Na Cocer Peptides 
hashize iminsi 29.
Sisitemu y'imitsi igenga kumenya, amarangamutima, n'imikorere y'umubiri binyuze mumiyoboro igoye ya neurotransmitter hamwe n'inzira zerekana ibimenyetso. Kwangirika cyangwa kwangirika muri iyi sisitemu birashobora gukurura ibibazo bikomeye byubuzima nkindwara ya Alzheimer, indwara ya Parkinson, guhangayika, kwiheba, nihungabana ry’imitsi. Inzira nyamukuru zo kubungabunga ubuzima bw’imyakura n’ubwenge - harimo na neuroprotection, kongera ubwenge, kugenzura amarangamutima, no gusana ibikomere by’imitsi - bishingiye ku bikorwa bifatika mu mibereho ya neuronal, plastique synaptic, neuroinflammation, hamwe nuburyo bushya bwo kuvugurura. Ibintu bya peptide, hamwe nibikorwa bya biologiya byinshi hamwe nubwonko bwamaraso-ubwonko bwinjira, byagaragaye nka molekile nziza yo kwibasira inzira zinzira. Batinda neurodegeneration kurwego rwa selire kandi bigateza imbere gusana imikorere, gufungura inzira nshya zo gukumira no kuvura indwara zifata ubwonko.
Igicapo 1 Uburyo bukoreshwa muburyo bwo gutera indwara. Inkomoko: Indwara yo kumenya imikorere: Kurenga pseudodementia (2024).
Uburyo hamwe nubuvuzi bwagaciro bwibanze
1. Neuroprotection: Ubwinshi bwokwirinda kwangirika kwa Neurodegenerative
Ibintu bya peptide byubaka inzitizi yo kwirinda ingirabuzimafatizo binyuze muri antioxyde, anti-inflammation, no kurinda mitochondrial.
Kugabanya ibyangiritse byangiza
Peptide yibasiwe na mitochondriya (urugero, SS-31) yashyizwe mu gice cy'imbere cya mito-iy'imbere, ikabuza gukora ogisijeni ikabije (ROS). Ibi birinda ADN ya mitochondial hamwe nuburinganire bwa membrane, bidindiza apoptose ya neuronal. Mubyitegererezo byindwara ya ischemic nindwara ya Parkinson, iyi peptide igabanya cyane gutakaza dopaminergic neuron.
Kubuza kasike ya neuroinflammatory
Peptide zimwe na zimwe (urugero, Cerebrolysin), nkibice bya neuropeptide, bigabanya inzira ya NF-κB. Bagabanya ibikorwa bya microglial birenze urugero na β-amyloide (Aβ) -bitera ibisubizo byokongoka mugihe biteza imbere kwerekana ibintu bya neurotrophique (BDNF, NGF), bikomeza ibidukikije byangiza ubuzima bwa neuronal.
Kurinda inzitizi yamaraso-ubwonko
Peptide nka TB 500 yongerera imbaraga za poroteyine zifatika zifatika mu ngirabuzimafatizo ya endoteliyale, bikagabanya kwinjira mu bintu byangiza. Ibi bigabanya cyane cyane ibyago byo kurwara ubwonko na neuronal necrosis mu gukomeretsa ubwonko.
2. Kumenyekanisha Kumenyekanisha: Kongera Synaptic Plastique hamwe nibikorwa byo kwibuka
Intego yo kugabanuka kwubwenge no kutamenya-kwibuka, ibintu bya peptide bikora mugutunganya neurotransmitter hamwe na synaptic.
Kwiyongera kwa synaptike na nootropic peptide
Peptide zimwe (urugero, Sema) bigana ibikorwa bya hormone irekura thyrotropine, bigatera irekurwa rya dopamine na norepinephrine. Ibi byongera plastike ya synaptique muri hippocampus, bigateza imbere kwibuka mumiterere yindwara ya Alzheimer. Ubuvuzi bwa Clinical bwerekana ko bushobora kuzamura amanota yo kumenya no kwihutisha amakuru.
Amabwiriza ya Cholinergic
Peptide zimwe na zimwe za cholinergique-yigana peptide zongera imbaraga zo kwanduza acetylcholine no kunoza ubukana bwa choline mu bice bya synaptique, bikagira ubushobozi bwo kugira uruhare mu bwonko bworoshye bwo kumenya no kugabanuka nyuma yo gutangira ubwenge.
Kurwanya amyloide:
Urutonde rwa Aβ (urugero, igice cya peptide 176–191) kibuza Aβ fibril guteranya, kugabanya imiterere ya plaque neurotoxique no gutinza iterambere ry’indwara ya Alzheimer, bigatuma iba ahantu hakorerwa ubushakashatsi kugirango hakorwe hakiri kare.
3. Amabwiriza y amarangamutima: Kuvugurura impirimbanyi ya Neurotransmitter hamwe nigisubizo cya Stress
Ibintu bya peptide bigira uruhare mubibazo byo guhungabana nko guhangayika no kwiheba ukora kuri sisitemu ya limbic na neuroendocrine axis.
5-HT inzira yo guhindura
Peptide zimwe (urugero, Sel), nka modulator nziza ya reseptor ya GABA_A, byongera aside γ-aminobutyric aside (GABA) kwanduza kwanduza, kugabanya ibimenyetso byihuse. Umuvuduko wabo wo gutangira numwirondoro wumutekano urenze benzodiazepine gakondo. Tachykinin reseptor antagonist peptide itezimbere anedoniya mukwiheba muguhagarika ibintu P.
Amabwiriza ya HPA
Peptide nka oxytocine yongerera imbere cortical cortical ya amygdala, igabanya imisemburo ya hormone cortisol. Ibi bitezimbere amarangamutima yibikorwa mumitekerereze yimibereho hamwe nihungabana ryihungabana (PTSD).
Gusana Neuroplastique
Peptide ikomoka kuri BDNF ituma imikurire ya dendritic ikura muri neuron ya hippocampal, igarura ubwinshi bwa synaptic yagabanijwe no guhangayika karande no gusana imirimo yo kugenzura amarangamutima kurwego rwimiterere.
4. Gusana ibikomere bya Neural: Gukora Gahunda Zisubiramo no Kwiyongera kwa Axonal
Kubikomere bidasubirwaho nko gukomeretsa uruti rwumugongo hamwe na neuropathie ya peripheri, ibintu bya peptide birenga mikorobe ikumira ibidukikije.
Guteza imbere gukura
NGF-yigana peptide ikora reseptor ya TrkA, itera kurambura neuronal axon. Muburyo bwo gukomeretsa imitsi ya sciatic, byihutisha kwiyongera kwa axon no kunoza imikorere ya moteri. Peptide ifitanye isano na Chondroitinase (urugero, Chonluten) itesha agaciro proteoglycans inhibitor nka sulfate ya chondroitine, ikuraho inzitizi z’inkovu nyuma yo gukomeretsa umugongo.
Kugenzura imikorere ya selire ya Schwann
Peptide ikingira Gastrointestinal (urugero, BPC-157) iteza ubwiyongere bwa selile ya Schwann hamwe na myelin, bigatuma umuvuduko wogutwara imitsi muri diabete ya peripheri ya neuropathie no kugabanya ububabare nuburyo budasanzwe bwo kumva.
Gukangurira ingirabuzimafatizo no gutandukanya
Peptide ikomoka kuri FGF-2 itera ingirabuzimafatizo ya endogenous selile yimuka yimuka ikomeretsa aho ikomeretsa kandi igatandukana muri neuron ikora na selile glial selile, itanga umusemburo wa selile yo kuvugurura sisitemu yo hagati.
Umwanzuro
Gukoresha ibintu bya peptide mubuzima bwubwonko nubwenge byerekana ihinduka kuva 'ibimenyetso byerekana ubutabazi ' ujya kuri 'imitekerereze mishya ' muri paradizo yo kuvura. Mu kurwanya impungenge za okiside, imikorere ya synaptique, neuroinflammation, hamwe n'inzira zisubiramo, ibyo bintu byerekana ibyiza byinshi byo guhuza imbaraga muri neuroprotection, kongera ubwenge, kugenzura amarangamutima, no gusana ibikomere - cyane cyane byerekana imbaraga zidasubirwaho mu ndwara zifata ubwonko no kuvura ihahamuka.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
