Cocer Peptides fɛ 
a bɛ tile 27 bɔ.
Farikolo ni farikolo yɔrɔw dilancogo ye farikoloɲɛnajɛ kɛcogo jɔnjɔnw ye minnu bɛ farikoloɲɛnajɛ baara, a jɔcogo dafalen, ani joginda kɔfɛ baarakɛcogo kura sabatili sabati, o bɛ kɛ ni fɛɛrɛ gɛlɛnw ye i n’a fɔ selilɛriw caya, selilu kɔkan matirili (ECM) labɛncogo kura, joli-sira-funu, ani sigida fitininw labɛnni min bɛ funu. Nin ko in na, ko jɔnjɔn minnu bɛ kɛ — i n’a fɔ farikolo falenni, joginda kɛnɛyali, kolotugudaw dilancogo, ani farikoloɲɛnajɛ joginw kɛnɛyali — olu bɛ tali kɛ fɛɛrɛ tigitigiw la sateliti selilɛriw baaracogo la, fibroblaste baarakɛcogo la, kolotugudaw matiriyali farikoloɲɛnajɛ la, ani farikolo yɔrɔw labɛnni na. Peptide fɛnw, n’u ka ɲɛnamaya kɛcogo ka bon ani u ka laɲini kɛrɛnkɛrɛnnenw, olu bɛ se ka selilɛriw ka taamasiɲɛw siraw sɛmɛntiya kɛrɛnkɛrɛnnenya la, ka farikolo yɔrɔw labɛn kokura, ani ka fiɲɛbana bali, ka bɔ kɛnɛ kan i n’a fɔ baarakɛminɛn nafamaw walasa ka se sɔrɔ gɛlɛyaw kan laadala dilan furakɛli la ani ka baarakɛcogo caman jira farikoloɲɛnajɛ furakɛli la, joginda opereli la, ani furakɛli la min bɛ mɔgɔ lasegin u cogo kɔrɔ la.
Jaa 1 Kolotugudaw dilancogo lajɛlen jogin kɔfɛ min bɛ farikolo dilancogo saba jira. Source: Seli ni farikolo yɔrɔw ɲinini.
Baarakɛyɔrɔ kolomaw
1. Farikolo bonya : Ka mikorositɛriw labɛn ani ka katabolisme bali
Peptide fɛnw bɛ farikolo fanga ni baara kɛcogo ɲɛ ni u bɛ anabolic ni catabolic siraw labɛn.
Sateliti selilɛriw ka baarakɛcogo ni u caya
Bonya hormone bɔli pepitiriw (misali la, CJC-1295) bɛ bonya hormone secretagogue receptors baara, ka pituitaire bonya hormone bɔli lawuli ani ka inisɔndiya ɲɔgɔnna bonya factor-1 (IGF-1) sɔrɔli sabati. O bɛ jiginɛ siraw baara walasa ka sateliti selilɛriw bila ka wuli ka bɔ lafiya cogo la ka taa u caya cogo la, o bɛ mikorofibrilari poroteyini sɔrɔli teliya. O pepitiriw fana bɛ ubiquitin-proteasome system baara bali, ka farikolojɔli dumuniw tiɲɛni dɔgɔya, o b’a to u bɛnnen don kɛrɛnkɛrɛnnenya la farikolojidɛsɛ ma min bɛ sɔrɔ kɔrɔya fɛ, baarabaliya fɛ, ani farikoloɲɛnajɛ kɔfɛ farikolo dilancogo la.
Fasa farikolojɔli ni farikolo lakanani
Pepitiri dɔw (misali la, AOD 9604) bɛ dɔ bɔ funufɛnw bɔli la farikolo tulumafɛnw ni mikorositɛriw cɛ, u kɛtɔ ka tulumafɛnw sɛnɛcogo ɲɛ ani ka tulumafɛnw finmanw kɛ, o bɛ farikolo yɔrɔ fitininw ɲɛ. U ka lakanani nɔ min bɛ mikorositɛri mitokondriyaw baara la, o bɛ dɔ bɔ farikoloɲɛnajɛ ka oksidan tiɲɛni na ani ka sɛgɛn kɛnɛya sabati.
2. Joginda kɛnɛyali: Dilancogo ɲɛnabɔli taabolo caman
K’a ta funu jaabi la ka se farikolo yɔrɔw labɛncogo kura ma, pepitiri fɛnw bɛ joginda kɛnɛyali sira bɛɛ labɛn.
Funu fasa labɛnni
Pepitidi minnu bɛ i n’a fɔ TB 500, olu bɛ neutrophils (neutrophils) baara kojugu ani ka radicals libres bɔli bali, o bɛ dɔ bɔ funu tiɲɛni na. U bɛ makɔrɔfagaw fana polarize (polarize) sabati ka ɲɛsin M2 fɛnɲɛnamafagalan ma, ka farikolo yɔrɔw bɔli teliya ani ka sigida fitinin bɛnnen dɔ dilan walasa ka dilan.
Banakisɛfagalan pepitiriw (misali la, LL37) bɛ banakisɛw faga k’a ɲɛsin farikolo tangalanw ma, o bɛ dɔ bɔ joginda banakisɛ sɔrɔli farati la. U ka farikolojidɛsɛ furaw minɛbagaw baarakɛli bɛ keratinocytes (keratinocytes) jiginni seko bonya.
Proliferation ani remodeling fasa yiriwali
Kɔnɔnatumu lakanani pepitiriw (misali la, BPC-157) bɛ joli siraw falenfalenni (VEGF) ni fibroblaste growth factor (FGF) taamasiɲɛw baara, o bɛ endoteliyali selilɛriw caya ani jolisiraw kuraya sabati walasa ka joginda joli sɔrɔli teliya. U fana bɛ kolajɛ suguya fɔlɔ ni fibɔrɔnɛkitini jiracogo kɔrɔta, ka granulasiyɔn farikolo fanga bonya.
Pepitidiw i n’a fɔ GHK-Cu, i n’a fɔ nɛgɛ ion tabaga, olu bɛ lisili ɔkisidazi baara sabati, ka kolajɛ fiyɛri ɲɔgɔndan teliya ani ka kɔgɔ walasa ka sɔgɔsɔgɔninjɛ fanga bonya. U ka matiriyali metalloprotéinases balili bɛ dɔ bɔ ECM tiɲɛni kojugu la, ka sɔgɔsɔgɔninjɛ bali.
Jaa 2 Pepitiriw ni farikolojɔlifɛnw bɛ ROS denbaya labɛn farikolo ni banako taabolo la. Soso: Pepitiriw ni poroteyini biyoaktifs ka ɲɛsin farikolo yɔrɔw dilancogo ma: microenvironnement modulation, delivery rational, ani clinical potential (2024).
3. Joli dilancogo : Kolotugudaw lakanani ani sɔgɔsɔgɔninjɛ funu ɲɛnabɔli
Ka ɲɛsin joli-sira-funu sɔgɔli ni sinovitis ma, pepitiri fɛnw bɛ kondrositɛriw lakana ani ka fiɲɛbana bali.
Cartilage matrix ladonni
Pepitidi minnu bɛ tali kɛ kɔndɔritini na (misali la, Kɔnlutɛni) bɛ kondrositɛriw ka protéoglycans ni kolajɛ suguya II sɔrɔli sabati, ka kolotugudaw tiɲɛni bali ani ka kolotugudaw tiɲɛni bila kɔfɛ kolotugudaw la. U ka jɛnɛya minnu bɛ tali kɛ ɲɔgɔn na, olu wulicogo bɛ kɔndɔrositɛriw ka fenotipi mara, ka dɔ bɔ hypertrophie ni calcification la.
Pepitidi minnu bɛ kolotugudaw tanga (misali la, Cartalax) bɛ sinoviyositɛri minnu bɛ i n’a fɔ fibroblaste (FLS) ni banakisɛfagalanw bɔli kojugu bali, ka kolotugudaw sɔgɔli nɔgɔya, o min bɛ sɔrɔ sɔgɔsɔgɔninjɛ fɛ, o bɛnnen don furakɛli dɛmɛnan ma sɔgɔsɔgɔninjɛ ni jolidɛsɛbanaw la.
Kɔnɔnatumuw lakanani ani apoptose balili
SS-31, n’o ye pepitiri ye min ɲɛsinnen bɛ mitokondriyaw ma, o bɛ don kondrositi mitokondriyaw membranes kɔnɔ, ka membrane seko sabatili sabati ani ka apoptose min bɛ sɔrɔ oksidan degun fɛ, o dɔgɔya walasa ka articular cartilage cellules jugumanw ka ɲɛnamaya lakana.
4. Spor joginw kɛnɛyali: Dilan teliya ani baarakɛcogo kura
Farikolo degunw, senkɔniw joginw, ani ligament ɲɛjiw kama, pepitiri fɛnw bɛ kɛnɛya sabatili nafa bonya ni u bɛ dilan selilɛriw ka baarakɛcogo ɲɛnabɔ ani ka ECM labɛn kokura.
Tendon/ligament dilancogo ɲɛtaa
Pepitiri dɔw (misali la, TB 500 yɔrɔ) bɛ senfagabana jirisunw danfara sabati ka kɛ tenositiw ye, ka tenasinɛ-C ni senkɔniw jiracogo kɔrɔta, ka kolajɛ fiyɛri labɛncogo ɲɛ, ka dɔ bɔ sɔgɔsɔgɔninjɛw sɔrɔli la, ani ka jogindaw ka masinko kɛcogo ɲɛ.
Pepitidiw i n’a fɔ CJC-1295, ni u bɛ kɛ sababu ye ka bonya hormone bɔli sabati, olu bɛ sateliti selilɛriw ka jiginni sabati ka taa ɲɛgɛnɛsira joginlenw na, ka kolajɛ fiyɛri sɔrɔli teliya ani ka farikoloɲɛnajɛ joginw kɛnɛyali waati surunya — kɛrɛnkɛrɛnnenya la, o nafa ka bon farikoloɲɛnajɛlamɔgɔw ka kɛnɛya teliya la.
Kuncɛli
Pepitiri fɛnw tali farikolo ni farikolo yɔrɔw dilancogo la, o bɛ furakɛli jiginni taamasyɛn ka bɔ 'dilan pasif' la ka taa 'segin kɛcogo la.' Ni u bɛ sira kolomaw laɲini i n’a fɔ sateliti selilɛriw baarakɛcogo, ECM labɛnni, joli-sira-funu, ani funu labɛnni, o fɛnw bɛ balansi anaboliki ni kataboliki farikoloɲɛnajɛw la farikolo falenni na, ka taabolo caman kɛcogo ɲɛnabɔ joginda la kɛnɛyali, ka kolotugudaw lakana ani ka funu bali kolotugudaw dilancogo la, ani ka baarakɛcogo kura teliya farikoloɲɛnajɛ joginw na — o bɛ nafa caman jira fɛɛrɛko siratigɛ la.
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
