Na Cocer Peptides 
hashize iminsi 25.
Ubuzima bw'imyororokere ni ikintu cy'ingenzi mu buzima rusange bwa muntu, hamwe n’ibanze byacyo biri mu buringanire bwimikorere yimyororokere ikurikiza imisemburo. Ubuzima bw'imyororokere no kugenga imisemburo byerekana imikorere yibanze ya sisitemu ya endocrine yumuntu, ikubiyemo inzira zingenzi zifatika nko gukora umukino wa gamete, kuringaniza imisemburo yimibonano mpuzabitsina, kubungabunga uburumbuke, no kugenzura imikorere yimibonano mpuzabitsina. Izi nzira zishingiye ku kugenzura neza hypothalamic-pituitar-gonadal (HPG), ikubiyemo isano nyamukuru nko kwinjiza intanga ngore, gusimbuza imisemburo y’imibonano mpuzabitsina, kuvura uburumbuke, no guhindura imikorere y’imibonano mpuzabitsina. Imiti ishingiye kuri peptide, irangwa nibikorwa biologiya byinshi, intego yihariye yihariye, hamwe na biocompatibilité nziza, byabaye ibikoresho byingenzi byo kwivanga mubibazo byimyororokere ya endocrine. Bakosora ubusumbane bwimisemburo kurwego rwubukanishi, batanga ibisubizo bishya kubibazo nko kutabyara, kubura imisemburo yimibonano mpuzabitsina, no kudakora neza imibonano mpuzabitsina.
Ibice byingenzi byo gusaba
1. Indwara ya Ovulation: Kuvugurura Iterambere rya Follicular na Ovulation Cycle
Indwara ya Ovulation ni ingamba zingenzi zo kuvura ubugumba bw'abagore. Imiti ishingiye kuri peptide igenga neza iterambere ryimitsi yigana imisemburo ya gonadotropine irekura (GnRH) cyangwa ikuzuza gonadotropine.
GnRH igereranya
Muguhindura ibikorwa bya reseptor ya GnRH ya pitoito, iyi miti irabuza kubaho hakiri kare imisemburo ya endogenous luteinizing hormone (LH), ikarinda luteinisation imburagihe. Ibi bituma habaho imiterere ihamye ya hormone kugirango igenzurwe na ovarian hyperstimulation (COH) muburyo bwa tekinoroji yimyororokere ifasha (ART), bizamura imikorere yokwinjiza neza.
Gukoresha peptide ya gonadotropine
Chorionic gonadotropin yumuntu (hCG) yigana imikorere ya LH kugirango itere intanga ngore mumitsi ikuze; menopausal ya gonadotropine yumuntu (hMG), ikubiyemo imisemburo itera imisemburo (FSH) hamwe nibikorwa bya LH, itera mu buryo butaziguye imikurire niterambere ryiterambere, byongera cyane intsinzi yibitekerezo bisanzwe hamwe na ART.
Igicapo 1 Kugenga imisemburo yo gukura no kwirukana. Ibice byambere byimuka mubyiciro byambere ukoresheje PI3K / AKT / mTOR byerekana ibimenyetso, hanyuma bigatera imbere muri sinus binyuze muri FSH nabashinzwe kugenzura ibikorwa. Hanyuma, LH itera gukura kwa oocyte na ovulation. Inkomoko: Imipaka mubuvuzi.
2. Gusimbuza imisemburo ya hormone: Kongera uburinganire bwa Endocrine
Ku ndwara zijyanye no kubura imisemburo yimibonano mpuzabitsina cyangwa kutaringaniza, imiti ishingiye kuri peptide igera ku musemburo wa hormone physiologique ugenga umurongo wa HPG cyangwa wuzuza imisemburo ibanziriza.
Ubuvuzi bwa GnRH
Yerekanwe ku barwayi bafite hypothalamic hypogonadism, ubu buvuzi burimo kwinjiza rimwe na rimwe ibigereranyo bya GnRH bigana imitekerereze ya physiologique pulsatile. Ibi bitera pitoito kurekura FSH / LH, guteza imbere iterambere rya gonadal hamwe na hormone yimibonano mpuzabitsina, no kugarura imbyaro cyangwa uburumbuke.
Testosterone na estrogene igenga peptide
Peptide zimwe na zimwe za syntetique zongera ibikorwa bya neuron ya GnRH, ziteza ururenda rwa pulsatile LH kugenzura mu buryo butaziguye urugero rwa testosterone / estrogene. Ibi bitezimbere ibimenyetso nka libido nkeya nindwara zimihango ziterwa na hypogonadism.
3. Kuvura uburumbuke: Inkunga ikomeye ya tekinoroji ifasha imyororokere
Mu rwego rwo kororoka kwifasha, imiti ishingiye kuri peptide ikoreshwa mugikorwa cyose - iterambere ryimitsi, kugarura oocyte, hamwe ninkunga ya luteal - kugirango umutekano wokuvurwa no gutsinda neza.
Icyiciro cya Hyperstimulation
HMG ifatanije na FSH peptide ya peptide igenzura neza kwinjiza abakozi, bigabanya ibyago byo kwandura syndrome ya ovarian hyperstimulation (OHSS); GnRH antagonist irabuza LH hakiri kare, irinda gukura kwa oocyte imburagihe cyangwa gutakaza.
Oocyte kugarura nicyiciro cya luteal:
HCG itera gukura kwa oocyte ya nyuma, hamwe no kuzuza nyuma ya oporisiyo hamwe na hCG cyangwa GnRH agoniste ikomeza imikorere ya luteal, itezimbere iyakira, kandi ikongera igipimo cyo gutera urusoro.
Kwivanga kwabagabo: Peptide irekura Gonadotropine igenga ururenda rwumugabo LH / FSH, igatera intanga ngabo no kurinda uburumbuke muri idiopathic oligoasthenospermia.
4. Guhindura Imikorere y'Igitsina: Guhuza Byombi mu nzira ya Neuroendocrine
Imikorere mibi yimibonano mpuzabitsina (urugero, imikorere mibi yumugabo, kugabanuka kwa libido) akenshi bifitanye isano nubusumbane bwimisemburo hamwe nibimenyetso bidasanzwe. Imiti ishingiye kuri peptide itezimbere imikorere ikoresheje uburyo bubiri bwo hagati na peripheri.
Peptide yo hagati
Ibicuruzwa bimwe na bimwe bya peptide (urugero, Pt141) bikora nka melanocortin reseptor agonist, bigakora inzira ya hypothalamic-spinal kugirango byongere imibonano mpuzabitsina. Zifite akamaro cyane cyane kumitsi cyangwa imitekerereze idakora neza kandi ntigire ingaruka kubiryo cyangwa inzoga.
Kugenga imisemburo no guhuza amarangamutima
Ibicuruzwa bya peptide nka oxytocine biteza imbere irekurwa rya neurotransmitter ijyanye nimyitwarire yimibonano mpuzabitsina, kunoza ibibazo byamarangamutima bijyana nimikorere yimibonano mpuzabitsina. Bagenga kandi kugabanuka kwa nyababyeyi no konsa, bakagira uruhare runini mubuzima bwimyororokere ya perinatal; gukura imisemburo ya hormone irekura peptide (urugero, ipamorelin) itezimbere mu buryo butaziguye libido yumugabo nigikorwa cyimibonano mpuzabitsina wongera testosterone.
Umwanzuro
Gukoresha imiti ishingiye kuri peptide mubuzima bwimyororokere no kugenzura imisemburo ya hormone byerekana ihinduka riva mubuvuzi bufatika bukoreshwa muburyo bwa mashini. Mu kwibasira neza inzira ya HPG, inzira ya neuroendocrine, n'imikorere ya gonadal, iyi miti yerekana ibyiza byinshi mu kwinjiza intanga ngabo, gusimbuza imisemburo y’imibonano mpuzabitsina, kuvura uburumbuke, no guhindura imikorere y’imibonano mpuzabitsina: ntabwo byujuje gusa ibisobanuro bihanitse by’ikoranabuhanga ry’imyororokere bifashwa ahubwo binatanga amabwiriza yihariye akurikije itandukaniro rya buri muntu.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
