Farikoloɲɛnajɛ bɛ dɔnniya, dusukunnataw ani farikolo baarakɛcogo ɲɛnabɔ ni hakilijagabɔlan gɛlɛnw ye ani selilɛriw ka taamasiɲɛw siraw fɛ. Tiɲɛni walima tiɲɛni min bɛ nin sigida in kɔnɔ, o bɛ se ka kɛ sababu ye ka kɛnɛyako gɛlɛyabaw lase mɔgɔ ma i n’a fɔ Alzheimer bana, Parkinson ka bana, jɔrɔnanko, degun, ani hakiliɲagami. Sira jɔnjɔn minnu bɛ kɛ walasa ka hakili ni hakili kɛnɛya sabati — i n’a fɔ hakililata, hakililata yiriwali, dusukunnataw labɛnni, ani hakili joginw dilancogo — olu bɛ tali kɛ fɛɛrɛ tigitigiw la minnu bɛ kɛ senfagabana ɲɛnamaya la, sinankunya plastiki, hakili funu ani u lasegincogo fɛɛrɛw la. Peptide fɛnw, n’u ka ɲɛnamaya kɛcogo ka bon ani u ka joli-sɔgɔsɔgɔninjɛ balilanw doncogo, olu bɔra kɛnɛ kan i n’a fɔ mɔlikulu ɲumanw walasa ka senfagabana siraw laɲini. U bɛ hakiliɲagami bila kɔfɛ selilɛriw ta fan fɛ ani ka baarakɛcogo dilancogo sabati, ka sira kura da wuli hakiliɲagami banaw kunbɛnni n’u furakɛli la. Aw ye kunnafoni wɛrɛw kalan

Pepitidiw dilanni bɛ tali kɛ asidi aminikiw sigiyɔrɔmali la ani ka amidi jɛɲɔgɔnyaw dilan (o kɔrɔ ye ko pepitiri jɛɲɔgɔnyaw) kemikɛli walima fɛnɲɛnamaw fɛ, o min bɛ kɛ sababu ye ka oligopɛtidi walima polipɛtidi mɔlikuluw jɔli kɛ cogo la min bɛ kɛ ni fɛnɲɛnamaw ka baara kɛrɛnkɛrɛnnenw ye. I n’a fɔ biyoorganiki chimie bolofara kɔrɔba dɔ, nin fɛɛrɛ in sinsinnen bɛ asidi aminikiw monomɛriw baaracogo sugandilen kan, sirako ɲɔgɔndan, ani ɲɔgɔndan lajɛli kɔlɔsili tigitigi, o bɛ tali kɛ fɛn bɛɛ lajɛlen na k’a ta miligaramu la laboratuwari labɛnni na ka se kilogaramu sɛgɛsɛgɛli ma izini dilanni na. Ka da sintetiki fɛɛrɛw kan minnu tɛ kelen ye, a bɛ tila ka kɛ biyosintɛtiki fɛɛrɛw ye minnu bɛ tali kɛ fɛnɲɛnamaw ka sigidaw la ani kemikɛli sintetiki fɛɛrɛw la minnu sinsinnen bɛ fɛnɲɛnamaw dilanni sariyaw kan. Aw ye kunnafoni wɛrɛw kalan

'peptide' daɲɛ bɔra Gɛrɛkikan daɲɛ na 'πέσσειν' (péssein), o kɔrɔ ye 'ka dumuni kɛ.' Pepitiri ye fɛn ye min bɛ dilan ni asidi aminikiw ye minnu bɛ tali kɛ pepitiri jɛɲɔgɔnyaw fɛ. Pepitidi jɛɲɔgɔnyaw, n’olu ye amidi jɛɲɔgɔnyaw ye, olu bɛ bɔ farikolojidɛsɛ sɔrɔli la asidi aminiki dɔ ka α-karɔkisili kulu ni asidi amino kulu wɛrɛ ka α-amino kulu cɛ. Ni an bɛ tila ka kɛɲɛ ni asidi aminikiw hakɛ ye, pepitiri minnu bɛ ni asidi aminikiw ye 2 fo 20, olu bɛ wele ko oligopɛtidi, minnu bɛ ni asidi aminikiw ye 20 fo 50, olu ye polipɛtidi ye, ani ɲɔgɔndan minnu ka ca ni asidi aminikiw 50 ye minnu ka yɔrɔ kɛrɛnkɛrɛnnenw bɛ u la, a ka c’a la, olu bɛ tila i n’a fɔ farikolojɔlifɛnw. A ka c’a la, pepitidiw girinya bɛ se kDa 10 ma. Aw ye kunnafoni wɛrɛw kalan

Cocerpeptides.com bɛ pepitiriw di minnu saniya bɛ tɛmɛ 99% kan. Cocer Peptides bɛ polipɛtidi saniya kɔlɔsili tigitigi sɔrɔ ani dɔnniya siratigɛ la, a kɛtɔ ka fɛɛrɛ kɔrɔw ni baarakɛcogo dafalen jogoɲini siratigɛ fara ɲɔgɔn kan: Sintezi taabolo la, pepitiri sintezi otomatiki fasa solide (SPPS) bɛ kɛ walasa ka asidi aminiki sinsinniw lajɛ ɲɔgɔn fɛ ka ɲɛ. Aw ye kunnafoni wɛrɛw kalan

Survodutide ye sɛgɛsɛgɛlikɛlan ye min bɛ baara kɛ waati jan kɔnɔ, min bɛ baara kɛ ni agoniste fila ye, min bɛ tali kɛ waati kelen na glucagon-like peptide-1 receptor (GLP-1R) ni glucose-dependent insulinotropic polypeptide receptor (GIPR) la. A bɛ kɛ siɲɛ kelen dɔrɔn dɔgɔkun kɔnɔ, o bɛ nɔgɔya caman di banabagatɔw ma ani ka furakɛli kuntaalajan labatoli ɲɛ. Aw ye kunnafoni wɛrɛw kalan

Ikomi farikoloɲɛnajɛ banaw i n’a fɔ farikolo girinya, fasa, ani sukarodunbana bɛ ka caya diɲɛ kɔnɔ, furakɛli fura minnu bɛ se ka kɛ kosɛbɛ, olu ɲinini kɛra barokun ye min bɛ fɔ kosɛbɛ furakɛli siratigɛ la. Aw ye kunnafoni wɛrɛw kalan

Farikoloɲɛnajɛ ni kɔnɔnatumuw bɛ hadamadenw ka fɛnw sɛnɛcogo, fanga balansi, ani bonya ni yiriwali ɲɛnabɔ ɔrimɔni rezo camanba dɔ sababu fɛ. Aw ye kunnafoni wɛrɛw kalan

Ɲininikalan pepitiriw ye fɛnɲɛnamafagalanw ye minnu dilannen don baarakɛcogo la, minnu dilannen don laboratuwaraw kɔnɔ, minnu nafa jɔnjɔn ye ka dɛmɛ don baarakɛminɛnw na ɲɛnamaya dɔnniyaw ɲinini na ani ka baara kɛ ni u ye dɔrɔn ɲininikɛyɔrɔw la in vitro. 'Sɛgɛsɛgɛli in vitro,' min bɔra latigɛkan daɲɛ na 'in vitro' (o kɔrɔ ye 'glasi kɔnɔ'), kɛrɛnkɛrɛnnenya la, o bɛ tali kɛ kalanw na minnu kɛra kɔlɔsili sigidaw la minnu bɛ kɔlɔsi ni fɛn dilannenw ye, i n'a fɔ selilɛriw ladonni, molekiyɔmuw ka jɛɲɔgɔnya sɛgɛsɛgɛli, walima biyokimiki waleyali sɛgɛsɛgɛliw. Aw ye kunnafoni wɛrɛw kalan

Pepitiri sirili ye jɛɲɔgɔnya kovalɛn taamasiɲɛ ye farikolojɔlifɛnw na, min bɛ sɔrɔ jibɔbaliya waleya fɛ asidi aminikiw kelen ka α-karɔbɔli kulu (α-COOH) ni asidi aminiki kɛrɛfɛ α-amino kulu (-NH2) cɛ. A ka kemikɛli cogoya ye amidi jɛɲɔgɔnya ye. Aw ye kunnafoni wɛrɛw kalan