Melanotan-2 (MT-2) ni heptapeptide ya sintetike ya sintetike kandi igereranya imisemburo itera α-melanocyte (α-MSH). Ifite uruhare runini mugutunganya imisemburo ya melanocyte itera imisemburo. MT-2 ikora cyane cyane ingaruka zayo muguhuza reseptor ya melanocortin 1 (MC1R). MC1R igaragara cyane hejuru ya melanocytes. Iyo ihujwe niyi reseptor, MT-2 itangiza urukurikirane rwinzira zerekana ibimenyetso, amaherezo igatera synthesis ya melanin no gukwirakwiza, bityo bigatera impinduka kumabara yuruhu. Soma Ibikurikira

Hamwe niterambere ryiterambere ryubumenyi bwubuzima, ubushakashatsi muburyo bwo gusaza bwarushijeho kwiyongera, kandi kubona uburyo bwiza bwo kurwanya gusaza byabaye ingingo yingenzi mubumenyi bwa siyanse. Telomeres, nkibikoresho byo kurinda impera za chromosomes, bifitanye isano rya bugufi no gusaza kwa selile. Epitalon, peptide ngufi ya syntetique ifite ingaruka zo kurwanya gusaza, yashimishije abantu mumyaka yashize. Soma Ibikurikira

Gusana imitsi hamwe nuduce ni inzira yibanze ya physiologiya ikomeza imikorere ya moteri, ubunyangamugayo bwimiterere, hamwe no kwiyubaka nyuma yimvune, birimo uburyo bukomeye nko gukwirakwiza selile, matrice idasanzwe (ECM) kuvugurura, angiogenez, no kugenzura ibidukikije. Ibintu by'ingenzi muri uru rwego - harimo gukura kw'imitsi, gukira ibikomere, gusana hamwe, no gukira ibikomere bya siporo - bishingiye ku bikorwa bifatika byakozwe mu ngirabuzimafatizo, imikorere ya fibroblast, metabolism ya karitsiye, no gusana imitsi ya neuromuscular. Ibintu bya peptide, hamwe nibikorwa bya biologiya bihanitse hamwe nibisobanuro byihariye, birashobora guhindura cyane inzira zerekana ibimenyetso bya selile, bigatera imbere kuvugurura ingirabuzimafatizo, kandi bikabuza fiboside, kugaragara nkibikoresho byingenzi byo kunesha inzitizi mubuvuzi gakondo bwo gusana no kwerekana ibyifuzo byinshi mubuvuzi bwa siporo, kubaga ihahamuka, nubuvuzi bushya. Soma Ibikurikira

Ubuzima bw'imyororokere ni ikintu cy'ingenzi mu buzima rusange bwa muntu, hamwe n’ibanze byacyo biri mu buringanire bwimikorere yimyororokere ikurikiza imisemburo. Ubuzima bw'imyororokere no kugenga imisemburo byerekana imikorere yibanze ya sisitemu ya endocrine yumuntu, ikubiyemo inzira zingenzi zifatika nko gukora umukino wa gamete, kuringaniza imisemburo yimibonano mpuzabitsina, kubungabunga uburumbuke, no kugenzura imikorere yimibonano mpuzabitsina. Izi nzira zishingiye ku kugenzura neza hypothalamic-pituitar-gonadal (HPG), ikubiyemo isano nyamukuru nko kwinjiza intanga ngore, gusimbuza imisemburo y’imibonano mpuzabitsina, kuvura uburumbuke, no guhindura imikorere y’imibonano mpuzabitsina.  Soma Ibikurikira

Sisitemu y'imitsi igenga kumenya, amarangamutima, n'imikorere y'umubiri binyuze mumiyoboro igoye ya neurotransmitter hamwe n'inzira zerekana ibimenyetso. Kwangirika cyangwa kwangirika muri iyi sisitemu birashobora gukurura ibibazo bikomeye byubuzima nkindwara ya Alzheimer, indwara ya Parkinson, guhangayika, kwiheba, nihungabana ry’imitsi. Inzira nyamukuru zo kubungabunga ubuzima bw’imyakura n’ubwenge - harimo na neuroprotection, kongera ubwenge, kugenzura amarangamutima, no gusana ibikomere by’imitsi - bishingiye ku bikorwa bifatika mu mibereho ya neuronal, plastique synaptic, neuroinflammation, hamwe nuburyo bushya bwo kuvugurura. Ibintu bya peptide, hamwe nibikorwa bya biologiya byinshi hamwe nubwonko bwamaraso-ubwonko bwinjira, byagaragaye nka molekile nziza yo kwibasira inzira zinzira. Batinda neurodegeneration kurwego rwa selire kandi bigateza imbere gusana imikorere, gufungura inzira nshya zo gukumira no kuvura indwara zifata ubwonko. Soma Ibikurikira

Peptide synthesis bivuga inzira yo kubaka aside amine ikurikirana no gukora amide (urugero, peptide bond) ikoresheje uburyo bwa chimique cyangwa biologiya, cyane cyane ituma hubakwa ibihimbano bya molekile ya oligopeptide cyangwa polypeptide ifite imikorere yihariye yibinyabuzima. Nka shami rikomeye rya chimie bioorganic, tekinoroji yibanda kubikorwa byo gutoranya aminide acide amino, guhuza icyerekezo, no kugenzura neza inteko ikurikirana, ikurikirana ibintu byose uhereye kuri miligarama nini ya laboratoire kugeza ku nganda zingana na kilo. Bishingiye ku ngamba zinyuranye za syntetique, ishyirwa muburyo bwa biosynetique bushingiye kuri sisitemu y'ibinyabuzima hamwe na synthesis ya chimique ishingiye kumahame ya synthesis. Soma Ibikurikira

Ijambo 'peptide ' rikomoka ku ijambo ry'Ikigereki 'πέσσειν ' (péssein), risobanura 'gusya. Peptide bond, ari amide bond, ituruka kumyuka ya dehidrasi hagati ya α-carboxyl groupe ya acide amine imwe na α-amino yandi. Urutonde rwa aminide acide, peptide ifite aside amine 2 kugeza kuri 20 yitwa oligopeptide, abafite 20 kugeza kuri 50 ni polypeptide, kandi urutonde rurenga 50 aside amine ifite imiterere yihariye isanzwe ishyirwa mubikorwa nka poroteyine. Peptide mubisanzwe ifite uburemere bwa molekile munsi ya 10 kDa. Soma Ibikurikira

Cocerpeptides.com itanga peptide ifite isuku irenga 99%. Cocer Peptides igera ku kugenzura neza no kugenzura siyanse yubuziranenge bwa polypeptide muguhuza tekinoroji igezweho hamwe na sisitemu yuzuye yo kugenzura ubuziranenge: Mu cyiciro cya synthesis, icyiciro cya peptide cyikora (SPPS) gikoreshwa kugirango gikusanyirizwe hamwe na aside amine ikurikirana. Soma Ibikurikira

Survodutide nubushakashatsi bumaze igihe kirekire bukora agonist yibasiye icyarimwe yibasira reseptor ya glucagon imeze nka peptide-1 (GLP-1R) hamwe na glucose iterwa na insulineotropique polypeptide reseptor (GIPR). Irasaba ubuyobozi rimwe gusa mucyumweru, butanga abarwayi korohereza no kunoza uburyo bwo kuvura igihe kirekire. Soma Ibikurikira