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ƆL DI ATIKUL ƐN PRODƆKT INFƆMƐSHƆN WE DƐN GI NA DIS WƐBSAYT NA FƆ ƆL DI INFƆMƐSHƆN DISƐMƐNƐSHƆN ƐN FƆ EDYUKESHƆN.
Di prɔdak dɛn we dɛn gi na dis wɛbsayt na fɔ in vitro risach nɔmɔ. in vitro risach (Latin: *in glas*, we min insay glas) dεn de du am ausayd mכtalman bכdi. Dɛn prɔdak ya nɔto mɛrɛsin, dɛn nɔ gɛt di aprɔval frɔm di US Food and Drug Administration (FDA), ɛn dɛn nɔ fɔ yuz dɛn fɔ protɛkt, trit, ɔ mɛn ɛni mɛrɛsin, sik, ɔ sik. Di lɔ nɔ gri fɔ mek dɛn put dɛn tin ya insay mɔtalman ɔ animal bɔdi ɛni we.
Ovaviu fɔ di tin dɛn we dɛn dɔn lan
taymulin na nyuroεndokrin כmon we dεn bin kכl fכs 'sεrum taymik fכktכ' (FTS). i fכs fכ prodyuz bay taymik εpitεlial sεl dεm εn i de εksyεrt in bayolojikal ifekt dεm na di bכdi in fכm we de bכnd to kכria protin dεm εn zink ayכn dεm (Zn⊃2;+). as pεptida כmon, Thymulin de ple wan indispεnsεbl rol insay di imyun rεguleshכn prכsεs fכ di bכdi. di taymus de ple imכtant rol fכ divεlכpmεnt εn machכ di imyun sistεm, εn as imכtant sכbstans we di taymus de kכl, di stεbiliti fכ di Taymulin in fכnshכn implεnt fכ mεnten nכmal imyun stetכs na di bכdi. as di ej de go כp, di taymus de atrofi sכmtεm, εn di Taymulin sekreshכn de dכn akɔdin to dat, we de sho se di imyun sistεm fכ wok we de dכn. pan di ol pipul dεm, di imyun fכnshכn jεnarali de dכn, εn pat pan dis kin bi fכ ridyus di Thymulin sekreshכn.
fig 1 wan skematik dayagram fכ di rol we taymulin de ple fכ rεgεl nyuro-imyun εndokrin akshכn dεm.
Di wok we di Imyun Sistɛm de du
T limfosayt difrεns: Taymulin na di kכl כmon we de mek di T limfosayt difrεns. di t limfosayt dεm de ple imכtant rol fכ di sεl imyuniti insay di imyun sistεm, inklud fכ no εn fכ pul di sεl dεm we di patכgens, tכmכro sεl dεm, εn כda wan dεm infεkt. taymulin de ple imכtant rol fכ difrεns sכmtεm di T limfosayt dεm frכm di projenitor sεl dεm na di taymus to machכ T sεl sכbsεt dεm wit difrεnt fכnshכn dεm, lεk εlp T sεl dεm (Th) εn saytotoksik T sεl dεm (Tc). insay dis difrεns prכsεs, taymulin de tek pat fכ rεgεl di εksprεshכn fכ wan siriכs jin dεm, we de protεkt di T limfosayt dεm fכ gεt spεsifi k sεf mak dεm εn fכnshכnal kכntribyushכn dεm, we de mek dεn ebul fכ no kכrekt wan εn rεspכnd to difrεn antijεnik stimuli dεm.
rεgεl di rεshכn fכ di T εlp sεl dεm to di sכpres sεl dεm: di taymulin de εp fכ mεnten di nכmal rεshכ bitwin di T εlp sεl dεm εn di sכpres sεl dεm. di t hεlp sεl dεm de εp di B limfosayt dεm fכ prodyuz antibodi dεm, de εnhans di fagosaytik kapasiti fכ makrofag dεm, εn de mek di T sεl dεm proliferashכn εn difrεns. di inhibitory T sel dεm, na di כda say, de sכpres di εksyכsiv aktibכshכn fכ di imyun rεspכns, we de mek di כtoimyun sik dεm nכ bigin. taymulin de mek sכh se di imyun sistεm kin ebul fכ kכmbat fכrin pathogens dεm fayn fayn wan we i de avכyd fכ pasmak imyun rεspכns we kin damej di bכdi in כwn tisu dεm bay we i de rεgεl di rεshכn fכ dεn tu tכp sεl dεm ya fayn fayn wan. di abnכmal taymulin lεvεl kin disrupt dis bεlε, we kin mek di imyun dεm nכ de wok fayn, lεk fכ inkrεs risk fכ כtoimyun sik dεm.
Anti-inflammatory ifekt dεm: Taymulin de sho signifyant anti-inflammatory prכpati dεm. i kin dכwnrεgul di rilis fכ inflammatory mεdiate dεm, lεk saytokεn dεm (εgz., tכmכro nεkrכsis fכktכ-α (TNF-α), intalyukin-6 (IL-6), εtk) εn kεmokin dεm, we de ple rol fכ rikrut imyun sεl dεm εn amplify inflammatory signal dεm di tεm we inflammatory rεspכns de. taymulin kin upregulate anti-inflammatory fכktכ dεm, lεk intalyukin-10 (IL-10), we de inhibit di aktibכshכn fכ inflammatory sεl dεm εn di prodyushכn fכ inflammatory mεdiate dεm, we de mek i de εksyεrt anti-inflammatory ifekt dεm. taymulin kin rεgεl bak transkripshכn fכktכ dεm εn riletid signal path dεm fכ kכntrכl di prכgreshכn fכ inflammatory rεspכns dεm na di mכlikul lεvεl. insay inflammatory stet, lεk insay wan rat mכdel fכ inflameshn we komplit Freund in adjuvant (CFA) indyuz, Thymulin tritmεnt sכmtεm rεdכks hayparaljεsia εn paw εdima, we i de dכn bak CFA-indyus maykroglia aktibכshכn, fכsfכrayleshכn fכ p38 maytojen-aktivεt protin kinaz (p38 MAPK), εn prodyushכn fכ pro-inflammatory saytokεn dεm na di spεnal kכd, we de sho se i de εliviet inflammatory rispכns dεm bay we i de inhεbit di aktibכshכn fכ di spεnal kכd maykroglia εn di prodyushכn fכ sεntri inflammatory mεdiate dεm.
rεgulεshכn fכ di fagosayt aktvכti: insay sכm εkspεriεns mכdel dεm, lεk di BCG-indyus maws granuloma mכdel, Thymulin 5CH tritmεnt impruv di granuloma inflammatory prכsεs. spεshal wan, i rεgεl di difrεns fכ lokal εn sistεmik fagosayt dεm, protεkt di difrεns fכ di pεritoneal B1 stεm sεl dεm insay fagosayt dεm, εn ridyus di nכmba fכ infεkt fagosayt dεm na di lεshכn, we sho se di infεkshכn de εliviet. di tritmεnt fכ di taymulin de inkrεs bak di nכmba fכ di fagosayt dεm we kכmכt frכm B1, CD4+, εn CD8+ T limfosayt dεm na di lokal limf no dεm, we sho se Thymulin nכ nכ de infכlכ di fagosayt difrεns bכt i de afekt di maygrεshכn fכ T sεl dεm to lokal limf no dεm, we de mek di lokal imyun difεns kεpabiliti dεm go bכku.
Aplikeshɔn dɛn
Tritmɛnt fɔ inflammatory sik dɛm: Giv Thymulin in anti-inflammatory prɔpati dɛm, i gɛt pɔtɛnɛshɛl aplikeshɔn valyu fɔ trit difrɛn inflammatory sik dɛm. Insay stεdi dεm pan di tritmεnt fכ krεse asma, dεn bin gi jin tεrapi bay we dεn inhal wan plasmid we de εksprεs Thymulin. Afta di sik bin ful stebul, dɛn gi mays wan singl doz tritmɛnt via trakial administreshɔn. Twɛnti dez afta dat, di men patɔlɔjik ficha dɛm fɔ asma na di lɔng dɛm, lɛk krɛse inflameshɔn, pulmonary fibrosis, ɛn abnɔmal mɛkanikal rigyuleshɔn, bin nɔmal. fכda tisu εn sεlyul analisis kכnfכm se dis tεrapi intavεnshכn bin achyv tru in anti-inflammatory εn anti-fibrotic ifekt dεm. Insay wan maws mɔdel fɔ ovalbumin-induced allergic asthma we dɛn trit wit DNA nanoparticles we de kɛr di Thymulin plasmid, wan singl-dos tritmɛnt bin ebul fɔ mek di pulmonary inflametion, collagen deposition, ɛn smooth muscle hypertrophy nɔ apin, we i bin de impruv di pulmonary mechanics, so dat i opin nyu we fɔ trit kronik asma. Insay ɔda inflammatory sik dɛm lɛk rεumatoid atraytis ɛn inflammatory bowel disease, pan ɔl we naw i de na di risach stej, bays pan Thymulin in anti-inflammatory mechanism, dɛn tink se fɔ rεgul di Thymulin lεvεl ɔr miks in ifekt kin mek di inflammatory simptom dεm εn kɔntrol di sik we de go bifo.
Sik dɛm we gɛt fɔ du wit imyun: Fɔ sik dɛm we di imyun nɔ de wok fayn, lɛk ɔtoimyun sik dɛm, Thymulin kin ple impɔtant pat bak. bay we i de rεgεl di T limfosayt difrεns εn di rεshכn fכ di T εlp sεl dεm to di sכpres sεl dεm, Thymulin kin kכrekt abnכmal imyun sistεm aktibכshכn εn ridyus di damej to di tisu dεm εn כgan dεm we כtoimyun atak de kכz. insay sכm animal εkspεriεns, Thymulin dכn sho sכm improvεmεnt pan sכm כtoimyun sik mכdel dεm.
Adjuvant tεrapi fכ infεkshכn sik dεm: Insay infεkshכn sik dεm, Thymulin kin εnhans di bכdi in abiliti fכ klia pathogens bay we i de rεgεl di imyun sistεm fכ wok. insay vayral infεkshכn, Thymulin kin εnhans di bכdi in sεlyul imyun rεspכns bay we i de rεgεl di T limfosayt fכnshכn, we de mek i klin di sεl dεm we di vayrus infεkt mכr ifektiv wan. di anti-inflammatory ifekt dεm we i de gi de εp bak fכ ridyus inflammation-induced tissue damej εn fכ mek sεkכnd harm we kכz fכ pasmak inflammatory rεspכns.
Dɔn
fכ sכmari, Thymulin de ple mכlti fכs rol insay imyun sistεm rεgulεshכn εn i gεt sכm aplikεshכn insay inflammatory sik dεm, imyun rεguleshכn-rεlatεd sik dεm, εn infεkshכn sik dεm.
Sos dɛn we dɛn pul
[1] Bonamin L, Sato C, Santana F, ɛn ɔda pipul dɛn. difrεns εn mכdulashכn fכ fagosayt aktvכti in mכrin granuloma afta tritmεnt wit taymulin 5cH[J]. Int ɛ rnash ɔ nal J ɔ rnal ɔ f Ay Dilushɔn Risach - Issn 1982-6206, 2021,11:148.DOI:10.51910/ijhdr.v11i40.580.
[2] Da S. A., de Oliveira G. P., Kim N, ɛn ɔda pipul dɛn. Nanoparticle-based thymulin jin tεrapi de tεrapi rivεs ki patכlayzm fכ εkspεriεns alerjik asma[J]. Sayns Advans, 2020,6(24):eaay7973.DOI:10.1126/sciadv.aay7973.
[3] Nasseri B, Zaringhalam J, Daniali S, ɛn ɔda pipul dɛn. thymulin tritmεnt de atεnuet inflammatory pen bay we i de mכdulet spεnal sεlyul εn mכlikul signal path dεm[J]. Int ɛ rnash ɔ nal Imyunofarmak ɔ l ɔ ji, 2019, 70: 225-234.DOI: 10.1016/j.intimp.2019.02.042.
[4] Da S. A., Martini S. V., Abreu S. C., ɛn ɔda pipul dɛn. DNA nanoparticle-mediated thymulin jin tεrapi de prεvεnt di aywe rimכdelin in εkspεriεns alerjik asma[J]. J ɔ rnal ov Kɔntrold Rilis, 2014,180:125-133.DOI:10.1016/j.jconrel.2014.02.010.
[5] Haddad JJE, ENES, Garabedian B S. Taymulin: Wan Imɛjin Anti-Inflammatory Mɔlikul[J]. Kɔrɛnt Mɛdisinal Kwɛstyɔn - Anti-Inflammatory & Anti-Alɛji Ejen, 2005,4:333-338. https://api.semanticscholar.org/CorpusID:55757311. Di wan dɛn we de stɔdi bɔt di Baybul
[6] Haddad J, Saadé N, Safieh-Garabedian B. Taymulin: Wan Imɛjin Anti-Inflammatory Mɔlikul[J]. Kɔrɛnt Mɛdisinal Kwɛstyɔn - Anti-Inflammatory & Anti-Alɛji Ejen, 2005,4:333-338.DOI:10.2174/ 15680140540 65195.
[7] Safieh B, Kendall M. D., Nɔman J. C., ɛn ɔda pipul dɛn. wan nyu raydioimyunoasεy fכ di taymik pεptida taymulin, εn in aplikεshכn fכ mεzj taymulin insay bכdi sεmpl[J]. J ɔ rnal ov Imyunolojikal Mɛtɔd, 1990,127(2):255-262.DOI:10.1016/0022-1759(90)90076-8.
Prodak we de fɔ yuz fɔ risach nɔmɔ:
