Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Umwijima, nk'ingingo ikomeye ya metabolike mu mubiri w'umuntu, irashobora kwangirika bitewe n'impamvu zitandukanye, nk'ibiyobyabwenge, inzoga, kwandura virusi, n'uburozi bwangiza ibidukikije. Niba kwangirika kwumwijima kutagenzuwe neza, birashobora gutera fibrosis yumwijima, cirrhose, cyangwa na kanseri yumwijima, bikaba byangiza ubuzima bwabantu. Guhangayikishwa na Oxidative bigira uruhare runini mu iterambere ryangiza umwijima. Iyo umwijima uhuye nibintu byangiza, uburinganire buri hagati ya sisitemu ya okiside yumubiri na antioxydeant burahungabana, bigatuma habaho umusaruro mwinshi wubwoko bwa ogisijeni (ROS) nubundi buryo bwa radicals yubuntu. Izi radicals zubuntu zirenze ubushobozi bwa sisitemu yo kwirwanaho ya antioxydeant yumubiri kugirango ibashe kubitesha agaciro, bigatera imbaraga za okiside. Izi radicals zirenze urugero zibasira macromolecules yibinyabuzima ya selile yumwijima, nka membrane selile, proteyine, na acide nucleic, bikaviramo kwangirika kwumwijima, apoptose, cyangwa na nérosose.
Igishushanyo 1 Gahunda rusange yuburyo bwa okiside iterwa nimpamvu zitandukanye zindwara zumwijima.
Livagen, nkibintu bifite antioxydeant ishobora kuba ishobora kugabanya kwangirika kwumwijima kwatewe numwijima muguhindura uburyo bwo kwirinda antioxydeant yumubiri, bigatanga uburyo bushya bwo gukumira no kuvura ibikomere by umwijima.
Uruhare rwa Livagen muri Antioxidant Stress no Gukomeretsa Umwijima
Kugenga ibikorwa bya Enzyme Antioxidant
Livagen yongera cyane ibikorwa bya enzymes za antioxydeant mu mwijima, nka superoxide dismutase (SOD) na glutathione peroxidase (GSH-Px). SOD niwo murongo wa mbere wo kwirwanaho muri sisitemu yo kwirinda umubiri wa antioxydeant, itera guhagarika reaction ya superoxide anion radicals yubusa kugirango ikore hydrogène peroxide na ogisijeni, bityo bigabanye ibyangijwe na superoxide anion yubusa ya selile yumwijima. GSH-Px ikoresha glutathione yagabanijwe (GSH) kugirango igabanye hydrogène peroxide kumazi na lipide peroxide kuri alcool ihuye nayo, ibuza neza iterambere ryimikorere ya lipide peroxidation no kurinda ubusugire bwimyanya ndangagitsina yumwijima.
Kubungabunga Glutathione (GSH) Urwego
GSH ni antioxydants idasanzwe idafite umwijima mu mwijima, igira uruhare runini mukubungabunga redox homeostasis. Livagen irashobora kugumana urugero rwa GSH mu mwijima iteza imbere synthesis ya GSH cyangwa ikabuza kuyikoresha. GSH ntabwo igira uruhare rutaziguye mubisubizo byubusa gusa ahubwo ikora nka substrate ya GSH-Px, ikongera ibikorwa byayo birwanya antioxydeant. Iyo umwijima uhuye na okiside, GSH ikoreshwa cyane, bigatuma igabanuka ryurwego rwayo. Kwivanga kwa Livagen birashobora kugarura urwego rwa GSH, bityo bikongerera imbaraga umwijima wo kwirinda umwijima no kugabanya kwangirika kwatewe na hepatocytes.
Kubuza kwerekana ibintu bitera umuriro
Guhangayikishwa na Oxidative hamwe nibisubizo bitera imbaraga kandi bigaterana imbaraga mugihe cyangirika cyumwijima. Livagen irashobora kugabanya uburibwe bwumwijima muguhagarika kwerekana ibintu bitera umuriro, bityo bikagira ingaruka zitaziguye kuri antioxydeant. Ikintu cya kirimbuzi-κB (NF-κB) ni ikintu cyingenzi cyo kwandukura kigira uruhare runini mugutunganya ibisubizo byumuriro. Iyo umwijima uhuye nibitera imvune, NF-κB irakora, biganisha ku kwerekana ibintu bitandukanye bitera umuriro nka tumeri nekrosis factor-α (TNF-α) na interleukin-1β (IL-1β). Ibi bintu bitera umuriro byongera imbaraga za okiside, bigatera uruziga rukabije. Livagen irashobora guhagarika ibikorwa bya NF-κB, kugabanya imvugo yibintu bitera umuriro, bityo bikagabanya kwangirika kwumwijima no kugabanya imbaraga za okiside.
Igishushanyo 2 Redox homeostasis mu mwijima.
Kugabanya ibyangiritse bya lipide peroxidation
Lipid peroxidation ni bumwe mu buryo bw'ingenzi butera imbaraga za okiside itera umwijima kwangirika. ROS yibasira aside irike ya polyunzure kuri membrane selile, itera lipide peroxidation reaction kandi ikabyara lipide peroxidation nka malondialdehyde (MDA). Ibicuruzwa ni cytotoxic, bihagarika imiterere nimikorere ya selile kandi bigatera kwangirika kwumwijima. Livagen, ibinyujije mu ngaruka zayo za antioxydeant, irashobora guhagarika neza uburyo bwa lipide peroxidation reaction, kugabanya urugero rwa MDA mu ngingo zumwijima, kugabanya ibyangiritse byangiza, no kurinda imikorere isanzwe yingirangingo zumwijima.
Gukoresha Livagen mukurinda ibikomere byumwijima
Gukomeretsa Umwijima Biterwa n'ibiyobyabwenge
Gukomeretsa umwijima biterwa nibiyobyabwenge ni imwe mu ndwara zumwijima zikunze kugaragara mubikorwa byubuvuzi. Imiti myinshi, nka acetaminofeni n'imiti igabanya ubukana, irashobora kwangiza umwijima mugihe ivura indwara. Livagen yerekana ingaruka nziza zo gukingira muburyo bw'inyamaswa zo gukomeretsa umwijima. Mu buryo bwo gukomeretsa umwijima biterwa na acetaminofeni, mbere yo kuvurwa na Livagen byatumye igabanuka rikabije rya serumu alanine transaminase (ALT) na transaminase transaminase (AST), byerekana ko kugabanuka k'uburemere bw'umwijima. Byongeye kandi, isuzumabumenyi rya histopathologique ryakozwe ku mwijima w’umwijima ryerekanye ko Livagen yahinduye ihinduka ry’imiterere ya hepatocytes, igabanya necrosis ya hepatocyte, kandi igabanya ubwinjira mu ngirabuzimafatizo. Ibi byerekana ko Livagen ifite agaciro gakoreshwa mugukumira no kuvura ibikomere byatewe numwijima kandi bishobora kuba uburyo bushya bwo kuvura imiti ivura umwijima iterwa nibiyobyabwenge.
Gukomeretsa umwijima
Kunywa inzoga zirenze urugero birashobora gukomeretsa umwijima inzoga, bikangiza cyane ubuzima bw’abarwayi n’ubuzima. Livagen yerekana kandi ingaruka zo gukingira umwijima w’umwijima. Mu bushakashatsi bw’inyamanswa zatewe no gukomeretsa umwijima w’umwijima, nyuma y’ubuyobozi bwa Livagen, ibimenyetso byerekana imbaraga za okiside mu mwijima byatejwe imbere, nko kongera ibikorwa bya SOD no kugabanya urugero rwa MDA. Livagen irashobora kandi kugenga ibikorwa byimisemburo ijyanye no guhindagurika kwa alcool, kugabanya umusaruro wa radicals yubusa mugihe cyo guhinduranya inzoga, bityo bikagabanya kwangirika kwumwijima biterwa ninzoga. Livagen irashobora kubuza umwijima guterwa n'umwijima, kugabanuka kurwego rwo hasi, kandi bikarinda umwijima kwangirika. Livagen ifite ubushobozi bwo kuba imiti ifatika yo gukumira no kuvura ibikomere by umwijima.
Umwanzuro
Livagen igira ingaruka ziterwa na antioxydeant binyuze muburyo bwinshi, harimo kugenzura ibikorwa bya enzyme ya antioxydeant, gukomeza urwego rwa GSH, kubuza kwerekana ibintu byangiza, no kugabanya ibyangiritse byangiza, bityo bigatanga ingaruka zo gukingira kwangirika kwumwijima biterwa nimpamvu zitandukanye. Irerekana agaciro gashobora gukoreshwa mubice nko kwangiza umwijima biterwa numwijima no kwangirika kwumwijima.
Inkomoko
[1] Liu Y, Liu Y, Dou B, n'abandi. Ingaruka zo Kurinda Resveratrol kuri Hepatocyte Apoptose mu mwijima w’inzoga [J]. Ikinyamakuru cyibikoresho bya Biobased na Bioenergy, 2021. https://api.semanticscholar.org/CorpusID:241263658
[2] Li S, Tan H, Wang N, n'abandi. Uruhare rwa Oxidative Stress na Antioxydants mu ndwara zumwijima [J]. Ikinyamakuru mpuzamahanga cyubumenyi bwa molecular, 2015,16 (11): 26087-26124.DOI: 10.3390 / ijms161125942.
[3] Zhang Z, Gao L, Cheng Y, n'abandi. Resveratrol, antioxydants karemano, igira ingaruka zo gukingira ibikomere by umwijima biterwa na arsenic organisant [J]. Ubushakashatsi bwa Biomed International, 2014,2014: 617202.DOI: 10.1155 / 2014/617202.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
