Na Cocer Peptides 
hashize iminsi 27.
Gusana imitsi hamwe nuduce ni inzira yibanze ya physiologiya ikomeza imikorere ya moteri, ubunyangamugayo bwimiterere, hamwe no kwiyubaka nyuma yimvune, birimo uburyo bukomeye nko gukwirakwiza selile, matrice idasanzwe (ECM) kuvugurura, angiogenez, no kugenzura ibidukikije. Ibintu by'ingenzi muri uru rwego - harimo gukura kw'imitsi, gukira ibikomere, gusana hamwe, no gukira ibikomere bya siporo - bishingiye ku bikorwa bifatika byakozwe mu ngirabuzimafatizo, imikorere ya fibroblast, metabolism ya karitsiye, no gusana imitsi ya neuromuscular. Ibintu bya peptide, hamwe nibikorwa bya biologiya bihanitse hamwe nibisobanuro byihariye, birashobora guhindura cyane inzira zerekana ibimenyetso bya selile, bigatera imbere kuvugurura ingirabuzimafatizo, kandi bikabuza fiboside, kugaragara nkibikoresho byingenzi byo kunesha inzitizi mubuvuzi gakondo bwo gusana no kwerekana ibyifuzo byinshi mubuvuzi bwa siporo, kubaga ihahamuka, nubuvuzi bushya.
Igishushanyo 1 Incamake yo gusana imitsi ya skeletale nyuma yimvune yerekana ibyiciro bitatu byo gusana imitsi. Inkomoko: Ubushakashatsi bwakagari nuduce.
Ibice byingenzi byo gusaba
1. Gukura kw'imitsi: Guteza imbere Synthesis ya Myocyte no Kubuza Catabolism
Ibintu bya peptide byorohereza imitsi n'imikorere muguhuza inzira ya anabolike na catabolika.
Gukora selile ya satelite no gukwirakwiza
Gukura imisemburo irekura peptide (urugero, CJC-1295) ikora imisemburo ikura ya hormone secretagogue reseptors, itera imisemburo ikura ya pituito no guteza imbere insuline imeze nkikura-1 (IGF-1). Ibi bikora inzira yo kumanuka kugirango itere ingirabuzimafatizo kugirango zive muntambwe ituje igana kuri leta ikwirakwira, byihutisha synthesis ya myofibrillar. Iyi peptide kandi irabuza ibikorwa bya sisitemu ya ubiquitin-proteasome, kugabanya kwangirika kwa poroteyine yimitsi, bigatuma bikenerwa cyane cyane no gusaza, kutangiza imitsi iterwa no gukoresha imitsi, no gusana imitsi nyuma yo gukora imyitozo.
Adipocyte metabolism no kurinda imitsi
Peptide zimwe na zimwe (urugero, AOD 9604) zigabanya gusohora ibintu hagati ya adipocytes na myocytes ukoresheje adipose tissue yumukara wa termogenezi na adipose yera yijimye, bitezimbere imitsi ya mikorobe. Ingaruka zo gukingira imikorere ya myocyte mitochondrial igabanya kwangirika kwa okiside iterwa na siporo kandi igatera umunaniro gukira.
2. Gukiza ibikomere: Amabwiriza menshi yuburyo bwo gusana
Uhereye ku gisubizo cyakongejwe no kuvugurura ingirabuzimafatizo, ibintu bya peptide bigenga ukwezi kwose gukira ibikomere.
Icyiciro cyo gutwika
Peptide nka TB 500 ibuza gukora neutrophil ikabije no kurekura bikabije, bikagabanya ibyangiritse. Bateza imbere kandi macrophage polarisiyasi yerekeza kuri anti-inflammatory M2 phenotype, kwihutisha gukuraho ingirabuzimafatizo no gukora ibidukikije bikwiye kugirango bisanwe.
Peptide yica mikorobe (urugero, LL37) yica virusi kandi igenga chemotaxis yumubiri, bikagabanya ibyago byo kwandura ibikomere. Gukora kwabo kwakirwa kwicyorezo cya epidermal byongera imbaraga za keratinocyte.
Gukwirakwiza no kuvugurura icyiciro cyo kuzamura
Indwara ya peptide irinda gastrointestinal (urugero, BPC-157) ikora ibintu bikura bikura mu mitsi (VEGF) hamwe na fibroblast yo gukura (FGF) byerekana ibimenyetso, bigatera ikwirakwizwa ry'uturemangingo twa endoteliyale hamwe na neovasculaire kugirango byihutishe kongera gutanga amaraso. Bagenzura kandi imvugo yubwoko I kolagen na fibronectine, byongera imbaraga za granulation tissue.
Peptide nka GHK-Cu, nk'abatwara ion z'umuringa, ziteza imbere ibikorwa bya lysyl oxydease, kwihutisha fibre ya kolagen ihuza no gukura kugirango byongere imbaraga zingirakamaro zumubiri. Kubuza matrix metalloproteinase kugabanya kwangirika gukabije kwa ECM, bikarinda hyperplasia yinkovu.
Igishushanyo 2 Bioactive peptide na proteyine bigenga umuryango wa ROS mugihe cyimikorere ya physiologique na patologi. Inkomoko: Bioactive peptide na proteyine zo gusana ingirangingo: guhinduranya ibidukikije, gutanga neza, hamwe nubuvuzi (2024).
3. Gusana hamwe: Kurinda Cartilage hamwe no kugenzura inkongi yumuriro
Intego yo kwambara artilage yambara hamwe na synovitis, ibintu bya peptide birinda chondrocytes kandi bikabuza fibrosis.
Kubungabunga matrix
Peptide ifitanye isano na Chondroitine (urugero, Chonluten) iteza imbere synthesis ya chondrocyte ya proteoglycans hamwe na kolagen yo mu bwoko bwa II, ikabuza kwangirika kwa matrix no gutinda kwangirika kwa osteoarthritis. Kugenzura ingirabuzimafatizo bifitanye isano na chondrocyte phenotype, bigabanya hypertrophy na calcium.
Peptide ikingira indwara ya karitsiye (urugero, Cartalax) ibuza ikwirakwizwa ryinshi rya fibroblast isa na synoviocytes (FLS) hamwe no gusohora ibintu byangiza, bikagabanya isuri ya sinovial inflammation iterwa na isuri, bikwiranye no kuvura indwara ya rubagimpande na rubagimpande.
Kurinda selile no kubuza apoptose
SS-31, peptide yibasiwe na mitochondriya, yinjira muri membrane ya chondrocyte mitochondrial membrane, ikomeza kugumya gukomera no kugabanya imbaraga ziterwa na okiside iterwa na apoptose kugirango irinde ubuzima bw'uturemangingo twinshi twa karitsiye.
4. Kugarura ibikomere bya siporo: Kwihutisha gusana no kwiyubaka
Kubibazo by'imitsi, ibikomere bya tendon, n'amarira ya ligament, ibintu bya peptide byongera imbaraga zo gukira muguhindura imikorere ya selile no kuvugurura ECM.
Kwiyongera kwa Tendon / ligament
Peptide zimwe na zimwe (urugero, agace ka TB 500) zitera itandukanyirizo ryingirabuzimafatizo muri tenocytes, kugenzura imvugo ya tenascin-C na tendonectine, kongera gahunda ya fibre fibre ya kolagen, kugabanya imitsi yinkovu, no kunoza imiterere yubukorikori bwaho bwakomeretse.
Peptide nka CJC-1295, binyuze mu gusohora imisemburo ikomeza y’imisemburo, iteza imbere kwimuka kw’ingirabuzimafatizo ku mitsi yakomeretse, kwihutisha intungamubiri za kolagen no kugabanya imvune z’imvune za siporo - cyane cyane bifasha abakinnyi mu buzima busanzwe.
Umwanzuro
Gukoresha ibintu bya peptide mugusana imitsi nuduce byerekana ibimenyetso byo kuvura bivuye kuri '' gusana pasiporo 'kugeza kuri ' kuvugurura imbaraga. ibyiza byinshi byubukanishi.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
