CJC1295, Ipa 10/10 (Kuvanga)

Ipa​

Ipa ni intungamubiri ya pentapeptide. Nkumunyamuryango wingenzi mumikurire ya hormone secretagogue, imiterere yimiterere ya molekile iha ubushobozi bwo kugenzura neza imisemburo ikura. Uru ruganda ruhuza cyane na hormone ikura ya reseptor ya reseptor (GHS-R), igakora inzira yerekana ibimenyetso byerekana inzira, bityo bigatuma habaho irekurwa rya pulsatile irekura imisemburo ikura (GH) kandi icyarimwe igateza imbere imvugo ya gene hamwe na protein synthesis ya insuline imeze nkikura-1 (IGF-1). Ubu buryo bubiri bwibikorwa ntabwo bugenga gusa uburyo bwo guhindura ingufu za metabolisme (harimo guteza imbere gufata aside amine, kwihutisha intungamubiri za poroteyine, no guhindura ibinure bya catabolisme), ariko kandi bigira uruhare runini mugusana ingirabuzimafatizo no gukura byongera ibimenyetso byo gukwirakwiza selile.

Mu bushakashatsi bwakoreshejwe mubuvuzi, Ipa yerekanye uburyo bwinshi bwo kugenzura ibintu: ingaruka zayo mugutezimbere umuvuduko wa gastrointestinal zigaragarira nko kwihutisha igifu. Cyane cyane muburyo bwa patologi ya ileus nyuma yo kubagwa, irashobora gukuraho neza indwara zo munda zitera imbere mugutezimbere inshuro ya peristaltike hamwe no kwikuramo ubukana bwimitsi ya gastrointestinal; mubijyanye no gucunga ububabare, iyi nteruro igenga kwanduza ibimenyetso bya nociceptive binyuze mumihanda yo hagati na peripheri, byerekana ingaruka zikomeye zo kugabanya ububabare bwimyanya myibarukiro nububabare bwa somatike. Uburyo bwibikorwa bushobora kuba bukubiyemo ibikorwa bya endogenous opioid peptide sisitemu no kugenzura ibikorwa bya ion umuyoboro.

Ugereranije na hormone gakondo ikura, ibyiza byingenzi bya Ipa biri muburyo bwo guhitamo imisemburo ikura - nubwo itera neza imisemburo ya GH, nta ngaruka nini bigira ku gusohora kw'indi misemburo ya pitoito-adrenal axis nka adrenocorticotropic hormone (ACTH) na cortisol, bityo bikagabanya ibyago byo kwitwara nabi biterwa na hormone. Uyu mutungo wa farumasi uyiha amahirwe yo kugira uruhare rugaragara mugusimbuza imiti yo kubura imisemburo ikura, kandi mugihe kimwe ikanatanga intego nshya yibiyobyabwenge kubushakashatsi ku ndwara ziterwa na gastrointestinal motility disorder no kunoza gahunda yo gusuzuma ububabare no kuvura. Kugeza ubu, hashingiwe ku buryo bwihariye bwibikorwa n’ibiranga umutekano, ubushakashatsi bwifashishijwe mu gusobanura Ipa mu bijyanye n’indwara ziterwa na endocrine, indwara zifata igogora, n’ubuvuzi bw’ububabare buragenda bwiyongera, bwerekana uburyo bwagutse bwo kuvura.

Incamake​

Guteza imbere imikurire no gusana:

Gukoresha hamwe CJC1295 Nta DAC na Ipa birashobora kongera cyane synthesis ya proteine ​​yimitsi kandi byihutisha gusana no kuvugurura ingirangingo. Uburyo bwibikorwa byabwo bushobora kuba bukubiyemo gutera imbaraga mu buryo butaziguye ingirangingo z'imitsi ikoresheje imisemburo ikura, ndetse no kuzamura mu buryo butaziguye imikurire y’imitsi igenga izindi mpamvu zikura n'inzira za metabolike. Mu rwego rwubuvuzi bwa siporo, guhuriza hamwe gukoresha ibi bintu byombi peptide bifite agaciro gakomeye. Kubakunda imyitozo ngororamubiri, irashobora guteza imbere imitsi nyuma yimyitozo ngororamubiri, kongera imbaraga nimitsi, no kunoza imyitozo. Ubushakashatsi bwerekanye ko imisemburo ikura ishobora gukora ingirangingo fatizo yimitsi, igatera ubwiyongere bwayo no gutandukanya ingirabuzimafatizo zikuze, bityo byihutisha gahunda yo gusana imitsi.

Kunoza ibinure byamavuta:

Gukoresha hamwe Ipa na CJC1295 Nta DAC ishobora kongera urwego rwimisemburo ikura, bityo bigatera kwangirika no okiside yibinure. Imisemburo ikura irashobora kongera ibikorwa byimisemburo ya lipolitike mungirangingo zamavuta, bigatera kwangirika kwamavuta muri acide yubusa na glycerol kugirango itange imbaraga kumubiri. Muri icyo gihe, irashobora kandi kunoza imikoreshereze y’amavuta, kugabanya ububiko bwamavuta yumubiri, no kunoza imiterere yumubiri. Ibi bifite akamaro kanini mugutakaza ibinure no kumubiri, cyane cyane kubashaka kugabanya ibinure byumubiri no kunoza imirongo yumubiri.

Kuzamura urwego rwingufu nibikorwa bya siporo:

Ubwiyongere bwa hormone yo gukura burashobora kongera umuvuduko wibanze wa metabolike no kongera imikorere yumusaruro ningufu. Kwiyongera kw'igipimo fatizo cya metabolike bivuze ko umubiri ushobora gukoresha imbaraga nyinshi ndetse no kuruhuka, ibyo bikaba bifasha kugumana imbaraga z'umubiri. Ibi bifasha abakoresha kubona ingufu nyinshi murwego rwibikorwa bya buri munsi no gukora siporo, kwagura imyitozo, no kunoza imikorere ya siporo.

Kunoza ubuziranenge bwibitotsi:

Imisemburo ikura igira uruhare runini mugutunganya ibitotsi nubuziranenge. Gukoresha hamwe Ipa na CJC1295 Nta DAC ishobora kunoza imiterere yo gusinzira no kongera igihe kinini cyo gusinzira. Gusinzira cyane ni ngombwa kugirango umubiri ukire kandi usanwe. Irashobora guteza imbere gusohora imisemburo ikura, ikongera imikorere yubudahangarwa bw'umubiri, ikanatezimbere ubushobozi bwubwenge bwubwonko.

Kuzamura imikorere yubudahangarwa:

Imisemburo ikura ishyigikira imikorere isanzwe ya sisitemu yumubiri. Irashobora kongera ibikorwa n'imikorere y'uturemangingo, ikongera ubudahangarwa bw'umubiri, kandi igafasha kurwanya indwara. Mu kongera urwego rwimisemburo ikura, gukoresha hamwe Ipa na CJC1295 Nta DAC ishobora kongera ubushobozi bwo gukwirakwiza no gutandukanya ingirabuzimafatizo z'umubiri, guteza imbere umusaruro wa antibodi, no kunoza umubiri kurwanya virusi.

2. Imirima yo gusaba

Ubuvuzi burwanya gusaza:

Hamwe no kwiyongera kwimyaka, urwego rwimisemburo ikura mumubiri wumuntu rugenda rugabanuka buhoro buhoro, biganisha ku gusaza nko gutakaza imitsi, kubyibuha amavuta, no kuruhura uruhu. Gukoresha hamwe Ipa na CJC1295 Nta DAC ishobora kongera urwego rwimisemburo ikura kandi ifite ingaruka zo kurwanya gusaza. Abashakashatsi barimo gukora ubushakashatsi ku ikoreshwa ry’ibi bintu bibiri bya peptide mu gutinda gusaza no kuzamura imibereho y’abasaza. Kurugero, zirashobora gukoreshwa mukurinda no kuvura indwara ziterwa no gusaza nka atrophy imitsi ya senile, osteoporose, n'indwara z'umutima.

Ubuvuzi bwa siporo:

Mu rwego rwa siporo, gukoresha hamwe CJC1295 Nta DAC na Ipa bishobora guteza imbere imikurire no gusana, kuzamura imikorere ya siporo, no kugabanya imvune za siporo. Abakunda imyitozo ngororamubiri barashobora gukoresha ibi bintu bibiri bya peptide nkuburyo bwabafasha kunoza ingaruka zamahugurwa no kwihutisha inzira yo gukira.

Kuvura indwara za Endocrine:

Ku ndwara za endocrine nko kubura imisemburo ikura no kutagira igihagararo kigufi, gukoresha hamwe Ipa na CJC1295 Nta DAC itanga ibitekerezo nuburyo bushya bwo kuvura. Muguhindura imisemburo ya hormone ikura, ifasha kunoza ibimenyetso byabarwayi no guteza imbere iterambere risanzwe niterambere ryumubiri.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.