Research Ubushakashatsi bwa Prostamax
Ni ubuhe bushakashatsi bwakozwe na Prostamax?
Iterambere ry’imibereho y’abantu hamwe n’ubusaza bw’abaturage, ubwiyongere bw’indwara ziterwa na prostate bwagiye bwiyongera uko umwaka utashye, bigira ingaruka zikomeye ku buzima bw’abagabo. Kubwibyo, gushakisha uburyo bwiza bwo kuvura prostate no kuvura byabaye ingingo yingenzi mubushakashatsi bwubuvuzi.
Mu bushakashatsi bwimbitse ku mikorere ya physiologique ya prostate hamwe n’uburyo bw’indwara za prostate, abahanga bavumbuye ko prostate ubwayo ishobora gusohora ibintu bitandukanye bioaktique, bigira uruhare runini mu kubungabunga imikorere isanzwe ya prostate no mu kubaho no gutera indwara. Binyuze mu gusesengura ibice bigize tissue ya prostate no kwiga imikorere yayo, abashakashatsi biyemeje gushakisha ibintu bishobora guteza imbere ubuzima bwa prostate. Prostamax yavumbuwe kandi yizwe muriki gice. Ifatwa nka peptide yibinyabuzima ifite imikorere yingenzi muri prostate, kandi ubushakashatsi ku nkomoko yabyo butanga icyerekezo gishya nuburyo bwo kurushaho gushakisha uburyo bwo gukumira no kuvura indwara za prostate no kubungabunga ubuzima bw’abagabo.
Nubuhe buryo bwo gukora bwa Prostamax?
Uburyo bwibikorwa mukuvura prostatite idakira idakira
Kugabanya ibimenyetso byerekana umuriro: Ubushakashatsi bwerekanye ko Prostamax ishobora kugabanya ibimenyetso by’umuriro udakira, nko kugabanya kubyimba, umuvuduko w’imitsi, no kugabanya ubwinjira bw’imitsi, mu kuvura prostatite idakira idakira n’ingaruka zayo [1] . Ibi birashobora kugerwaho muguhuza ubudahangarwa bw'umubiri mumyanya ya prostate, kandi inzira yihariye igenga ubudahangarwa iracyakeneye ubushakashatsi bwimbitse.
Kurinda inzira ya sclerose na atrophy: Prostamax irashobora kubuza iterambere ryimikorere ya sclerose na atrophy mumyanya ya prostate. Uburyo bwibikorwa bushobora kuba bukubiyemo kugenzura metabolisme ya selile ya prostate no kubuza inzira ya patrophysiologique iganisha kuri tissue sclerose na atrophy.
Ugereranije nindi miti ivura prostate: Ingaruka zo kuvura Prostamax zirenze iz'imiti imwe n'imwe ikoreshwa cyane yo kuvura prostate ikomoka ku musemburo wa palmetto na prostate. Ibi biterwa nuburyo bwihariye bwimiti nuburyo bukoreshwa, bikabasha kurushaho gukora neza inzira ya patrophysiologique ya prostatite idakira idakira [1].
Uburyo bwibikorwa kuri heterochromatine ya lymphocytes zabantu
Isaranganya ryubushyuhe nubushyuhe bwubushyuhe Prostamax irashobora gutuma igabanywa ryumuriro wa chromatine muri lymphocytes zabantu kandi bigahindura ubushyuhe bubiri (TdVII na TdVIII) kugirango ubushyuhe bugabanuke kuri 2,9 na 1.0 ° C. : Isaranganya ryumuriro rishobora kuba rifitanye isano no kuruhuka igice cya fibre 30-yuburebure bwa fibre 10 ya nanometero 10, byerekana ko Prostamax ishobora kugira ingaruka muguhindura imiterere ya chromatine.
Impinduka mu muteguro wa nucleosome: TdVII na TdVIII ya lymphocytes zavuwe na Prostamax ziri munsi gato ugereranije n’utugingo ngengabuzima tutavuwe, ibyo bikaba bifitanye isano n’imihindagurikire y’imiterere mu mikorere ya nucleosome ya fibre 10- na 30 ya nanometero yuburebure [2].
Ni ubuhe buryo bukoreshwa na Prostamax?
1. Kunoza ubuzima bwa prostate
Kugabanya ibimenyetso bya hyperplasia nziza ya prostate: hyperplasia ya Benign prostatique ni imwe mu ndwara zisanzwe zibangamira abasaza. Uko imyaka igenda yiyongera, tissue ya prostate igenda yiyongera buhoro buhoro, igabanya urethra kandi igatera ibimenyetso nko kwihagarika kenshi, kwihagarika byihutirwa, no kugora inkari. Prostamax irashobora guteza imbere imikorere myiza ya selile. Mugutegekanya metabolism selile hamwe ninzira yo gutambutsa ibimenyetso, bigabanya ibimenyetso biterwa na hyperplasia prostate. Irashobora gukora ku bintu bikura, iyakirwa, na enzymes za selile ya prostate, ikabuza ikwirakwizwa ryinshi rya selile, kandi igateza imbere kuringaniza itandukaniro rya selile na apoptose, bityo bikagabanya umuvuduko wimitsi ya prostate no kunoza imiterere yinkari [3].
Guteza imbere kuvugurura ingirangingo za prostate: Kuvugurura ingirangingo za prostate ni ngombwa mu kubungabunga imiterere myiza ya prostate. Ibintu nko gusaza, indwara, no gukomeretsa bishobora gutera impinduka zangirika mubice bya prostate, bikagira ingaruka kumikorere isanzwe. Prostamax ifasha gushyigikira kuvugurura ingirangingo za prostate, birashoboka mugutezimbere uburyo bwo gusana ingirabuzimafatizo. Kurugero, irashobora gukangura ikwirakwizwa ryingirabuzimafatizo no gutandukanya ingirabuzimafatizo, kongera umubare w'uturemangingo twinshi mu ngingo ya prostate, bityo bigateza imbere gusana ingirangingo zangiritse. Byongeye kandi, Prostamax irashobora kandi kugenga synthesis no gutesha agaciro matrice idasanzwe kugirango igumane ubusugire bwimiterere yimitsi ya prostate [2, 4].
2. Ingaruka zo kurwanya inflammatory
Kugabanya uburibwe bwa prostate: Indwara ziterwa na prostate nka prostatite idakira izana abarwayi ububabare bukabije. Igisubizo cyo gutwika kizatera ibimenyetso nko kubyimba, umuvuduko w'amaraso, hamwe na lymphocytike yinjira muri prostate, bigatera ububabare no kutamererwa neza. Prostamax irashobora kugira ingaruka zo kurwanya inflammatory igenga sisitemu yumubiri ndetse n’umusaruro w’abunzi batera umuriro kugirango ugabanye prostate. Irashobora kubuza gukora no kwimuka kwingirabuzimafatizo kandi bikagabanya irekurwa ryibintu bitera umuriro, nkibibyimba bya niyosezi-α (TNF-α), interleukin-1β (IL-1β), na interleukin-6 (IL-6). Byongeye kandi, Prostamax irashobora kandi guteza imbere umusaruro wa cytokine irwanya inflammatory, nka interleukin-10 (IL-10), bityo bikagenga uburinganire bwikibazo cyo gutwika no kugabanya ibimenyetso by’umuriro [3].
3. Ingaruka zo kurwanya gusaza
Gutinda gusaza kwa selile: Gusaza kwa selile bifitanye isano rya bugufi no kubaho no gutera indwara zitandukanye. Prostamax irashobora kugira ingaruka kumiterere ya chromatine, igabanya ubukana bwa ADN, kandi igakomeza ingirabuzimafatizo. Imihindagurikire yimiterere ya chromatine irashobora kugira ingaruka kumagambo ya gene no kugenzura, bityo bikagira ingaruka kumikorere no mubuzima bwa selile. Prostamax irashobora kugenga ibikorwa bya chromatin ivugurura imisemburo, igahindura imiterere ya chromatine, kandi igateza imbere gene no kwerekana imvugo. Ibi bifasha kugumana imikorere isanzwe nubuzima bwingirabuzimafatizo kandi bidindiza inzira yo gusaza kwakagari. Byongeye kandi, Prostamax irashobora kandi kugabanya umusaruro no kwangirika kwa radicals yubusa binyuze mu ngaruka za antioxydeant, bikarinda kandi ingirabuzimafatizo ingaruka zo gusaza [2].
4. Gushyigikira imikorere yumubiri
Sisitemu yubudahangarwa igira uruhare runini mukubungabunga ubuzima bwabantu. Prostamax irashobora kugira ingaruka nziza mumikorere yubudahangarwa, kongera ibikorwa bya lymphocytes, no kunoza ubushobozi bwumubiri. Lymphocytes nigice cyingenzi mumikorere yubudahangarwa bw'umubiri, ishobora kumenya no gutera virusi kandi ikarinda umubiri kwandura. Prostamax irashobora kongera ibikorwa byubudahangarwa bwa lymphocytes muguhuza ikwirakwizwa ryayo, itandukaniro, nimirimo. Kurugero, irashobora guteza lymphocytes kubyara cytokine na antibodies, bikongerera ubushobozi bwo kwica virusi. Byongeye kandi, Prostamax irashobora kandi kugenga imikorere yizindi selile zumubiri, nka macrophage na selile selile zica, hamwe bikazamura ubushobozi bwo kwirinda umubiri [5].
5. Kugenga imisemburo ya hormone
Kuringaniza imisemburo nka testosterone na dihydrotestosterone ni ingenzi cyane kubungabunga ubuzima bwa prostate nubuzima rusange bwumugabo. Ubusumbane bwa hormone bushobora gutuma habaho indwara nka hyperplasia prostate na prostatite. Prostamax ifasha kugenzura urwego rwa hormone, bishoboka muguhindura synthesis, metabolism, hamwe na reseptor ya hormone. Kurugero, irashobora kugenga ibikorwa bya synthesis ya testosterone na enzyme ya metabolism, bigira ingaruka kumusaruro no guhindura testosterone. Byongeye kandi, Prostamax irashobora kandi kugenga imvugo ya reseptor ya dihydrotestosterone, igahindura ingaruka za dihydrotestosterone kuri selile prostate. Muguhuza imisemburo ya hormone, Prostamax irashobora kugumana imikorere isanzwe ya prostate no gukumira no kuvura indwara za prostate [3].
Mu gusoza, nka peptide igenga ibinyabuzima ikomoka kuri prostate, Prostamax igira ingaruka zidasanzwe mukuzamura ubuzima bwa prostate. Ntishobora kugabanya gusa ibimenyetso bya hyperplasia nziza ya prostate kandi igateza imbere kuvugurura ingirangingo za prostate ariko kandi igabanya no gutwika prostate no gutinda gusaza kwa selile. Ifite kandi uruhare runini mu kugenzura imikorere y’ubudahangarwa n’imisemburo ya hormone, itanga inkunga ikomeye mu kubungabunga ubuzima bwa prostate y’abagabo ndetse n’ubuzima rusange muri rusange, kandi ifite agaciro gakomeye n’akamaro mu bijyanye n’ubuzima.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Karthaus WR numushakashatsi ukomeye mubijyanye na oncology na biologiya selile. Yakoze imyanya mu bigo byinshi byubahwa, birimo Ikigo cy’Ubusuwisi gishinzwe ubushakashatsi kuri kanseri y’ubushakashatsi (ISREC) na École Polytechnique Fédérale de Lausanne (EPFL). Karthaus yifatanije kandi n’Urwibutso rwa Sloan Kettering Kanseri, aho yagize uruhare mu bushakashatsi bwa kanseri. Urugendo rwe rw’amasomo rurimo ubufatanye n’ikigo cy’ubuvuzi cya kaminuza ya Utrecht n’ikigo cya Hubrecht (KNAW) mu Buholandi. Byongeye kandi, afite aho ahurira na kaminuza ya Johns Hopkins.
Ubushakashatsi bwa Karthaus bushingiye kuri oncologiya, ibinyabuzima ngengabuzima, ibinyabuzima, ibinyabuzima bya molekile, n'ubuvuzi bw'ubushakashatsi. Ibikorwa bye akenshi bikubiyemo kwiga imisemburo ya steroid hormone igengwa ningingo nka prostate, glande y’inyamabere, na endometrium. Akoresha uburyo butandukanye, ahuza imico ya organoide, imiterere yimbeba, genomics, hamwe nubuhanga bumwe bwakagari kugirango akemure ibibazo bigoye biologiya. Laboratwari ye yibanda ku gusobanukirwa ibitera ibibyimba gutangira, gutera imbere, no kurwanya ibiyobyabwenge muri kanseri iterwa na hormone steroid. Karthaus WR yanditse murutonde rwibisobanuro [4].
