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ụbọchị 29 gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Nchịkọta
Imeju, dị ka akụkụ ahụ dị mkpa nke metabolic na ahụ mmadụ, na-enwe ike imebi ya site na ihe dị iche iche, dị ka ọgwụ ọjọọ, mmanya, nje nje, na nsị gburugburu ebe obibi. Ọ bụrụ na a naghị achịkwa mmebi imeju nke ọma, ọ nwere ike ịga n'ihu na fibrosis imeju, cirrhosis, ma ọ bụ ọbụna ọrịa cancer imeju, na-etinye nnukwu ihe ize ndụ nye ahụike mmadụ. Nchegbu oxidative na-ekere òkè dị mkpa na mmepe nke mmebi imeju. Mgbe imeju na-ekpughe ihe ndị na-emebi emebi, nguzozi n'etiti sistemu oxidative na antioxidant nke anụ ahụ na-akụghasị, na-eduga n'ịmepụta oke nke ụdị oxygen na-emeghachi omume (ROS) na radicals ndị ọzọ n'efu. Ndị a free radicals karịrị ikike nke usoro nchebe antioxidant nke anụ ahụ nwere ike ịkwụsị ha, na-akpalite mmeghachi omume oxidative. Ihe ndị a na-emebiga ihe ókè n'efu na-awakpo macromolecules ndu nke mkpụrụ ndụ imeju, dị ka membranes cell, protein, na nucleic acid, na-ebute mmebi imeju cell, apoptosis, ma ọ bụ necrosis.
Ọgụgụ 1 Atụmatụ usoro izugbe nke nrụgide oxidative nke ihe dị iche iche kpatara na ọrịa imeju.
Livagen, dị ka ihe nwere ikike antioxidant nwere ike ibelata mmebi imeju na-akpata nrụgide oxidative site n'ịhazi usoro nchebe nke antioxidant nke anụ ahụ, na-enye ụzọ ọhụrụ maka mgbochi na ọgwụgwọ nke mmerụ imeju.
Ọrụ Livagen na Nchegbu Antioxidant na Mmerụ Imeju
Na-achịkwa ọrụ Antioxidant Enzyme
Livagen na-abawanye ọrụ nke enzymes antioxidant na imeju, dị ka superoxide dismutase (SOD) na glutathione peroxidase (GSH-Px). SOD bụ usoro nchebe mbụ na sistemu nchekwa antioxidant nke anụ ahụ, na-eme ka mmeghachi omume nhụsianya nke superoxide anion free radicals mepụta hydrogen peroxide na oxygen, si otú a na-ebelata mmebi nke radicals free superoxide anion kpatara na sel imeju. GSH-Px na-eji glutathione belatara (GSH) iji belata hydrogen peroxide na mmiri yana lipid peroxides na mmanya mmanya kwekọrọ na ya, na-egbochi ọganihu nke mmeghachi omume lipid peroxidation nke ọma ma na-echebe iguzosi ike n'ezi ihe nke membranes cell imeju.
Idokwa ọkwa Glutathione (GSH).
GSH bụ ihe dị mkpa na-abụghị enzymatic antioxidant na imeju, na-arụ ọrụ dị mkpa na-edobe intracellular redox homeostasis. Livagen nwere ike idowe ọkwa GSH n'ime imeju site n'ịkwalite njikọ GSH ma ọ bụ gbochie oriri ya. GSH abụghị naanị na-ekere òkè ozugbo na mmeghachi omume mkpachapụ radical free kamakwa ọ na-ejekwa ozi dị ka mkpụrụ maka GSH-Px, na-akwalite ọrụ antioxidant ya. Mgbe imeju na-enwe nrụgide oxidative, a na-eri GSH n'ọtụtụ buru ibu, na-eduga n'ibelata ọkwa ya. Ntinye aka nke Livagen nwere ike iweghachi ọkwa GSH, si otú a na-eme ka ikike nchebe nke imeju dịkwuo elu na ibelata nrụgide oxidative na-akpata mmebi nke hepatocytes.
Na-egbochi nkwupụta nke ihe ndị na-akpata mkpasu iwe
Nchegbu oxidative na nzaghachi mkpali na-emekọrịta ma na-ewusi ibe ha ike n'oge mmebi imeju. Livagen nwere ike belata mbufụt imeju site na igbochi nkwupụta nke ihe mkpali, si otú a na-egosipụta mmetụta antioxidant na-apụtaghị ìhè. Nuclear factor-κB (NF-κB) bụ isi ihe ntụgharị ederede nke na-arụ ọrụ dị mkpa n'ịhazi nzaghachi mkpali. Mgbe imeju na-ekpughe ihe ndị na-emerụ ahụ, NF-κB na-arụ ọrụ, na-eduga n'igosipụta ihe dị iche iche na-egbuke egbuke dị ka tumor necrosis factor-α (TNF-α) na interleukin-1β (IL-1β). Ihe ndị a na-akpasu iwe na-eme ka nrụgide oxidative dịkwuo njọ, na-emepụta usoro ọjọọ. Livagen nwere ike igbochi ọrụ NF-κB, belata nkwupụta nke ihe ndị na-eme ka ọ dị ọkụ, si otú ahụ na-ebelata mmebi imeju imeju na ịkwụsị nrụgide oxidative.
Ọgụgụ 2 The redox homeostasis na imeju.
Na-ebelata mmebi peroxidation lipid
Lipid peroxidation bụ otu n'ime isi usoro nke nrụgide oxidative na-akpata mmebi mkpụrụ ndụ imeju. ROS na-awakpo polyunsaturated fatty acids na akpụkpọ ahụ cell, na-ebute mmeghachi omume peroxidation lipid na ịmepụta ngwaahịa peroxidation lipid dị ka malondialdehyde (MDA). Ngwaahịa ndị a bụ cytotoxic, na-akpaghasị nhazi na ọrụ nke membranes cell ma na-akpata mmebi imeju. Livagen, site na mmetụta antioxidant ya, nwere ike igbochi mmeghachi omume lipid peroxidation nke ọma, belata ọkwa MDA na anụ ahụ imeju, belata mmebi akpụkpọ ahụ cell, ma chebe ọrụ nkịtị nke mkpụrụ ndụ imeju.
Ngwa nke Livagen na Nchekwa mmerụ ahụ imeju
Mmerụ imeju nke ọgwụ butere
Ọrịa imeju na-ebute ọgwụ ọjọọ bụ otu n'ime ọrịa imeju na-emekarị na ụlọ ọgwụ. Ọtụtụ ọgwụ, dị ka acetaminophen na ọgwụ mgbochi ụkwara nta, nwere ike imebi imeju mgbe a na-agwọ ọrịa. Livagen na-egosiputa mmetụta nchebe magburu onwe ya na ụdị anụmanụ nke mmerụ imeju na-akpata ọgwụ ọjọọ. N'ụdị mmerụ ahụ nke imeju kpatara acetaminophen, tupu ọgwụgwọ Livagen butere mbelata dị ukwuu na serum alanine transaminase (ALT) na aspartate transaminase (AST), nke na-egosi mbelata ịdị njọ nke imeju. Na mgbakwunye, nyocha histopathological nke anụ ahụ imeju gosiri na Livagen kwalitere mgbanwe mgbanwe ọdịdị nke hepatocytes, belata necrosis hepatocyte, yana mbelata ntinye sel mkpali. Nke a na-egosi na Livagen nwere uru ngwa ngwa na mgbochi na ọgwụgwọ nke mmerụ imeju nke ọgwụ na-ebute ma nwee ike bụrụ nhọrọ ọhụrụ maka ọgwụgwọ mgbakwunye na mmerụ imeju ọgwụ.
Imeju imeju mmanya na-egbu egbu
Ịṅụbiga mmanya ókè na-adịghị ala ala nwere ike ibute mmerụ ahụ imeju mmanya na-egbu egbu, na-emebi ụdị ndụ na ahụike nke ndị ọrịa nke ukwuu. Livagen na-egosipụtakwa mmetụta nchebe megide mmerụ ahụ imeju mmanya na-egbu egbu. N'ime nnwale anụmanụ nke mmerụ ahụ imeju mmanya na-egbu egbu, na-esochi nchịkwa nke Livagen, a na-emezi ihe nrịbama nrụgide oxidative na imeju, dị ka mmụba ọrụ SOD na belata ọkwa MDA. Livagen nwekwara ike ịhazi ọrụ nke enzymes metụtara mmanya na-aba n'anya, na-ebelata mmepụta nke free radicals n'oge metabolism mmanya, si otú ahụ na-ebelata mmebi imeju mmanya na-akpata. Livagen nwere ike igbochi mmeghachi omume mkpali imeju nke mmanya na-akpata, obere ihe na-akpata mkpali, ma na-echebekwa imeju site na mmebi. Livagen nwere ikike ịghọ ọgwụ dị irè maka mgbochi na ọgwụgwọ nke mmerụ imeju mmanya na-egbu egbu.
Mmechi
Livagen na-egosipụta mmetụta nrụgide antioxidant site na ọtụtụ usoro, gụnyere ịhazi ọrụ enzyme antioxidant, na-edobe ọkwa GSH, na-egbochi okwu mkpali, na ibelata mmebi peroxidation lipid, si otú ahụ na-enye mmetụta nchebe megide mmebi imeju nke ihe dị iche iche kpatara. Ọ na-egosipụta uru ngwa nwere ike na mpaghara dị ka mmebi imeju nke ọgwụ na-akpata na mmebi imeju mmanya na-egbu egbu.
Isi mmalite
[1] Liu Y, Liu Y, Dou B, et al. Mmetụta Nchedo nke Resveratrol na Hepatocyte Apoptosis na Imeju mmanya na-egbu egbu [J]. Akwụkwọ akụkọ nke Biobased Materials and Bioenergy, 2021. https://api.semanticscholar.org/CorpusID:241263658
[2] Li S, Tan H, Wang N, et al. Ọrụ nke Nchegbu Oxidative na Antioxidants na Ọrịa Imeju [J]. Akwụkwọ akụkọ International nke Science Molecular, 2015,16 (11): 26087-26124.DOI: 10.3390/ijms161125942.
[3] Zhang Z, Gao L, Cheng Y, et al. Resveratrol, antioxidant sitere n'okike, nwere mmetụta nchebe na mmerụ imeju nke mkpughe arsenic inorganic [J]. Biomed Research International, 2014,2014:617202.DOI:10.1155/2014/617202.
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