By Cocer Peptides 
kwanaki 29 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Dubawa
Hanta, a matsayin muhimmiyar kwayar halitta a cikin jikin mutum, tana da saukin kamuwa da lalacewa daga abubuwa daban-daban, kamar kwayoyi, barasa, cututtuka na kwayar cuta, da gubar muhalli. Idan ba a sarrafa lalacewar hanta yadda ya kamata, zai iya ci gaba zuwa hanta fibrosis, cirrhosis, ko ma ciwon hanta, yana haifar da mummunar barazana ga lafiyar ɗan adam. Danniya na Oxidative yana taka muhimmiyar rawa wajen haɓaka lalacewar hanta. Lokacin da hanta ta fallasa ga abubuwa masu lalacewa, daidaito tsakanin tsarin oxidative da antioxidant na jiki yana rushewa, wanda ke haifar da yawan samar da nau'in oxygen mai amsawa (ROS) da sauran radicals kyauta. Wadannan radicals na kyauta sun zarce karfin tsarin kariya na antioxidant na jiki don kawar da su, yana haifar da halayen danniya. Wadannan tsattsauran ra'ayi da suka wuce kima suna kai hari ga macromolecules na halitta na kwayoyin hanta, irin su membranes cell, sunadarai, da acid nucleic, wanda ke haifar da lalacewar hanta, apoptosis, ko necrosis.
Hoto 1 Tsarin tsarin tsarin gaba ɗaya na damuwa na oxyidative da aka haifar da abubuwa daban-daban akan cutar hanta.
Livagen, a matsayin abu mai yuwuwar kaddarorin antioxidant, na iya rage lalacewar hanta da ke haifar da iskar oxygen ta hanyar daidaita tsarin kariyar antioxidant na jiki, yana ba da sabuwar hanya don rigakafi da magance raunin hanta.
Matsayin Livagen a cikin Damuwar Antioxidant da Raunin Hanta
Gudanar da Ayyukan Enzyme Antioxidant
Livagen yana haɓaka aikin enzymes antioxidant a cikin hanta, kamar su superoxide dismutase (SOD) da glutathione peroxidase (GSH-Px). SOD shine layin farko na tsaro a cikin tsarin kariya na antioxidant na jiki, yana haifar da ɓacin rai na superoxide anion free radicals don samar da hydrogen peroxide da oxygen, don haka rage lalacewar da superoxide anion free radicals ga hanta Kwayoyin. GSH-Px yana amfani da rage glutathione (GSH) don rage hydrogen peroxide zuwa ruwa da lipid peroxides zuwa barasa masu dacewa, yana hana ci gaban sarkar peroxidation na lipid da kuma kare mutuncin membranes hanta.
Kula da Matakan Glutathione (GSH).
GSH muhimmin antioxidant ne mara enzymatic a cikin hanta, yana taka muhimmiyar rawa wajen kiyaye redox homeostasis na intracellular. Livagen na iya kula da matakan GSH a cikin hanta ta hanyar inganta haɗin GSH ko hana amfani da shi. GSH ba kawai yana shiga kai tsaye a cikin halayen ɓarna na ɓacin rai ba amma kuma yana aiki azaman ma'auni don GSH-Px, yana haɓaka ayyukan antioxidant. Lokacin da hanta ta kasance cikin damuwa na oxidative, GSH yana cinyewa da yawa, yana haifar da raguwa a matakansa. Sa baki na Livagen na iya mayar da matakan GSH, ta haka ne ke haɓaka ƙarfin kare hanta na hanta da kuma rage lalacewar oxidative da ke haifar da lalacewar hanta.
Hana bayyanar cututtuka masu kumburi
Danniya mai oxidative da amsa mai kumburi suna hulɗa tare da ƙarfafa juna yayin lalacewar hanta. Livagen na iya rage kumburin hanta ta hanyar hana maganganun abubuwan da ke haifar da kumburi, ta haka a kaikaice yana yin tasirin antioxidant. Nukiliya factor-κB (NF-κB) shine maɓalli mai mahimmanci wanda ke taka muhimmiyar rawa wajen daidaita martanin kumburi. Lokacin da hanta ya bayyana ga raunin raunin da ya faru, NF-κB yana kunna, yana haifar da bayyanar cututtuka daban-daban na kumburi irin su ƙwayar cuta necrosis factor-α (TNF-α) da interleukin-1β (IL-1β). Wadannan abubuwan da ke haifar da kumburi suna kara tsananta danniya na oxidative, haifar da mummunan zagayowar. Livagen zai iya hana NF-κB kunnawa, rage maganganun abubuwan da ke haifar da kumburi, ta haka ne ya rage lalacewar hanta da kuma kawar da damuwa na oxidative.
Hoto 2 Redox homeostasis a cikin hanta.
Rage lalacewar lipid peroxidation
Lipid peroxidation yana daya daga cikin mahimman hanyoyin da damuwa na oxidative ke haifar da lalacewar hanta. ROS ta kai hari ga ƙwayoyin kitse masu ƙima a kan membrane na tantanin halitta, yana haifar da halayen peroxidation na lipid da samar da samfuran peroxidation na lipid kamar malondialdehyde (MDA). Wadannan samfurori sune cytotoxic, suna rushe tsarin da aikin membranes cell kuma suna haifar da lalacewar hanta. Livagen, ta hanyar tasirinsa na antioxidant, na iya hana halayen halayen lipid peroxidation yadda ya kamata, rage matakan MDA a cikin hanta nama, rage lalacewar membrane cell, da kare aikin al'ada na ƙwayoyin hanta.
Aikace-aikacen Livagen a cikin Kariyar Raunin Hanta
Raunin Hanta da Magani ya jawo
Raunin hanta da aka haifar da miyagun ƙwayoyi yana ɗaya daga cikin cututtukan hanta da aka fi sani da su a aikin asibiti. Magunguna da yawa, irin su acetaminophen da magungunan rigakafin tarin fuka, na iya haifar da lalacewar hanta yayin da suke magance cututtuka. Livagen yana nuna kyakkyawan sakamako na kariya a cikin nau'ikan dabbobi na raunin hanta da ke haifar da miyagun ƙwayoyi. A cikin nau'in ciwon hanta da aka haifar da acetaminophen, riga-kafi tare da Livagen ya haifar da raguwa mai yawa a cikin maganin alanine transaminase (ALT) da matakan aspartate transaminase (AST), yana nuna raguwa a cikin mummunan rauni na hanta. Bugu da ƙari, nazarin ilimin tarihin hanta na hanta ya nuna cewa Livagen ya inganta sauye-sauyen yanayi a cikin hepatocytes, rage yawan necrosis na hanta, da kuma rage ƙwayar ƙwayar ƙwayar cuta. Wannan yana nuna cewa Livagen yana da ƙimar aikace-aikacen da za a iya amfani da shi a cikin rigakafi da kuma kula da raunin hanta da aka haifar da miyagun ƙwayoyi kuma yana iya zama sabon zaɓi don maganin haɗin gwiwa a cikin raunin hanta.
Raunin hanta barasa
Yawan shan barasa na yau da kullun na iya haifar da raunin hanta na barasa, yana haifar da lahani sosai ga ingancin rayuwa da lafiyar marasa lafiya. Livagen kuma yana nuna tasirin kariya daga raunin hanta na barasa. A cikin gwaje-gwajen dabba na raunin hanta na barasa, biyo bayan gudanarwa na Livagen, an inganta alamun damuwa na oxidative a cikin hanta, kamar ƙara yawan aikin SOD da rage matakan MDA. Hakanan Livagen na iya daidaita ayyukan enzymes da ke da alaƙa da haɓakar barasa, rage samar da radicals kyauta yayin metabolism na barasa, don haka rage lalacewar hanta da barasa ta haifar. Livagen na iya hana barasa da ke haifar da haɓakar hanta, ƙananan matakan ƙwayar cuta, da kuma kara kare hanta daga lalacewa. Livagen yana da yuwuwar zama magani mai inganci don rigakafi da maganin raunin hanta na barasa.
Kammalawa
Livagen yana haifar da tasirin danniya na antioxidant ta hanyoyi da yawa, ciki har da daidaita ayyukan enzyme antioxidant, kiyaye matakan GSH, hana bayyanar cututtukan kumburi, da rage lalacewar peroxidation na lipid, ta haka ne ke ba da kariya ga lalacewar hanta ta hanyar dalilai daban-daban. Yana nuna yuwuwar ƙimar aikace-aikacen a fagage kamar lalacewar hanta da ke haifar da miyagun ƙwayoyi da lalacewar hanta ta barasa.
Sources
[1] Liu Y, Liu Y, Dou B, et al. Tasirin Kariya na Resveratrol akan Hepatocytes Apoptosis a cikin Hanta Barasa[J]. Jaridar Materials da Bioenergy, 2021. https://api.semanticscholar.org/CorpusID:241263658
[2] Li S, Tan H, Wang N, et al. Matsayin Damuwa na Oxidative da Antioxidants a cikin Cututtukan Hanta[J]. Jarida ta Duniya na Kimiyyar Kwayoyin Halitta, 2015,16 (11):26087-26124.DOI:10.3390/ijms161125942.
[3] Zhang Z, Gao L, Cheng Y, et al. Resveratrol, antioxidant na halitta, yana da tasirin kariya akan raunin hanta wanda ya haifar da bayyanar arsenic na inorganic [J]. Biomed Research International, 2014,2014:617202.DOI:10.1155/2014/617202.
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