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1kits（10Vials）
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▎Ovagen Structure
Source: PubChem | Sequence: EDL Molecular Formula: C15H25N3O8 Molecular Weight: 375.37 g/mol PubChem CID：444128 Synonyms: NH2-Glu-Asp-Leu-COOH; glutamyl-aspartyl-leucine |
▎Ovagen Research
What is the research background of Ovagen?
Amidst evolving living conditions—including increased environmental toxins, antibiotic overuse, widespread chemotherapy and radiotherapy, and population aging—the incidence of liver and gastrointestinal diseases has risen sharply. Conditions like chronic persistent hepatitis and cirrhosis severely impact patients' quality of life and health. Traditional treatments struggle to efficiently restore normal liver and gastrointestinal function, fail to comprehensively prevent and treat diseases caused by various etiologies, and show limited efficacy in alleviating complications from radiotherapy, chemotherapy, and side effects of antibiotics. This underscores the urgent need for novel therapeutic approaches.
Peptides, due to their diverse structures, can interact with multiple intracellular molecules, influencing cellular processes such as metabolism, growth, and repair. Ovagen's core components include peptide complexes composed of specific amino acids, such as AC-3 formed by glutamic acid, aspartic acid, and leucine. This composition influences its regulatory mechanisms on liver and gastrointestinal function. Through research on Ovagen, scientists have explored a more effective method for modulating liver and gastrointestinal function to meet clinical treatment and disease prevention needs.
What is Ovagen's mechanism of action?
Receptor Binding Initiates Signal Transduction
Specific Receptor Binding: Many peptide hormones exert their effects by binding to specific high-affinity receptors, which are integral proteins spanning the plasma membrane. Each peptide hormone interacts with its designated receptor like a key fitting a lock, ensuring precise signal transmission. Upon binding, a cascade of biochemical events connects the initial site of peptide hormone action—the plasma membrane—to diverse target cell responses [1,2].
Activating Signaling Pathways: Receptor-peptide binding activates intracellular signaling pathways. For instance, certain peptide hormones bind to receptors that activate adenylate cyclase, promoting the production of the intracellular second messenger cyclic AMP (cAMP). As a key messenger, cAMP activates protein kinases, leading to the phosphorylation of specific substrates and regulating target cell functions. In certain target tissues, such as the liver and adipose tissue, cAMP serves as the primary second messenger triggering hormone-specific biochemical responses. Beyond cAMP, other signaling pathways and messenger molecules participate in peptide mechanisms; for instance, calcium ions play a crucial role in regulating cellular responses in some tissues [2].
Figure 1 Diagram of the pathways involved in the regulation of steroidogenesis in gonadal tissue by luteinizing hormone[2].
What is the function of Ovagen?
Ovagen promotes hepatocyte growth and prevents liver fibrosis and cirrhosis. It improves liver function by regulating hepatocyte DNA structure and transcription patterns. Ovagen also exhibits anti-aging effects, reversing age-related DNA alterations to restore hepatocytes to a more youthful state. Ovagen enhances gastrointestinal mucosal barrier function, mitigating damage to the gastrointestinal tract caused by factors such as antibiotic therapy, environmental toxins, chemotherapy, and malnutrition. Its regulatory effects on liver and gastrointestinal function across various inflammatory and disease states offer broad application prospects. It can be utilized in postoperative care, long-term antibiotic treatment, alleviating cancer treatment side effects, and diabetes prevention.
Ovagen and HIV
Ovagen has garnered attention in HIV research due to its demonstrated inhibitory effect on HIV-1 protease. HIV-1 protease is a critical enzyme for viral survival, responsible for cleaving viral proteins into functional subunits. As an HIV-1 protease inhibitor, Ovagen ranks among the smallest and most potent known protease inhibitors. This inhibitory action may aid in controlling HIV replication, opening new avenues for HIV treatment research.
Research by Badaya A indicates that Ovagen can inhibit HIV-1 protease activity[3]. HIV-1 protease is a critical enzyme in viral replication, responsible for cleaving polyproteins to mature and assemble them into infectious viral particles. Inhibiting protease activity disrupts the viral replication process[3]. Ovagen inhibits protease catalytic function by binding to its active site or altering its conformation. By binding to the active site, it prevents substrate entry and the cleavage reaction[3].
Conclusion
Ovagen is a tripeptide compound exhibiting multifaceted biological activities, primarily regulating liver and gastrointestinal functions. It promotes hepatocyte growth, prevents liver fibrosis and cirrhosis, enhances liver function by modulating DNA structure and transcriptional patterns, and demonstrates anti-aging potential. Ovagen strengthens the gastrointestinal mucosal barrier function, mitigating damage from antibiotics, environmental toxins, chemotherapy, and malnutrition.
Ovagen is a tripeptide compound with multifaceted biological activities, primarily regulating liver and gastrointestinal function. It promotes hepatocyte growth, prevents liver fibrosis and cirrhosis, enhances liver function by modulating DNA structure and transcriptional patterns, and exhibits anti-aging potential. Ovagen strengthens the gastrointestinal mucosal barrier function, mitigating damage caused by antibiotics, environmental toxins, chemotherapy, and malnutrition.
About The Author
The above-mentioned materials are all researched, edited and compiled by Cocer Peptides.
Scientific Journal Author
Apoorva Badaya is a researcher specializing in computational biophysics and structural bioinformatics. He has co-authored studies focusing on the molecular dynamics of HIV-1 protease, particularly in relation to antibody binding and mutations. His work employs advanced simulation techniques to explore protein dynamics and inform therapeutic strategies. Apoorva Badaya is listed in the reference of citation [3].
