By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Nchịkọta
N'ime usoro endocrine nke ịmụ nwa, Luteinizing Hormone (LH) na-arụ ọrụ dị oke mkpa, na-ahazi ọtụtụ usoro ọmụmụ nke ọma, site na mmepe follicle, ovulation, na nhazi corpus luteum na mmezi, nzọụkwụ ọ bụla chọrọ ntinye aka LH. Chonluten, dị ka ihe nwere njikọ chiri anya na usoro endocrine ọmụmụ, enwetala nlebara anya dị ukwuu maka mmetụta ya na-akpali akpali nke luteinizing. Ọ nwere ike imetụta nzuzo nke LH, ọrụ, na ọrụ physiological nke mkpụrụ ndụ ndị metụtara ya site na usoro dị iche iche, si otú a na-enwe mmetụta dị ukwuu na nguzozi nke endocrinology ọmụmụ.
Ọgụgụ 1 Atụmatụ nke endocrinology ịmụ nwa na nwanyị.
Mmetụta luteinizing nke Chonluten
Iwu nke nzuzo nzuzo LH
Chonluten nwere ike ime ihe na hypothalamic-pituitary axis, na-emetụta usoro nzuzo na ntọhapụ nke gonadotropin na-ahapụ hormone (GnRH). GnRH bụ isi homonụ nke na-akpali akpali pituitary gland na-ezo LH na follicle-stimulating hormone (FSH). Chonluten nwere ike ịkwalite njikọ na ntọhapụ nke hypothalamus nke GnRH, si otú ahụ na-akwalite njikọ na nzuzo nke LH site na mkpụrụ ndụ basophilic nke gland pituitary nke mbụ. N'ụzọ dị otú a, Chonluten na-enyere aka ịnọgide na-enwe ọkwa LH kwụsiri ike na ahụ, na-enye ntọala hormonal zuru oke maka usoro luteinization na-esote. Dịka ọmụmaatụ, na nnwale anụmanụ, achọpụtara na mgbe ọgwụgwọ Chonluten gasịrị, ọkwa mRNA nke GnRH na hypothalamus mụbara, ebe ntinye LH na ọbara dị n'akụkụ bilitere n'ihi ya, na-egosi mmetụta nchịkwa dị mma nke Chonluten na nzuzo nzuzo LH.
Mmetụta na cell theca na granulosa cell
N'oge mmepe nke follicle, mkpụrụ ndụ theca na sel granulosa na-enweta mgbanwe dị iche iche n'okpuru mkpali LH, n'ikpeazụ na-akpụ corpus luteum. Chonluten na-akwalite mmetụta nke LH na sel ndị a. Ọ na-emezi okwu nke ndị na-anabata LH (LHCGR) n'elu sel theca na sel granulosa, na-eme ka mkpụrụ ndụ ndị a nwee mmetụta na LH. Ndị na-anabata LH ndị ọzọ pụtara na mkpụrụ ndụ nwere ike jikọta LH karịa, si otú a na-ebute ntụgharị mgbama intracellular siri ike. Chonluten nwere ike isonye ozugbo na nhazi nke ụzọ mgbaàmà intracellular, na-arụkọ ọrụ protein kinases na ihe odide ederede na LH iji kwalite mmụba cell, ọdịiche, na njikọ homonụ steroid. Nnyocha egosiwo na Chonluten nwere ike ime ka nkwupụta nke isi enzymes na-etinye aka na njikọ hormone steroid na mkpụrụ ndụ granulosa nke LH, na-eme ka njikọ nke hormones steroid dị ka progesterone dịkwuo elu, si otú ahụ na-enye ihe ndabere maka nhazi na ịrụ ọrụ nke corpus luteum.
Na-akwalite nhazi nke corpus luteum na nhazi ọrụ
The corpus luteum bụ vaskụla glandular owuwu nke etolite ngwa ngwa site na follicle mgbe ovulation gasịrị, ọrụ ya bụ isi bụ secretion nke progesterone, nke dị mkpa maka ịnọgide na-enwe afọ ime. Chonluten na-akwalite omume nke LH, na-enyere aka na mgbanwe ngwa ngwa nke mkpụrụ ndụ granulosa fọdụrụnụ na sel theca n'ime sel corpus luteum mgbe mgbawa follicle gasịrị. Ọ na-akwado ikike njikọ homonụ steroid nke mkpụrụ ndụ corpus luteum. N'oge mmalite nke nhazi corpus luteum, Chonluten na-ejikọta ya na LH iji mee ka mkpụrụ ndụ corpus luteum na-emepụta ma na-ezobe nnukwu progesterone, na-ejigide uto na nkwụsi ike nke endometrium na ịmepụta ebe kachasị mma maka ịkụnye embrayo na mmalite mmalite. N'oge nhazi nke corpus luteum, Chonluten na-aga n'ihu na-eme ihe, na-ahụ na mkpụrụ ndụ corpus luteum na-anọgide na-ezobe progesterone zuru ezu iji gbochie ime ọpụpụ nke erughi progesterone kpatara. N'ime nnwale in vitro na mkpụrụ ndụ luteal, mgbakwunye nke Chonluten na-eme ka luteal cell viability na progesterone secretion, na-egosi ọrụ dị mkpa ya n'ịkwado ọrụ luteal.
Ngwa nke Chonluten na Reproductive Endocrine Regulation
Ngwa na teknụzụ gbasara ịmụ nwa enyere aka
Na nkà na ụzụ na-enyere aka ịmụ nwa (ART), dị ka in vitro fertilization-embrayo transfer (IVF-ET), hyperstimulation ovarian a na-achịkwa bụ nzọụkwụ dị oke egwu. Enwere ike iji Chonluten dị ka ọgwụ mgbakwunye yana yana ọgwụ na-ebute ovulation iji kwalite protocol induction ovulation. Site n'ịkwalite mmetụta luteinizing nke na-ebute luteinizing hormone (LH), ọ na-enyere aka melite ogo mmepe nke follicle na ọnụ ọgụgụ ovulation, si otú ahụ na-amụba ọnụ ọgụgụ nke embrayo dị elu nwetara. Maka ndị ọrịa nwere nzaghachi ovarian na-adịghị mma, ịgbakwunye Chonluten na ọkọlọtọ induction protocol na-eme ka mmepe follicle dịkwuo mma, na-eme ka ọkwa LH serum dị mma, ma na-eme ka ọrụ luteal dịkwuo elu, si otú ahụ na-abawanye ọnụego ọganihu nke IVF-ET. Na-esochi nnyefe embrayo, Chonluten nwekwara ike iji nọgide na-arụ ọrụ luteal, nye nkwado luteal exogenous, belata ihe ize ndụ nke ime ọpụpụ, na melite ọnụego afọ ime ụlọ ọgwụ.
Ọgwụgwọ nsogbu ọmụmụ
Maka nsogbu ịmụ nwa kpatara site na nzuzo nzuzo LH na-adịghị mma ma ọ bụ ọrụ luteal ezughi oke, Chonluten nwere uru ọgwụgwọ. Ndị ọrịa nwere polycystic ovary syndrome (PCOS) na-egosipụtakarị ọkwa LH dị elu nke ukwuu ma ọ bụ mebie oke LH/FSH, nke na-emebi mmepe follicle na ovulation, na-eduga na-amụghị nwa. Chonluten nwere ike ịhazi nzuzo nzuzo LH na ime ihe iji melite arụ ọrụ endocrine, na-akwalite mmepe follicle nkịtị na ovulation. N'ọmụmụ ihe ụlọ ọgwụ, mgbe ha nyechara ndị ọrịa PCOS ọgwụgwọ Chonluten, oge ịhụ nsọ ha na-akawanye mma, ovulation maliteghachiri, na ụfọdụ ndị ọrịa tụụrụ ime nke ọma. Maka ndị ọrịa nwere ime ọpụpụ ugboro ugboro na-akpata site na ụkọ luteal, Chonluten nwere ike ịkwalite ọrụ luteal, mụbaa ọkwa progesterone, belata ihe ize ndụ nke ime ọpụpụ nke ọma, ma hụ na ọganihu dị mma nke afọ ime.
Ngwa na mmepụta anụmanụ
Maka ụfọdụ anụmanụ akụ na ụba, dị ka ehi mmiri ara ehi na ịgha mkpụrụ, imeziwanye mmepụta ọmụmụ bụ isi ihe dị mkpa na ọrụ ugbo. Enwere ike iji Chonluten na-achịkwa ọrụ endocrine nke ịmụ nwa, na-akwalite ovulation na nhazi corpus luteum, na ịbawanye ọnụ ọgụgụ echiche na nha nha.
Mmechi
Chonluten na-arụ ọrụ sara mbara ma dị mkpa n'ịkwalite luteinization n'ime usoro endocrine ọmụmụ. Site n'ịchịkwa nzuzo nzuzo LH na-akwalite nhazi nke corpus luteum na ịnọgide na-arụ ọrụ ya, yana ngwa ya na teknụzụ ọmụmụ enyere aka, ọgwụgwọ ọrịa ịmụ nwa, na mmepụta anụmanụ, Chonluten na-ejide ihe dị mkpa.
Isi mmalite
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[2] Przygrodzka E, Plewes MR, Davis JS. Luteinizing Hormone Regulation nke Inter-Organelle Communication na Fate of the Corpus Luteum[J]. Akwụkwọ akụkọ International nke Science Molecular, 2021,22 (18).DOI:10.3390/ijms22189972.
[3] Roudebush W, Kivens W, Tubman J. Biomarkers nke Ovarian Reserve[J]. Nghọta biomarker, 2008,3:259-268.DOI:10.4137/BMI.S537.
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