BPC157 ， TB500 5mg ＋ 5mg （Kuvanga）

▎ TB500

TB500, ikomoka kuri synthique ya Thymosine Beta-4 (Tβ4), ni molekile ya polypeptide. Uburyo bwibanze bugera kumabwiriza agenga kugenzura neza uburinganire hagati yinteko no gusenya actin muri cytoskeleton. Iyi molekile irashobora kuzamura cyane ubushobozi bwimuka ryimuka, gukwirakwizwa, no gutandukana, bityo bikagira uruhare runini mugutegeka mugikorwa cyo gusana no kuvugurura. Mu rwego rwo gusana ibikomere byuruhu, TB500 irashobora kwihutisha uburyo bwo gufunga ibikomere, guteza imbere kolagen igenda neza, kandi ikabuza ikwirakwizwa ridasanzwe ryimyanya ndangagitsina; ku ndwara ziterwa na metabolike, irashobora kugabanya neza inzira ya pathologiya yunganirwa no gutwikwa, nk'indwara y'umwijima idafite inzoga na fibrosis yo mu bihaha, mu kubuza irekurwa rya cytokine itera umuriro; mubijyanye no kurinda umutima nimiyoboro y'amaraso, mugihe cyicyiciro cya infarction myocardial, TB500 irashobora kurinda kardiomyocytes ikiriho, igakora gahunda ya endogenous angiogenez, igahindura imiyoboro ya microcirculation ya myocardial, kandi amaherezo ikazamura imikorere yumutima.

Birakwiye ko tumenya ko TB500 yerekana bioavailable nyinshi, intego-yo guhuza byinshi, hamwe na biocompatibilité nziza. Umutungo wihariye wihariye wibanda kumubiri bituma ushobora gukora neza kuri microen ibidukikije yimitsi yangiritse, bikagabanya cyane ibyago byo guhura na sisitemu mugihe ugera kubuvuzi bugamije. Ubu buryo bwa molekile bushingiye ku kugenga imikorere ya actin ntabwo butanga gusa uburyo bushya bwo kuvura imiti ivura ingirabuzima fatizo gusa ahubwo inashyiraho urufatiro rukomeye hamwe n’inkunga ifatika yo gukoresha amavuriro. Mugukoresha icyarimwe inzira nyinshi za angiogenez, anti-inflammation, na cytoprotection, TB500 yerekana uburyo bwagutse bwo gukoresha mugukomeza urugo rwa homeostasis no gusana imikorere.

Incamake​

Gukoresha hamwe BPC 157 na TB500 byerekana ingaruka zikomeye mubikorwa bitandukanye nko gusana ingirangingo, kurwanya inflammatory, na angiogenez. Izi ngaruka zo guhuza imbaraga ntizongera gusa ingaruka zo kuvura molekile imwe gusa ahubwo inagura uburyo ikoreshwa, itanga uburyo bushya bwo kuvura indwara zitandukanye.

Gusana imyenda no kuvugurura

BPC 157 yihutisha gusana ingirabuzimafatizo iteza imbere synthesis ya kolagen, ikwirakwizwa no kwimuka kwa fibroblast, no kongera angiogenez. TB500 iteza imbere kwimuka kwakagari no gutandukana muguhuza imbaraga za actin, itanga inkunga yuburyo bwo gusana ingirangingo. Iyo ikoreshejwe hamwe, BPC 157 na TB500 ikorana murwego rwakagari, byongera cyane ubushobozi bwo kuvugurura ingirangingo. Kurugero, mugukosora ibikomere byuruhu, BPC 157 yihutisha gufunga ibikomere, mugihe TB500 iteza imbere gahunda ya kolagen ikurikirana, hamwe ikabuza hyperplasia idasanzwe yimitsi yinkovu. Mu gukomeretsa kw'imitsi no mu mitsi, BPC 157 itera angiogenez, itanga infashanyo zintungamubiri zo gusana, mugihe TB500 iteza kwimuka kwakagari aho yakomeretse igenga cytoskeleton, yihutisha kuvugurura ingirangingo.

Kurwanya Kurwanya no Kurinda Immune

BPC 157 ifite ibintu byingenzi birwanya inflammatory, bishobora kugabanya irekurwa ryibintu bitera nka TNF-α na IL-6, kandi icyarimwe bikazamura imvugo yibintu birwanya inflammatory nka IL-10. TB500 irongera kugabanya uburibwe muguhagarika ubudahangarwa bw'umubiri bujyanye no gutwika. Iyo ikoreshejwe hamwe, BPC 157 na TB500 bigira ingaruka zifatika muguhagarika igisubizo cyumuriro, kidashobora gusa kugabanya vuba umuriro ukabije ariko kandi kikanagenzura neza iterambere ryumuriro udakira. Izi ngaruka zo guhuza imbaraga zifite akamaro kanini cyane mu ndwara ziterwa no gutwikwa nk'indwara y'umwijima idafite inzoga na fibrosis yo mu bihaha, ishobora guteza imbere inzira ya pathologiya kandi igateza imbere imikorere yimitsi.

Angiogenezi no Gutanga Intungamubiri

BPC 157 na TB500 byombi birashobora gutera angiogenez no kunoza itangwa ryamaraso kumitsi yangiritse. BPC 157 iteza imbere angiogenezez mu kongera ubushobozi bwo gukwirakwiza, kwimuka, hamwe na lumen yo gukora ingirabuzimafatizo ya endoteliyale, itanga intungamubiri zikenewe na ogisijeni yo gusana ingirangingo. TB500 iteza imbere kwimuka no gutandukanya ingirabuzimafatizo ya endoteliyale mu kugenzura imikorere ya actin, bikarushaho kunoza imikorere y'urusobe rw'imitsi. Iyo ikoreshejwe hamwe, BPC 157 na TB500 bigize uburyo bwuzuzanya mugikorwa cya angiogenez. BPC 157 itanga ubufasha bwibanze kuri angiogenez, mugihe TB500 itezimbere imiterere nimikorere yimiyoboro yamaraso, bityo bikazamura cyane imikorere nubwiza bwo gusana ingirangingo.

Imyitozo yo gukira no kurwanya umunaniro

Kubijyanye no gukira imyitozo, gukoresha hamwe BPC 157 na TB500 birashobora kugabanya cyane igihe cyo gukira kwimvune zatewe na siporo. BPC 157 igabanya ububabare bwimitsi no gutwika binyuze mugutezimbere gusana ingirangingo n'ingaruka zo kurwanya inflammatory, mugihe TB500 yongerera ubushobozi bwo gusana no kuvugurura ingirabuzimafatizo imitsi igenga cytoskeleton. Iyo ikoreshejwe hamwe, BPC 157 na TB500 bigira uruhare runini mugusana imvune yimitsi, ntibishobora gusa kugabanya ububabare bwimitsi gusa ahubwo binatezimbere cyane imbaraga zimitsi no kwihangana, byihutisha kugarura imikorere yimikino.

Kurwanya gusaza

Gukoresha hamwe BPC 157 na TB500 byerekana imbaraga zishobora kurwanya gusaza no kuramba mugutezimbere gusana no kuvugurura no gushyigikira ubuzima bwimikorere yimitsi yumutima nimiyoboro. BPC 157 irinda ingirabuzimafatizo kwangirika kwubusa binyuze mu kurwanya anti-inflammatory na antioxydeant, naho TB500 ikomeza imikorere isanzwe n’imiterere ya selile igenga cytoskeleton. Iyo ikoreshejwe hamwe, BPC 157 na TB500 ikora uburyo bwo gukingira hamwe kurwego rwakagari, ibyo ntibishobora gutinza gusaza ingirabuzimafatizo gusa ahubwo binongera ubushobozi bwo kuvugurura ingirabuzimafatizo, bityo bizamura ubuzima rusange bwumubiri kandi bidindiza gusaza.

Nyuma yo gukira no gucunga indwara zidakira

Mugihe cyo gukira nyuma yo gukira no gucunga indwara zidakira, gukoresha hamwe BPC 157 na TB500 birashobora kwihutisha gusana ingirabuzimafatizo no kuzamura ubuzima muri rusange. BPC 157 igabanya ibibazo nyuma yibikorwa binyuze mugutezimbere gusana ingirangingo n'ingaruka zo kurwanya inflammatory, mugihe TB500 yongerera ubushobozi bwo kuvugurura ingirabuzimafatizo muguhindura cytoskeleton. Iyo ikoreshejwe hamwe, BPC 157 na TB500 bigira uruhare runini mugukiza nyuma yo kubagwa, ibyo ntibishobora kwihutisha gukira ibikomere gusa ahubwo binatezimbere cyane gukira kwimikorere nyuma yo kubagwa no kuzamura imibereho yabarwayi.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

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