Los ntawm Cocer Peptides 
29 hnub dhau los
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Lub siab, uas yog ib qho tseem ceeb hauv lub cev metabolic hauv tib neeg lub cev, muaj kev cuam tshuam rau kev puas tsuaj los ntawm ntau yam, xws li tshuaj, cawv, kab mob, thiab tej co toxins. Yog tias daim siab tsis raug tswj tau zoo, nws tuaj yeem ua rau daim siab fibrosis, cirrhosis, lossis txawm tias mob qog noj ntshav, ua rau muaj kev hem thawj rau tib neeg noj qab haus huv. Oxidative stress plays lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm daim siab puas. Thaum lub siab raug cuam tshuam los ntawm kev puas tsuaj, qhov sib npaug ntawm lub cev oxidative thiab antioxidant systems raug cuam tshuam, ua rau ntau dhau ntawm cov pa oxygen reactive (ROS) thiab lwm yam dawb radicals. Cov dawb radicals no dhau lub cev tiv thaiv kab mob antioxidant lub peev xwm los ua kom tsis muaj zog, ua rau muaj kev ntxhov siab oxidative. Cov dawb radicals ntau dhau los tua cov kab mob macromolecules ntawm daim siab hlwb, xws li cell membranes, proteins, thiab nucleic acids, ua rau lub siab puas hlwb, apoptosis, los yog necrosis.
Daim duab 1 Lub tswv yim dav dav ntawm oxidative kev nyuaj siab tshwm sim los ntawm ntau yam ntawm kab mob siab.
Livagen, raws li ib yam khoom uas muaj peev xwm antioxidant, tuaj yeem txo oxidative kev ntxhov siab vim lub siab puas tsuaj los ntawm kev tswj lub cev tiv thaiv kab mob antioxidant, muab txoj hauv kev tshiab rau kev tiv thaiv thiab kho mob siab.
Lub luag haujlwm ntawm Livagen hauv Antioxidant Stress thiab Mob Siab
Regulating Antioxidant Enzyme Kev Ua Haujlwm
Livagen nce kev ua haujlwm ntawm cov enzymes antioxidant hauv lub siab, xws li superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px). SOD yog thawj kab ntawm kev tiv thaiv hauv lub cev tiv thaiv kab mob antioxidant, catalyzing dismutation cov tshuaj tiv thaiv ntawm superoxide anion dawb radicals los tsim hydrogen peroxide thiab oxygen, yog li txo qhov kev puas tsuaj los ntawm superoxide anion dawb radicals rau daim siab hlwb. GSH-Px siv txo glutathione (GSH) kom txo cov hydrogen peroxide rau dej thiab lipid peroxides rau lawv cov cawv sib xws, zoo inhibiting kev loj hlob ntawm lipid peroxidation chain reactions thiab tiv thaiv kev ncaj ncees ntawm daim siab cell membranes.
Tuav Glutathione (GSH) Qib
GSH yog ib qho tseem ceeb uas tsis yog-enzymatic antioxidant nyob rau hauv daim siab, ua lub luag haujlwm tseem ceeb hauv kev tswj hwm intracellular redox homeostasis. Livagen tuaj yeem tswj hwm qib GSH hauv siab los ntawm kev txhawb nqa GSH synthesis lossis inhibiting nws noj. GSH tsis tsuas yog koom ncaj qha rau hauv cov tshuaj dawb radical scavenging nkaus xwb tab sis kuj tseem ua lub substrate rau GSH-Px, txhim kho nws cov haujlwm antioxidant. Thaum lub siab raug rau oxidative kev nyuaj siab, GSH yog noj nyob rau hauv ntau qhov ntau, ua rau txo qis hauv nws qib. Livagen txoj kev cuam tshuam tuaj yeem rov qab GSH qib, yog li txhim kho lub siab lub peev xwm tiv thaiv antioxidant thiab txo oxidative kev ntxhov siab vim kev puas tsuaj rau hepatocytes.
Inhibiting kev qhia ntawm inflammatory yam
Oxidative stress thiab inflammatory teb cuam tshuam thiab txhawb ib leeg thaum lub siab puas tsuaj. Livagen tuaj yeem txo lub siab mob los ntawm inhibiting kev qhia ntawm cov kab mob inflammatory, yog li indirectly exerting ib tug antioxidant nyhuv. Nuclear factor-κB (NF-κB) yog qhov tseem ceeb ntawm kev hloov pauv uas ua lub luag haujlwm tseem ceeb hauv kev tswj cov lus teb inflammatory. Thaum lub siab raug rau kev raug mob stimuli, NF-κB tau qhib, ua rau kev qhia ntawm ntau yam inflammatory yam xws li qog necrosis factor-α (TNF-α) thiab interleukin-1β (IL-1β). Cov inflammatory yam tseem ceeb ntxiv exacerbate oxidative kev nyuaj siab, tsim ib tug vicious voj voog. Livagen tuaj yeem cuam tshuam NF-κB kev ua haujlwm, txo cov kev qhia ntawm cov kab mob inflammatory, li no alleviating daim siab inflammatory puas thiab relieving oxidative kev nyuaj siab.
Daim duab 2 Lub redox homeostasis hauv daim siab.
Alleviating lipid peroxidation puas
Lipid peroxidation yog ib qho ntawm cov txheej txheem tseem ceeb uas oxidative kev nyuaj siab ua rau lub siab puas hlwb. ROS nres polyunsaturated fatty acids ntawm lub cell membrane, ua rau lipid peroxidation cov tshuaj tiv thaiv thiab tsim lipid peroxidation cov khoom xws li malondialdehyde (MDA). Cov khoom no yog cytotoxic, cuam tshuam cov qauv thiab kev ua haujlwm ntawm cell membranes thiab ua rau daim siab cell puas. Livagen, los ntawm nws cov teebmeem antioxidant, tuaj yeem cuam tshuam cov tshuaj tiv thaiv lipid peroxidation, txo MDA qib hauv daim siab cov ntaub so ntswg, txo cov cell membrane puas, thiab tiv thaiv lub cev ua haujlwm ntawm daim siab hlwb.
Kev siv Livagen hauv Kev Tiv Thaiv Mob Siab
Drug-Induced Liver Injury
Drug-induced daim siab raug mob yog ib qho ntawm cov kab mob siab tshaj plaws hauv kev kho mob. Ntau cov tshuaj, xws li acetaminophen thiab tshuaj tiv thaiv tuberculosis, yuav ua rau lub siab puas tsuaj thaum kho cov kab mob. Livagen qhia txog kev tiv thaiv zoo heev hauv cov tsiaj qauv ntawm kev raug mob rau lub siab. Hauv cov qauv kev raug mob ntawm daim siab acetaminophen, kev kho ua ntej nrog Livagen ua rau txo qis hauv cov ntshav alanine transaminase (ALT) thiab aspartate transaminase (AST) qib, qhia txog kev txo qis ntawm daim siab raug mob. Tsis tas li ntawd, kev soj ntsuam histopathological ntawm daim siab tau pom tias Livagen txhim kho kev hloov pauv ntawm cov kab mob hepatocytes, txo cov hepatocyte necrosis, thiab txo qis cov cell infiltration. Qhov no qhia tau hais tias Livagen muaj peev xwm siv tau tus nqi hauv kev tiv thaiv thiab kev kho mob ntawm cov tshuaj ua rau lub siab raug mob thiab tej zaum yuav yog ib qho kev xaiv tshiab rau kev kho mob ntxiv rau hauv kev raug mob lub siab.
Alcoholic daim siab raug mob
Kev haus cawv ntau dhau tuaj yeem ua rau lub siab mob cawv, ua rau cov neeg mob lub neej zoo thiab kev noj qab haus huv. Livagen kuj pom muaj kev tiv thaiv tiv thaiv kab mob cawv ua rau lub siab raug mob. Hauv kev sim tsiaj ntawm kev raug mob ntawm lub siab cawv, tom qab kev tswj hwm ntawm Livagen, oxidative stress markers hauv daim siab tau txhim kho, xws li nce SOD kev ua si thiab txo MDA qib. Livagen tseem tuaj yeem tswj hwm kev ua haujlwm ntawm cov enzymes cuam tshuam nrog cawv metabolism, txo qis kev tsim tawm ntawm cov dawb radicals thaum lub sijhawm cawv metabolism, yog li txo cov cawv ua rau lub siab puas tsuaj. Livagen tuaj yeem cuam tshuam kev haus dej cawv ua rau lub siab ua rau cov lus teb, txo qis qhov ua rau mob, thiab tiv thaiv daim siab ntxiv los ntawm kev puas tsuaj. Livagen muaj peev xwm los ua ib qho tshuaj zoo rau kev tiv thaiv thiab kev kho mob ntawm daim siab mob cawv.
Xaus
Livagen tawm dag zog tiv thaiv kev ntxhov siab los ntawm ntau lub tswv yim, suav nrog kev tswj hwm kev ua haujlwm antioxidant enzyme, tswj GSH qib, inhibiting inflammatory factor qhia, thiab txo lipid peroxidation kev puas tsuaj, yog li muab kev tiv thaiv rau daim siab puas tsuaj los ntawm ntau yam. Nws qhia tau tias muaj peev xwm siv tau rau hauv thaj chaw xws li tshuaj tiv thaiv lub siab puas tsuaj thiab ua rau lub siab qaug cawv.
Qhov chaw
[1] Liu Y., Li Y., Dou B., et al. Kev Tiv Thaiv Cov nyhuv ntawm Resveratrol ntawm Hepatocyte Apoptosis hauv Cawv Cawv [J]. Phau ntawv Journal of Biobased Materials thiab Bioenergy, 2021. https://api.semanticscholar.org/CorpusID: 241263658
[2] Li S, Tan H, Wang N, et al. Lub luag haujlwm ntawm Oxidative Stress thiab Antioxidants hauv Kab Mob Siab [J]. International Journal of Molecular Sciences, 2015,16(11):26087-26124.DOI:10.3390/ijms161125942.
[3] Zhang Z, Gao L, Cheng Y, et al. Resveratrol, ntuj antioxidant, muaj kev tiv thaiv ntawm daim siab raug mob los ntawm inorganic arsenic raug [J]. Biomed Research International, 2014, 2014: 617202.DOI: 10.1155/2014/617202.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
