Site na Cocer Peptides 
ụbọchị 25 gara aga.
Ahụike ịmụ nwa bụ akụkụ dị mkpa nke ahụike mmadụ n'ozuzu ya, yana isi ya dabere na nguzozi na-arụ ọrụ nke usoro ọmụmụ n'okpuru ụkpụrụ hormonal. Usoro ahụike ịmụ nwa na usoro homonụ na-anọchite anya ọrụ etiti nke sistemu endocrine mmadụ, gụnyere usoro physiological isi dị ka mmepụta gamete, nguzozi nke homonụ mmekọahụ, mmezi ọmụmụ, na nhazi ọrụ mmekọahụ. Usoro ndị a na-adabere na njikwa ziri ezi nke hypothalamic-pituitary-gonadal (HPG) axis, na-agụnye njikọ ndị dị ka induction ovulation, nnọchi homonụ mmekọahụ, ọgwụgwọ ọmụmụ, na mgbanwe ọrụ mmekọahụ. Ọgwụ ndị sitere na peptide, nke a na-eji ọrụ ndụ dị elu mara, ebumnuche ebumnuche siri ike, yana ezigbo bioacompatibility, abụrụla ngwa dị mkpa maka itinye aka na nsogbu endocrine nke ịmụ nwa. Ha na-edozi nsogbu nke hormonal na ọkwa nhazi, na-enye ngwọta ọhụrụ maka nsogbu ndị dị ka enweghị ọmụmụ, ụkọ hormone mmekọahụ, na arụrụ ọrụ mmekọahụ.
Mpaghara Ngwa Isi
1. Induction Ovulation: Nhazigharị mmepe Follicular na okirikiri ime nwa
Induction ovulation bụ atụmatụ dị mkpa maka ọgwụgwọ amụghị nwa nwanyị. Ọgwụ ndị sitere na peptide na-ahazi nke ọma mmepe follicular site na iṅomi homonụ na-ahapụ gonadotropin (GnRH) ma ọ bụ na-agbakwunye gonadotropins ozugbo.
GnRH analog ụkpụrụ
Site n'ịgbanwe ọrụ nke ndị na-anabata ndị na-anabata pituitary GnRH, ọgwụ ndị a na-egbochi ihe omume akabeghị aka nke endogenous luteinizing hormone (LH), na-egbochi luteinization follicular akaghi aka. Nke a na-emepụta ọnọdụ hormonal kwụsiri ike maka hyperstimulation ovarian a na-achịkwa (COH) na nkà na ụzụ na-enyere aka ịmụ nwa (ART), na-eme ka arụmọrụ nke nchịkọta follicle dị elu dị elu.
Ngwa nke gonadotropin peptides
gonadotropin chorionic mmadụ (hCG) na-eṅomi ọrụ LH iji kpalite ovulation na follicles tozuru okè; gonadotropin menopausal mmadụ (hMG), nke nwere hormone na-akpali akpali (FSH) na ọrụ LH, na-akpali uto na mmepe nke follicular ozugbo, na-eme ka ọnụ ọgụgụ ịga nke ọma nke echiche okike na ART dịkwuo elu.
Ọgụgụ 1 Usoro homonụ nke uto follicle na ịchụpụ. Akpa follicles na-atụgharị gaa na ọkwa mbụ site na nrịbama PI3K/AKT/mTOR, wee malite ghọọ sinus follicles site na FSH na ndị na-achịkwa mpaghara. N'ikpeazụ, LH na-akpalite oocyte maturation na ovulation. Isi mmalite: Frontiers in Medicine.
2. Mgbanwe Hormone Mmekọahụ: Nrụghachi Balance Endocrine
Maka ọrịa ndị metụtara ụkọ homonụ mmekọahụ ma ọ bụ enweghị ahaghị nhata, ọgwụ ndị sitere na peptide na-enweta nnọchi homonụ physiological site na ịhazi axis HPG ma ọ bụ na-agbakwunye ndị na-ebu ụzọ homonụ ozugbo.
GnRH ọgwụgwọ pulse
Egosiputara maka ndị ọrịa nwere hypothalamic hypogonadism, ọgwụgwọ a gụnyere infusion nke GnRH analogs kwa oge iji ṅomie secretion pulsatile physiological. Nke a na-akpali pituitary ịhapụ FSH/LH, na-akwalite mmepe gonadal na njikọ homonụ mmekọahụ, na iweghachi mmepe mmepe ma ọ bụ ọmụmụ.
Testosterone na estrogen-na-achịkwa peptides
Ụfọdụ peptides sịntetik na-akwalite ọrụ neuron GnRH, na-akwalite nzuzo nzuzo LH ka ọ na-achịkwa ọkwa testosterone/estrogen na-edoghị anya. Nke a na-eme ka mgbaàmà dịkwuo mma dịka obere libido na nsogbu ịhụ nsọ nke hypogonadism kpatara.
3. Ọgwụgwọ ọmụmụ: Nkwado siri ike maka teknụzụ ịmụ nwa enyere aka
N'ihe gbasara mmeputakwa enyere aka, a na-eji ọgwụ peptide eme ihe n'ime usoro dum - mmepe follicular, weghachite oocyte, na nkwado luteal-iji kwalite nchekwa ọgwụgwọ na ọnụego ọganihu.
Oge hyperstimulation
hMG jikọtara ya na FSH peptide formulations na-achịkwa nke ọma mbanye follicle, na-ebelata ihe ize ndụ nke ọrịa hyperstimulation ovarian (OHSS); Ndị na-emegide GnRH na-egbochi mbido LH mbụ, na-egbochi ntozu oke ma ọ bụ mfu oocyte.
Iweghachite Oocyte na akụkụ luteal:
hCG na-akpalite maturation oocyte ikpeazụ, yana mgbakwunye mgbatị ahụ na hCG ma ọ bụ GnRH agonists na-ejigide ọrụ luteal, na-eme ka nnabata endometrial dịkwuo elu, ma na-ebuli ọnụego ntinye embrayo.
Ntinye aka nke nwoke: peptides na-ewepụta Gonadotropin na-achịkwa nzuzo nwoke LH / FSH, na-akwalite spermatogenesis na ichebe ọmụmụ na idiopathic oligoasthenospermia.
4. Mgbanwe Ọrụ Mmekọahụ: Ntinye aka Bidirectional na Ụzọ Neuroendocrine
Mmekọahụ mmekọ nwoke na nwanyị (dịka ọmụmaatụ, arụrụ arụ erectile, mbelata libido) na-ejikọta ya na ndakpọ nke homonụ na nrịbama akwara. Ọgwụ ndị dabere na peptide na-eme ka ọrụ ya dịkwuo mma site na usoro etiti etiti na akụkụ akụkụ.
Central excitatory peptides
Ụfọdụ ngwaahịa peptide (dịka ọmụmaatụ, Pt141) na-eme dị ka melanocortin agonists, na-arụ ọrụ ụzọ hypothalamic-spinal iji kwalite agụụ mmekọahụ. Ha na-adị irè karịsịa maka vaskụla ma ọ bụ psychogenic erectile dysfunction na nri ma ọ bụ mmanya anaghị emetụta ya.
Usoro hormonal na njikọ mmetụta uche
Ngwaahịa Peptide dị ka oxytocin na-akwalite ntọhapụ nke neurotransmitters metụtara mmekọrịta chiri anya, na-eme ka nsogbu mmetụta uche na-ejikọta na ọrụ mmekọahụ. Ha na-achịkwa nkwekọrịta uterine na lactation, na-arụ ọtụtụ ọrụ na ahụike ịmụ nwa; peptides na-ewepụta homonụ na-eto eto (dịka ọmụmaatụ, ipamorelin) na-emeziwanye agụụ mmekọahụ na mmekọ nwoke na nwanyị site na ịbawanye ọkwa testosterone.
Mmechi
Ntinye ọgwụ peptide dabere na ahụike ịmụ nwa na usoro homonụ na-egosi mgbanwe site na ọgwụgwọ anụ ahụ gaa na ntinye aka n'ọrụ. Site n'ịtụkwasị anya na axis HPG, ụzọ neuroendocrine, na ọrụ gonadal, ọgwụ ndị a na-egosipụta uru dị iche iche na ntinye ovulation, nnọchi hormone mmekọahụ, ọgwụgwọ ọmụmụ, na mgbanwe ọrụ mmekọahụ: ọ bụghị nanị na ha na-ezute ihe dị elu nke nkà na ụzụ na-enyere aka, kamakwa na-eme ka nhazi ahaziri iche dị ka ndịiche dị n'otu n'otu.
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
