Na Cocer Peptides 
hashize iminsi 25.
Kurenga ibyingenzi nkibisanzwe byo guhinduranya no kurwanya indwara, peptide yerekana agaciro kihariye mubihe byihariye birimo kwivanga indwara zubuhumekero, kurinda imikorere yumutima nimiyoboro, hamwe niterambere ryibikoresho byubushakashatsi, bitewe nuburyo butandukanye bwubatswe hamwe nibikorwa byibinyabuzima. Izi porogaramu zirenga ku mipaka y’imiti gakondo, itanga ibisubizo bishya byo kuvura indwara zigoye hamwe nubushakashatsi bwibanze bwa siyansi binyuze mu gusana mucosal igamije sisitemu yubuhumekero, kugenzura inzira zifata umutima zerekana ibimenyetso, no kugenzura neza imiterere yubushakashatsi. Ibyiza byabo byingenzi-intego yihariye yihariye, ubudahangarwa buke, hamwe na synthesis yihariye - itera kwaguka kwambukiranya peptide kuva mubuvuzi bwa clinique kugeza mubikorwa byinshi.
Igishushanyo 1. Igishushanyo mbonera cyerekana ubudahangarwa bw'umubiri mu kirere. Inkomoko: Cytokine ya Proinflammatory Indwara zubuhumekero zidakira no kuyiyobora (2025).
Ahantu ho gusaba
1. Sisitemu y'ubuhumekero: Gusana inzira no kugenzura umuriro
Ku ndwara zidakira nka indwara zidakira zifata ibihaha (COPD), fibrosis yo mu bihaha, na asima ya allergique, ibintu bya peptide bikora binyuze mu kurwanya indwara, antioxyde, no gusana mucosal.
Kurinda mucosal guhumeka no gusana
Peptide yo gusana ya bronchial itera ubwiyongere bwimyanya myuka ya epithelia selile hamwe no guhuza intungamubiri za poroteyine zifatika mugukoresha reseptor yo gukura kwa epidermal no guhindura ibintu bikura-β inzira, gusana ibyangiritse byatewe no kunywa itabi cyangwa umwanda. Kubuza ibintu bya neutrophil chemotactique ibintu bigabanya ibisubizo byumuriro uhumeka kubarwayi, bikagabanya inshuro zo kwiyongera gukabije.
Peptide ya antibicrobial (urugero, ibikomoka kuri LL37) bigabanya ibyago byo kwandura ibihaha muri fibrosis ya cystic mu guhagarika biofilm ya Pseudomonas aeruginosa no kugenzura macrophage phagocytose. Barabuza kandi kurekura birenze urugero ibintu bitera umuriro, bidindiza iterambere rya fibrosis.
Kwivanga kwa fibrosis
Peptide igenga pineide (urugero, Pinealon) irabuza gukora cyane fibroblast yibihaha muguhindura imikorere ya mitochondrial nigikorwa cya telomerase, kugabanya kwibiza bidasanzwe byubwoko bwa I kolagen na fibronectine. Muri moderi ya blomycine iterwa na fibrosis ya fibrosis, igabanya cyane umubyimba wa alveolar septal no kunoza imikorere yibihaha.
2. Sisitemu yumutima nimiyoboro: Kurinda imitsi no gusana Myocardial
Ku ndwara nka atheroskoloseze, infirasiyo ya myocardial, no kunanirwa k'umutima, ibintu bya peptide bikora bigenga angiogenezi, anti-myocardial apoptose, no kunoza metabolism.
Angiogenezi no kurinda endoteliyale
Peptide ya Angiogenic yigana imikorere yimikurire yimitsi iva mu mitsi, itera ikwirakwizwa rya selile endoteliyale, kwimuka, hamwe na lumen. Indwara z'umutima ziterwa na ischemic, zitera ingwate zingirakamaro kugirango amaraso atembera neza. Gukora kwabo kwa endoteliyale ya nitric okiside synthase yongerera imitsi kwaguka kandi bikagabanya ibyago byo gushiraho plaque ya aterosklerotike.
Peptide yumutima (urugero, Corgaten) yibasira myocardial mitochondrial membrane, ikabuza kurekura cytochrome C hamwe no gukora inzira ya apoptose. Ibi bigabanya myocardial selile necrosis iterwa no gukomeretsa ischemia-reperfusion, kunoza imikorere yumutima wa systolique nyuma yindwara ya myocardial, kugabanya agace ka fibrosis, no kudindiza iterambere ryumutima.
Antithrombotic na lipid
Peptide ikomoka kuri RGD ibuza gukusanya platine mu guhagarika guhuza ubuso bwa platine ihuza fibrinogen, ikora nka molekile zingenzi mugutezimbere imiti igabanya ubukana bwa antithrombotique. Ibyiza byabo biri mubyago byo kuva amaraso ugereranije na anticagulants gakondo.
Igishushanyo 2. Ibigize sisitemu ya vasopressine igira uruhare mu kugenga umuvuduko wamaraso mu bwonko, umutima, imiyoboro, impyiko, ibihaha na sisitemu yumubiri. AVP - vasopressine ya arginine; SNS - sisitemu yimpuhwe zimpuhwe; V1aR - vasopressine V1a yakira; V1bR - vasopressine V1b yakira; V2R - vasopressine V2 yakira. Inkomoko: Umutima nkintego ya Vasopressine nizindi Peptide yumutima nimiyoboro yubuzima nindwara zifata umutima (2022).
3. Ubushakashatsi Bwubushakashatsi: Gutezimbere no Gushyira mu bikorwa Igikoresho cya Peptide
Mubuvuzi bwibanze no guteza imbere ibiyobyabwenge, ibintu bya peptide bikora nkibikoresho byiza bya molekile kugirango biteze imbere ubushakashatsi bunoze no kubaka icyitegererezo.
Ibimenyetso byerekana inzira
Peptide zimwe na zimwe (urugero, Src kinase inhibitory peptide) zihagarika cyane cyane ibikorwa byumuryango wa Src kinase, bikoreshwa mukwiga uburyo bwo guhererekanya ibimenyetso mugukwirakwiza kwimuka no kwimuka. Kuba hafi yabo bifasha spatiotemporal kugenzura neza inzira zihariye.
G poroteyine ihujwe na reseptor (GPCR) ligand peptide (urugero, PT141 igereranya)
Iyi peptide ikoreshwa mugutandukanya imiyoboro ya GPCR yunganirwa na selile yohereza ibimenyetso, itanga icyitegererezo cyo gusuzuma intego zibiyobyabwenge mu ndwara ziterwa na metabolike.
Umwanzuro
Ikoreshwa ryibintu bya peptide mubindi bikorwa bidasanzwe byerekana guhuza n'imihindagurikire ya molekile mu bihe bitandukanye. Muri sisitemu yubuhumekero, batanga uburinzi bwanyuma kugeza kurangiza kurinda mucosal kugeza fibrosis intervention; muri kardiologiya, baca mumacenga gakondo yo kuvura bakoresheje angiogenezi no kurinda myocardial; mubushakashatsi bwubushakashatsi, bakora nkibikoresho byuzuye kugirango bateze imbere isesengura ryuburyo no kuvumbura ibiyobyabwenge. Izi porogaramu ntizuzuza gusa icyuho cyo kuvura indwara zihariye ahubwo inerekana uruhare rukomeye rwibintu bya peptide mubushakashatsi bwibanze no guhindura ivuriro.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
