Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Nkibintu bifite ibikorwa byindwara ya hepatoprotective, Livagen ikoresha ingaruka zayo za hepatoprotective ikoresheje uburyo bwinshi, harimo ingaruka kumiterere yimikorere nimikorere ya selile, kugenzura imikorere yumwijima ijyanye numwijima, no gukora muburyo butandukanye bwo gukomeretsa umwijima. Ibice bikurikira bizatanga ikiganiro kirambuye kubyerekeye ingaruka za hepatoprotective ya Livagen.
Igishushanyo 1 Imiterere yimiti ya Livagen.
Ingaruka za Livagen ku miterere y'utugingo ngengabuzima n'imikorere
Kurwego rwa selile, Livagen igira uruhare runini mugutegeka mumikorere n'imikorere y'uturemangingo twumwijima. Imibare yatanzwe na immunocytochemie hamwe nisesengura rya morphometricike yerekana ko Livagen ishobora gutera imiterere yimikorere ya homeostasis yabaturage ba selile mumico yumwijima. By'umwihariko, uburyo bwibanze bwibikorwa bya Livagen biri muburyo bwo guhuza ubudahangarwa bwimikorere ya selile no kuzamura imikorere yimikorere ningirabuzimafatizo. Ifasha kugumana morphologie isanzwe ya selile yumwijima, ibafasha gukora imirimo yabo ya physiologique neza. Iyo selile yumwijima ihuye n’imivurungano yo hanze ishobora gutera ihinduka ryimiterere cyangwa kwangirika, Livagen irashobora gukora kugirango ifashe ingirabuzimafatizo gukomeza morphologie zisanzwe zishoboka, bityo bikore imikorere isanzwe yimirimo yabo.
Ukurikije intungamubiri za poroteyine, Livagen nayo yerekana ingaruka nziza. Ubushakashatsi bwakozwe ku njyana ya sikadiyani ya sintezamubiri ya poroteyine mu mico ya monolayeri y’umwijima ituruka ku mbeba z’imyaka itandukanye (amezi 1-24) yasanze Livagen (Lys-Glu-Asp-Ala), yabonetse binyuze mu mikorere ya chimique ishingiye ku isesengura rya aside amine y’imyororokere ya peptide y’umwijima, ishobora kongera intungamubiri za poroteyine mu ngirabuzimafatizo z’imyaka itandukanye. Izi ngaruka zigaragara cyane cyane mu ngirabuzimafatizo ziva ku mbeba zishaje, aho Livagen itongera gusa intungamubiri za poroteyine gusa ahubwo inongerera amplitione ihindagurika rya poroteyine. Poroteyine nizo ngingo zingenzi zifatika kugirango selile zikore imirimo itandukanye. Ingaruka ya Livagen kuri poroteyine ifasha kugumana imikorere isanzwe ya metabolike na physiologique ya selile yumwijima. Imisemburo myinshi igira uruhare mu kwangiza umwijima, guhuza ibintu, no gutesha agaciro ni poroteyine. Mugutezimbere poroteyine, Livagen irashobora kongera ibirimo nibikorwa byiyi misemburo, bityo bikazamura imikorere rusange yumwijima.
Amabwiriza ya Livagen yimikorere yumwijima
Umwijima ugira uruhare runini mubikorwa byimikorere yabantu, kandi Livagen irashobora kugira ingaruka nziza mumikorere itandukanye ya hepatike. Mu mbaraga za metabolism, umwijima ni urubuga rwingenzi rwa karubone, lipide, na protein metabolism. Livagen irashobora kugenga imbaraga zingirakamaro mu mwijima muguhindura ibikorwa byimisemburo ya metabolike. Irashobora guteza imbere synthesis cyangwa ibikorwa bya enzymes zingenzi muri gluconeogenez, bigafasha umwijima guhindura neza ibintu bitari karubone ya glucose muri glucose mugihe umubiri ubikeneye, bityo bigatanga imbaraga kumubiri. Kubijyanye no guhinduranya ibinure, Livagen irashobora kugenga β-okiside ya aside irike, ikarinda amavuta menshi mwumwijima bityo bigafasha kwirinda indwara nkindwara zumwijima.
Kubijyanye na synthesis material na catabolic metabolism, Livagen nayo igira uruhare. Umwijima ufite inshingano zo guhuza ibintu bitandukanye byingenzi, nka albumin nibintu byambaye. Mugutezimbere intungamubiri za poroteyine, Livagen ifasha mu buryo butaziguye kongera umusaruro wibi bintu, igakomeza imikorere isanzwe yumubiri. Albumin ningirakamaro mukubungabunga plasma colloid osmotic. Kwamamaza kwa Livagen kuzamura synthesis ya albumin bifasha guhagarika plasma colloid osmotic, birinda ibintu nka tissue edema. Kubijyanye na metabolism ya catabolique, Livagen irashobora kongera ubushobozi bwumwijima kumeneka no guhindura ibintu byangiza. Uburozi bwa Exogenous cyangwa endogenous metabolic imyanda yinjira mu mwijima bigomba guhura nuruhererekane rwo guhindura metabolike mbere yo gusohoka mu mubiri. Livagen irashobora kugenga imikorere yimisemburo ya metabolike ijyanye no kwihutisha ihinduka ryimiterere yibi bintu, bityo bikagabanya umutwaro wangiza umwijima kandi ukarinda kwangirika.
Imikorere ya Livagen muburyo butandukanye bwo gukomeretsa umwijima
Mubigeragezo bimwe byatewe no gukomeretsa umwijima, Livagen yerekanye ingaruka nziza zo kurinda umwijima. Mu ngero zigereranya kwangirika kwumwijima ziterwa nuburozi, Livagen irashobora kugabanya urugero rwangirika kwingirangingo zumwijima ziterwa nuburozi. Iyo selile yumwijima ihuye nuburozi bwa chimique, imiterere ya membrane na organelles birashobora kwangirika, bigatuma imikorere mibi ya selile cyangwa urupfu. Nyuma yo kuvurwa na Livagen, urugero rw’ibyangiritse byagabanutse cyane, kandi urwego rwibimenyetso bimwe byangiritse muri selile rwaragabanutse. Ibi byerekana ko Livagen ishobora kurwanya muburyo runaka kurwanya uburozi bwibasira umwijima, bikarinda ubusugire bwimikorere.
Muburyo bwo gukingira umwijima gukingira indwara, Livagen nayo igaragaza ingaruka nziza. Gukora bidasanzwe kwimikorere yumubiri birashobora gutera umwijima umwijima, bigatera kwangirika kwinyama. Livagen irashobora kugabanya uburibwe bwumwijima muguhindura imikorere yingirabuzimafatizo no kurekura ibintu bitera umuriro. Irashobora kubuza umusaruro wa cytokine zimwe na zimwe zitera inflammatory (nka tumor necrosis factor-α, nibindi) mugihe utezimbere ururenda rwa cytokine anti-inflammatory (nka interleukin-10, nibindi), bityo bigahindura microen ibidukikije yangiza umwijima yerekeza mubyerekezo bifasha gusana ingirabuzimafatizo, kugabanya kwangirika kwingirangingo zumwijima, no guteza imbere gusana no kuvugurura ingirangingo zumwijima.
Ibishobora gukoreshwa na Livagen mukurinda no kuvura indwara zumwijima
Ukurikije imikorere myiza ya Livagen muri selile yumwijima nuburyo butandukanye bwo gukomeretsa, ifite agaciro gakoreshwa mugukumira no kuvura indwara zumwijima. Mu rwego rwo kwirinda, kubantu bafite ibyago byinshi nkabanywa igihe kirekire, abantu bafite umubyibuho ukabije, hamwe nitsinda ryabakozi bahuye nibintu bya hepatotoxique, Livagen irashobora kuba inyongera yimirire ikumira. Muguhora ufata Livagen, ifasha kubungabunga ubuzima bwingirangingo zumwijima, kongera imikorere yumwijima no kwangiza, no kugabanya ibyago byindwara zumwijima. Ku bakoresha inzoga zidakira, inzoga na metabolite zirashobora kwangiza umwijima. Livagen irashobora kugabanya ibyo byangiritse ku rugero runaka, ikarinda ingirangingo z'umwijima ingaruka ziterwa n'inzoga, kandi ikarinda kwandura indwara y'umwijima.
Ku bijyanye no kuvura, ku barwayi bamaze gufatwa n'indwara y'umwijima, Livagen irashobora kuba uburyo bwo kuvura bufatika. Kurugero, kubarwayi barwaye hepatite idakira, Livagen irashobora gukoreshwa ifatanije n'imiti gakondo ya virusi cyangwa anti-inflammatory. Itera umwijima gusana no kuvugurura, kongera imikorere yumubiri wumwijima, kunoza imikorere yimiti, kugabanya gucana na fibrosis mumwijima, kandi bidindiza iterambere ryindwara. Ku barwayi barwaye cirrhose, Livagen ifasha kunoza microcirculaire yumwijima, guteza imbere intungamubiri zitanga ingirabuzimafatizo zumwijima, no kugenga metabolisme idasanzwe yo mu mwijima, bityo bikagabanuka cyane. Ibi birashobora kunoza imikorere yumwijima kurwego runaka kandi bikazamura imibereho yabarwayi.
Ubushakashatsi bwuburyo bwibikorwa bya Livagen mukurinda umwijima
Urebye inzira ya selile yerekana inzira, Livagen irashobora kugira uruhare mugutunganya inzira zijyanye no gukura kwakagari, gukwirakwizwa, no kubaho. Kurugero, irashobora gukora mitogen-ikora protein kinase (MAPK) yerekana inzira, igira uruhare runini mukuzamuka kwakagari, gutandukana, no gusubiza ibibazo. Mugukoresha inzira ya MAPK yerekana inzira, Livagen irashobora guteza imbere ikwirakwizwa ryumwijima no kubaho, byihutisha gusana no kuvugurura igihe umwijima wangiritse.
Livagen irashobora gukorana nibintu byandikirwa muri selile kugirango igenzure imvugo ya gen. Impapuro zandikirwa ni urwego rwa poroteyine zihuza uturere tumwe na tumwe twa porotokoro kugira ngo tugenzure gene. Livagen irashobora guhindura ibikorwa cyangwa imvugo yibintu bimwe na bimwe byandikirwa, bityo bigahindura imvugo ya gen zijyanye no gufata neza ingirabuzimafatizo yumwijima, kugenzura imikorere ya metabolike, no kwirinda antioxydeant, bityo bikagira ingaruka zo kurinda umwijima. Kurugero, irashobora kugenga ibikorwa byibintu bya kirimbuzi E2 bifitanye isano na 2 (Nrf2), ikintu cyingenzi cyandikirwa muri sisitemu yo kwirinda antioxydeant selile igenzura imvugo ya genoside ya antioxydeant. Mugukora Nrf2, Livagen iteza imbere synthesis ya enzymes ya antioxydeant, ikongera ubushobozi bwa antioxydeant yingirangingo zumwijima, kandi ikarinda umwijima kwangirika kwatewe na okiside.
Duhereye ku itumanaho rishingiye ku mitsi, umwijima urimo ubwoko butandukanye bwa selile, nka hepatocytes, selile hepatel selile, na selile Kupffer, zikorana binyuze mu itumanaho hagati kugira ngo imikorere yumwijima isanzwe. Livagen irashobora guhindura uburyo bwitumanaho hagati yutugari, igenga imikoranire yabo. Irashobora kugena imikorere yimikorere ya selile stellate selile, igira uruhare runini muri fibrosis yumwijima. Livagen igabanya synthesis hamwe nogusohora kwa matrice idasanzwe muguhagarika imikorere ya selile stellate selile, bityo bikagabanya ubukana bwa fiboside yumwijima. Byongeye kandi, Livagen irashobora guhindura imikorere yubudahangarwa bwimikorere ya selile ya Kupffer, ibafasha kugira uruhare runini mubisubizo byumwijima no guteza imbere gusana no kuvugurura ingingo zumwijima.
Umwanzuro
Muri make, Livagen yerekanye uruhare runini mukurinda umwijima. Binyuze mu bushakashatsi bwimbitse ku buryo bukoreshwa mu gukora no gukomeza gushakisha uburyo bukoreshwa mu mavuriro, bushobora kugira uruhare mu gukumira no kuvura indwara z’umwijima.
Inkomoko
[1] Riadnova I, Filippov SV, Iuzhakov V V. Iterambere muri Gerontologiya, 2002,10: 88-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12577697&query_hl=1.
[2] Brodskiĭ V, Khavinson V, Zolotarev I, n'abandi. [Injyana ya synthesis ya protein mumico ya hepatocytes kuva imbeba zimyaka itandukanye. Ubusanzwe n'ingaruka za peptide livagen] [J]. Izv Akad Nauk Ser Biol, 2001 (5): 517-521. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15926314&query_hl=1
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
