Site Cocer Peptides 
ụbọchị 27 gara aga.
Nrụzi akwara na anụ ahụ bụ isi usoro physiological nke na-ejigide ọrụ moto, nguzozi n'ezi ihe, na nrụghachi ọrụ nke mmerụ ahụ gasịrị, gụnyere usoro mgbagwoju anya dị ka mmụba cell, extracellular matrix (ECM) remodeling, angiogenesis, na mkpali microenvironment ụkpụrụ. Ihe ndapụta dị mkpa na mpaghara a-gụnyere uto muscle, ọgwụgwọ ọnya, nrụzi nkwonkwo, na mgbake mmerụ egwuregwu-na-adabere na ntinye aka kpọmkwem na ntinye cell cell satịlaịtị, ọrụ fibroblast, cartilage matrix metabolism, na nrụzi nkwụsị nke neuromuscular. Ngwakọta peptide, yana ọrụ ndụ ha dị elu na ebumnuche ebumnuche ha, nwere ike gbanwee ụzọ akara ekwentị, kwalite nrụpụta anụ ahụ, na igbochi fibrosis, na-apụta dị ka ngwaọrụ dị oke mkpa iji merie ihe mgbakasị na usoro ọgwụgwọ ọdịnala na igosipụta atụmanya ngwa ngwa na ọgwụ egwuregwu, ịwa ahụ trauma, na ọgwụ na-emegharị ahụ.
Nleba anya nke nrụzi akwara skeletal na-esote mmerụ ahụ na-egosi akụkụ atọ nke nrụzi ahụ. Isi mmalite: Cell na Tissue Research.
Mpaghara Ngwa Isi
1. Uto Akwara: Ịkwalite Synthesis Myocyte na igbochi Catabolism
Ihe peptide na-ebuli oke akwara na arụ ọrụ site na ịhazi ụzọ anabolic na catabolic.
Satellite cell ịgbalite na mmụba
peptides na-ewepụta homonụ na-eto eto (dịka, CJC-1295) na-eme ka ndị na-anabata homonụ nke uto na-eto eto, na-akpali mwepụta homonụ uto pituitary na ịkwalite njikọ insulin-dị ka ihe uto-1 (IGF-1). Nke a na-arụ ọrụ ụzọ mgbada ala iji mee ka mkpụrụ ndụ satịlaịtị gbanwee site na ọnọdụ dị jụụ gaa na ọnọdụ ịba ụba, na-eme ka njikọ protein myofibrillar dịkwuo elu. Ndị peptides ndị a na-egbochikwa ọrụ sistemụ ubiquitin-proteasome, na-ebelata mmebi nke protein muscle, na-eme ka ha dị mma maka ịka nká, atrophy muscle na-eme ka a ghara iji ya mee ihe, na nrụzi ahụ ike mgbe emegasịrị.
Adipocyte metabolism na nchekwa anụ ahụ
Ụfọdụ peptides (dịka, AOD 9604) na-ebelata ihe nzuzo na-akpali akpali n'etiti adipocytes na myocytes site na ịgbalite thermogenesis nke adipose anụ ahụ na-acha aja aja na adipose browning, na-eme ka microenvironment muscle dịkwuo mma. Mmetụta nchebe ha na ọrụ myocyte mitochondrial na-ebelata mmega ahụ na-akpata mmebi oxidative ma na-akwalite mgbake ike ọgwụgwụ.
2. Ọgwụgwọ Ọnya: Usoro nhazi ọtụtụ nke usoro mmezi ahụ
Site na mmeghachi omume mkpali na imegharị anụ ahụ, ihe peptide na-achịkwa usoro ọgwụgwọ ọnya niile.
Usoro nchịkwa nke mbufụt
Peptides dị ka TB 500 na-egbochi ọrụ neutrophil gabigara ókè yana ntọhapụ nke radical n'efu, na-ebelata mmebi mkpali. Ha na-akwalite macrophage polarization na mgbochi mkpali M2 phenotype, na-eme ngwa ngwa mkpochapụ nke anụ ahụ necrotic na ịmepụta microenvironment kwesịrị ekwesị maka nrụzi.
Antimicrobial peptides (dịka ọmụmaatụ, LL37) na-egbu nje nje ozugbo ma na-achịkwa chemotaxis cell na-alụso ọrịa ọgụ, na-ebelata ihe ize ndụ nke ibute ọnya. Nkwalite ha nke ndị na-anabata ihe na-eto eto epidermal na-eme ka ikike ịkwaga keratinocyte dịkwuo elu.
Mgbasawanye na nhazigharị oge nkwalite
Gastrointestinal peptides na-echebe (dịka, BPC-157) na-arụ ọrụ vascular endothelial growth factor (VEGF) na fibroblast growth factor (FGF) na-egosi, na-akwalite mgbasa endothelial cell proliferation na neovascularization iji mee ka ọnya na-enye ọbara nwughari. Ha na-edozi okwu nke ụdị m collagen na fibronectin, na-eme ka anụ ahụ dị ike.
Peptides dị ka GHK-Cu, dị ka ndị na-ebu ọla kọpa ion, na-akwalite ọrụ lysyl oxidase, na-eme ka njikọ njikọ fiber collagen dịkwuo elu na maturation iji meziwanye ike ike nke anụ ahụ. Mgbochi ha nke matriks metalloproteinases na-ebelata oke ECM mmebi, na-egbochi hyperplasia afụ.
Ọgụgụ 2 Bioactive peptides na protein na-achịkwa ezinụlọ ROS n'oge usoro physiological na pathological. Isi mmalite: peptides bioactive na protein maka ndozi anụ ahụ: mgbanwe microenvironment, nnyefe ezi uche, na ikike ụlọ ọgwụ (2024).
3. Ndozi nkwonkwo: Nchekwa cartilage na Synovial Inflammation Regulation
N'ịchọ na cartilage wear na synovitis, ihe peptide na-echebe chondrocytes ma gbochie fibrosis.
Nlekọta matriks cartilage
Chondroitin metụtara peptides (dịka ọmụmaatụ, Chonluten) na-akwalite njikọ chondrocyte nke proteoglycans na ụdị II collagen, na-egbochi mmebi nke cartilage matrix na-egbu oge mmebi nke cartilage na osteoarthritis. Mwelite ha nke mkpụrụ ndụ ihe nketa metụtara na-edobe chondrocyte phenotype, na-ebelata hypertrophy na calcification.
Ihe peptides na-echebe cartilage (dịka ọmụmaatụ, Cartalax) na-egbochi ịba ụba nke fibroblast dị ka synoviocytes (FLS) na ihe nzuzo pro-inflammatory, na-ebelata mbufụt nke cartilage na-akpata synovial, nke kwesịrị ekwesị maka ọgwụgwọ adjuvant na rheumatoid na ọrịa ogbu na nkwonkwo.
Nchekwa cell na mgbochi apoptosis
SS-31, peptide ezubere iche nke mitochondria, na-etinye na membran chondrocyte mitochondrial, na-ejigide nkwụsi ike nke akpụkpọ ahụ yana ibelata nrụgide oxidative na-akpata apoptosis iji chebe ndụ nke mkpụrụ ndụ cartilage miri emi.
4. Mgbake mmerụ ahụ egwuregwu: Mmezi ngwa ngwa na nrụpụta ọrụ
Maka eriri akwara, mmerụ ahụ akwara, na anya mmiri ligament, ihe peptide na-eme ka mgbake dị mma site n'ịhazi ọrụ cell nrụzi na nhazigharị ECM.
Nkwalite mmezi akwara akwara/ligament
Ụfọdụ peptides (dịka ọmụmaatụ, TB 500 iberibe) na-akwalite ọdịiche dị n'etiti mkpụrụ ndụ akwara n'ime tenocytes, na-edozi okwu tenascin-C na tendonectin, na-eme ka nhazi nke eriri collagen dị n'usoro, na-ebelata nhazi anụ ahụ, ma melite njirimara arụ ọrụ nke saịtị ndị merụrụ ahụ.
Peptides dị ka CJC-1295, site na ntọhapụ homonụ na-eto eto na-adịgide adịgide, na-akwalite mbugharị cell satịlaịtị gaa na akwara ndị merụrụ ahụ, na-eme ka njikọ fiber collagen dị ngwa ma na-ebelata usoro mgbake nke mmerụ egwuregwu-karịsịa bara uru maka nhazigharị ngwa ngwa nke ndị egwuregwu.
Mmechi
Ngwa nke ihe peptide n'ime akwara na nrụzi anụ ahụ na-egosi nkwalite ọgwụgwọ site na 'nrụzi ngafe' gaa na mmeghari ohuru.' Site n'ichekwa ụzọ ndị bụ isi dị ka ịgbalite cell cell, mgbanwe ECM, angiogenesis, na usoro mbufụt, ihe ndị a na-edozi anabolic na catabolic metabolism na uto muscle, na-ahazi nkwonkwo na-edozi ahụ, na-echebe ma na-eme ka ọnya ọnya na-agwọ ọrịa matriks na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-arụ ọrụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-edozi ahụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-arụ ọrụ. mee ka nrụgharị arụ ọrụ dịkwuo ngwa na mmerụ egwuregwu - na-egosipụta uru usoro nhazi multidimensional.
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
