Site Cocer Peptides 
ụbọchị 26 gara aga.
Imeju, dị ka akụkụ dị n'etiti maka metabolism na detoxification na ahụ mmadụ, na-arụ ọrụ dị oke mkpa dị ka biosynthesis, nchekwa ike, na mkpochapụ ihe ndị na-emerụ ahụ. Nchegbu oxidative, nchịkọta nsí, na nsogbu nke metabolic bụ isi ihe na-akpata mmerụ imeju, imeju abụba abụba, na imeju fibrosis. Ihe bụ isi nke nchebe imeju, nbipu, na nrụgide antioxidative bụ iji nọgide na-arụ ọrụ hepatocyte, na-eme ka ọrụ enzyme na-emebi emebi, na ikpochapụ radicals n'efu. Peptide bekee, na ha elu ndu ọrụ na lekwasịrị kpọmkwem kpọmkwem, nwere ike kpọmkwem mezie hepatic metabolic ụzọ, na-echebe hepatocytes si oxidative mmebi, na-akwalite biotransformation na excretion nke toxins, apụta dị ka ọhụrụ ngwaọrụ maka igbochi na itinye aka na ọrịa imeju-gosipụta dị ịrịba ike na ọrịa imeju mmanya, ndị na-abụghị mmanya na-aba n'anya imeju ọrịa imeju (NAFLD) butere ọrịa imeju.
Ọgụgụ 1 Ihe ize ndụ nke ọrịa imeju na-adịghị egbu egbu (NAFLD). Isi mmalite: Nlebanya na Mmetụta Nchebe na Usoro Molecular nke Berries megide Nchegbu Ahụike Ọha na-adịghị jụụ: Ọrịa imeju na-adịghị egbu egbu (2024).
Mpaghara Ngwa Isi
1. Nchedo ịba ọcha n'anya: Ịkwado Ọdịdị Hepatocyte na arụrụ arụ ọrụ.
Ihe peptide na-ewu ihe mgbochi maka imeju site na mgbochi apoptosis, pro-repair, na nhazi nke metabolism hepatocyte.
Mgbochi nke hepatocyte apoptosis
Mitochondria-ezubere iche peptides (dịka, SS-31) agbakwunyere na imeju na mitochondrial membranes, na-eme ka akpụkpọ ahụ mitochondrial guzosie ike ma na-egbochi mwepụta nke cytochrome C na ịgbalite caspase-3. Nke a na-ebelata nrụgide oxidative- ma ọ bụ apoptosis hepatocyte na-ebute ọgwụ. Mmetụta nchebe ha na ogige mitochondrial na-edobe ike hepatocyte ume metabolism, karịsịa na-ebelata necrosis hepatic lobular necrosis na ischemia-reperfusion mmerụ.
Peptides ọla kọpa (dịka, GHK-Cu) na-akwalite phosphorylation nke ndị na-anabata ihe na-eto eto hepatocyte, na-arụ ọrụ ụzọ mgbada iji mee ka nrụzi DNA dịkwuo elu na mmụgharị organelle na hepatocytes mebiri emebi. Ha na-egbochikwa ngbanwe ihe na-eto eto-β (TGF-β) - mgbasa ozi fibrogenic mgbasa ozi, na-egbu oge ọganihu nke fibrosis imeju.
Nchekwa imeju
peptides na-echebe imeju na-ebelata ntinye trans-membrane nke endotoxins na metabolites na-egbu egbu site na ịkwalite nkwupụta nke protein njikọ siri ike na membranes imeju, na-ebelata mmebi nke hepatocytes ozugbo site na ihe mkpali. Nke a na-eme ka ha dabara adaba n'oge mbụ na ọrịa imeju na-egbu egbu.
Nleba 2 Nuclear factor erythroid 2-related factor 2 (NRF2) ụkpụrụ na NRF2-mitochondrial interplay na ọrịa imeju na-adịghị ala ala. Isi mmalite: Ọrụ nke NFR2-Mmetụta Oxidative Nchekwa na njikwa mma Mitochondrial na ọrịa imeju na-adịghị ala ala (2023).
2. Detoxification: Ịkwalite ịba ọcha n'anya Biotransformation na Excrection Ọrụ
Imeju na-arụ ọrụ dị ka akụkụ ahụ na-emezi ihe, na-ahụ maka metabolize na ikpochapụ ihe ndị na-apụ apụ dị ka nsị na ọgwụ. peptides na-echebe imeju na-ekere òkè na usoro imeju imeju, na-akwalite metabolism na nsị nke ihe na-egbu egbu iji belata mmetụta hepatotoxic ha.
Ịgbalite usoro ụzọ metabolic nke A/II
Glutathione (GSH, dị ka GSH precursor peptides), dị ka ihe dị mkpa antioxidant na conjugation mkpụrụ na hepatocytes, na-ekere òkè ozugbo na Phase II detoxification mmeghachi omume site na-ejikọta na electrophilic toxins na-etolite mmiri-soluble ogige pụta site bile. Ụfọdụ peptides na-abawanye nchekwa GSH intracellular ma kwalite ọrụ nke glutathione S-transferase (GST), na-eme ngwa ngwa detoxification nke acetaminophen na metabolites mmanya (dịka, acetaldehyde).
Nicotinamide adenine dinucleotide (NAD, dị ka peptides metụtara NAD), dị ka coenzyme maka mmeghachi omume redox, na-ekere òkè na mmeghachi omume catalytic nke Phase I enzymes dị ka mmanya dehydrogenase na cytochrome P450, na-akwalite ntụgharị nke toxins lipophilic n'ime metabolites polar. Mmụba ọkwa NAD na-eme ka nrụpụta imeju na-arụ ọrụ nke ọma maka ọgwụ na nsị.
Nhazi nke bile acid metabolism
A na-echedo peptides na-echebe imeju (dịka, Pnc 27) iji rụọ ọrụ farnesoid X receptor (FXR) ma ọ bụ pregnane X receptor (PXR), na-achịkwa ngosipụta nke isi enzymes na ndị na-ebugharị na-etinye aka na njikọ bile acid. Nke a na-akwalite mmịpụta bile acid, na-ebelata mkpokọta intrahepatic nke bile acid na-egbu egbu, ma na-emezi ọnọdụ pathological nke ọrịa imeju cholestatic.
3. Nchegbu Antioxidative: Na-ekpochapụ Radicals efu na Imezi Mmebi Oxidative
mmerụ ahụ hepatocyte kpatara nrụgide oxidative bụ nzọụkwụ dị oke egwu na ọganihu ọrịa imeju. Ngwakọta peptide na-arụ ọrụ nchebe site na antioxidation ọtụtụ ebumnuche.
Usoro mkpochapu radical na-akwụghị ụgwọ na njikwa ọrụ enzyme
Glutathione na-ekpochapụ radicals efu dị ka anions superoxide na hydrogen peroxide. Dị ka mkpụrụ maka glutathione peroxidase, ọ na-eme ka mbelata nke peroxides lipid, na-ebelata mmebi nke lipid peroxidation membrane.
Antimicrobial peptides (dịka, LL37), gafere ọrụ mgbochi ha, na-egbochi NADPH oxidase iji belata mmepụta oxygen intracellular reactive (ROS) na hepatocytes, na-egbochi nrụgide oxidative na-eme ka ụzọ ụzọ rụọ ọrụ ma si otú a na-egbochi apoptosis hepatocyte apoptosis na ihe nzuzo na-akpali akpali.
Nchekwa ọrụ Mitochondrial
Mitochondria-ezubere iche peptides (dịka, SS-31) na-edobe nguzozi ike mitochondrial, na-ebelata nkewa mitochondrial na arụ ọrụ. Nke a na-eme ka ike dị ike na hepatocytes na-ebelata ma na-ebelata ohere nke mmebi oxidative na DNA na protein.
Mmechi
Ngwa nke peptide bekee na antioxidation na ahụike imeju na-elekwasị anya na isi usoro nke nchebe hepatocyte, nkwalite ụzọ detoxification, na nhazi nrụgide oxidative, na-enye ngwọta multidimensional maka mgbochi na ọgwụgwọ nke ọrịa imeju. Site n'ịchụso ọrụ mitochondrial, detoxifying enzyme system, and redox balance, ihe ndị a abụghị naanị na-ekpochapụ radicals n'efu ma na-egbochi hepatocyte apoptosis kamakwa na-emegharị phenotypes hepatic metabolic phenotypes site na usoro nnabata nuklia-gosipụta uru usoro na njikwa zuru oke nke imeju abụba, mmerụ ahụ fibrosis na hepatic.
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
