Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Intangiriro
Igituntu 500 (Thymosin Beta-4 Igice cya 17-23) nigice cya bioactive gifitanye isano rya bugufi ninzira zingenzi zingenzi muri physiologiya yabantu, cyane cyane mugusana ingirabuzimafatizo no kwimuka kwakagari.
Igishushanyo 1 Imiterere yimiti ya TB 500 Igice (17-23).
Amakuru Yibanze Yerekeye Igituntu 500 (17-23)
TB 500 Igice (17-23) nigice cya N-terminal acetylated 17-23 igice cya thymosine beta-4 (Thymosin Beta-4). N-terminal acetylation igira uruhare runini muguhuza poroteyine-poroteyine hamwe n’imiterere y’imitsi. Kubaho kwa matsinda ya acetyl birashobora guhindura ikwirakwizwa rya molekile ikwirakwizwa no guhinduranya ahantu, bityo bikagira ingaruka kubushobozi bwayo bwo guhuza nibindi binyabuzima. Mu mubiri w'umuntu, thymosine β4 ni peptide ikwirakwizwa cyane, kandi TB 500 Fragment (17-23), nkigice cyayo cyihariye, irashobora kubyara binyuze muri proteolitike ya endogene.
Uburyo bwibikorwa bya TB 500 Igice (17-23)
(1) Kwimuka kwakagari na Chemotaxis
Ingaruka ku ngirabuzimafatizo za Endothelia: Igice cya TB 500 (17-23) gitera kwimuka kwimuka kwimuka, inzira ikomeye kuri angiogenez. Mugihe cyo gukiza ibikomere cyangwa gusana ingirabuzimafatizo, selile endothelia igomba kwimukira ahantu yangiritse kugirango habeho imiyoboro mishya yimitsi, kugirango itange ogisijeni nintungamubiri mubice. TB 500 Igice (17-23) gishobora kongera kwimuka kwimuka ya endoteliyale mugukoresha urukurikirane rwinzira zerekana ibimenyetso, nka PI3K-Akt yerekana inzira, igenga ivugurura rya cytoskeleton. Gukora inzira ya PI3K-Akt yerekana inzira itera polymerisation na depolymerisation ya actin, ituma selile yagura pseudopodiya kandi igatera imbere.
Ingaruka ya chimotactique ku ngirabuzimafatizo z'umubiri: Iki gice kigaragaza kandi ingaruka za chimotactique ku ngirabuzimafatizo z'umubiri, zikurura macrophage, neutrophile, n'utundi tugingo ngengabuzima aho twakongeje cyangwa twakomeretse. Macrophage igira uruhare runini mugusana ingirangingo, kuko zishobora gukuraho ingirangingo zanduye na virusi mugihe zihisha ibintu bitandukanye bikura hamwe na cytokine kugirango biteze imbere gusana no kuvugurura. Igice cya TB 500 (17-23) gihuza reseptor yihariye hejuru yingirabuzimafatizo, ikora inzira yerekana ibimenyetso byerekana inzira yo kuyobora ingirabuzimafatizo zigana aho yakomeretse.
(2) Gusana imyenda no kuvugurura
Gutezimbere ikwirakwizwa rya fibroblast hamwe na synthesis ya kolagen: Fibroblast nubwoko bwambere bwingirabuzimafatizo mu ngingo zihuza kandi zifite inshingano zo guhuza no gusohora ibice bigize matrice idasanzwe nka kolagen mugihe cyo gukira ibikomere. TB 500 Igice (17-23) kirashobora gutuma fibroblast ikwirakwira, ikongera umubare wimikorere bityo ikihutisha synthesis. Iki gice gishobora kugenzura imiterere ya gen zijyanye na synthesis ya kolagen, nka COL1A1 na COL3A1, mugihe iteza imbere guhindura ibisobanuro byahinduwe na kolagen muri fibroblast, bityo bikazamura ubwiza bwa kolagen hamwe n’umutekano. Izi ngaruka zigira uruhare mu gushiraho matrise ikomeye idasanzwe, itera gukira ibikomere no gusana ingirangingo.
Gusana ingirangingo z'imitsi: Mugukosora imitsi, TB 500 Igice (17-23) nacyo kigira uruhare runini. Itezimbere gukora no gukwirakwiza ingirabuzimafatizo za satelite, arizo selile myogenic stem selile mumitsi ya skeletale ifite ubushobozi bwo kwivugurura no gutandukanya imitsi. Igituntu 500 Igice (17-23) kigenga inzira ya MyoD-Myogenin yerekana inzira mungirangingo ya satelite, igateza imbere itandukaniro ryayo muri myotubes, hanyuma igahuza gukora fibre nshya yimitsi, bityo ikagera no gusana imitsi no kuvugurura. Iki gice kirashobora kandi kugabanya ibisubizo byumuriro nyuma yo gukomeretsa imitsi, bikagabanya kwangirika kwimitsi yimitsi iterwa no gutwikwa.
(3) Ingaruka zo kurwanya inflammatory
Kubuza imvugo yibintu byerekana: TB 500 Igice (17-23) kirashobora kubuza kwerekana ibintu bitandukanye bitera umuriro, harimo ibibyimba bya niyosezi-α (TNF-α) na interleukin-1β (IL-1β). Ibi bintu bitera umuriro bigira uruhare runini mubisubizo byokongoka, kandi imvugo yabo ikabije irashobora gutuma umuntu yiyongera kandi agakomeza gutwika, bigatera kwangirika kwinyama. TB 500 Igice (17-23) kirashobora kugabanya kwandukura no guhindura ibintu bitera umuriro muguhagarika imikorere yikintu cya kirimbuzi-κB (NF-κB) cyerekana inzira yerekana inzira, bityo bikagabanya igisubizo cyakongejwe. NF-κB ni ikintu cyingenzi cyo kwandukura intandaro yo kwanduza ibimenyetso byerekana ibimenyetso, kandi kuyikora birashobora kugenzura imiterere ya genes nyinshi zijyanye no gutwika.
Kugena ibisubizo byokwirinda ingirabuzimafatizo: Usibye kubuza kwerekana ibintu bitera umuriro, TB 500 Fragment (17-23) irashobora kandi kugenga uburyo bwo gutwika ingirabuzimafatizo. Irashobora guhagarika polarisiyasi ya macrophage yerekeza ku bwoko bwa pro-inflammatory (ubwoko bwa M1) kandi igateza polarisiyasi yabo yerekeza ku bwoko bwa anti-inflammatory (ubwoko bwa M2). M1 yo mu bwoko bwa macrophage cyane cyane isohora ibintu bitera inflammatory, igira uruhare mugutangiza no kongera umuriro; mugihe macrophage yo mu bwoko bwa M2 isohora ibintu birwanya inflammatory, bigatera gusana ingirabuzimafatizo no kugenzura indwara. Igituntu 500 Igice (17-23) kigenga imiterere ya macrophage ya polarisiyasi, ikayobora igisubizo cyumuriro ugana icyerekezo cyiza cyo gusana ingirangingo.
Gukoresha igituntu 500 Igice (17-23) murwego rwubuvuzi
(1) Gukiza ibikomere
Ibikomere byuruhu: Mugukiza ibikomere byuruhu, TB 500 Igice (17-23) cyerekana ingaruka zikomeye zo kwamamaza. Ubushakashatsi bwibanze bwerekana ko gushyira mu bikorwa ingingo zirimo TB 500 Igice (17-23) byihutisha gufunga ibikomere kandi bikazamura ubuvuzi bwiza. Ibi biterwa cyane cyane ningaruka zayo zinyuranye zigenga ingirabuzimafatizo, fibroblast, na selile selile. Kwimuka kwihuta kwimikorere ya selile itera imiyoboro mishya mishya, itanga imirire ihagije kubikomere; kwiyongera kwa fibroblast hamwe na synthesis ya kolagen bivamo ingirabuzimafatizo zikomeye zihuza ahakomeretse; n'ingaruka za chimotactique na anti-inflammatory ingirabuzimafatizo zigabanya ingaruka zo kubuza ibisubizo gukira gukira ibikomere. Mu kuvura ibikomere bimwe na bimwe bidakira, nk'ibisebe byo mu birenge bya diyabete, Igice cya TB 500 (17-23) nacyo kigaragaza agaciro ko kuvura. Abarwayi ba diyabete bahura no gukira ibikomere no kongera ibyago byo kwandura bitewe n’isukari nyinshi mu maraso. Igituntu 500 Igice (17-23) kirashobora guteza imbere ibidukikije byaho, bigatera kwimuka kwimuka no gukwirakwira, kandi bikongerera amahirwe yo gukira mubikomere bidakira.
Ibikomere by'imbere: Ku bikomere by'imbere, nk'ibisebe byo mu gifu no kwangirika kw'umwijima, TB 500 Fragment (17-23) nayo ifite ingaruka zo kuvura. Mu gisebe cya gastrointestinal, imiyoborere ya TB 500 Fragment (17-23) iteza ikwirakwizwa no gusana ingirabuzimafatizo mu kibisebe, bikagabanya ibisebe. Uburyo bwibikorwa bifitanye isano no guteza imbere kwimuka kwakagari, kugenzura ibisubizo byumuriro, no kongera synthesis idasanzwe ya matrix. Muburyo bwo gukomeretsa umwijima, TB 500 Fragment (17-23) irashobora guteza imbere ingirabuzimafatizo yumwijima, kugabanya kwangirika kwimyanya yumwijima, no kunoza imikorere yumwijima.
(2) Kuvura Indwara Zimitsi
Imitsi n'imvune: Mubuvuzi bwa siporo, imitsi n'imvune nibibazo bisanzwe. Igituntu cya 500 500 (17-23), kubera ingaruka zacyo zigaruka kumitsi yimitsi, cyagaragaye nkumuti ushobora kuvura ibikomere. Ubuyobozi bwa TB 500 Igice (17-23) gikurikira imitsi irashobora kwihutisha kugarura imbaraga zimitsi no kugabanya imitsi ya fibrosis. Fibrosis yimitsi nikibazo gikunze gukurikira gukomeretsa imitsi, biganisha ku gukomera kwimitsi yimitsi, kugabanya ubukana, no kwangirika kwimitsi. Igituntu 500 Igice (17-23) gitera gukora no gukwirakwiza ingirabuzimafatizo za satelite, bikabuza kwifata, kandi bikagabanya imitsi ya fibrosis, bityo bikazamura ibikomere byimitsi.
Osteoarthritis: Osteoarthritis ni indwara ikunze kwangirika ifitanye isano no kwangirika kwa karitsiye, gutwika synovial, no gukwirakwiza amagufwa. Igituntu 500 Igice (17-23) cyerekanye kandi ubushobozi bwo kuvura osteoarthritis. Irashobora guteza imbere ikwirakwizwa rya matrix hamwe na matrix ya chondrocytes, ikabuza chondrocyte apoptose, bityo bikadindiza kwangirika kwa karitsiye. Ingaruka zo kurwanya indwara ya TB 500 Igice (17-23) zirashobora kugabanya uburibwe bwa synovial, kugabanya ububabare bufatanye, no kugabanya kubyimba. Ubushakashatsi bw’inyamaswa bwerekanye ko inshinge zo mu bwoko bwa TB 500 Fragment (17-23) zishobora kunoza imikorere ihuriweho n’inyamaswa z’icyitegererezo cya osteoarthritis no kugabanya kwangirika kwa karitsiye.
(3) Kuvura indwara z'umutima
Indwara ya Myocardial: Indwara ya Myocardial ni indwara ikomeye yumutima nimiyoboro y'amaraso iterwa na myocardial ischemia na necrosis bitewe no guhagarika imiyoboro y'amaraso. Igituntu 500 Igice (17-23) gifite agaciro gashoboka mukuvura infira ya myocardial. Nyuma yindwara ya myocardial, tissue myocardial ikorerwa ibisubizo byumuriro hamwe na apoptose selile, biganisha kumikorere yumutima. Igituntu 500 Igice (17-23) kirashobora kunoza imikorere yumutima nyuma yindwara ya myocardial muguhagarika ibisubizo byumuriro, kugabanya selile myocardial apoptose, no guteza imbere angiogenez. Ubushakashatsi bwerekanye ko mubyitegererezo byinyamanswa ziterwa na myocardial infarction, gukoresha TB 500 Fragment (17-23) bishobora kugabanya ubunini bwa infarct, kunoza igice cyo gusohora k'umutima, no kongera umutima no kwikuramo umutima.
Gusana ibikomere byamaraso: Mugihe habaye ibikomere byamaraso, nko kwangirika kwa endoteliyale nyuma yo guterwa kwamaraso, TB 500 Fragment (17-23) irashobora guteza imbere kwimuka kwimuka no gukwirakwira, kwihutisha gusana endoteliyale, no kugabanya ibyago byo guterwa na trombus. Nyuma yo gukomeretsa kw'imitsi y'amaraso, kolagen igaragara munsi ya endotelium irashobora gutera platel gufatana hamwe no guteranya, bigatuma habaho trombus. TB 500 Igice (17-23) iteza imbere gusana ingirabuzimafatizo, kugarura ubudahangarwa bwimitsi y'amaraso, bityo bikagabanya imiterere ya trombus no kurinda imikorere yimitsi isanzwe.
Umwanzuro
Igituntu cya 500 500 (17-23), nkigice cya peptide gifite ibikorwa byihariye byibinyabuzima, byerekana imbaraga mugusana ingirangingo, kwimuka kwakagari, nibindi bice.
Inkomoko
[1] Esposito S, Deventer K, Goeman J, n'abandi. Synthesis hamwe no kuranga N-terminal acetylated 17-23 agace ka thymosine beta 4 yagaragaye muri TB-500, igicuruzwa gikekwa kuba gifite ubushobozi bwa doping [J]. Gupima no gusesengura ibiyobyabwenge, 2012,4 (9): 733-738.DOI: 10.1002 / dta.1402.
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