By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Gabatarwa
TB 500 (Thymosin Beta-4 Fragment 17-23) wani yanki ne na rayuwa mai alaƙa da alaƙa da maɓalli da yawa a cikin ilimin halittar ɗan adam, musamman a gyaran kyallen takarda da ƙaura ta tantanin halitta.
Hoto 1 Tsarin sinadarai na TB 500 Fragment (17-23).
Bayani na asali game da TB 500 Fragment (17-23)
TB 500 Fragment (17-23) shine N-terminal acetylated 17-23 guntun beta-4 na thymosin beta-4 (Thymosin Beta-4). N-terminal acetylation yana taka muhimmiyar rawa wajen daidaita ma'amalar furotin-protein da kuma yanayin cikin salula. Kasancewar ƙungiyoyin acetyl na iya canza rarraba cajin ƙwayoyin cuta da daidaituwar sararin samaniya, ta yadda hakan ke rinjayar ikonsa na ɗaure da sauran kwayoyin halitta. A cikin jikin mutum, thymosin β4 shine peptide da aka rarraba a ko'ina, kuma TB 500 Fragment (17-23), a matsayin takamaiman guntu, ana iya samar da shi ta hanyar hanyoyin proteolytic endogenous.
Tsarin Ayyukan Ayyukan TB 500 (17-23)
(1) Hijirar Cell da Chemotaxis
Tasiri akan Kwayoyin Endothelial: TB 500 Fragment (17-23) yana inganta ƙaurawar cell endothelial, wani tsari mai mahimmanci ga angiogenesis. Lokacin warkar da rauni ko gyaran nama, dole ne ƙwayoyin endothelial suyi ƙaura zuwa wuraren da suka lalace don samar da sabbin hanyoyin sadarwa na jijiyoyin jini, don samar da iskar oxygen da abinci mai gina jiki ga nama. TB 500 Fragment (17-23) na iya haɓaka ƙaurawar sel ta endothelial ta hanyar kunna jerin hanyoyin siginar siginar ciki, irin su hanyar siginar PI3K-Akt, wanda ke daidaita tsarin sake tsara cytoskeleton ta salula. Kunna hanyar siginar siginar PI3K-Akt yana haɓaka polymerization da depolymerization na actin, yana ba da damar sel don ƙara pseudopodia da ci gaba.
Tasirin Chemotactic akan Kwayoyin rigakafi: Wannan guntu kuma yana nuna tasirin chemotactic akan ƙwayoyin rigakafi, yana jawo macrophages, neutrophils, da sauran ƙwayoyin rigakafi zuwa wuraren kumburi ko rauni. Macrophages suna taka muhimmiyar rawa wajen gyaran gyare-gyaren nama, kamar yadda za su iya kawar da nama mai lalacewa da ƙwayoyin cuta yayin da suke ɓoye abubuwan haɓaka daban-daban da cytokines don inganta gyaran nama da farfadowa. Rukunin TB 500 (17-23) yana ɗaure ga takamaiman masu karɓa akan saman ƙwayoyin rigakafi, kunna hanyoyin siginar intracellular don jagorantar ƙwayoyin rigakafi zuwa wurin rauni.
(2) Gyaran Nama da Farfaɗowa
Haɓaka haɓakar fibroblast da haɓakar collagen: Fibroblasts sune nau'in tantanin halitta na farko a cikin nama mai haɗawa kuma suna da alhakin haɗawa da ɓoye abubuwan abubuwan matrix na waje kamar collagen yayin warkar da rauni. TB 500 Fragment (17-23) na iya tada haɓakar fibroblast, ƙara yawan lambobi kuma ta haka yana haɓaka haɗin collagen. Wannan juzu'in na iya daidaita maganganun kwayoyin halittar da ke da alaƙa da haɗin gwiwar collagen, irin su COL1A1 da COL3A1, yayin da ke haɓaka gyare-gyare bayan fassarar collagen a cikin fibroblasts, ta haka inganta haɓakar collagen da kwanciyar hankali. Wadannan tasirin suna ba da gudummawa ga samuwar matrix mai ƙarfi mai ƙarfi, inganta warkar da rauni da gyaran nama.
Gyaran ƙwayar tsoka: A cikin gyaran raunin tsoka, TB 500 Fragment (17-23) kuma yana taka muhimmiyar rawa. Yana haɓaka kunnawa da haɓakar ƙwayoyin tauraron dan adam, waɗanda sune ƙwayoyin ƙwayoyin cuta na myogenic a cikin tsokar kwarangwal tare da ikon sabunta kansu da bambanta cikin filayen tsoka. TB 500 Fragment (17-23) yana daidaita hanyar siginar MyoD-Myogenin a cikin sel tauraron dan adam, yana haɓaka bambance-bambancen su zuwa myotubes, wanda sannan ya haɗa su don samar da sabbin ƙwayoyin tsoka, don haka samun gyare-gyaren ƙwayar tsoka da haɓakawa. Wannan ɓangarorin kuma zai iya rage martani mai kumburi bayan rauni na tsoka, yana rage ƙarin lalacewar ƙwayar tsoka da kumburi ya haifar.
(3) Abubuwan da ke hana kumburi
Hana bayyanar cututtuka na kumburi: TB 500 Fragment (17-23) na iya hana bayyanar cututtuka daban-daban, ciki har da ƙwayar necrosis factor-α (TNF-α) da interleukin-1β (IL-1β). Wadannan abubuwan da ke haifar da kumburi suna taka muhimmiyar rawa a cikin amsawar kumburi, kuma yawan maganganun su na iya haifar da haɓakawa da dagewar kumburi, haifar da lalacewar nama. TB 500 Fragment (17-23) na iya rage rubutun da fassarar abubuwan da ke haifar da kumburi ta hanyar hana kunna hanyar siginar nukiliya-κB (NF-κB), don haka ya rage amsawar kumburi. NF-κB wani muhimmin abu ne mai mahimmanci na rubutun ra'ayi a cikin ainihin fassarar siginar mai kumburi, kuma kunnawa zai iya daidaita maganganun ƙwayoyin ƙwayoyin cuta masu yawa.
Daidaita amsawar ƙwayoyin cuta na ƙwayoyin cuta: Bugu da ƙari ga hana bayyanar cututtuka masu kumburi, TB 500 Fragment (17-23) kuma zai iya daidaita tsarin ƙwayar cuta na ƙwayoyin cuta. Yana iya hana polarization na macrophages zuwa nau'in pro-mai kumburi (nau'in M1) kuma yana haɓaka haɓakarsu zuwa nau'in anti-mai kumburi (nau'in M2). M1-nau'in macrophages da farko suna ɓoye abubuwan da ke haifar da kumburi, shiga cikin farawa da haɓaka kumburi; yayin da nau'in nau'in macrophages na M2 ke ɓoye abubuwan da ke haifar da kumburi, inganta gyaran nama da tsarin rigakafi. TB 500 Fragment (17-23) yana daidaita yanayin polarization na macrophages, yana jagorantar amsawar kumburi zuwa ga alkibla mai dacewa don gyara nama.
Aikace-aikace na TB 500 Fragment (17-23) a cikin Filin Kiwon Lafiya
(1) Warkar da Rauni
Raunin fata: A cikin warkar da rauni na fata, TB 500 Fragment (17-23) yana nuna gagarumin tasirin talla. Bincike na farko ya nuna cewa aikace-aikacen da ake amfani da su na kayan da ke dauke da TB 500 Fragment (17-23) yana hanzarta rufe raunuka kuma yana inganta ingancin warkarwa. Wannan shi ne da farko saboda tasirinsa mai yawa akan ƙwayoyin endothelial, fibroblasts, da ƙwayoyin rigakafi. Ƙaurawar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta tana inganta sabon ƙwayar jini, samar da isasshen abinci mai gina jiki ga rauni; ƙara yawan haɓakar fibroblast da haɗin gwiwar collagen yana haifar da ƙarin ƙarfin haɗin gwiwa a wurin rauni; da kuma tasirin chemotactic da anti-mai kumburi na ƙwayoyin cuta na ƙwayoyin cuta suna rage tasirin hanawa na ƙwayoyin cuta akan raunin rauni. A cikin maganin wasu raunuka na yau da kullun, irin su ciwon ƙafar ƙafa masu ciwon sukari, TB 500 Fragment (17-23) kuma yana nuna ƙimar warkewa. Marasa lafiya masu ciwon sukari suna samun jinkirin warkar da rauni da kuma ƙara haɗarin kamuwa da cuta saboda girman matakan sukari na jini. TB 500 Fragment (17-23) zai iya inganta microenvironment na gida, inganta ƙaurawar cell da yaduwa, da haɓaka yiwuwar warkarwa a cikin raunuka na kullum.
Raunin nama na ciki: Don raunin nama na ciki, irin su gyambon ciki da lalacewar hanta, TB 500 Fragment (17-23) shima yana da tasirin warkewa. A cikin nau'in ciwon ciki na ciki, gudanarwa na TB 500 Fragment (17-23) yana inganta haɓakawa da gyaran ƙwayoyin mucosal a wurin miki, rage ƙwayar miki. Tsarin aikinsa yana da alaƙa da haɓaka ƙaura ta tantanin halitta, daidaita martanin kumburi, da haɓaka haɗin matrix na extracellular. A cikin samfurin raunin hanta, TB 500 Fragment (17-23) na iya inganta haɓakar hanta hanta, rage lalacewar ƙwayar hanta, da inganta alamun aikin hanta.
(2) Maganin Cututtukan Musculoskeletal
Ƙunƙarar ƙwayar tsoka da raunin da ya faru: A cikin maganin wasanni, ƙwayar tsoka da raunin da ya faru sune al'amura na kowa. TB 500 Fragment (17-23), saboda sakamakonsa na gyarawa akan nama na tsoka, ya fito a matsayin wakili mai mahimmanci don raunin tsoka. Gudanar da TB 500 Fragment (17-23) bin ƙwayar tsoka zai iya hanzarta dawo da ƙarfin tsoka da rage abin da ya faru na fibrosis na tsoka. Fibrosis na tsoka yana da rikitarwa na yau da kullun bayan raunin tsoka, wanda ke haifar da taurin nama na tsoka, rage elasticity, da rashin aikin tsoka. TB 500 Fragment (17-23) yana haɓaka kunnawa da haɓakar ƙwayoyin tauraron dan adam, yana hana amsawar kumburi, kuma yana rage samuwar fibrosis na tsoka, ta haka yana haɓaka gyaran raunin tsoka.
Osteoarthritis: Osteoarthritis cuta ce ta haɗin gwiwa ta gama gari wacce ke da lalacewar guringuntsi, kumburin synovial, da haɓakar kashi. TB 500 Fragment (17-23) kuma ya nuna yuwuwar a cikin maganin osteoarthritis. Zai iya inganta haɓakawa da haɓakar matrix na chondrocytes, hana chondrocyte apoptosis, ta haka yana rage jinkirin lalata guringuntsi. Sakamakon anti-mai kumburi na TB 500 Fragment (17-23) zai iya rage kumburi na synovial, kawar da ciwon haɗin gwiwa, da rage kumburi. Nazarin dabba ya nuna cewa allurar intra-articular na TB 500 Fragment (17-23) na iya inganta aikin haɗin gwiwa a cikin dabbobin samfurin osteoarthritis kuma rage lalacewar guringuntsi.
(3) Maganin cututtukan zuciya
Ciwon zuciya: Ciwon zuciya mai tsanani cuta ce ta zuciya da jijiyoyin jini da ke haifar da ischemia na myocardial da necrosis saboda toshewar jijiyoyin jini. TB 500 Fragment (17-23) yana da yuwuwar ƙimar aikace-aikacen a cikin maganin ciwon zuciya na zuciya. Bayan ciwon zuciya na zuciya, nama na tsokar zuciya yana samun amsa mai kumburi da kuma apoptosis na cell, wanda ke haifar da rashin aiki na zuciya. TB 500 Fragment (17-23) zai iya inganta aikin zuciya na zuciya bayan ciwon zuciya ta hanyar hana amsawar kumburi, rage apoptosis cell myocardial, da inganta angiogenesis. Nazarin ya nuna cewa a cikin nau'o'in dabba na ciwon zuciya na zuciya, yin amfani da TB 500 Fragment (17-23) zai iya rage girman ƙwayar cuta, inganta ƙwayar ƙwayar zuciya, da haɓaka ƙwayar zuciya da ayyukan shakatawa.
Gyaran rauni na jijiyoyi: A lokuta na raunin da ya faru, irin su lalacewar endothelial bayan shiga tsakani na jijiyoyin jini, TB 500 Fragment (17-23) na iya inganta ƙaurawar kwayar halitta da haɓakawa, haɓaka gyaran gyare-gyare na endothelial, da rage haɗarin samuwar thrombus. Bayan raunin endothelial na jijiyoyin jini, fallasa collagen da ke ƙarƙashin endothelium na iya haifar da mannewar platelet da haɗuwa, wanda zai haifar da samuwar thrombus. TB 500 Fragment (17-23) yana inganta gyaran gyare-gyare na endothelial, maido da mutuncin ƙwanƙwasa na jijiyoyi, don haka rage ƙwayar thrombus da kuma kare aikin jijiyoyi na al'ada.
Kammalawa
TB 500 Fragment (17-23), a matsayin guntun peptide tare da aikin ilimin halitta na musamman, yana nuna inganci a gyaran nama, ƙaura ta cell, da sauran wurare.
Sources
[1] Esposito S, Deventer K, Goeman J, et al. Haɗawa da sifa na N-terminal acetylated 17-23 guntun thymosin beta 4 da aka gano a cikin TB-500, samfurin da ake zargin ya mallaki yuwuwar doping[J]. Gwajin Magunguna da Bincike, 2012,4 (9): 733-738.DOI: 10.1002/dta.1402.
Samfura akwai don amfani da bincike kawai :
