Na Cocer Peptides 
hashize iminsi 25.
Sisitemu yubudahangarwa ikomeza homeostasis yumubiri binyuze mumurongo utoroshye wa selile na molekile, mugihe ibisubizo byubudahangarwa bwumubiri bishobora gutera indwara, gutwika indwara zidakira, cyangwa indwara ziterwa na autoimmune. Intandaro yo kugenzura ubudahangarwa bw'umubiri, kugabanya ibicanwa, hamwe no kuvura indwara ziterwa na autoimmune zishingiye ku gutabara neza mu gukora ingirabuzimafatizo, inzira zerekana ibimenyetso, hamwe n'uburyo bwo kwihanganira ubudahangarwa bw'umubiri. Nka molekile ya bioaktike, ibintu bya peptide, hamwe nintego zabo zihariye hamwe na biocompatibilité, birashobora guhindura cyane imikorere yimikorere yumubiri, guhagarika kwanduza ibimenyetso byanduza, no kuvugurura ibidukikije byangiza umubiri, bigatanga ibisubizo bishya byokuvura indwara zandura, indwara ziterwa na autoimmune, hamwe nibibazo biterwa no gutwika.
Igishushanyo 1 Gahunda rusange yo gusobanura inkomoko yumuriro udashira. Inkomoko: Ubudahangarwa bushya bwagiye nabi: Guhuza indwara ziterwa na mikorobe na kanseri idakira na kanseri (2006).
Ibice byingenzi byo gusaba
1. Amabwiriza yubudahangarwa: Kuvugurura ingirabuzimafatizo ya selile iringaniza
Ibintu bya peptide bigera ku byerekezo byombi byerekana ubukana nicyerekezo cyibisubizo byubudahangarwa muguhindura itandukaniro, ikwirakwizwa, nibikorwa byingirabuzimafatizo.
Amabwiriza ayobora T selile ya sisitemu
Peptide nka Thymosine Alpha-1, nka peptide ya bioactive peptide ikomoka kuri thymus, cyane cyane iteza imbere gukura kwa T preursors T selile ikora T, bikongerera imbaraga zo guhuza imbaraga hagati ya CD4⁺ umufasha T na selile CD8⁺ cytotoxic T. Mugukoresha inzira yerekana ibimenyetso, iyi peptide itezimbere ubushobozi bwa antigen bwo kumenya selile T, igatera ururenda rwa cytokine, kandi ikongera imikorere yumubiri mugukuraho virusi na selile zidasanzwe, bigatuma ikwirakwizwa no kwandura indwara kubantu badafite ubudahangarwa no kuvura kanseri.
Igenzura T selile itera peptide
Peptide ngufi ikomoka kuri poroteyine karemano yabantu irashobora guhitamo gukora ikwirakwizwa rya selile T igenga (Tregs) kandi ikabuza ingirabuzimafatizo T gukora cyane. Izi Tregs zigumana kwihanganira ubudahangarwa bw'umubiri mu kwangwa no kwandura indwara ziterwa na autoimmune mu gusohora cytokine zibuza guhagarika ibikorwa birenze urugero.
Kongera imikorere yimikorere yumubiri
Peptide yica mikorobe (AMPs) nka LL37 yerekana imirimo ibiri yibikorwa bya mikorobe no kugenzura ubudahangarwa. Zikora ku buryo butaziguye indwara ziterwa na bagiteri kandi zigatera gukura kwa selile dendritic, zigatera imbere kwerekana antigen no gukora T selile, bityo zikagira uruhare runini mu kurinda ubudahangarwa ku mbogamizi z'umubiri nk'uruhu na mucosa.
Igishushanyo 2 Uburyo bwo kugenzura AMP kuri macrophage. Inkomoko: Umusanzu wa Peptide ya antibicrobial mumikorere ya selile Immune: Isubiramo ryiterambere (2023).
2. Kugabanya Umuriro: Inzira nyinshi-Guhagarika Cascades Yaka
Kwibanda kumurongo wingenzi wibisubizo byumuriro, ibintu bya peptide bigira ingaruka muguhagarika ibimenyetso byerekana umuriro, guteza imbere umusaruro w’abunzi barwanya inflammatory, no gusana ibidukikije byangiza ibidukikije.
Hagati yo kubuza inzira ya NF-κB
Peptide ikingira Gastrointestinal nka BPC-157 igira uruhare mubintu bya kirimbuzi κB (NF-κB) byerekana inzira yerekana inzira, guhagarika iyandikwa no kurekura cytokine itera umuriro no kugabanya ingirabuzimafatizo zaho. Byongeye kandi, bateza imbere imiterere ya genoside zijyanye no gusana, kwihutisha gukira kwinyama zangiritse, kwerekana ingaruka zibiri zirwanya inflammatory ndetse nindishyi zindwara nkindwara zifata amara n ibisebe byo munda.
Kininogen ikomoka kuri peptide
Peptide nka KPV igenga ibikorwa bya neutrophil hamwe na molekile ya molekules ya adhesion, igabanya iyinjira ryingirabuzimafatizo aho yakomeretse, kugabanya kwangirika kwa okiside, no guteza imbere ibidukikije byaho. Iyi miterere ituma ibereye kuvura indwara ziterwa no gutwika nka ischemia-reperfusion igikomere na ibisebe bya diyabete.
Guhuza imbaraga za mitochondriya hamwe na stress ya okiside
Peptide yibasiwe na mitochondriya nka SS-31 yibasira imiterere ya mitochondrial membrane, kurinda ubudahangarwa bwimikorere ya mitochondial, kugabanya ubwoko bwa ogisijeni ikabije (ROS), no kubuza gukora ibimenyetso bya apoptose. Ibi bigabanya imbaraga za okiside iterwa no kwangirika kwinyama kandi bigatanga uburinzi bwumubiri mu gutwika umutima nindwara zifata ubwonko.
3. Ubuvuzi bwa Adjuvant kuburwayi bwa Autoimmune: Kwubaka Microen ibidukikije
Intego yibasiwe nabi na sisitemu yubudahangarwa yibigize ubwikorezi bwindwara ziterwa na autoimmune, ibintu bya peptide bigira ingaruka mbi zo kuvura muguhuza imenyekanisha ryimikorere nimirimo ikora.
Indigen yihariye yo kwihanganira ubudahangarwa bw'umubiri
Peptide ngufi ikomoka kuri epitopi yonyine-antigen ihuza molekile hejuru ya selile-antigen-selile, bigatuma kwihanganira ingirabuzimafatizo zirwanya antigene. Ibi bigabanya umusaruro wa autoantibodies hamwe nigitero cya tissue cyakozwe na selile effektor T, gitanga ingamba zigamije gutabara indwara nka rubagimpande ya rubagimpande na sisitemu ya lupus erythematosus.
Kuringaniza kuringaniza ya cytokine
Peptide zimwe na zimwe zihindura itandukaniro rya selile ya Th1 / Th2 / Th17 hamwe nuburyo bwo gusohora cytokine, bikabuza kwerekana cyane ibintu bitera kwanduza no guteza imbere umusaruro wa cytokine irwanya inflammatory. Ibi bigabanya ibisubizo byigihe kirekire byindwara ziterwa na autoimmune kandi bigatera kwangirika kwinyama.
Umwanzuro
Ibintu bya peptide mubijyanye nubudahangarwa no kurwanya ibicanwa byahindutse ibikoresho byingenzi bigenga uburinganire bw’umubiri no kugenzura ibisubizo by’umuriro bitewe n’intego nyayo yihariye hamwe n’ingaruka zishingiye ku mikorere myinshi. Mu kwivanga mu gutandukanya T selile, inzira yerekana ibimenyetso byerekana inzira, hamwe nuburyo bwo kwihanganira ubudahangarwa bw'umubiri, ibyo bintu ntabwo byongera umubiri kurinda umubiri indwara ziterwa na virusi gusa ahubwo binabuza kwangirika kwinyama zatewe no gukingira indwara birenze urugero, bitanga ibisubizo bitandukanye byo kuvura indwara zandura, indwara ziterwa na autoimmune, hamwe n’umuriro udakira.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
