Cocer Peptides ye ŋlɔe 
ŋkeke 26 enye sia.
Aklã, abe ŋutinu vevi aɖe si naa lãmenugbagbeviwo ƒe dɔwɔwɔ kple aɖiɖeɖe le amegbetɔ ƒe ŋutilã me ene, wɔa dɔ veviwo abe nugbagbewo ƒe dɔwɔwɔ, ŋusẽdzraɖoƒe, kple nusiwo gblẽa nu le ame ŋu ɖeɖeɖa ene. Oxidative stress, aɖi ƒe ƒuƒoƒo, kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxiwoe nye nu vevi siwo hea aklã ƒe abixɔxɔ, aklã si me ami le, kple aklã me fibrosis vɛ. Aklã takpɔkpɔ, aɖi ɖeɖeɖa, kple antioxidative nuteɖeamedzi ƒe nu vevitɔe nye aklãmenugbagbeviwo ƒe dɔwɔwɔ ƒe blibonyenye me léle ɖe asi, aɖi ɖeɖeɖa ƒe enzyme ƒe dɔwɔwɔ dodo ɖe ŋgɔ, kple free radicals siwo gbɔ eme ɖeɖeɖa. Peptide-nu siwo ƒe dɔlékuiwo ƒe dɔwɔwɔ lolo eye woƒe taɖodzinu tɔxɛwo le wo ŋu la ate ŋu aɖɔ aklã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔnuwo ɖo etɔxɛe, akpɔ aklãmenugbagbeviwo ta tso oxidative ƒe nugbegblẽ me, eye woado nugbagbewo ƒe tɔtrɔ kple aɖiwo ƒe dodo ɖe ŋgɔ, si do abe dɔwɔnu yeye siwo woatsɔ axe mɔ ɖe aklãdɔlélewo nu ahade nu wo me ene—si ɖea ŋutete gã aɖe fiana le aklãdɔléle si me ahanono le, aklãdɔ si me ami mele o (NAFLD), kple aklã ƒe abixɔxɔ si atikewo hena vɛ.
Nɔnɔmetata 1 Afɔku siwo le aklãdɔ si me ami mele o (NAFLD) me. Dzɔtsoƒe: Totoɖeme le Ametakpɔkpɔ ƒe Ŋusẽkpɔɖeamedziwo Kple Molekyulãwo ƒe Dɔwɔnawo ŋu le Atikutsetsewo ƒe Dɔwɔnawo Ŋu le Dukɔa ƒe Lãmesẽnyawo Ŋuti Dzitsitsi Si Meɖoa To O Ŋu: Aklãdɔléle si Me Ami Mele O (2024).
Dɔdamɔnu Veviwo
1. Aklã Takpɔkpɔ: Aklãmenugbagbeviwo ƒe Dɔwɔɖoɖo Kple Dɔwɔwɔ ƒe Fɔmaɖimaɖi me léle ɖe asi
Peptide-nuawo wɔa mɔxenu si kpɔa aklãa ta to anti-apoptosis, pro-repair, kple hepatocyte metabolism ƒe ɖoɖowɔwɔ me.
Aklãmenugbagbeviwo ƒe tsɔtsrɔ̃ ƒe mɔxexe
Peptide siwo woɖo ɖe mitochondria ŋu (le kpɔɖeŋu me, SS-31) gena ɖe aklã kple mitochondria ƒe lãkusiwo me, si naa mitochondria ƒe lãkusi ƒe ŋutete li ke eye wòxea mɔ na cytochrome C ƒe dodo kple caspase-3 ƒe dɔwɔwɔ. Esia ɖea aklã me lãmenugbagbeviwo ƒe tsɔtsrɔ̃ si oxidative stress- alo atike hena vɛ dzi kpɔtɔna. Woƒe ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe mitochondrial complexes dzi nana aklãmenugbagbeviwo ƒe ŋusẽ ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu nɔa te, vevietɔ eɖea aklã ƒe lobular necrosis dzi kpɔtɔna le ischemia-reperfusion injury me.
Akɔbli peptidewo (le kpɔɖeŋu me, GHK-Cu) doa aklãmenugbagbevi ƒe tsitsi ƒe nuwɔna ƒe xɔlawo ƒe phosphorylation ɖe ŋgɔ, si wɔnɛ be mɔ siwo le anyime la wɔa dɔ be DNA ɖɔɖɔɖo kple ŋutinuwo ƒe gbugbɔgadzɔ kabakaba le aklãmenugbagbevi siwo gblẽ me. Woxea mɔ na fibrogenic signaling si trɔna si nye transforming growth factor-β (TGF-β)-mediated fibrogenic signaling hã, si hea aklã me fibrosis ƒe ŋgɔyiyi ɖe megbe.
Aklã ƒe lãkusi takpɔkpɔ
Peptide siwo kpɔa aklã ta ɖea endotoxins kple aɖinuwo ƒe gege ɖe lãkusi me dzi kpɔtɔna to protein siwo ƒoa ƒu sesĩe ƒe ɖeɖefia le aklã ƒe lãkusiwo me dzi ɖeɖe kpɔtɔ me, si ɖea nusiwo dɔdzẽ gblẽna le aklã me lãmenugbagbeviwo ŋu tẽ dzi kpɔtɔna. Esia na wosɔ na nudede aklãdɔ si me ahatsunono le me kaba.
Nutata 2 Nuclear factor erythroid 2-related factor 2 (NRF2) ƒe ɖoɖowɔwɔ kple NRF2-mitochondrial ƒe kadodo le aklãdɔléle si nɔa anyi didi me. Dzɔtsoƒe: Akpa siwo NFR2-Regulated Oxidative Stress kple Mitochondrial Quality Control wɔna le aklãdɔléle siwo nɔa anyi didi me (2023).
2. Detoxification: Aklã ƒe Biotransformation kple Excretion Dɔwɔwɔwo Dodo Ðe Ŋgɔ
Aklã nye ŋutilãa ƒe aɖi ɖeɖeɖa ƒe ŋutinu, si ƒe dɔe nye be wòatrɔ asi le nusiwo le gota abe aɖi kple atikewo ene ŋu ahaɖe wo ɖa. Peptide siwo kpɔa aklã ta kpɔa gome le aklã me aɖi ɖeɖeɖa ƒe ɖoɖowo me, si doa aɖinuwo ƒe asitɔtrɔ kple wo dodo ɖe ŋgɔ be woaɖe woƒe aklã me aɖi ƒe ŋusẽkpɔɖeamedzi dzi akpɔtɔ.
Akpa I/II ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔnuwo ƒe dɔwɔwɔ
Glutathione (GSH, abe GSH precursor peptides ene), abe antioxidant kple conjugation substrate vevi aɖe le aklãmenugbagbeviwo me ene, kpɔa gome le Akpa II ƒe aɖiɖeɖeɖa ƒe dɔwɔwɔwo me tẽ to babla ɖe aɖi siwo lɔ̃a elektrikŋusẽ ŋu be woawɔ nusiwo me tsi le siwo dona to ʋumenugbagbeviɣi me. Peptide aɖewo dzia GSH si le lãmenugbagbeviwo me ɖe edzi eye wodoa glutathione S-transferase (GST) ƒe dɔwɔwɔ ɖe ŋgɔ, si wɔnɛ be aɖiɖeɖe le acetaminophen kple aha ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu (le kpɔɖeŋu me, acetaldehyde) me kabakaba.
Nicotinamide adenine dinucleotide (NAD, abe peptide siwo do ƒome kple NAD ene), abe coenzyme na redox reactions ene, kpɔa gome le Phase I enzymes abe alcohol dehydrogenase kple cytochrome P450 ƒe catalytic reactions me, si doa lipophilic toxins ƒe tɔtrɔ ɖe polar metabolites me ɖe ŋgɔ. NAD ƒe agbɔsɔsɔ si dzina ɖe edzi nana aklãa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie na atikewo kple aɖinuwo.
Bile acid ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe ɖoɖowɔwɔ
Wosusu be aklã takpɔnu peptidewo (le kpɔɖeŋu me, Pnc 27) naa farnesoid X xɔla (FXR) alo pregnane X xɔla (PXR) wɔa dɔ, si kpɔa enzyme veviwo kple mɔzɔla siwo kpɔa gome le bile acid ƒe wɔwɔme me ƒe ɖeɖefia dzi. Esia doa ʋumenugbagbeviɣidɔ ƒe dodo ɖe ŋgɔ, eɖea ʋumenugbagbevi dzĩ siwo me aɖi le ƒe ƒoƒo ɖe aklã me dzi kpɔtɔna, eye wònaa aklãdɔléle si tsoa aklã me ƒe dɔléle ƒe nɔnɔme nyona ɖe edzi.
3. Antioxidative Stress: Free Radicals ɖeɖeɖa kple Oxidative ƒe Nugblẽfexexe Dzadzraɖo
Aklãmenugbagbeviwo ƒe abi si oxidative stress hena vɛ nye afɔɖeɖe vevi aɖe le aklãdɔléle ƒe ŋgɔyiyi me. Peptide-nuawo wɔa ametakpɔnu to antioxidation si woɖo taɖodzinu geɖe na me.
Free radical scavenging kple enzyme ƒe dɔwɔwɔ dzi kpɔkpɔ
Glutathione ɖea free radicals abe superoxide anions kple hydrogen peroxide ɖa tẽ. Abe nusi wotsɔ wɔa glutathione peroxidase ene la, enaa lipid peroxides dzi ɖena kpɔtɔna, si ɖea membrane lipid peroxidation ƒe gbegblẽ dzi kpɔtɔna.
Dɔlékuiwutike peptidewo (le kpɔɖeŋu me, LL37), le woƒe dɔlékuiwutikewo godo, xea mɔ na NADPH oxidase be wòaɖe intracellular reactive oxygen species (ROS) wɔwɔ dzi akpɔtɔ le aklãmenugbagbeviwo me, si xea mɔ na oxidative stress-induced pathway activation eye wòtoa esia me xea mɔ na hepatocyte apoptosis kple inflammatory factor secretion.
Mitochondrial ƒe dɔwɔwɔ takpɔkpɔ
Peptide siwo woɖo ɖe mitochondria ŋu (le kpɔɖeŋu me, SS-31) léa mitochondria ƒe ŋusẽ ƒe dadasɔ me ɖe asi, si ɖea mitochondria ƒe mama kple dɔmawɔmawɔ nyuie dzi kpɔtɔna. Esia wɔnɛ be ŋusẽ li ke le aklãmenugbagbeviwo me eye wòɖea afɔku si le oxidative ƒe nugbegblẽ le DNA kple proteinwo ŋu dzi kpɔtɔna le mɔ si mele tẽ o nu.
Nyanuwuwuw
Peptide-nu siwo wozãna le antioxidation kple aklã ƒe lãmesẽ me la ku ɖe mɔnu vevi siwo wozãna tsɔ kpɔa aklãmenugbagbeviwo ta, aɖiɖeɖeɖa ƒe mɔnu ƒe nyonyo, kple oxidative stress dzikpɔkpɔ ŋu, si naa egbɔkpɔnu siwo le akpa vovovowo me hena mɔxexe ɖe aklãdɔlélewo nu kple wo dada. To mitochondria ƒe dɔwɔwɔ, aɖi ɖeɖeɖa ƒe enzyme ƒe ɖoɖowo, kple redox ƒe dadasɔ me la, menye ɖeko nu siawo ɖea free radicals ɖa tẽ eye woxea mɔ na hepatocyte apoptosis ko o, ke wogbugbɔ trɔa asi le aklã ƒe metabolic phenotypes hã ŋu to nuclear receptor regulation dzi—si ɖea mɔ̃ɖaŋununya ƒe viɖewo fiana le aklã si me ami le, aklã ƒe abixɔxɔ, kple aklã ƒe fibrosis dzi kpɔkpɔ bliboe me.
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
