Snap-8 10mg

▎SNAP-8 Structure

▎SNAP-8 Research

What is SNAP-8?

SNAP-8 is a synthetic peptide composed of 8 amino acids.

What is the research background of SNAP-8?

Skin aging research: 

With the increase of age, the skin shows signs of aging such as wrinkles. The formation of dynamic wrinkles is closely related to the frequent contraction of facial muscles. Muscle contraction is mediated by neurotransmitters. Therefore, finding a substance that can regulate neurotransmitter release and reduce muscle contraction has become an important direction in skin anti-aging research.

Neuroscience research: 

The research on the mechanism of neurotransmitter release has been deepened continuously, and it has been found that the Soluble NSF Attachment Protein Receptor (SNARE) complex plays a central role in it. SNAP-25 is an important component of the SNARE complex. Understanding its structure and function provides a theoretical basis for the development of substances that can interfere with neurotransmitter release. Based on these studies, researchers hope to develop a safe and effective substance that can not only play an anti-wrinkle role in skin care but also provide new tools and ideas for neuroscience research. SNAP-8 emerged in this context and gradually became a research hotspot in related fields.

What is the mechanism of action of SNAP-8?

1. Skin anti-aging

Reducing wrinkles: 

SNAP-8 reduces dynamic and static wrinkles on the skin surface by reducing muscle contractions, improving the overall appearance of the skin. Dynamic wrinkles are caused by the contraction of facial expression muscles, while static wrinkles gradually form with age and the decrease of skin elasticity. The mechanism of action of SNAP-8 weakens muscle contractions, thus reducing the generation of dynamic wrinkles. At the same time, since it reduces the nerve stimulation to the skin, it also helps to slow down the skin aging process and reduce the formation of static wrinkles.

Promoting collagen production: 

SNAP-8 may also promote the production of collagen in the skin by regulating cellular signaling pathways. Collagen is the main structural protein in the skin, which endows the skin with elasticity and toughness. With age, the content of collagen in the skin gradually decreases, leading to skin relaxation and the appearance of wrinkles. SNAP-8 may promote collagen synthesis by activating certain signaling pathways, such as the TGF-β/Smad signaling pathway. In addition, SNAP-8 may also increase the content of collagen in the skin by inhibiting collagen degradation.

2. Neuromuscular regulation

Interfering with the SNARE complex: 

SNAP-8 is an N-terminal mimic of SNAP-25 and can compete with SNAP-25 for its position in the SNARE complex. The SNARE complex plays a key role in the process of neurotransmitter release. Normally, the SNARE complex is composed of syntaxin on the presynaptic membrane, synaptobrevin, and SNAP-25 on the synaptic vesicle membrane. When a nerve impulse reaches the presynaptic membrane, the influx of calcium ions triggers the fusion of synaptic vesicles with the presynaptic membrane, thus releasing neurotransmitters. However, when SNAP-8 competes with SNAP-25 for the position in the SNARE complex, it interferes with the formation of the SNARE complex. This makes it impossible for synaptic vesicles to release neurotransmitters effectively, resulting in weakened muscle contractions.

Reducing neurotransmitter release: 

By interfering with the SNARE complex, SNAP-8 reduces the release of neurotransmitters. Neurotransmitters are chemical substances that transmit signals between nerve cells. Excessive neurotransmitter release will lead to excessive nerve stimulation of muscles. The action of SNAP-8 reduces the nerve stimulation of muscles, thereby reducing the formation of wrinkles.

3. Neurobiological research

Regulating neurotransmitter release: 

Due to the structural similarity between SNAP-8 and SNAP-25, it may have potential application value in neurobiological research ^[1]. In neurodegenerative diseases, excessive neurotransmitter release may lead to neuronal damage.

Affecting neuroinflammation: 

SNAP-8 may regulate the secretion of pro-inflammatory cytokines in immune cells by affecting the fusion of synaptic vesicles, thus having an impact on the inflammatory response^[1]. Neuroinflammation plays an important role in many neurodegenerative diseases. The activation of immune cells and the secretion of pro-inflammatory cytokines will lead to the damage and death of neurons. SNAP-8 may affect the secretion of pro-inflammatory cytokines in immune cells by regulating the fusion of synaptic vesicles, thus reducing the neuroinflammatory response.

What are the applications of SNAP-8?

1. Anti-wrinkle effect

As a new type of octapeptide, SNAP-8 shows significant anti-wrinkle effects in the field of skin care. It reduces the excessive contraction of facial muscles by inhibiting the release of neurotransmitters, and then reduces the formation of dynamic and static wrinkles. A number of studies have shown that SNAP-8 can effectively act on facial expression lines and wrinkles. Using SNAP-8 twice a day can significantly reduce expression lines and wrinkles by up to 63% within 30 days, which provides strong support for its application in the field of skin anti-wrinkle. This anti-wrinkle mechanism is different from traditional anti-wrinkle methods. It does not use physical filling or chemical peeling, but starts from the perspective of neurotransmitter release, providing a new idea for skin anti-wrinkle.

2. Promoting collagen production

SNAP-8 may also promote the production of collagen in the skin by regulating cellular signaling pathways, thereby enhancing the structure and elasticity of the skin. Collagen is an important component of the skin, which can maintain the firmness and elasticity of the skin. With age, the collagen in the skin gradually decreases, leading to skin relaxation and more wrinkles. This mechanism of action of SNAP-8 provides a new way to solve the problem of skin aging. By promoting the production of collagen, SNAP-8 can effectively improve the texture and appearance of the skin, making the skin smoother and firmer.

3. Non-invasive alternative

As a natural-derived, non-toxic, and non-invasive alternative to botulinum toxin, SNAP-8 has no side effects of injectable botulinum toxin. Although botulinum toxin has certain effects in anti-wrinkle, its injection process may cause adverse reactions such as pain, swelling, and bruising, and requires the operation of a professional doctor. In contrast, SNAP-8 is safer and more convenient and can be used as a daily skin care product. Its appearance provides a new choice for consumers who are concerned about injectable cosmetic products.

4. Regulating neurotransmitter release

Due to the structural similarity between SNAP-8 and SNAP-25, it has potential application value in neurobiological research^[1]. In neurodegenerative diseases, excessive neurotransmitter release may lead to neuronal damage. SNAP-8 may reduce this damage by regulating neurotransmitter release. Neurotransmitters play an important role in transmitting information in the nervous system, and abnormal release of neurotransmitters may trigger a variety of nervous system diseases. This mechanism of action of SNAP-8 provides a new idea for the treatment of neurodegenerative diseases. By regulating the release of neurotransmitters, SNAP-8 is expected to reduce neuronal damage and slow down the progression of the disease.

5. Affecting neuroinflammation

SNAP-8 may regulate the secretion of pro-inflammatory cytokines in immune cells by affecting the fusion of synaptic vesicles, thus having an impact on the inflammatory response^[1]. Neuroinflammation plays an important role in the occurrence and development of a variety of nervous system diseases. This mechanism of action of SNAP-8 provides a new way to regulate neuroinflammation. By affecting the fusion of synaptic vesicles, SNAP-8 can regulate the secretion of pro-inflammatory cytokines in immune cells, thus reducing the inflammatory response and protecting neurons.

In conclusion, SNAP-8 has a wide range of effects and great significance. In skin care, it can reduce muscle contractions, promote collagen production, and help the skin resist wrinkles and become firm; in neurobiological research, it can regulate neurotransmitter release and affect neuroinflammation.

About The Author

The above-mentioned materials are all researched, edited and compiled by Cocer Peptides.

Scientific Journal Author

Lemos M is associated with various organizations and subject categories. In terms of organizations, they are linked to Cesumar Inst Sci Technol & Innovat, Cesumar Univ, Univ Cesumar, Cesumar Inst Sci, UniCesumar - Centro Universitario Cesumar, Universidade de Lisboa, North Lisbon Hosp Ctr, Ctr Hosp Univ Lisboa Norte, Centro Hospitalar de Lisboa Ocidental, EPE, and Universidade Estadual de Maringa. Regarding subject categories, Lemos M is involved in Psychiatry, Physiology, Cardiovascular System & Cardiology, Oncology, and Respiratory System. Lemos M is listed in the reference of citation [1].

▎Relevant Citations

[1] Lemos M, Queirós T. What lies underneath: The genetics and neurobiology of psychopathy[J]. European Psychiatry, 2021,64(S1):S442.DOI:DOI: 10.1192/j.eurpsy.2021.1179.

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