Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Thymuline ni imisemburo ya neuroendocrine yabanje kwitwa 'serum thymic factor ' (FTS). Ikorwa cyane cyane na thymic epithelial selile kandi ikagira ingaruka yibinyabuzima mumubiri muburyo buhujwe na poroteyine zitwara na ion zinc (Zn⊃2; ⁺). Nka misemburo ya peptide, Thymuline igira uruhare rukomeye mugutunganya ubudahangarwa bw'umubiri. Tymus igira uruhare runini mu mikurire no gukura kwa sisitemu y’umubiri, kandi nkikintu cyingenzi cyasohowe na thymus, ituze ryimikorere ya Thymuline ningirakamaro mugukomeza ubudahangarwa busanzwe mumubiri. Uko imyaka igenda yiyongera, thymus igenda itera buhoro buhoro, kandi ururenda rwa Thymuline rugabanuka uko bikwiye, ibyo bikaba bifitanye isano no kugabanuka kwimikorere yumubiri. Mubasaza, imikorere yumubiri iragabanuka muri rusange, kandi igice cyibi gishobora kuba kijyanye no kugabanuka kwa Thymuline.
Igishushanyo 1 Igishushanyo cyerekana uruhare rwa thymuline mugutunganya ibikorwa bya neuro-immunite endocrine.
Uruhare muri sisitemu yubudahangarwa
T lymphocyte itandukanya: Thymuline numusemburo wingenzi mugutandukanya T lymphocyte. Lymphocytes T igira uruhare runini mubudahangarwa bw'umubiri muri sisitemu yumubiri, harimo kumenya no kurandura selile zanduye virusi, selile yibibyimba, nizindi. Thymuline igira uruhare runini mugutandukanya buhoro buhoro lymphocytes T na selile progenitor muri thymus mubice bya T bikuze bikuze bifite imirimo itandukanye, nkumufasha T selile (Th) na cytotoxic T selile (Tc). Muri ubu buryo bwo gutandukanya, thymuline igira uruhare mukugenzura imiterere yuruhererekane rwa gen, guteza imbere lymphocytes T kubona ibimenyetso byihariye biranga imiterere yimiterere, bityo bikabafasha kumenya neza no gusubiza ibintu bitandukanye biterwa na antigenic.
Kugena igipimo cya selile zifasha T na selile suppressor: Thymuline ifasha kugumana igipimo gisanzwe hagati ya T umufasha wa selile na suppressor selile. Utugingo ngengabuzima T dufasha lymphocytes B mu gukora antibodies, kuzamura ubushobozi bwa fagocytike ya macrophage, no guteza imbere ikwirakwizwa rya selile T. Inhibitory T selile kurundi ruhande, ihagarika ibikorwa birenze urugero byubudahangarwa bw'umubiri, birinda indwara ziterwa na autoimmune. Thymuline yemeza ko ubudahangarwa bw'umubiri bushobora kurwanya virusi itera indwara mu gihe hirindwa ubudahangarwa bukabije bw’umubiri bushobora kwangiza umubiri w’umubiri mu kugenzura neza igipimo cy’ubwo bwoko bubiri. Urwego rwa thymuline rudasanzwe rushobora guhungabanya iyi mpirimbanyi, bishobora gutera ubudahangarwa bw'umubiri, nk'ubwiyongere bw'indwara ziterwa na autoimmune.
Ingaruka zo kurwanya inflammatory: Thymuline yerekana ibintu byingenzi birwanya inflammatory. Irashobora kugabanya irekurwa ryabunzi batera umuriro, nka cytokine (urugero, ikibyimba cya nekrosis yibintu-α (TNF-α), interleukin-6 (IL-6), nibindi) na chemokine, bigira uruhare mugushakisha ingirabuzimafatizo no kongera ibimenyetso byerekana umuriro mugihe cyo gusubiza. Thymuline irashobora kugenzura ibintu birwanya inflammatory, nka interleukin-10 (IL-10), ibuza gukora ingirabuzimafatizo no kubyara abunzi batera umuriro, bityo bikagira ingaruka zo kurwanya inflammatory. Thymuline irashobora kandi kugenga ibintu byandikirwa hamwe ninzira zerekana ibimenyetso kugirango igenzure iterambere ryibisubizo byumuriro kurwego rwa molekile. Muri leta zitera umuriro, nko muburyo bw'imbeba yo gutwikwa iterwa na progaramu ya Freund yuzuye (CFA), kuvura Thymulin byagabanije cyane hyperalgesia na paw edema, mu gihe kandi byagabanije gukora mikorobe iterwa na CFA, fosifora ya p38 mitogen-ikora protein kinase (p38 MAPK), kandi ikabyara umusaruro wa sikokine ikingira uruti rw'umugongo. n'umusaruro w'abunzi bo hagati.
Kugena ibikorwa bya fagocyte: Mubitegererezo bimwe byubushakashatsi, nkicyitegererezo cyimbeba ya granuloma ya BCG, kuvura Thymulin 5CH byateje imbere uburyo bwo gutwika granuloma. By'umwihariko, yagengaga itandukanyirizo rya fagocytes yaho na sisitemu, iteza imbere gutandukanya ingirabuzimafatizo ya B1 ya peritoneal B1 muri fagocytes, kandi igabanya umubare wa fagocytes yanduye muri lesion, byerekana ko kwandura kugabanuka. Ubuvuzi bwa Thymuline kandi bwongera umubare wa B1 ukomoka kuri fagocytes, CD4⁺, na CD8⁺ T lymphocytes mu mitsi ya lymph yaho, byerekana ko Thymulin itagira uruhare mu gutandukanya fagocyte gusa ahubwo inagira ingaruka ku kwimuka kw ingirabuzimafatizo za T mu mitsi ya lymph yaho, bityo bikazamura ubushobozi bwo kwirinda indwara.
Porogaramu
Kuvura indwara zanduza: Urebye imiti ya Thymuline irwanya inflammatory, ifite agaciro gakoreshwa mukuvura indwara zitandukanye. Mu bushakashatsi bujyanye no kuvura asima idakira, ubuvuzi bwa gene bwakozwe hakoreshejwe guhumeka plasmid igaragaza Thymuline. Indwara imaze guhagarara neza, imbeba zahawe imiti imwe yo kuvura hakoreshejwe ubuyobozi bwa tracheal. Nyuma y'iminsi 20, ibintu by'ingenzi by’indwara ya asima mu bihaha, nko gutwika indwara zidakira, fibrosis yo mu bihaha, no kugenzura imashini zidasanzwe, byari bisanzwe. Ubundi isesengura ryakozwe hamwe na selile yemeje ko ubwo buvuzi bwagezweho binyuze mu kurwanya anti-inflammatory na anti-fibrotic. Muburyo bwimbeba ya asima ya ovalbumin iterwa na asima ya allergique ivurwa hamwe na ADN nanoparticles itwara plasmide ya Thymulin, imiti imwe yonyine yashoboye gukumira ibihaha, kwanduza kolagen, hamwe na hypertrophy yimitsi yoroshye, mugihe byanonosoye ubukanishi bwibihaha, bityo bikingura inzira nshya zo kuvura asima idakira. Mu zindi ndwara zanduza nka rubagimpande ya rubagimpande n'indwara zifata amara, nubwo kuri ubu ziri mu rwego rw'ubushakashatsi, zishingiye ku buryo bwa Thymulin bwo kurwanya inflammatory, biteganijwe ko kugenzura urugero rwa Thymuline cyangwa kwigana ingaruka zabyo bishobora kugabanya ibimenyetso by’umuriro no kugenzura indwara.
Indwara ziterwa n'ubudahangarwa: Ku ndwara ziterwa no kutagabanya ubudahangarwa bw'umubiri, nk'indwara ziterwa na autoimmune, Thymulin nayo ishobora kugira uruhare runini. Mugutandukanya itandukanyirizo rya lymphocyte T hamwe nikigereranyo cya selile zifasha T na selile suppressor, Thymulin irashobora gukosora imikorere yumubiri udasanzwe kandi ikagabanya kwangirika kwinyama ningingo ziterwa nigitero cya autoimmune. Mu bushakashatsi bumwe na bumwe bw’inyamaswa, Thymulin yerekanye ko hari byinshi byahinduye muburyo bwindwara ziterwa na autoimmune.
Ubuvuzi bujyanye n'indwara zandura: Mu ndwara zandura, Thymuline irashobora kongera ubushobozi bw'umubiri bwo gukuraho indwara ziterwa na virusi mu kugenzura imikorere y’umubiri. Mu kwandura virusi, Thymuline irashobora kongera ubudahangarwa bw'umubiri mu kugabanya imikorere ya lymphocyte T, bityo igahanagura neza selile zanduye virusi. Ingaruka zayo zo kurwanya inflammatory nazo zifasha kugabanya kwangirika kwinyama ziterwa no gutwika no gukumira ibyangiritse byatewe no gukabya gukabije.
Umwanzuro
Muri make, Thymulin igira uruhare runini mugutunganya sisitemu yumubiri kandi ifite uruhare runini mu ndwara zanduza, indwara ziterwa n’ubudahangarwa, n’indwara zanduza.
Inkomoko
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