Cocer Peptides ye ŋlɔe 
ŋkeke 29 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Aklã, abe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ŋutinu vevi aɖe le amegbetɔ ƒe ŋutilã me ene, ate ŋu agblẽ nu le eŋu bɔbɔe tso nu vovovowo, abe atike vɔ̃ɖiwo, aha sesẽ, dɔlékuiwo ƒe dɔlékuiwo, kple aɖi siwo le nutoa me ene gbɔ. Ne womekpɔ aklã ƒe gbegblẽ dzi nyuie o la, ate ŋu ava zu aklã me fibrosis, aklã me dɔdzẽ, alo aklã me kansa gɔ̃ hã, si ate ŋu ade amegbetɔ ƒe lãmesẽ afɔku gã aɖe me. Oxidative stress wɔa akpa vevi aɖe le aklã ƒe gbegblẽ ƒe dzɔdzɔ me. Ne aklãa do go nusiwo gblẽa nu la, dadasɔ si le ŋutilãa ƒe oxidative kple antioxidant system dome me gblẽna, si wɔnɛ be reactive oxygen species (ROS) kple free radicals bubuwo dona fũ akpa. Free radicals siawo wu ŋutete si le ŋutilãa ƒe antioxidant defense system si be wòaɖe wo ɖa, si hea oxidative stress reactions vɛ. Free radicals siawo siwo gbɔ eme dzea aklã me lãmenugbagbeviwo ƒe nugbagbeviwo ƒe molecule gãwo abe lãmenugbagbeviwo ƒe lãkusiwo, proteinwo, kple nucleic acids ene dzi, si wɔnɛ be aklã me lãmenugbagbeviwo gblẽna, woƒe kuku, alo woƒe kuku.
Figure 1 Oxidative stress si nu vovovowo hena vɛ le aklãdɔléle dzi ƒe mɔnu ƒe ɖoɖo si bɔ.
Livagen, abe nusi ate ŋu anye antioxidant ŋutetewo ene, ate ŋu aɖe aklã ƒe gbegblẽ si oxidative stress hena vɛ dzi akpɔtɔ to ŋutilã ƒe antioxidant defense system dzi kpɔkpɔ me, si ana mɔnu yeye aɖe si woatsɔ axe mɔ ɖe aklã ƒe abixɔxɔ nu ahadae.
Akpa Si Livagen Wɔna Le Antioxidant Nuteɖeamedzi Kple Aklã ƒe Nuveviwɔame Me
Antioxidant Enzyme ƒe Dɔwɔwɔ Dzi Kpɔkpɔ
Livagen dzia dɔlékui siwo tsia dzoxɔxɔ nu le aklã me, abe superoxide dismutase (SOD) kple glutathione peroxidase (GSH-Px) ene ƒe dɔwɔwɔ ɖe edzi ŋutɔ. SOD nye ametakpɔnu gbãtɔ le ŋutilã ƒe ametakpɔnu si tsia dzoxɔxɔ nu, si naa superoxide anion free radicals ƒe tɔtrɔ ƒe dɔwɔwɔ wɔa hydrogen peroxide kple oxygen, si wɔnɛ be superoxide anion free radicals gblẽna le aklã me lãmenugbagbeviwo ŋu dzi kpɔtɔna. GSH-Px zãa glutathione si dzi woɖe kpɔtɔ (GSH) tsɔ ɖea hydrogen peroxide dzi kpɔtɔna wòzua tsi eye wòɖea lipid peroxides dzi kpɔtɔna wòzua aha siwo sɔ, si xea mɔ na lipid peroxidation chain reactions ƒe ŋgɔyiyi nyuie eye wòkpɔa aklã me lãmenugbagbeviwo ƒe lãkusiwo ƒe blibonyenye ta.
Glutathione (GSH) ƒe Agbɔsɔsɔme Dzi Kpɔkpɔ
GSH nye antioxidant vevi aɖe si menye enzyme o le aklã me, si wɔa akpa vevi aɖe le lãmenugbagbeviwo me redox homeostasis me léle ɖe asi me. Livagen ate ŋu alé GSH ƒe agbɔsɔsɔ ɖe te le aklã me to GSH ƒe wɔwɔme dodo ɖe ŋgɔ alo mɔxexe ɖe eƒe zazã nu me. Menye ɖeko GSH kpɔa gome le free radical scavenging reactions me tẽ ko o, ke ewɔa dɔ abe substrate na GSH-Px hã, si doa eƒe antioxidant dɔwɔwɔ ɖe ŋgɔ. Ne wotsɔ oxidative stress de aklãa me la, woɖua GSH le agbɔsɔsɔ gã aɖe me, si wɔnɛ be eƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Livagen ƒe nudede eme ate ŋu ana GSH ƒe agbɔsɔsɔ nagaɖo eŋu, si ana aklã ƒe antioxidant takpɔkpɔ ŋutete nadzi ɖe edzi eye wòaɖe nusiwo oxidative stress hena vɛ na aklãmenugbagbeviwo dzi akpɔtɔ.
Mɔxexe ɖe dɔdzẽ ƒe nusiwo woɖena fiana nu
Oxidative stress kple inflammatory responses wɔa dɔ aduadu eye wodoa ŋusẽ wo nɔewo le aklã ƒe gbegblẽɣi. Livagen ate ŋu aɖe aklã ƒe dɔdzẽ dzi akpɔtɔ to mɔxexe ɖe dɔdzẽ ƒe nusiwo woɖena fiana nu, si wɔnɛ be wòawɔ dɔ si tsia dzoxɔxɔ nu le mɔ si mele tẽ o nu. Nuclear factor-κB (NF-κB) nye nuŋɔŋlɔ ƒe akpa vevi aɖe si wɔa akpa vevi aɖe le dɔdzẽ ƒe ŋuɖoɖowo dzi kpɔkpɔ me. Ne aklãa do go abi ƒe nuwɔna la, NF-κB wɔa dɔ, si wɔnɛ be dɔdzẽ ƒe nu vovovowo abe tumor necrosis factor-α (TNF-α) kple interleukin-1β (IL-1β) ene dzena. Dɔdzẽ siawo gagblẽa nu le oxidative stress ŋu, si wɔnɛ be tsatsam vɔ̃ɖi aɖe dona. Livagen ate ŋu axe mɔ ɖe NF-κB ƒe dɔwɔwɔ nu, aɖe dɔdzẽ ƒe nusiwo woɖena fiana dzi akpɔtɔ, si ana aklã ƒe dɔdzẽ ƒe gbegblẽ dzi naɖe akpɔtɔ eye wòaɖe oxidative stress dzi akpɔtɔ.
Nɔnɔmetata 2 Redox ƒe homeostasis le aklã me.
Lipid peroxidation ƒe nugbegblẽ dzi ɖeɖe kpɔtɔ
Lipid peroxidation nye mɔnu vevi siwo dzi oxidative stress tona nana aklã me lãmenugbagbeviwo gblẽna la dometɔ ɖeka. ROS dzea ami siwo me ami ʋeʋĩ le siwo le lãmenugbagbeviwo ƒe lãkusi dzi dzi, si wɔnɛ be ami ƒe ʋuʋu ƒe dɔwɔwɔ eye wònaa ami ƒe ʋuʋu ƒe nuwɔna abe malondialdehyde (MDA) ene dona. Atike siawo nyea aɖi wu lãmenugbagbeviwo, wogblẽa lãmenugbagbeviwo ƒe lãkusiwo ƒe wɔwɔme kple dɔwɔwɔ me eye wogblẽa nu le aklã me lãmenugbagbeviwo ŋu. Livagen, to eƒe antioxidant ŋusẽkpɔɖeamedziwo dzi, ate ŋu axe mɔ ɖe lipid peroxidation reactions nu nyuie, aɖe MDA ƒe agbɔsɔsɔ dzi akpɔtɔ le aklã ƒe lãkusiwo me, aɖe lãmenugbagbeviwo ƒe lãkusi ƒe gbegblẽ dzi akpɔtɔ, eye wòakpɔ aklã me lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie ta.
Livagen Zazã le Aklã ƒe Nuveviwɔame Takpɔkpɔ Me
Atike Vɔ̃ɖiwo Ƒe Aklã ƒe Nuveviwɔame
Aklã ƒe abixɔxɔ si atikewo hena vɛ nye aklãdɔléle siwo bɔ wu le atikewɔƒewo dometɔ ɖeka. Atike geɖe, abe acetaminophen kple yɔmekpetikewo ene, ate ŋu agblẽ nu le aklã ŋu ne wole dɔlélewo dam. Livagen ɖea ametakpɔnu nyui aɖe fiana le lãwo ƒe kpɔɖeŋu siwo wowɔ le aklã ƒe abi si atikewo hena vɛ ŋu me. Le aklã ƒe abixɔxɔ ƒe kpɔɖeŋu si acetaminophen hena vɛ me la, Livagen zazã do ŋgɔ na serum alanine transaminase (ALT) kple aspartate transaminase (AST) ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ ŋutɔ, si fia be aklã ƒe abixɔxɔ ƒe sesẽ dzi ɖe kpɔtɔ. Tsɔ kpe ɖe eŋu la, aklã ƒe lãkusiwo me dzodzro le lãmenugbagbeviwo me ɖee fia be Livagen na aklãmenugbagbeviwo ƒe nɔnɔme ƒe tɔtrɔwo nyo ɖe edzi, eɖe aklãmenugbagbeviwo ƒe kuku dzi kpɔtɔ, eye wòɖe dɔdzẽ ƒe lãmenugbagbeviwo ƒe gege ɖe lãme dzi kpɔtɔ. Esia fia be asixɔxɔ si woate ŋu azã le Livagen ŋu le mɔxexe ɖe aklã ƒe abi si atikewo hena vɛ nu kple edada me eye ate ŋu anye tiatia yeye na atikewɔwɔ kpeɖeŋutɔ le aklã ƒe abi si atikewo hena vɛ me.
Ahatsunono ƒe aklã ƒe abixɔxɔ
Ahanono fũu akpa atraɖii ate ŋu ana woaxɔ abi le aklã me le aha sesẽ ta, si agblẽ nu le dɔnɔwo ƒe agbenɔnɔ kple lãmesẽ ŋu ŋutɔ. Livagen ɖea ametakpɔnu hã fiana tso ahanono ƒe aklã ƒe abixɔxɔ me. Le lãwo ƒe dodokpɔ siwo wowɔ le ahanono ƒe aklã ƒe abixɔxɔ ŋu me la, le Livagen dodo vɔ megbe la, oxidative stress markers le aklã me nyo ɖe edzi, abe SOD ƒe dɔwɔwɔ ƒe dzidziɖedzi kple MDA ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ ene. Livagen ate ŋu aɖɔ enzyme siwo do ƒome kple aha ƒe asitɔtrɔ ƒe dɔwɔwɔ hã ɖo, si aɖe free radicals ƒe wɔwɔ dzi akpɔtɔ le aha ƒe asitɔtrɔ me, si wɔnɛ be aklã ƒe gbegblẽ si aha sesẽ hena vɛ dzi naɖe akpɔtɔ. Livagen ate ŋu axe mɔ ɖe aklã ƒe dɔdzẽ ƒe ŋuɖoɖo siwo aha sesẽ hena vɛ nu, aɖe dɔdzẽ ƒe agbɔsɔsɔ dzi akpɔtɔ, eye wòagakpɔ aklãa ta tso nusiwo agblẽ le eŋu me. Ŋutete le Livagen ŋu be wòazu atike nyui aɖe si woatsɔ axe mɔ ɖe abi si woxɔna le aklã me le ahanono me kple edada me.
Nyanuwuwuw
Livagen wɔa antioxidant ƒe nuteɖeamedzi ƒe ŋusẽkpɔɖeamedzi to mɔnu vovovowo dzi, siwo dometɔ aɖewoe nye antioxidant enzyme ƒe dɔwɔwɔ dzi kpɔkpɔ, GSH ƒe agbɔsɔsɔ dzi kpɔkpɔ, mɔxexe ɖe inflammatory factor ƒe ɖeɖefia nu, kple lipid peroxidation ƒe gbegblẽ dzi ɖeɖe kpɔtɔ, si wɔnɛ be wònaa ametakpɔnu tso aklã ƒe gbegblẽ si nu vovovowo hena vɛ me. Eɖea asixɔxɔ si ate ŋu anɔ eŋudɔwɔwɔ ŋu le agblewo abe aklã ƒe gbegblẽ si atikewo hena vɛ kple aklã ƒe gbegblẽ le ahanono me ene fiana.
Dzɔtsoƒewo
[1] Liu Y, Liu Y, Dou B, kple ame bubuwo. Resveratrol ƒe Ametakpɔkpɔ ƒe Ŋusẽkpɔɖeamedzi ɖe Aklãmenugbagbeviwo ƒe Apoptosis dzi le Ahanono ƒe Aklã me[J]. Journal of Biobased Nuwo kple Bioenergy, 2021. https://api.semanticscholar.org/CorpusID: 241263658. Ƒe 1999 ƒe ɣleti gbãtɔ me
[2] Li S, Tan H, Wang N, kple ame bubuwo. Akpa si Oxidative Stress kple Antioxidants wɔna le aklãdɔlélewo me[J]. Dukɔwo Dome Molekyulãŋutinunya ƒe Agbalẽ, 2015,16 (11): 26087-26124.DOI: 10.3390 / ijms161125942.
[3] Zhang Z, Gao L, Cheng Y, kple ame bubuwo. Resveratrol, si nye dzɔdzɔmenu si tsia dzoxɔxɔ nu, kpɔa ame ta ɖe aklã ƒe abi si arsenic si me agbe mele o ƒe dɔwɔwɔ hena vɛ dzi[J]. Biomed Numekuku Dukɔwo Dome, 2014,2014:617202.DOI:10.1155/2014/617202.
Adzɔnu si li na numekuku zazã ɖeɖeko:
