Sisitemu y'imitsi igenga kumenya, amarangamutima, n'imikorere y'umubiri binyuze mumiyoboro igoye ya neurotransmitter hamwe n'inzira zerekana ibimenyetso. Kwangirika cyangwa kwangirika muri iyi sisitemu birashobora gukurura ibibazo bikomeye byubuzima nkindwara ya Alzheimer, indwara ya Parkinson, guhangayika, kwiheba, nihungabana ry’imitsi. Inzira nyamukuru zo kubungabunga ubuzima bw’imyakura n’ubwenge - harimo na neuroprotection, kongera ubwenge, kugenzura amarangamutima, no gusana ibikomere by’imitsi - bishingiye ku bikorwa bifatika mu mibereho ya neuronal, plastique synaptic, neuroinflammation, hamwe nuburyo bushya bwo kuvugurura. Ibintu bya peptide, hamwe nibikorwa bya biologiya byinshi hamwe nubwonko bwamaraso-ubwonko bwinjira, byagaragaye nka molekile nziza yo kwibasira inzira zinzira. Batinda neurodegeneration kurwego rwa selire kandi bigateza imbere gusana imikorere, gufungura inzira nshya zo gukumira no kuvura indwara zifata ubwonko. Soma Ibikurikira

Peptide synthesis bivuga inzira yo kubaka aside amine ikurikirana no gukora amide (urugero, peptide bond) ikoresheje uburyo bwa chimique cyangwa biologique, cyane cyane ituma hubakwa ibihimbano bya molekile ya oligopeptide cyangwa polypeptide ifite imikorere yihariye yibinyabuzima. Nka shami rikomeye rya chimie bioorganic, tekinoroji yibanda kubikorwa byo gutoranya aminide acide amino, guhuza icyerekezo, no kugenzura neza inteko ikurikirana, ikurikirana ibintu byose uhereye kuri miligarama nini ya laboratoire kugeza ku nganda zingana na kilo. Bishingiye ku ngamba zinyuranye za syntetique, ishyirwa muburyo bwa biosynetique bushingiye kuri sisitemu y'ibinyabuzima hamwe na synthesis ya chimique ishingiye kumahame ya synthesis. Soma Ibikurikira

Ijambo 'peptide ' rikomoka ku ijambo ry'Ikigereki 'πέσσειν ' (péssein), risobanura 'gusya. Peptide bond, ari amide bond, ituruka kumyuka ya dehidrasi hagati ya α-carboxyl groupe ya acide amine imwe na α-amino yandi. Urutonde rwa aminide acide, peptide ifite aside amine 2 kugeza kuri 20 yitwa oligopeptide, abafite 20 kugeza kuri 50 ni polypeptide, kandi urutonde rurenga 50 aside amine ifite imiterere yihariye isanzwe ishyirwa mubikorwa nka poroteyine. Peptide mubisanzwe ifite uburemere bwa molekile munsi ya 10 kDa. Soma Ibikurikira

Cocerpeptides.com itanga peptide ifite isuku irenga 99%. Cocer Peptides igera ku kugenzura neza no kugenzura siyanse yubuziranenge bwa polypeptide muguhuza tekinoroji igezweho hamwe na sisitemu yuzuye yo kugenzura ubuziranenge: Mu cyiciro cya synthesis, icyiciro cya peptide cyikora (SPPS) gikoreshwa kugirango gikusanyirizwe hamwe na aside amine ikurikirana. Soma Ibikurikira

Survodutide nubushakashatsi bumaze igihe kirekire bukora agonist yibasiye icyarimwe yibasira reseptor ya glucagon imeze nka peptide-1 (GLP-1R) hamwe na glucose iterwa na insulineotropique polypeptide reseptor (GIPR). Irasaba ubuyobozi rimwe gusa mucyumweru, butanga abarwayi korohereza no kunoza uburyo bwo kuvura igihe kirekire. Soma Ibikurikira

Mu gihe umubare w'indwara ziterwa na metabolike nk'umubyibuho ukabije, umubyibuho ukabije, na diyabete ukomeje kwiyongera ku isi yose, gushakisha imiti ivura neza byahindutse ingingo ishyushye mu rwego rw'ubuvuzi. Soma Ibikurikira

Sisitemu ya metabolike na endocrine igenga metabolism yibintu byabantu, kuringaniza ingufu, no gukura niterambere binyuze mumiyoboro ihanitse ya hormone. Soma Ibikurikira

Ubushakashatsi bwa peptide bwakozwe na molekile ikora neza ikomatanyirizwa muri laboratoire, agaciro kayo kibanze mugutanga inkunga yibikoresho byubushakashatsi bwubuzima kandi bigakoreshwa gusa mubushakashatsi bwa vitro. ' Soma Ibikurikira

Umubumbe wa peptide ni umwihariko wa covalent muri molekile ya poroteyine, ikorwa hifashishijwe uburyo bwo kubura umwuma hagati ya α-carboxyl (α-COOH) ya aside amine hamwe nitsinda α-amino (-NH₂) ya aside amine yegeranye. Imiterere yimiti ni isano hagati. Soma Ibikurikira