Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
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Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Daminɛ kuma
TB 500 (Thymosin Beta-4 Fragment 17–23) ye fɛn ye min bɛ baara kɛ ni fɛnɲɛnamaw ye, a ni taabolo jɔnjɔn caman bɛ tali kɛ ɲɔgɔn na kosɛbɛ hadamaden farikololabɔli la, kɛrɛnkɛrɛnnenya la farikolo yɔrɔw dilancogo ni selilɛriw ka jiginni na.
Jaa 1 TB 500 Fragment (17–23) ka kemikaliya cogoya.
Kunnafoni jɔnjɔnw TB 500 Fragment kan (17–23) .
TB 500 Fragment (17–23) ye hadamaden ka timosini beta-4 (Thymosin Beta-4) yɔrɔ 17–23 asetilalen N-terminal ye. N-terminal asetilasi jɔyɔrɔ ka bon kosɛbɛ farikolojɔli dumuniw ni farikolojɔlifɛnw ka jɛɲɔgɔnyaw labɛnni na ani selilu kɔnɔ sigiyɔrɔmali la. Asetili kuluw sɔrɔli bɛ se ka molekiyɔmuw ka charge (molecules charge) tilatilali ni yɔrɔ-yɔrɔ-ko caman Changer, o la, a bɛ se ka nɔ bila a ka se ka siri ni biomolecules wɛrɛw ye. Adamaden farikolo la, timosini β4 ye pepitiri ye min jɛnsɛnnen don kosɛbɛ, wa TB 500 Fragment (17–23), n’o ye a yɔrɔ kɛrɛnkɛrɛnnen ye, o bɛ se ka dilan ni kɔnɔnatumuw ye minnu bɛ wele ko proteolytic processes.
Tubabufura 500 yɔrɔ dɔ ka baara kɛcogo (17–23) .
(1) Selilɛriw ka jiginni ani u ka kemotaksi
A nɔ minnu bɛ sɔrɔ endoteliyali selilɛriw la : TB 500 Fragment (17–23) bɛ endoteliyali selilɛriw ka jiginni sabati, o ye wale ye min nafa ka bon joli-sira-funu na. Joginda kɛnɛyali walima farikolo yɔrɔw dilan waati, endoteliyali selilɛriw ka kan ka taa yɔrɔ tiɲɛnenw na walasa ka joli sira kuraw dilan, walasa ka oksizɛni ni balofɛnw di farikolo yɔrɔw ma. TB 500 Fragment (17–23) bɛ se ka endoteliyali selilɛriw ka jiginni sabati ni a bɛ selilɛri kɔnɔ taamasiɲɛw sira caman baara, i n’a fɔ PI3K-Akt taamasiɲɛw sira, o min bɛ selilɛriw ka sitokolo labɛncogo kura ɲɛnabɔ. PI3K-Akt taamasiɲɛ sira baarakɛli bɛ actin polimɛrizi ni depolimɛrize sabati, o bɛ kɛ sababu ye ka seliluw dɛmɛ u ka pseudopodia janya ani ka taa ɲɛ.
Chimiotactic nɔ min bɛ farikolo tangalanw kan: Nin yɔrɔ in bɛ kemikorosi nɔ jira fana farikolo tangalanw na, ka makɔrɔfagaw, neutrophils ani farikolo tangalan wɛrɛw sama ka taa funu walima jogin yɔrɔw la. Makrofagaw jɔyɔrɔ ka bon farikolo yɔrɔw dilancogo la, barisa u bɛ se ka farikolo yɔrɔ tiɲɛnenw ni banakisɛw bɔ u la ka sɔrɔ u bɛ bonyafɛn suguya caman ni sitokiniw bɔ walasa ka farikolo yɔrɔw dilancogo ni u lasegincogo sabati. TB 500 Fragment (17–23) bɛ siri farikolo tangalan kɛrɛnkɛrɛnnenw na farikolo tangalanw sanfɛ, ka selilɛri kɔnɔ taamasiɲɛw siraw baara walasa ka farikolo tangalanw bilasira ka taa joginda yɔrɔ la.
(2) Farikolo yɔrɔw dilancogo ani u lasegincogo kura
Fibɔrɔsiw caya ni kolajɛni sɔrɔli sabatili : Fiɲɛbɔlanw ye selilɛri suguya fɔlɔ ye jɛɲɔgɔnya yɔrɔw la, wa u bɛ se ka farikolo kɔkanfɛnw labɛn ani k’u bɔ i n’a fɔ kolajɛni joginda kɛnɛyali waati. TB 500 Fragment (17–23) bɛ se ka fibroblaste caya, ka dɔ fara selilɛri hakɛ kan ani ka kolajɛ teliya. Nin yɔrɔ in bɛ se ka jɛnɛya jiracogo kɔrɔta min bɛ tali kɛ kolajɛ sɔrɔli la, i n’a fɔ COL1A1 ani COL3A1, ka sɔrɔ ka kolajɛ caman cili sabati bamanankan na, fibroblaste kɔnɔ, o la, kolajɛ jogo ni a sabatili bɛ ɲɛ. O nɔ ninnu bɛ kɛ sababu ye ka farikolo kɔkanna matiriyali barikama dɔ dilan, min bɛ joginda kɛnɛyali ni farikolo yɔrɔw dilancogo sabati.
Farikolo yɔrɔw dilancogo : Farikolo joginw dilancogo la, TB 500 Fragment (17–23) fana jɔyɔrɔ ka bon. A bɛ sateliti selilɛriw baarakɛli n’u caya sabati, olu minnu ye miyɔjeni jirisunw ye kolotugudaw la ni se bɛ u yɛrɛ kura ye ani ka danfara don u ni ɲɔgɔn cɛ ka kɛ farikolo yɔrɔw ye. TB 500 Fragment (17–23) bɛ MyoD-Myogenin taamasiɲɛ sira labɛn sateliti selilɛriw kɔnɔ, k’u danfara sabati ka kɛ miyɔtubuw ye, o kɔfɛ, olu bɛ fara ɲɔgɔn kan ka farikolo yɔrɔ kuraw dilan, o la, farikolo yɔrɔw dilancogo ni u lasegincogo bɛ se ka kɛ. Nin yɔrɔ in bɛ se ka dɔ bɔ funu jaabiw fana na farikolo jogin kɔfɛ, ka farikolo yɔrɔw tiɲɛni wɛrɛw nɔgɔya min bɛ sɔrɔ funu fɛ.
(3) A bɛ banakisɛfagalanw kɛlɛ
Funubanakisɛ jirali balili : TB 500 Fragment (17–23) bɛ se ka funufɛn suguya caman jirali bali, i n’a fɔ tumor necrosis factor-α (TNF-α) ani interleukin-1β (IL-1β). Nin funu ninnu jɔyɔrɔ ka bon funu jaabiw la, wa u jirali kojugu bɛ se ka kɛ sababu ye ka funu bonya ani ka to a la, o bɛ kɛ sababu ye ka farikolo yɔrɔw tiɲɛ. TB 500 Fragment (17–23) bɛ se ka dɔ bɔ funufɛnw sɛbɛnni ni u bamanankan na, a kɛtɔ ka nukilila facteur-κB (NF-κB) taamasiɲɛw sira baarakɛli bali, o la, a bɛ funu jaabi nɔgɔya. NF-κB ye sɛbɛnnikɛlan nafama ye min bɛ funu taamasiɲɛw cili kɔnɔ, wa a baarakɛli bɛ se ka funu ni ɲɔgɔn cɛ jamu caman jirali kɔrɔta.
Banakisɛfagalanw ka funu jaabi labɛnni : Ka fara funufɛnw jirali balili kan, TB 500 Fragment (17–23) bɛ se ka farikolo tangalanw ka funu jaabi fana labɛn. A bɛ se ka makɔrɔfagaw ka polarize bali ka taa pro-inflammatory type (M1 suguya) la ani ka u polarisation (polarize) sabati ka taa anti-inflammatory type (M2 type) fan fɛ. M1 suguya makɔrɔfagaw bɛ funu dɛmɛnanw bɔ fɔlɔ, u bɛ u sen don funu daminɛni ni a bonya la; k’a sɔrɔ M2 suguya makɔrɔfagaw bɛ banakisɛfagalanw bɔ, minnu bɛ farikolo yɔrɔw dilancogo ni farikolo tangacogo ɲɛnabɔ. TB 500 Fragment (17–23) bɛ makɔrɔfagaw ka polarize cogoya labɛn, ka funu jaabi ɲɛsin sira ma min ka ɲi farikolo yɔrɔw dilancogo la.
TB 500 Fragment (17–23) tali furakɛli siratigɛ la
(1) Joginda kɛnɛyali
Fari joginda : Fari joginda kɛnɛyali la, TB 500 Fragment (17–23) bɛ ɲɛtaa nɔba jira. Kɔlɔsili minnu kɛra ka kɔn kɛnɛyaso ɲɛ, olu y’a jira ko TB 500 Fragment (17–23) bɛ furakisɛ minnu na, olu tali fari la, o bɛ joginda datuguli teliya ani ka kɛnɛyacogo ɲɛ. O bɛ bɔ fɔlɔ a ka ɲɛnabɔli kɛcogo caman na endothéliale cellules, fibroblastes ani immunités cellules kan. Endoteliyali selilɛriw ka jiginni teliya bɛ joli sira kura sɔrɔli sabati, o bɛ balo ɲuman di joginda ma; fibroblaste (fibroblaste) caya ni kolajɛni sɔrɔli bɛ na ni jɛɲɔgɔnya farikolo barikama ye joginda yɔrɔ la; ani farikolo tangalanw ka kemikoro ni funu kɛlɛli nɔ bɛ funu jaabiw balili nɔ nɔgɔya joginda kɛnɛyali la. Joginda basigilen dɔw furakɛli la, i n’a fɔ sukarodunbana senkɔniw, TB 500 Fragment (17–23) fana bɛ furakɛli nafa jira. Jabɛtibanabagatɔw bɛ joginda kɛnɛyali bila kɔfɛ ani banakisɛ sɔrɔli farati bɛ bonya ka a sababu kɛ sukaro hakɛ caya ye u joli la. TB 500 Fragment (17–23) bɛ se ka sigida lamini fitininw ɲɛ, ka selilɛriw ka jiginni ni u caya sabati, ani ka joginda basigilenw kɛnɛyali caya.
Kɔnɔnafɛnw joginda : Kɔnɔnafɛnw joginda la, i n’a fɔ kɔnɔboli ani sugunɛ tiɲɛni, TB 500 Fragment (17–23) fana bɛ se ka furakɛli kɛ. Kɔnɔbara basigilen misali la, TB 500 Fragment (17–23) tali bɛ ɲɛgɛnɛsiralabanaw caya ani ka u dilan kirinni yɔrɔ la, o bɛ dɔ bɔ kirinni yɔrɔ la. A kɛcogo bɛ tali kɛ selilɛriw ka jiginni sabatili la, ka funu jaabiw labɛn, ani ka dɔ fara selilu kɔkan matiriyali kan. Sugunɛ jogincogo misali la, TB 500 Fragment (17–23) bɛ se ka sugunɛbilenniw labɛn kokura, ka funu tiɲɛni dɔgɔya sugunɛbara la, ani ka sugunɛ baarakɛcogo jiralanw ɲɛ.
(2) Farikolo ni kolotugudaw banaw furakɛli
Farikolo degunw ni joginw : Spor furakɛli la, farikolo degun ni joginw ye ko ye min ka teli ka kɛ. TB 500 Fragment (17–23), ka da a ka furakɛli nɔ kan farikolo yɔrɔw la, o bɔra kɛnɛ kan i n’a fɔ furakɛli fɛɛrɛ min bɛ se ka kɛ farikolo joginw furakɛli la. Tubabufura 500 Fragment (17–23) tali farikolojidɛsɛ kɔfɛ, o bɛ se ka farikolo fanga seginni teliya ani ka dɔ bɔ farikolojidɛsɛ sɔrɔli la. Farikolo fiyɛli ye gɛlɛya ye min ka teli ka sɔrɔ farikolo jogin kɔfɛ, o bɛ na ni farikolo yɔrɔw gɛlɛyali ye, ka dɔ bɔ farikolo lamagacogo la, ani ka farikolo baara dɔgɔya. TB 500 Fragment (17–23) bɛ sateliti selilɛriw ka baara kɛ ani ka caya, ka funu jaabiw bali, ka farikolojidɛsɛ sɔrɔli dɔgɔya, o la, a bɛ farikolo joginw dilancogo ɲɛ.
Kolotugudaw : Kolotugudaw ye kolotugudaw bana ye min bɛ sɔrɔ kolotugudaw tiɲɛni fɛ, kolotugudaw funu, ani kolo caya. TB 500 Fragment (17–23) fana y’a jira ko a bɛ se ka kɛ kolotugudaw furakɛli la. A bɛ se ka kondrositɛriw caya ni u matiriyali sabatili sabati, ka kɔndɔsi apoptose bali, o la ka kolotugudaw tiɲɛni sumaya. TB 500 Fragment (17–23) ka banakisɛfagalanw bɛ se ka sɔgɔsɔgɔninjɛ funu nɔgɔya, ka kolotugudaw dimi nɔgɔya, ka funu dɔgɔya. Baganw ka sɛgɛsɛgɛliw y’a jira ko TB 500 Fragment (17–23) pikiri kɛli joli la, o bɛ se ka kolotugudaw baara ɲɛ kolotuguda misali baganw na ani ka dɔ bɔ kolotugudaw tiɲɛni na.
(3) Dusukunnabanaw furakɛli
Dusukun tantanni : Dusukun tantanni ye dusukunnabana jugumanba ye min bɛ sɔrɔ dusukun tantanni ni dusukun tantanni fɛ ka a sababu kɛ koronawirisi ye. TB 500 Fragment (17–23) nafa bɛ se ka kɛ a la dusukun tantanni furakɛli la. Dusukun tantanni kɔfɛ, dusukun tantanni bɛ kɛ ni funu jaabiw ye ani selilɛriw ka apoptose, o bɛ na ni dusukun baarakɛbaliya ye. TB 500 Fragment (17–23) bɛ se ka dusukun baara ɲɛ dusukun tantanni kɔfɛ ni a bɛ funu jaabiw bali, ka dusukun tantanni selilɛriw ka apoptose dɔgɔya, ani ka joli-sira-funu sabati. Kɔlɔsiliw y’a jira ko baganw ka dusukun tantanni misaliw la, TB 500 Fragment (17–23) tali bɛ se ka dɔ bɔ dusukun tantanni hakɛ la, ka dusukun bɔli yɔrɔ ɲɛ, ani ka dusukun tantanni ni lafiya baarakɛcogo ɲɛ.
Joli joginni dilancogo : Ni joli siraw jogincogo don, i n’a fɔ endoteliyali tiɲɛni joli siraw tali kɔfɛ, TB 500 Fragment (17–23) bɛ se ka endoteliyali selilɛriw ka jiginni ni u caya sabati, ka endoteliyali dilan teliya, ani ka dɔ bɔ trombos sɔrɔli farati la. Jolilabanaw jogin kɔfɛ, kolajɛ min bɛ sɔrɔ endoteliyali jukɔrɔ, o bɛ se ka joli segin furakisɛw nɔrɔli ni u farali bila mɔgɔ la, o bɛ na ni joli kuruw (trombus) sɔrɔli ye. TB 500 Fragment (17–23) bɛ endoteliyali selilɛri dilancogo sabati, ka joli siraw kɔnɔnatumuw dafalen segin, o la, a bɛ dɔ bɔ jolisiraw sɔrɔli la ani ka joli siraw baarakɛcogo ɲuman lakana.
Kuncɛli
TB 500 Fragment (17–23), i n’a fɔ pepitiri fragment min bɛ ni ɲɛnamaya kɛcogo kɛrɛnkɛrɛnnen ye, o bɛ nafa jira farikolo yɔrɔw dilancogo la, selilɛriw ka jiginni na, ani yɔrɔ wɛrɛw la.
Sosow (Sɔrɔyɔrɔw).
[1] Esposito S, Deventer K, Goeman J, ani mɔgɔ wɛrɛw. Timosini beta 4 N-terminal acetylated 17-23 fragment min jirala TB-500 kɔnɔ, o dilanni ni a cogoya jirali, o ye fura ye min bɛ siga la ko doping potentiel bɛ a la[J]. Fura sɛgɛsɛgɛli ni u sɛgɛsɛgɛli, 2012,4(9):733-738.DOI:10.1002/dta.1402.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama :
