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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Muri sisitemu yimyororokere ya endocrine, Luteinizing Hormone (LH) igira uruhare runini, igenga neza ibyiciro byinshi byimyororokere, uhereye kumikurire yumusemburo, ovulation, kugeza corpus luteum no kuyitaho, buri ntambwe isaba uruhare rwa LH. Chonluten, nkibintu bifitanye isano rya bugufi n’imyororokere ya endocrine yimyororokere, yitabiriwe cyane ningaruka zayo zitera imisemburo ya luteinizing. Irashobora kugira uruhare mu gusohora kwa LH, ibikorwa, n'imikorere ya physiologique y'utugingo ngengabuzima bifitanye isano hakoreshejwe uburyo bwihariye, bityo bikagira ingaruka zikomeye ku buringanire bwa endocrinology yimyororokere.
Igishushanyo 1 Igishushanyo cya endocrinology yimyororokere ku bagore.
Ingaruka ya Luteinizing ya Chonluten
Amabwiriza ya LH
Chonluten irashobora gukora kuri hypothalamic-pituito axis, bigira ingaruka kumasohoro no kurekura imisemburo ya gonadotropine irekura (GnRH). GnRH ni imisemburo yingenzi itera glande yimbere ya pitoito kugirango isohore LH na hormone itera imisemburo (FSH). Chonluten irashobora kongera hypothalamus ikomatanya no kurekura GnRH, bityo igateza imbere mu buryo butaziguye synthesis hamwe n’isohoka rya LH na selile basofilique ya glande ya pitoito yimbere. Muri ubu buryo, Chonluten ifasha kugumana urwego rwa LH ruhamye mumubiri, rutanga umusingi uhagije wa hormone kubikorwa bya luteinisation. Kurugero, mubushakashatsi bwibikoko, byagaragaye ko nyuma yo kuvurwa kwa Chonluten, urwego rwa mRNA rwerekana GnRH muri hypothalamus rwiyongereye, mugihe LH yibanze mumaraso ya peripheri nayo yazamutse bikurikije, byerekana ingaruka nziza za Chonluten kumikorere ya LH.
Ingaruka kuri selile ya selile na granulosa selile
Mugihe cyiterambere rya follicle, selile ya selile na granulosa bigenda bihinduka murukurikirane rwa LH, amaherezo bigakora corpus luteum. Chonluten yongera ingaruka za LH kuri selile. Igenzura imvugo ya LH yakira (LHCGR) hejuru ya selile ya selile na granulosa selile, bigatuma utugingo ngengabuzima twumva LH. Ibindi byinshi byakira LH bivuze ko selile zishobora guhuza LH nyinshi, bityo zigatangira gukwirakwizwa kwimyanya ndangagitsina. Chonluten irashobora kugira uruhare rutaziguye mu kugenzura inzira zerekana ibimenyetso, guhuza poroteyine bifitanye isano na poroteyine hamwe na LH kugira ngo biteze ikwirakwizwa ry'uturemangingo, itandukaniro, hamwe na synthesis ya hormone steroid. Ubushakashatsi bwerekanye ko Chonluten ishobora kongera imvugo ya enzymes zingenzi zigira uruhare muri synthesis ya hormone steroid mungirangingo ya LH iterwa na granulosa, byihutisha guhuza imisemburo ya steroid nka progesterone, bityo bigatanga umusingi wibintu byo gushiraho no gufata neza corpus luteum.
Gutezimbere corpus luteum no kubungabunga imikorere
Corpus luteum ni imiterere y'amaraso ya glandulaire ikorwa vuba kuva mumitsi nyuma yintanga ngore, umurimo wibanze wacyo ukaba ururenda rwa progesterone, rukaba rukomeye mugukomeza gutwita. Chonluten iteza imbere ibikorwa bya LH, ifasha muguhindura byihuse ingirabuzimafatizo za granulosa zisigaye hamwe na tca selile muri corpus luteum selile nyuma yo guturika. Ikomeza imisemburo ya steroid hormone synthesis ya corpus luteum selile. Mugihe cyambere cyo gushinga corpus luteum, Chonluten ikorana na LH kugirango ikangure selile corpus luteum kugirango ihuze kandi isohore progesterone nyinshi, ikomeza gukura no gutuza kwa endometrium no gushyiraho ibidukikije byiza byo gutera urusoro no gukura hakiri kare. Mugihe cyokubungabunga corpus luteum, Chonluten ikomeje gukora, yemeza ko selile corpus luteum selile isohora progesterone ihagije kugirango ikingire inda ziterwa no kubura progesterone. Mubushakashatsi bwa vitro hamwe na selile luteal, kongeramo Chonluten byongera cyane ingirabuzimafatizo ya luteal selile na progesterone, byerekana uruhare rukomeye mukubungabunga imikorere ya luteal.
Gushyira mu bikorwa Chonluten mu myororokere ya Endocrine
Porogaramu muri Tekinoroji Yimyororokere Ifashwa
Muri tekinoroji yimyororokere ifashwa (ART), nko muri vitro ifumbira-mvubura (IVF-ET), hyperstimulation ovarian igenzurwa nintambwe ikomeye. Chonluten irashobora gukoreshwa nkumuti wongeyeho ufatanije n’imiti itera intanga ngore kugirango hongerwe protocole ya ovulation. Mugutezimbere imisemburo ya luteinizing (LH) iterwa na luteinizing, ifasha kuzamura ireme ryiterambere ryumusemburo hamwe nintanga ngore, bityo bikongera umubare wintangangore zujuje ubuziranenge zabonetse. Ku barwayi bafite intanga ngore idahwitse, kongeramo Chonluten muri protocole isanzwe ya ovulation induction itezimbere imikurire yimitsi, igahindura urwego rwa serumu LH, kandi ikongera imikorere ya luteal, bityo bikongerera intsinzi ya IVF-ET. Nyuma yo kwimura urusoro, Chonluten irashobora kandi gukoreshwa mugukomeza imikorere ya luteal, gutanga infashanyo zidasanzwe, kugabanya ibyago byo gukuramo inda, no kuzamura igipimo cyo gutwita kwa muganga.
Kuvura indwara zimyororokere
Kubibazo byimyororokere biterwa no gusohora kwa LH bidasanzwe cyangwa imikorere ya luteal idahagije, Chonluten ifite agaciro ko kuvura. Abarwayi bafite syndrome ya polycystic ovary (PCOS) bakunze kwerekana urugero rwa LH rudasanzwe cyangwa bagahagarika igipimo cya LH / FSH, kibangamira imikurire ya ovulation, bigatera ubugumba. Chonluten irashobora kugenga ururenda rwa LH nigikorwa cyo kunoza imikorere mibi ya endocrine, igateza imbere imikurire isanzwe na ovulation. Mu bushakashatsi bw’ubuvuzi, nyuma yo gutanga imiti ya Chonluten ku barwayi ba PCOS, ukwezi kwabo kwarahindutse, ovulation irakomeza, kandi abarwayi bamwe basamye neza. Ku barwayi bafite gukuramo inda kenshi biterwa no kubura luteal, Chonluten irashobora kongera imikorere ya luteal, kongera urugero rwa progesterone, kugabanya neza ibyago byo gukuramo inda, kandi bigatuma inda igenda neza.
Porogaramu mu myororokere yinyamaswa
Ku nyamaswa zimwe na zimwe zubukungu, nkinka n’amata, kuzamura imikorere y’imyororokere nicyo kintu cyingenzi mu bworozi. Chonluten irashobora gukoreshwa mugutunganya imikorere yimyororokere yinyamanswa, guteza imbere ovulation na corpus luteum, no kongera igipimo cyo gusama nubunini bwimyanda.
Umwanzuro
Chonluten igira uruhare runini kandi runini mugutezimbere luteinisation mu myororokere ya endocrine. Kuva kugenga ururenda rwa LH kugeza guteza imbere ishingwa rya corpus luteum no gukomeza imikorere yaryo, ndetse nuburyo bukoreshwa muburyo bwa tekinoroji y’imyororokere ifasha, kuvura indwara z’imyororokere, no kororoka kw’inyamaswa, Chonluten ifite akamaro kanini.
Inkomoko
[1] Li J, Wang W, Zhang D, n'abandi. Amajyambere yubushakashatsi kuri Luteinizing Hormone na Syndrome ya Polycystic Ovary [J]. Ikinyamakuru cyubuvuzi bwa none, 2024,6: 117-121.DOI: 10.53469 / jcmp.2024.06 (10) .23.
[2] Przygrodzka E, Plewes MR, Davis J. S. Ikinyamakuru mpuzamahanga cya siyansi yubumenyi, 2021,22 (18) .DOI: 10.3390 / ijms22189972.
[3] Roudebush W, Kivens W, Tubman J. Biomarkers ya Ovarian Reserve [J]. Ubushishozi bwa Biomarker, 2008,3: 259-268.DOI: 10.4137 / BMI.S537.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
