Site na Cocer Peptides 
ụbọchị 25 gara aga.
Na mgbakwunye na ngalaba isi dị ka usoro metabolic na mgbochi mgbochi mkpali, ihe ndị peptide na-egosipụta uru pụrụ iche na ọnọdụ pụrụ iche gụnyere itinye aka na ọrịa iku ume, nchebe ọrụ obi, na mmepe ngwa nyocha nnwale, n'ihi oke nhazi ha dị iche iche na ọrụ ndu. Ngwa ndị a na-agbaji na njedebe nke ọgwụ ọdịnala, na-enye ihe ngwọta ọhụrụ maka ọgwụgwọ ọrịa mgbagwoju anya na nchọpụta sayensị bụ isi site na nrụzi mucosal ezubere iche na usoro iku ume, nhazi nke ụzọ mgbaàmà cell cardiovascular, na njikwa ziri ezi nke ụdị nnwale. Uru ha bụ isi - nkọwapụta ebumnuche dị elu, obere immunogenicity, na nhazi nhazi - na-eme ka mgbasawanye nke peptides sitere na ọgwụgwọ ụlọ ọgwụ gaa na ngwa multidisciplinary.
Ọnụọgụ 1. Ngosipụta atụmatụ nke nzaghachi mgbochi ọrịa pathologic na ikuku. Isi mmalite: Cytokines proinflammatory na ọrịa iku ume na-adịghị ala ala na njikwa ha (2025).
Mpaghara Ngwa
1. Usoro iku ume: Ndozi ụgbọ elu na nchịkwa ọkụ
Maka ọrịa refractory dị ka ọrịa na-adịghị ala ala obstructive pulmonary (COPD), fibrosis pulmonary, na nfụkasị ụkwara ume ọkụ, peptide bekee na-eme site na mgbochi mkpali, antioxidation, na mucosal nrụzi.
Nchekwa mucosal ikuku na ịrụzi
Bronchial mmezi peptides na-akwalite mgbasa nke cell epithelial nke ikuku na njikọ protein njikọ siri ike site n'ime ka onye na-anabata ihe na-eto eto epidermal na-agbanwe ihe na-eto eto-β ụzọ, na-edozi mmebi nke mucosal site na ise siga ma ọ bụ mmetọ. Mgbochi ha nke neutrophil chemotactic ihe na-ebelata mmeghachi omume mkpali nke ikuku na ndị ọrịa, na-ebelata ugboro ugboro nke nnukwu mkparị.
Antimicrobial peptides (dịka ọmụmaatụ, LL37 derivatives) na-ebelata ihe ize ndụ nke ọrịa akpa ume na cystic fibrosis site na imebi Pseudomonas aeruginosa biofilms na ịhazi macrophage phagocytosis. Ha na-egbochikwa ntọhapụ dị ukwuu nke ihe ndị na-akpasu iwe, na-egbu oge ọganihu nke fibrosis pulmonary.
Ntinye aka nke fibrosis pulmonary
Pineal regulatory peptides (dịka ọmụmaatụ, Pinealon) na-egbochi oke ịgbalite fibroblasts nku ume site na ịhazi ọrụ mitochondrial na ọrụ telomerase, na-ebelata ntinye na-adịghị mma nke ụdị m collagen na fibronectin. N'ụdị fibrosis pulmonary na-ebute bleomycin, ha na-ebelata oke alveolar septal ma melite ọrụ ngụgụ.
2. Sistemụ Cardiovascular: Nchedo Vascular na Mmezi Myocardial
Maka ọrịa ndị dị ka atherosclerosis, infarction myocardial, na nkụda obi, ihe ndị peptide na-eme site n'ịhazi angiogenesis, apoptosis mgbochi myocardial, na imeziwanye ike metabolism.
Angiogenesis na nchebe endothelial
Angiogenic peptides na-eṅomi ọrụ nke vascular endothelial growth factor, na-akwalite endothelial cell proliferation, Mbugharị, na lumen guzobere. N'ime ọrịa obi ischemic, ha na-eme ka usoro mgbasa ozi na-arụ ọrụ na-eme ka ọbara myocardial dịkwuo mma. Ha ịgbalite vaskụla endothelial endothelial nitric oxide synthase na-eme ka mgbasa nke vaskụla dịkwuo elu ma belata ohere nke ịmepụta plaque atherosclerotic.
Cardioprotective peptides (dịka ọmụmaatụ, Corgaten) lekwasịrị anya membranes mitochondrial myocardial, na-egbochi mwepụta cytochrome C na ịgbalite ụzọ apoptosis. Nke a na-ebelata necrosis myocardial cell necrosis nke ọrịa ischemia-reperfusion na-akpata, na-eme ka ọrụ systolic obi dịkwuo mma mgbe myocardial infarction gasịrị, na-ebelata mpaghara fibrosis, na-egbu oge ọganihu obi mgbada.
Ọgwụ antithrombotic na lipid
peptides sitere na RGD na-egbochi nchịkọta platelet site na igbochi njikọ nke integrins elu platelet na fibrinogen, na-eje ozi dị ka ụmụ irighiri ihe dị mkpa na mmepe nke ọgwụ antithrombotic ọhụrụ. Uru ha dị n'ihe ize ndụ ọbara ọgbụgba dị ala ma e jiri ya tụnyere ọgwụ mgbochi ọbara ọgbụgba ọdịnala.
Ọgụgụ 2. Akụkụ nke usoro vasopressin na-etinye aka na nhazi nke ọbara na ụbụrụ, obi, arịa, akụrụ, ngụgụ na usoro nri nri. AVP-arginine vasopressin; SNS - sistem obi ọmịiko; V1aR-vasopressin V1a anabata; V1bR-vasopressin V1b anabata; V2R-vasopressin V2 anabata. Isi mmalite: Obi dị ka ebumnuche nke Vasopressin na Peptides Cardiovascular ndị ọzọ na ahụike na ọrịa obi (2022).
3. Nchọpụta Nnwale: Mmepe na Ngwa Ngwa Ngwa Ngwa Peptides
N'ime ọgwụ bụ isi na mmepe ọgwụ, ihe peptide na-arụ ọrụ dị ka ụmụ irighiri ihe eji arụ ọrụ nke ọma na-aga n'ihu nyocha usoro na nrụpụta ihe atụ.
Nchọpụta ụzọ akara
Ụfọdụ peptides (dịka ọmụmaatụ, Src kinase inhibitory peptides) na-egbochi ọrụ nke Src ezinụlọ kinases, nke a na-eji amụ usoro ntụgharị mgbaàmà na mgbasawanye cell na mbugharị. Mmekọrịta ha dị elu na-enyere aka ịhazi nhazi nke ọma nke ụzọ ndị akọwapụtara.
G-protein jikọtara ihe nnabata (GPCR) ligand peptides (dịka ọmụmaatụ, PT141 analogs)
A na-eji peptides ndị a na-ekesa netwọk mgbasa ozi ekwentị na-agbasa GPCR, na-enye ụdị maka nyochaa ebumnuche ọgwụ na ọrịa metabolic.
Mmechi
Ntinye peptide n'ime ngwa ndị ọzọ pụrụ iche na-egosipụta ngbanwe na ihe ọhụrụ nke ụmụ irighiri ihe ndị a n'ọhụhụ nke usoro ọzụzụ. Na usoro iku ume, ha na-enye nchebe njedebe na njedebe site na nrụzi mucosal na ntinye aka fibrosis; na cardiology, ha na-agbaji site na mgbochi ọgwụgwọ ọdịnala site na angiogenesis na nchebe myocardial; N'ime nyocha nnwale, ha na-arụ ọrụ dị ka ngwaọrụ ziri ezi iji kwalite nyocha usoro na nchọpụta ọgwụ. Ngwa ndị a abụghị naanị na-ejuputa oghere ọgwụgwọ maka ọrịa ụfọdụ mana ha na-egosipụtakwa nchikota ọrụ peptide n'ime nyocha bụ isi na ntụgharị ụlọ ọgwụ.
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
