Mu gihe umubare w'indwara ziterwa na metabolike nk'umubyibuho ukabije, umubyibuho ukabije, na diyabete ukomeje kwiyongera ku isi yose, gushakisha imiti ivura neza byahindutse ingingo ishyushye mu rwego rw'ubuvuzi. Soma Ibikurikira

Sisitemu ya metabolike na endocrine igenga metabolism yibintu byabantu, kuringaniza ingufu, no gukura niterambere binyuze mumiyoboro ihanitse ya hormone. Soma Ibikurikira

Ubushakashatsi bwa peptide bwakozwe na molekile ikora neza ikomatanyirizwa muri laboratoire, agaciro kayo kibanze mugutanga inkunga yibikoresho byubushakashatsi bwubuzima kandi bigakoreshwa gusa mubushakashatsi bwa vitro. ' Soma Ibikurikira

Umubumbe wa peptide ni umwihariko wa covalent muri molekile ya poroteyine, ikorwa hifashishijwe uburyo bwo kubura umwuma hagati ya α-carboxyl (α-COOH) ya aside amine hamwe nitsinda α-amino (-NH₂) ya aside amine yegeranye. Imiterere yimiti ni isano hagati. Soma Ibikurikira

Amino acide ni ibinyabuzima birimo α-amino itsinda (α-NH₂) nitsinda α-carboxyl (α-COOH), hamwe na formula rusange RCH (NH₂) COOH. Atom α-karubone ihujwe nitsinda ryihariye ryuruhererekane (R itsinda), rigizwe nibice shingiro byimiterere ya macromolecules. Soma Ibikurikira

Peptide yoza ni inzira yo gutandukanya no gukungahaza imvange ya peptide yimbuto yabonetse binyuze muri synthesis cyangwa imvugo ukoresheje uburyo bwumubiri, imiti, cyangwa ibinyabuzima kugirango ubone peptide yibintu byera cyane. Soma Ibikurikira

Peptide solubilité bivuga umubare ntarengwa wa peptide ushobora gushonga mubunini bwumubyimba wubushyuhe bwihariye nubushyuhe bwa pH, mubisanzwe birangwa nubushuhe bwinshi (g / L) cyangwa kwibumbira hamwe (mol / L). Nkumutungo wingenzi wa fiziki-chimique, bigira uruhare runini muburyo bwo kwinjiza, gukwirakwiza, metabolisme, no gusohora (ADME) ya peptide muri vivo, kandi ikanagena ikoranabuhanga ryitegura, ihagarikwa ryububiko, hamwe nubuvuzi bukoreshwa nubuvuzi bwa peptide. Soma Ibikurikira

Peptide ivanze, bitewe na aside amine yihariye ikurikirana hamwe nuburyo butandukanye, bifite ibimenyetso biranga ibikorwa byabo byibinyabuzima byibasirwa cyane n’ibidukikije. Impamvu y'ibanze yo kubika peptide ni ukurinda imiti y’imiti nko kwangirika, okiside, hamwe no kwegeranya, bityo bikagumana ubusugire bwimiterere n'imikorere yibinyabuzima. Soma Ibikurikira

Dermorphine ikora cyane cyane ingaruka zayo zo gusesengura ikorana na μ-opioid reseptor (MOP). Reseptor ya μ-opioid ni umunyamuryango wingenzi wumuryango wa reseptor ya opioid kandi igira uruhare runini muguhindura ububabare. Soma Ibikurikira