Los ntawm Cocer Peptides 
25 hnub dhau los.
Tshaj li cov ntsiab lus tseem ceeb xws li kev tswj hwm metabolic thiab tiv thaiv kab mob tiv thaiv kab mob, cov tshuaj peptide muaj txiaj ntsig tshwj xeeb hauv cov xwm txheej tshwj xeeb suav nrog kev cuam tshuam cov kab mob ua pa, kev tiv thaiv kab mob plawv, thiab kev sim kev tshawb fawb cov cuab yeej tsim kho, vim lawv cov txheej txheem ntau haiv neeg thiab kev ua haujlwm lom neeg. Cov ntawv thov no cuam tshuam los ntawm cov kev txwv ntawm cov tshuaj ib txwm siv, muab cov kev daws teeb meem tshiab rau kev kho kab mob nyuaj thiab kev tshawb fawb tshawb fawb yooj yim los ntawm kev kho cov mucosal nyob rau hauv txoj kev ua pa, kev tswj hwm ntawm cov hlab plawv cell signaling pathways, thiab kev tswj xyuas cov qauv kev sim. Lawv cov txiaj ntsig tseem ceeb - lub hom phiaj siab, tsis tshua muaj kev tiv thaiv kab mob, thiab kev sib xyaw ua kom haum - tsav kev nthuav dav ntawm peptides los ntawm kev kho mob mus rau kev siv ntau yam.
Daim duab 1. Schematic sawv cev ntawm cov kab mob tiv thaiv kab mob hauv cov hlab ntsha. Tau qhov twg los: Proinflammatory Cytokines nyob rau hauv cov kab mob ua pa ntev thiab lawv txoj kev tswj hwm (2025).
Cov cheeb tsam thov
1. Kev ua pa ntawm lub ntsws: Kev kho cua thiab kev ua pa
Rau cov kab mob refractory xws li mob ntsws obstructive pulmonary disease (COPD), pulmonary fibrosis, thiab allergic asthma, peptide tshuaj ua los ntawm kev tiv thaiv kab mob, tiv thaiv oxidation, thiab kho mucosal.
Airway mucosal tiv thaiv thiab kho
Bronchial kho peptides txhawb nqa txoj hlab cua ntawm epithelial cell proliferation thiab nruj junction protein synthesis los ntawm activating epidermal loj hlob yam receptor thiab transforming kev loj hlob factor-β txoj kev, kho mucosal puas los ntawm kev haus luam yeeb los yog kuab paug. Lawv inhibition ntawm neutrophil chemotactic yam tseem ceeb txo cov hlab cua inflammatory teb rau cov neeg mob, txo qhov zaus ntawm mob exacerbations.
Antimicrobial peptides (xws li, LL37 derivatives) txo qhov kev pheej hmoo ntawm kev mob ntsws ntsws hauv cystic fibrosis los ntawm kev cuam tshuam Pseudomonas aeruginosa biofilms thiab tswj cov macrophage phagocytosis. Lawv kuj inhibit qhov tso tawm ntau dhau ntawm cov kab mob inflammatory, ncua kev loj hlob ntawm pulmonary fibrosis.
Pulmonary fibrosis cuam tshuam
Pineal regulatory peptides (piv txwv li, Pinealon) inhibit kev ua haujlwm ntau dhau ntawm lub ntsws fibroblasts los ntawm kev tswj hwm mitochondrial kev ua haujlwm thiab kev ua haujlwm telomerase, txo qis qis qis ntawm hom I collagen thiab fibronectin. Hauv bleomycin-induced pulmonary fibrosis qauv, lawv txo qis alveolar septal thickening thiab txhim kho lub ntsws ua haujlwm.
2. Kab Mob plawv: Kev Tiv Thaiv Kab Mob thiab Kho Myocardial
Rau cov kab mob xws li atherosclerosis, myocardial infarction, thiab lub plawv tsis ua hauj lwm, cov tshuaj peptide ua los ntawm kev tswj cov angiogenesis, tiv thaiv myocardial apoptosis, thiab txhim kho cov metabolism hauv lub zog.
Angiogenesis thiab kev tiv thaiv endothelial
Angiogenic peptides ua rau kev ua haujlwm ntawm vascular endothelial kev loj hlob zoo, txhawb nqa endothelial cell proliferation, migration, thiab lumen tsim. Hauv cov kab mob ischemic plawv, lawv ua rau muaj kev sib koom ua ke los txhim kho cov ntshav myocardial. Lawv ua kom cov vascular endothelial nitric oxide synthase txhim kho vascular dilation thiab txo qhov kev pheej hmoo ntawm atherosclerotic plaque tsim.
Cardioprotective peptides (xws li, Corgaten) lub hom phiaj myocardial mitochondrial membranes, inhibiting cytochrome C tso tawm thiab apoptosis txoj kev ua kom. Qhov no txo qis myocardial cell necrosis tshwm sim los ntawm ischemia-reperfusion raug mob, txhim kho plawv systolic muaj nuj nqi tom qab myocardial infarction, txo qis thaj tsam fibrosis, thiab ncua lub plawv tsis ua haujlwm.
Antithrombotic thiab lipid tswj
RGD-derived peptides inhibit platelet aggregation los ntawm kev thaiv kev khi ntawm platelet nto integrins rau fibrinogen, ua haujlwm tseem ceeb hauv kev tsim cov tshuaj antithrombotic tshiab. Lawv qhov zoo dua yog nyob rau hauv qhov kev pheej hmoo los ntshav qis dua piv rau cov tshuaj anticoagulants.
Daim duab 2. Cheebtsam ntawm vasopressin system koom nrog kev tswj cov ntshav khiav hauv lub hlwb, lub plawv, cov hlab ntsha, lub raum, lub ntsws thiab lub plab zom mov. AVP-arginine vasopressin; SNS-sympathetic paj hlwb; V1aR-vasopressin V1a receptors; V1bR-vasopressin V1b receptors; V2R-vasopressin V2 receptors. Tau qhov twg los: Lub plawv raws li lub hom phiaj ntawm Vasopressin thiab Lwm Cov Kab Mob Ntshav Qab Zib hauv Kev Noj Qab Haus Huv thiab Kab Mob plawv (2022).
3. Kev Tshawb Fawb Kev Tshawb Fawb: Kev txhim kho thiab kev siv cov cuab yeej Precision Peptides
Hauv cov tshuaj thiab kev tsim kho tshuaj, cov tshuaj peptide ua haujlwm zoo li cov cuab yeej molecules kom ua tiav cov kev tshawb fawb txog kev tshawb fawb thiab kev tsim qauv.
Signaling pathway probes
Qee cov peptides (piv txwv li, Src kinase inhibitory peptides) tshwj xeeb thaiv cov haujlwm ntawm Src tsev neeg kinases, siv los kawm txog cov teeb liab hloov pauv hauv cov xov tooj ntawm tes thiab kev tsiv teb tsaws. Lawv cov affinity siab ua rau spatiotemporal meej kev cai ntawm txoj kev tshwj xeeb.
G protein-coupled receptor (GPCR) ligand peptides (piv txwv li, PT141 analogs)
Cov peptides no yog siv los txiav GPCR-mediated cellular signal transduction networks, muab cov qauv rau kev tshuaj xyuas cov hom phiaj tshuaj hauv cov kab mob metabolic.
Xaus
Kev siv cov tshuaj peptide hauv lwm daim ntawv thov tshwj xeeb qhia txog kev hloov pauv thiab kev tsim kho tshiab ntawm cov molecules hauv cov xwm txheej hla kev qhuab qhia. Hauv kev ua pa, lawv muab kev tiv thaiv kawg ntawm kev kho mucosal rau kev cuam tshuam fibrosis; nyob rau hauv cardiology, lawv ua txhaum los ntawm ib txwm kho lub bottlenecks ntawm angiogenesis thiab myocardial tiv thaiv; Hauv kev tshawb nrhiav kev sim, lawv ua raws li cov cuab yeej muaj tseeb txhawm rau txhim kho kev tsom xam thiab kev tshawb nrhiav tshuaj. Cov ntawv thov no tsis tsuas yog sau cov kev kho mob tshwj xeeb rau cov kab mob tshwj xeeb tab sis kuj qhia txog lub luag haujlwm ntawm cov tshuaj peptide hauv kev tshawb fawb thiab kev kho mob txhais lus.
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
