Cocer Peptides fɛ 
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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
I n’a fɔ fɛn min bɛ se ka sugunɛ lakanani baara kɛ, Livagen b’a ka sugunɛ lakanani nɔw kɛ fɛɛrɛ caman fɛ, i n’a fɔ a bɛ nɔ bila selilɛriw jɔcogo n’u baara la, sugunɛ ni farikoloɲɛnajɛ taabolo labɛnni, ani baarakɛcogo sugunɛ jogincogo misali suguya caman na. Nin yɔrɔ nataw bɛna baro caman kɛ Livagen ka sugunɛ lakanani nɔw ni a kɛcogo kan.
Jaa 1 Livagen ka kemikaliya cogoya.
Livagen ka nɔ bila sugunɛbilenniw jɔcogo n’u baarakɛcogo la
Kɔnɔnatumuw ta fan fɛ, Livagen jɔyɔrɔ ka bon kosɛbɛ labɛnni na sugunɛbilenniw cogoya n’u baara la. Kunnafoni minnu bɔra immunocytochimie ni morphometrie analyse la, olu b’a jira ko Livagen bɛ se ka selilɛriw ka homeostasis sigicogo ni baarakɛcogo lawuli sugunɛ sɛnɛcogo la. Kɛrɛnkɛrɛnnenya la, Livagen ka baara kɛcogo fɔlɔ bɛ se ka kɛ ka selilɛriw ka cogoya dafalen sabati ani ka selilɛriw ni selilɛriw kɔnɔ u ka segin-ka-bɔnyew yiriwa. A bɛ dɛmɛ ka sugunɛbilenniw cogoya ɲuman sabati, o b’a to u bɛ se k’u farikolo baara kɛ ka ɲɛ. Ni sugunɛbilenniw kɛra kɛnɛma fɛn dɔw ye minnu bɛ se ka kɛ sababu ye ka u cogoya caman Changer walima ka tiɲɛni kɛ, Livagen bɛ se ka baara kɛ walasa ka farikolokisɛw dɛmɛ u ka u cogoya la cogo bɛnnen na, o la, u ka baara kɛcogo bɛ kɛ cogo bɛnnen na.
Ka bɔ farikolojɔlifɛnw dilanni siratigɛ la, Livagen fana bɛ nɔ ɲumanw jira. Sɛgɛsɛgɛli dɔ kɛra farikolojɔli dumuniw dilanni cogoya kan sugunɛbilenniw la minnu bɛ bɔ sosow la minnu si hakɛ tɛ kelen ye (kalo 1–24) o y’a jira ko Livagen (Lys-Glu-Asp-Ala), min bɛ sɔrɔ furakisɛw dilanni siratigɛ la min sinsinnen bɛ sugunɛ pepitiri labɛncogo dɔ ka asidi aminikiw sɛgɛsɛgɛli kan, o bɛ se ka dɔ fara farikolojɔlifɛnw sɔrɔli hakɛ kan sugunɛbilenniw la ka bɔ sosow la minnu si hakɛ tɛ kelen ye. O nɔ in bɛ ye kɛrɛnkɛrɛnnenya la wulukɔrɔbaw ka seliluw la, yɔrɔ min na Livagen tɛ dɔ fara farikolojɔli dumuniw sɔrɔli hakɛ kan dɔrɔn, nka a bɛ farikolojɔlifɛnw dilanni jiginni caman fana bonya. Protéines ye fɛn nafamaw ye minnu bɛ se ka kɛ sababu ye ka seliluw kɛ walasa ka baara suguya caman kɛ. Livagen ka ɲɛtaa nɔ min bɛ farikolojɔli dumuniw dilanni na, o bɛ dɛmɛ ka sugunɛbilenniw ka farikoloɲɛnajɛ ni u farikolo baara kɛcogo ɲuman sabati. Enzyme caman minnu bɛ sugunɛ ka baga bɔli la, fɛnw dilanni na ani u tiɲɛcogo la, olu ye farikolojɔlifɛnw ye. Ni Livagen ye farikolojɔli dumuniw dilanni sabati, a bɛ se ka dɔ fara o anzimu ninnu kɔnɔfɛnw ni u baara kan, o la, a bɛ sugunɛ ka baara bɛɛ lajɛlen ɲɛ.
Livagen ka farikoloɲɛnajɛ kɛcogo minnu bɛ tali kɛ sugunɛ na, olu labɛnni
Sugunɛ jɔyɔrɔ ka bon hadamadenw ka farikoloɲɛnajɛ kɛcogo la, wa Livagen bɛ se ka nɔ ɲumanw bila sugunɛ farikoloɲɛnajɛ baara suguya caman na. Fanga sɛnɛcogo la, sugunɛ ye witaminiw, tulumafɛnw ani farikolojɔli dumuniw sɛnɛyɔrɔ jɔnjɔn ye. Livagen bɛ se ka fanga farikoloɲɛnajɛ balansi labɛn sugunɛ kɔnɔ ni a bɛ nɔ bila farikoloɲɛnajɛ farikolojɔlifɛn nafamaw baara la. A bɛ se ka kɛ sababu ye ka anzimu kolomaw labɛnni walima u baara sabati sukaro sɔrɔli la, o bɛ kɛ sababu ye ka sugunɛ kɛ ka fɛn minnu tɛ witaminiw ye, olu caman tigɛli ka ɲɛ ka kɛ sukaro ye ni farikolo mago bɛ a la, o bɛ fanga di farikolo ma. Tumu sɛnɛcogo kama, Livagen bɛ se ka asidi tulumaw ka β-oxydation kɛcogo ɲɛnabɔ, ka tulumafɛnw dalajɛ kojugu sugunɛ na, ka dɛmɛ don ka cogoyaw bali i n’a fɔ tulumabana.
Fɛnɲɛnɛmaw dilanni ni kataboliki farikoloɲɛnajɛ siratigɛ la, Livagen fana jɔyɔrɔ ka bon. Sugunɛ bɛ fɛn nafama suguya caman dilan, i n’a fɔ albumin ani joli kurulenw. Ni Livagen bɛ farikolojɔli dumuniw labɛnni sabati, a bɛ dɛmɛ don cogo la min tɛ ɲɛ, ka dɔ fara o fɛnw dilanni kan, ka farikolo baara kɛcogo ɲumanw mara. Albumin nafa ka bon kosɛbɛ walasa ka joli la kolosinsinnan osmotique tansiyɔn sabati. Livagen ka albumin sɔrɔli sabatili bɛ dɛmɛ ka joli la kolosinsinnan osmotique tansiyɔn sabati, ka banaw bali i n’a fɔ farikolo yɔrɔw sɔgɔsɔgɔninjɛ. Kataboliki farikoloɲɛnajɛ siratigɛ la, Livagen bɛ se ka sugunɛ ka se ka fɛn juguw tiɲɛ ani ka u sɛmɛntiya. Tosini minnu bɛ bɔ kɛnɛma walima farikolojɔli fɛnɲɛnamafagalan minnu bɛ don sugunɛ na, olu ka kan ka farikoloɲɛnajɛ caman tigɛli kɛ sani u ka bɔ farikolo la. Livagen bɛ se ka farikolojɔlifɛn nafamaw ka baara ɲɛnabɔ walasa ka nin fɛn ninnu farikolojɔli teliya, o la, a bɛ dɔ bɔ sugunɛ ka baga bɔli doni na ani k’a tanga tiɲɛni ma.
Livagen ka baarakɛcogo sugunɛ jogincogo suguya wɛrɛw la
Sugunɛ jogincogo misali dɔw la minnu kɛra k’a lajɛ, Livagen ye sugunɛ tangacogo ɲuman jira. Modeli minnu bɛ sugunɛ tiɲɛni ladege min bɛ sɔrɔ bagaw fɛ, Livagen tun bɛ se ka dɔ bɔ sugunɛbilenni tiɲɛni hakɛ la bagaw fɛ. Ni sugunɛbilenniw bilala kemikɛlifɛn dɔw la, u farikolo yɔrɔw ni u farikolo yɔrɔw bɛ se ka tiɲɛ, o bɛ na ni selilɛriw ka baarakɛbaliya ye walima hali u ka saya. Furakɛli kɔfɛ ni Livagen ye, selilɛri tiɲɛni hakɛ dɔgɔyara kosɛbɛ, wa tiɲɛni taamasiɲɛ dɔw hakɛ dɔgɔyara selilu kɔnɔ. O b’a jira ko Livagen bɛ se ka baga binkanni kunbɛn fo ka se hakɛ dɔ ma sugunɛbilenniw kan, k’u dafalen ni u baara lakana.
Sugunɛ jogincogo misali la min bɛ kɛ ni farikolo tangalanw ye, Livagen fana bɛ nɔ ɲumanw jira. Banakisɛfagalanw baarakɛbaliya bɛ se ka funu jaabiw bila sugunɛ na, o bɛ na ni farikolo yɔrɔw tiɲɛni ye. Livagen bɛ se ka sugunɛ funu nɔgɔya ni a bɛ farikolo tangalanw ka baara labɛn ani ka funufɛnw bɔ. A bɛ se ka sitokini dɔw bɔli bali minnu bɛ funu dɛmɛ (i n’a fɔ tumor necrosis factor-α, a ɲɔgɔnnaw) ka sɔrɔ ka sitokiniw bɔli sabati (i n’a fɔ interleukin-10, a ɲɔgɔnnaw), o la, a bɛ funu sigida fitininw wuli sugunɛ kɔnɔ ka taa sira fɛ min ka ɲi farikolo yɔrɔw dilancogo ma, ka funu tiɲɛni dɔgɔya sugunɛbilenniw la, ani ka furakɛli ni sugunɛbaralabana seginni.
Livagen kɛcogo minnu bɛ se ka kɛ sugunɛbana kunbɛnni ni u furakɛli la
Ka da Livagen ka baara kɛcogo ɲuman kan sugunɛbilenniw la ani jogincogo misali suguya caman, a bɛ se ka kɛ sababu ye ka nafa sɔrɔ sugunɛbanaw kunbɛnni n’u furakɛli la. Bana kunbɛnni siratigɛ la, faratiba bɛ mɔgɔ minnu na i n’a fɔ minnu bɛ dɔlɔ min waati jan kɔnɔ, mɔgɔ fasalenw, ani baarakɛyɔrɔ minnu bɛ sugunɛbilenni furaw la, Livagen bɛ se ka kɛ balodɛsɛ fura ye min bɛ bana kunbɛn. Ni a bɛ Livagen ta tuma bɛɛ, a bɛ sugunɛbilenniw kɛnɛya sabati, ka sugunɛ farikoloɲɛnajɛ ni baga bɔli baara ɲɛ, ani ka sugunɛbana farati dɔgɔya. Dɔlɔminna basigilenw fɛ, dɔlɔ ni a fɛnɲɛnamafagalanw bɛ se ka tiɲɛni basigilen kɛ sugunɛ na. Livagen bɛ se ka o tiɲɛni nɔgɔya fo ka se hakɛ dɔ ma, ka sugunɛbilenniw tanga dɔlɔ ka tiɲɛni ma, ani ka dɔlɔminbana daminɛ bali.
Furakɛli siratigɛ la, banabagatɔ minnu ka sugunɛbana sɔrɔla kaban, Livagen bɛ se ka kɛ furakɛli fɛɛrɛ wɛrɛ ye. Misali la, sugunɛbilenni basigilen bɛ banabagatɔ minnu na, Livagen bɛ se ka kɛ ka fara tubabufura walima banakisɛfagalanw kan. A bɛ sugunɛbilenniw dilancogo ni u lasegincogo sabati, ka sugunɛ farikolo tangacogo ɲɛ, ka furaw nafa bonya, ka funu ni fiɲɛ bila sugunɛ na, ka banaw taabolo sumaya. Sirozi bɛ banabagatɔ minnu na, Livagen bɛ dɛmɛ don ka sugunɛ ka mikorocirculation ɲɛ, ka balofɛnw di sugunɛbilenniw ma, ani ka selilu kɔkan matiriyali metabolism labɛn sugunɛ kɔnɔ, o la, a bɛ dɔ bɔ fibreus tissues (fibres tissues) bɔli kojugu la. O bɛ se ka sugunɛ baara ɲɛ fo ka se hakɛ dɔ ma ani ka banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ.
Livagen ka baarakɛcogo ɲinini sugunɛ lakanani na
Ni an bɛ selilɛriw ka taamasiɲɛw siraw jateminɛ, Livagen bɛ se ka a sen don siraw labɛnni na minnu ɲɛsinnen bɛ selilɛriw ka bonya, u caya ani u ka ɲɛnamaya ma. Misali la, a bɛ se ka mitogène-activé proteine kinase (MAPK) taamasiɲɛw sira baara, o min jɔyɔrɔ ka bon selilɛriw ka bonya la, u ka danfara la ani u ka degun jaabiw la. Ni MAPK taamasiɲɛw sira baara, Livagen bɛ se ka sugunɛbilenniw caya ani ka ɲɛnamaya sabati, ka dilancogo ni u lasegincogo teliya ni sugunɛ tiɲɛna.
Livagen bɛ se ka jɛɲɔgɔnya kɛ ni sɛbɛnnikɛlanw ye selilu kɔnɔ walasa ka jɛnɛya minnu bɛ tali kɛ ɲɔgɔn na, olu jiracogo ɲɛnabɔ. Transcription factors ye farikolojɔlifɛnw kulu ye minnu bɛ siri jɛnɛya yiriwali yɔrɔ kɛrɛnkɛrɛnnenw na walasa ka jeninida sɛbɛnni ɲɛnabɔ. Livagen bɛ se ka nɔ bila sɛbɛnnikɛlan dɔw ka baara walima u jiracogo hakɛ la, o la, a bɛ fɛn dɔw jirali caman sɛmɛntiya minnu bɛ tali kɛ sugunɛbilenniw jɔcogo ladonni na, farikoloɲɛnajɛ baarakɛcogo ɲɛnabɔli la, ani farikolo tangacogo la, o la, a bɛ a ka sugunɛ lakanani nɔw jira. Misali la, a bɛ se ka nukliyɛri facteur E2-related factor 2 (Nrf2) baara ɲɛnabɔ, o ye sɛbɛnnikɛlan jɔnjɔn ye selilɛriw ka farikolo tangacogo la min bɛ farikolo tangalan anzimu jamu caman jirali kɔlɔsi. Ni Livagen bɛ Nrf2 baara, a bɛ farikolo tangalanw dilanni sabati, ka sugunɛbilenniw ka farikolo tangacogo fanga bonya, ani ka sugunɛ tanga tiɲɛni ma min bɛ sɔrɔ oksidan degun fɛ.
Ni an bɛ seliluw ni ɲɔgɔn cɛ kumaɲɔgɔnya siratigɛ la, sugunɛ suguya caman bɛ sɔrɔ sugunɛ na, i n’a fɔ sugunɛbilenniw, sugunɛbilenniw, ani Kupffer selilɛriw, olu bɛ jɛ ka baara kɛ ɲɔgɔn fɛ seliluw ni ɲɔgɔn cɛ kumaɲɔgɔnya fɛ walasa ka sugunɛ baara kɛcogo ɲuman sabati. Livagen bɛ se ka nɔ bila o farikolokisɛw ni ɲɔgɔn cɛ kumaɲɔgɔnya kɛcogo la, ka u ka jɛɲɔgɔnyaw ɲɛnabɔ. A bɛ se ka sugunɛbilenni selilɛriw ka baarakɛcogo ɲɛnabɔ, olu minnu jɔyɔrɔ ka bon sugunɛbilenni na. Livagen bɛ dɔ bɔ selilu kɔkan matirili sɔrɔli ni a bɔli la ni a bɛ sugunɛbilenni selilɛriw baarakɛli bali, o bɛ sugunɛbilenni juguya nɔgɔya. Ka fara o kan, Livagen bɛ se ka Kupffer selilɛriw ka farikolo tangacogo baarakɛcogo sɛmɛntiya, o bɛ se ka kɛ sababu ye u ka jɔyɔrɔ nafamaba ta sugunɛ funu jaabiw la ani ka sugunɛbaralabana dilancogo ni a lasegincogo sabati.
Kuncɛli
Kuma surun na, Livagen ye jɔyɔrɔba jira sugunɛ lakanani na. Sɛgɛsɛgɛli kunbabaw fɛ a kɛcogoyaw kan ani a kɛcogo ɲininiw fɛ kɛnɛyaso la, a bɛ se ka kɛ sababu ye ka sugunɛbanaw kunbɛnni ni u furakɛ.
Sosow (Sɔrɔyɔrɔw).
[1] Riadnova I, Filippov SV, Iuzhakov V V. [Sɔgɔsɔgɔninjɛ sɛnɛcogo organotipiki dɔ baarakɛcogo cogoya min bɛ sɔrɔ pepitiri livagen na][J]. Ɲɛtaa minnu kɛra mɔgɔkɔrɔbaw ka dɔnniya la, 2002,10:88-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Sɔrɔ&db=pubmed&dopt=Abstract&list_uids=12577697&query_hl=1.
[2] Brodskiĭ V, Khavinson V, Zolotarev I, ani a ɲɔgɔnnaw. [Protéines synthèse rythme sugunɛbilenniw ladamuni na ka bɔ sosow la minnu si hakɛ tɛ kelen ye. Pepitiri livagen [J] ka cogoya ni a nɔfɛkow]. Izv Akad Nauk Ser Biol, 2001 (5): 517-521. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Sɔrɔ&db=pubmed&dopt=Abstract&list_uids=15926314&ɲininkali_hl=1
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