwe ryimyanya ndangagitsina; ku ndwara ziterwa na metabolike, irashobora kugabanya neza inzira ya pathologiya yunganirwa no gutwikwa, nk'indwara y'umwijima idafite inzoga na fibrosis yo mu bihaha, mu kubuza irekurwa rya cytokine itera umuriro; mu rwego rwo kurinda umutima-mitsi, mugihe cyicyiciro cya infarction myocardial, TB4 irashobora kurinda kardiomyocytes ikiriho, igakora gahunda ya endogenous angiogenez, igahindura imiyoboro ya microcirculation myocardial, hanyuma amaherezo ikazamura imikorere yo kuvoma umutima.
Birakwiye ko tumenya ko TB4 yerekana bioavailability nyinshi, intego-yo guhuza intego nyinshi, hamwe na biocompatibilité nziza. Umutungo wacyo udasanzwe ugamije gukora neza bituma ukora neza kuri microen ibidukikije yingirangingo zangiritse, bikagabanya cyane ibyago byo guhura na sisitemu mugihe ugera kubuvuzi bugamije. Ubu buryo bwa molekuline bushingiye ku kugenga imbaraga za actin ntabwo butanga gusa uburyo bushya bwo kuvura imiti ivura ingirabuzima fatizo gusa ahubwo inashyiraho urufatiro rukomeye kandi rushyigikiwe n’ubuvuzi bukoreshwa mu buvuzi. Mugukoresha icyarimwe inzira nyinshi za angiogenez, anti-inflammation, na cytoprotection, TB4 yerekana uburyo bwagutse bwo gukoresha mugukomeza urugingo rwa homeostasis no gusana imikorere.
Incamake
Gukoresha hamwe BPC 157 na TB4 byerekana ingaruka zikomeye mubikorwa bitandukanye nko gusana ingirangingo, kurwanya inflammatory, na angiogenez. Izi ngaruka zo guhuza imbaraga ntizongera gusa ingaruka zo kuvura molekile imwe gusa ahubwo inagura uburyo ikoreshwa, itanga uburyo bushya bwo kuvura indwara zitandukanye.
Gusana imyenda no kuvugurura
BPC 157 yihutisha gusana ingirabuzimafatizo iteza imbere synthesis ya kolagen, ikwirakwizwa no kwimuka kwa fibroblast, no kongera angiogenez. TB4 iteza imbere kwimuka kwakagari no gutandukana muguhuza imbaraga za actin, itanga inkunga yuburyo bwo gusana ingirangingo. Iyo ikoreshejwe hamwe, BPC 157 na TB4 ikorana murwego rwakagari, byongera cyane ubushobozi bwo kuvugurura ingirangingo. Kurugero, mugukosora ibikomere byuruhu, BPC 157 yihutisha gufunga ibikomere, mugihe TB4 iteza imbere gahunda ya kolagen ikurikirana, hamwe ikabuza hyperplasia idasanzwe yimitsi yinkovu. Mu gukomeretsa kw'imitsi no mu mitsi, BPC 157 itera angiogenez, itanga infashanyo zintungamubiri zo gusana, mugihe TB4 iteza kwimuka kwakagari aho yakomeretse igenga cytoskeleton, yihutisha kuvugurura ingirangingo.
Kurwanya Kurwanya no Kurinda Immune
BPC 157 ifite ibintu byingenzi birwanya inflammatory, bishobora kugabanya irekurwa ryibintu bitera nka TNF-α na IL-6, kandi icyarimwe bikazamura imvugo yibintu birwanya inflammatory nka IL-10. TB4 irongera kugabanya uburibwe muguhagarika ubudahangarwa bw'umubiri bujyanye no gutwika. Iyo ikoreshejwe hamwe, BPC 157 na TB4 bigira ingaruka zingirakamaro muguhagarika igisubizo cyumuriro, kidashobora gusa kugabanya vuba umuriro ukabije ariko kandi kikanagenzura neza iterambere ryumuriro udakira. Izi ngaruka zo guhuza imbaraga zifite akamaro kanini cyane mu ndwara ziterwa no gutwikwa nk'indwara y'umwijima idafite inzoga na fibrosis yo mu bihaha, ishobora guteza imbere inzira ya pathologiya kandi igateza imbere imikorere yimitsi.
Angiogenezi no Gutanga Intungamubiri
BPC 157 na TB4 byombi bishobora gutera angiogenez no kunoza amaraso kumitsi yangiritse. BPC 157 iteza imbere angiogenezez mu kongera ubushobozi bwo gukwirakwiza, kwimuka, hamwe na lumen yo gukora ingirabuzimafatizo ya endoteliyale, itanga intungamubiri zikenewe na ogisijeni yo gusana ingirangingo. TB4 iteza imbere kwimuka no gutandukanya ingirabuzimafatizo ya endoteliyale mu kugenzura imikorere ya actin, bikarushaho kunoza imikorere y'urusobe rw'imitsi. Iyo ikoreshejwe hamwe, BPC 157 na TB4 bigize uburyo bwuzuzanya mugikorwa cya angiogenez. BPC 157 itanga ubufasha bwibanze kuri angiogenez, mugihe TB4 itezimbere imiterere nimikorere yimiyoboro yamaraso, bityo bikazamura cyane imikorere nubwiza bwo gusana ingirangingo.
Imyitozo yo gukira no kurwanya umunaniro
Kubijyanye no gukira imyitozo, gukoresha hamwe BPC 157 na TB4 birashobora kugabanya cyane igihe cyo gukira kwimvune zatewe na siporo. BPC 157 igabanya ububabare bwimitsi no gutwika binyuze mugutezimbere gusana ingirangingo n'ingaruka zo kurwanya inflammatory, mugihe TB4 yongerera ubushobozi bwo gusana no kuvugurura ingirangingo z'imitsi igenga cytoskeleton. Iyo ikoreshejwe hamwe, BPC 157 na TB4 bigira uruhare runini mugusana imvune yimitsi, ntibishobora gusa kugabanya ububabare bwimitsi gusa ahubwo binatezimbere cyane imbaraga zimitsi no kwihangana, byihutisha kugarura imikorere yimikino.
Kurwanya gusaza
Gukoresha hamwe BPC 157 na TB4 byerekana imbaraga zishobora kurwanya gusaza no kuramba mugutezimbere gusana no kuvugurura no gushyigikira ubuzima bwimikorere yimitsi yumutima nimiyoboro. BPC 157 irinda selile kwangirika kwubusa binyuze mu kurwanya anti-inflammatory na antioxydeant, mugihe TB4 ikomeza imikorere isanzwe nimiterere ya selile igenga cytoskeleton. Iyo ikoreshejwe hamwe, BPC 157 na TB4 bigize uburyo bwo gukingira hamwe kurwego rwakagari, ntibishobora kudindiza gusaza kwingirabuzimafatizo gusa ahubwo binongera ubushobozi bwo kuvugurura ingirabuzimafatizo, bityo kuzamura ubuzima rusange bwumubiri no gutinda gusaza.
Kwakira nyuma yo gukira no gucunga indwara zidakira
Mugukiza nyuma yubuvuzi no gucunga indwara zidakira, gukoresha BPC 157 na TB4 birashobora kwihutisha gusana ingirabuzimafatizo no kuzamura ubuzima muri rusange. BPC 157 igabanya ibibazo nyuma yo kubagwa binyuze mugutezimbere gusana ingirangingo n'ingaruka zo kurwanya inflammatory, mugihe TB4 yongerera ubushobozi bwo kuvugurura ingirabuzimafatizo muguhindura cytoskeleton. Iyo ikoreshejwe hamwe, BPC 157 na TB4 bigira uruhare runini mugukiza nyuma yo kubagwa, ibyo ntibishobora kwihutisha gukira ibikomere gusa ahubwo binatezimbere cyane gukira kwimikorere nyuma yo kubagwa no kuzamura imibereho yabarwayi.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.