Na Cocer Peptides 
hashize iminsi 26.
Umwijima, nk'urwego nyamukuru rwo guhinduranya no kwangiza umubiri w'umuntu, ukora imirimo ikomeye nka biosynthesis, kubika ingufu, no kurandura ibintu byangiza. Guhangayikishwa na Oxidative, kwirundanyiriza uburozi, hamwe no guhungabana kwa metabolike ni byo bitera intandaro yo gukomeretsa umwijima, umwijima w'amavuta, na fibrosis ya hepatike. Intandaro yo kurinda umwijima, kwangiza, no guhangayikishwa na antioxydeide ni ukugumana ubusugire bwimikorere ya hepatocyte, kongera ibikorwa bya enzyme yangiza, no kwikuramo radicals yubusa. Ibintu bya peptide, hamwe nibikorwa bya biologiya byinshi hamwe nibisobanuro byihariye, birashobora kugenga cyane cyane inzira ya metabolike ya hepatike, kurinda hepatocytes kwangirika kwa okiside, no guteza imbere biotransformation no gusohora uburozi, bikagaragara nkibikoresho bishya byo gukumira no kwivanga mu ndwara z’umwijima - byerekana imbaraga zikomeye z’indwara z’umwijima z’umwijima, indwara y’umwijima iterwa n’umwijima (NAFLD), n’umwijima w’umwijima w’umwijima (NAFLD).
Igicapo 1 Impamvu zishobora gutera indwara zumwijima zidafite inzoga (NAFLD). Inkomoko: Isubiramo ku ngaruka zo kurinda hamwe nuburyo bwa molekuline bwimbuto zirwanya ubuzima bwicecekeye bwubuzima rusange: Indwara yumwijima idafite inzoga (2024).
Ibice byingenzi byo gusaba
1. Kurinda Hepatique: Kubungabunga Hepatocyte Imiterere nubusugire bwimikorere
Ibintu bya peptide byubaka inzitizi irinda umwijima binyuze muri anti-apoptose, pro-gusana, no kugenzura metabolism ya hepatocyte.
Kubuza hepatocyte apoptose
Peptide yibasiwe na Mitochondria (urugero, SS-31) yashyizwe mu mitsi ya hepatike na mitochondial, ihagarika ubushobozi bwa mitochondrial membrane kandi ikabuza irekurwa rya cytochrome C no gukora caspase-3. Ibi bigabanya imbaraga za okiside- cyangwa ibiyobyabwenge biterwa na hepatocyte apoptose. Ingaruka zo gukingira inganda za mitochondrial zigumana ingufu za hepatocyte metabolisme, cyane cyane kugabanya indwara ya hepular lobular necrosis mu gukomeretsa ischemia-reperfusion.
Peptide y'umuringa (urugero, GHK-Cu) iteza fosifora yo gukura kwa hepatocyte ikura, igakora inzira zimanuka kugirango yihutishe gusana ADN no kuvugurura ingirabuzimafatizo muri hepatocytes yangiritse. Barabuza kandi guhindura ibintu bikura-β (TGF-β) -ibimenyetso bya fibrogenic byerekana ibimenyetso, bidindiza iterambere rya fiboside ya hepatike.
Kurinda indwara ya Hepatique
Peptide irinda umwijima igabanya trans-membrane yinjira muri endotoxine na metabolite yubumara mu kongera imvugo ya poroteyine zifatika zifatika mu gice cya hepatike, bikagabanya kwangirika kwa hepatocytes biturutse ku mpamvu zitera umuriro. Ibi bituma bakwirakwira hakiri kare indwara yumwijima.
Igishushanyo cya 2 Ibintu bya kirimbuzi erythroide 2 bifitanye isano na 2 (NRF2) hamwe na NRF2-mitochondrial imikoranire yindwara zumwijima zidakira. Inkomoko: Uruhare rwa NFR2 Igengwa na Oxidative Stress hamwe no kugenzura ubuziranenge bwa Mitochondrial mu ndwara zidakira (2023).
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Umwijima ukora nk'umubiri wangiza umubiri, ushinzwe guhinduranya no kurandura ibintu bidasanzwe nk'uburozi n'ibiyobyabwenge. Peptide irinda umwijima igira uruhare mubikorwa byo kwangiza umwijima, bigatera metabolisme no gusohora ibintu byuburozi kugirango bigabanye ingaruka za hepatotoxic.
Gukora Icyiciro I / II inzira ya metabolike
Glutathione (GSH, nka peptide ya GSH precursor peptide), nka antioxydeant na conjugation substrate ikomeye muri hepatocytes, igira uruhare rutaziguye mu kwangiza uburozi bwa Phase II ihuza uburozi bwa electrophilique kugirango habeho ibishishwa byamazi biva mu mazi. Peptide zimwe na zimwe zongera ububiko bwa GSH zidasanzwe kandi zongera ibikorwa bya glutathione S-transfert (GST), byihutisha kwangiza acetaminofeni na metabolite ya alcool (urugero, acetaldehyde).
Nikotinamide adenine dinucleotide (NAD, nka peptide ifitanye isano na NAD), nka coenzyme ya reaction ya redox, igira uruhare mubitekerezo bya catalitike yimisemburo ya Phase I nka alcool dehydrogenase na cytochrome P450, bigatera ihinduka ryuburozi bwa lipofilique muri metabolite. Kwiyongera kurwego rwa NAD byongera umwijima gukora neza kubiyobyabwenge nuburozi.
Kugena metabolisme ya aside aside
Peptide irinda umwijima (urugero, Pnc 27) irakekwa kugirango ikore farnesoid X reseptor (FXR) cyangwa reseptor X itwite (PXR), igenga imvugo yimisemburo yingenzi nabatwara abantu bagize uruhare muri synthesis ya aside aside. Ibi biteza aside aside isohoka, bigabanya kwirundanya kwa acide acide acide, kandi bigahindura imiterere yindwara yumwijima ya cholestique.
3. Antioxidative Stress: Gukuramo Radicals yubusa no gusana ibyangiritse
Imvune ya Hepatocyte iterwa no guhagarika umutima ni intambwe ikomeye mu gutera indwara zumwijima. Ibintu bya peptide bigira ingaruka zo gukingira binyuze muri antioxyde-nyinshi.
Ubusa radical scavenging na enzyme kugenzura ibikorwa
Glutathione itesha agaciro radicals yubusa nka anion ya superoxide na hydrogen peroxide. Nka substrate ya glutathione peroxidase, ituma igabanuka rya lipide peroxide, igabanya ibyangiritse bya lipide peroxidation.
Peptide yica mikorobe (urugero, LL37), irenze imirimo ya mikorobe, irabuza okiside ya NADPH kugabanya ubwoko bwa ogisijeni yo mu bwoko bwa ogisijeni (ROS) itera indwara ya hepatocytes, ikabuza okiside itera imbaraga ziterwa n'inzira bityo bikabuza hepatocyte apoptose no gusohora ibintu.
Kurinda imikorere ya mitochondial
Peptide yibasiwe na mitochondriya (urugero, SS-31) igumana imbaraga za mito-iyambere, igabanya gucikamo ibice no gukora nabi. Ibi bituma ingufu zitangwa muri hepatocytes kandi bikagabanya mu buryo butaziguye ibyago byo kwangiza okiside kuri ADN na proteyine.
Umwanzuro
Gukoresha ibintu bya peptide muri antioxyde nubuzima bwumwijima byibanda ku buryo bwibanze bwo kurinda hepatocyte, kongera inzira ya disoxifike, no kugabanya ibibazo bya okiside, bitanga ibisubizo byinshi mu gukumira no kuvura indwara z’umwijima. Mu kwibanda ku mikorere ya mitochondrial, sisitemu yangiza imisemburo ya enzyme, hamwe nuburinganire bwa redox, ibyo bintu ntabwo bihindura gusa radicals yubusa kandi bikabuza na hepatocyte apoptose ahubwo binasubiramo fenotipike ya hepatike metabolike binyuze mumabwiriza ya reseptor ya kirimbuzi - byerekana ibyiza byubukorikori mugucunga neza umwijima wamavuta, gukomeretsa umwijima, na fibrosis.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
