Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Hauv kev tsim cov kab mob endocrine, Luteinizing Hormone (LH) plays lub luag haujlwm tseem ceeb, ua tib zoo tswj ntau theem ntawm cov txheej txheem kev ua me nyuam, los ntawm kev loj hlob hauv follicle, ovulation, mus rau corpus luteum tsim thiab tu, txhua kauj ruam yuav tsum tau LH kev koom tes. Chonluten, raws li ib yam khoom uas cuam tshuam nrog kev tsim cov kab mob endocrine, tau txais txiaj ntsig zoo rau nws cov tshuaj luteinizing hormone-stimulating. Nws tuaj yeem cuam tshuam LH secretion, kev ua haujlwm, thiab kev ua haujlwm ntawm lub cev ntawm cov hlwb los ntawm cov txheej txheem tshwj xeeb, yog li ua rau muaj kev cuam tshuam loj heev ntawm kev sib npaug ntawm kev ua me nyuam endocrinology.
Daim duab 1 Schematic ntawm kev yug me nyuam endocrinology hauv poj niam.
Luteinizing nyhuv ntawm Chonluten
Kev cai ntawm LH Secretion
Chonluten tuaj yeem ua rau ntawm hypothalamic-pituitary axis, cuam tshuam rau kev tso tawm thiab tso tawm cov qauv ntawm gonadotropin-tso hormone (GnRH). GnRH yog cov tshuaj hormones tseem ceeb uas txhawb nqa lub caj pas anterior pituitary kom tso LH thiab follicle-stimulating hormone (FSH). Chonluten tuaj yeem txhim kho lub hypothalamus cov synthesis thiab tso tawm ntawm GnRH, yog li indirectly txhawb lub synthesis thiab secretion ntawm LH los ntawm basophilic hlwb ntawm lub anterior pituitary caj pas. Nyob rau hauv txoj kev no, Chonluten pab tswj cov qib LH ruaj khov hauv lub cev, muab lub hauv paus hormonal txaus rau cov txheej txheem luteinization tom ntej. Piv txwv li, hauv kev sim tsiaj, nws tau pom tias tom qab kev kho mob Chonluten, mRNA qhia theem ntawm GnRH hauv hypothalamus nce, thaum LH concentration hauv peripheral ntshav kuj nce raws li, qhia txog Chonluten qhov kev tswj xyuas zoo ntawm LH secretion.
Cov teebmeem ntawm theca cells thiab granulosa hlwb
Thaum lub sij hawm kev loj hlob ntawm follicle, theca hlwb thiab granulosa hlwb raug hloov pauv raws li LH stimulation, thaum kawg tsim lub corpus luteum. Chonluten txhim kho cov teebmeem ntawm LH ntawm cov hlwb no. Nws upregulates qhov kev qhia ntawm LH receptors (LHCGR) nyob rau saum npoo ntawm theca hlwb thiab granulosa hlwb, ua rau cov hlwb rhiab heev rau LH. Ntau LH receptors txhais tau hais tias cov hlwb tuaj yeem khi ntau LH, yog li pib muaj zog intracellular teeb liab hloov. Chonluten tuaj yeem koom ncaj qha rau hauv kev tswj hwm ntawm intracellular signaling pathways, co-activating ntsig txog protein kinases thiab transcription yam nrog LH los txhawb cell proliferation, sib txawv, thiab steroid hormone synthesis. Cov kev tshawb fawb tau pom tias Chonluten tuaj yeem txhim kho qhov kev qhia ntawm cov enzymes tseem ceeb koom nrog hauv steroid hormone synthesis hauv LH-induced granulosa hlwb, ua kom cov synthesis ntawm cov tshuaj hormones steroid xws li progesterone, yog li muab cov khoom hauv paus rau kev tsim thiab kev ua haujlwm ntawm corpus luteum.
Txhawb nqa corpus luteum tsim thiab ua haujlwm zoo
Lub corpus luteum yog lub vascular glandular qauv tsim sai sai los ntawm cov follicle tom qab ovulation, nrog rau nws lub luag haujlwm tseem ceeb yog kev tso tawm ntawm progesterone, uas yog qhov tseem ceeb rau kev xeeb tub. Chonluten txhawb nqa qhov kev txiav txim ntawm LH, pab hauv kev hloov pauv sai ntawm cov hlwb granulosa thiab theca hlwb rau hauv corpus luteum hlwb tom qab follicle rupture. Nws tuav lub steroid hormone synthesis muaj peev xwm ntawm corpus luteum hlwb. Thaum lub sij hawm thaum ntxov ntawm corpus luteum tsim, Chonluten synergizes nrog LH los txhawb corpus luteum hlwb los synthesize thiab secrete loj npaum li cas ntawm progesterone, tswj kev loj hlob thiab stability ntawm endometrium thiab tsim ib qho chaw zoo rau embryo implantation thiab kev loj hlob thaum ntxov. Thaum lub sij hawm txij nkawm ntawm lub corpus luteum, Chonluten tseem ua, kom ntseeg tau tias corpus luteum hlwb sustainably secrete txaus progesterone los tiv thaiv nchuav menyuam los ntawm progesterone deficiency. Hauv kev sim hauv vitro nrog luteal hlwb, qhov sib ntxiv ntawm Chonluten ho txhim kho luteal cell viability thiab progesterone secretion, qhia nws lub luag haujlwm tseem ceeb hauv kev tswj luteal muaj nuj nqi.
Kev siv Chonluten nyob rau hauv Reproductive Endocrine Regulation
Cov ntawv thov hauv Assisted Reproductive Technology
Hauv kev pabcuam kev ua menyuam yaus (ART), xws li hauv vitro fertilization-embryo hloov pauv (IVF-ET), tswj zes qe menyuam hyperstimulation yog ib kauj ruam tseem ceeb. Chonluten tuaj yeem siv los ua ib qho tshuaj ntxiv hauv kev sib xyaw nrog ovulation-inducing tshuaj los ua kom zoo rau ovulation induction raws tu qauv. Los ntawm kev txhim kho cov tshuaj luteinizing hormone (LH)-induced luteinizing nyhuv, nws pab txhim kho follicle txoj kev loj hlob zoo thiab ovulation tus nqi, yog li nce tus naj npawb ntawm cov embryos zoo tau txais. Rau cov neeg mob uas tsis zoo ntawm zes qe menyuam cov lus teb, ntxiv Chonluten rau tus qauv ovulation induction raws tu qauv txhim kho follicle txoj kev loj hlob, normalizes ntshav LH qib, thiab txhim kho luteal muaj nuj nqi, yog li nce tus nqi ntawm IVF-ET. Tom qab hloov lub embryo, Chonluten kuj tseem siv tau los tswj kev ua haujlwm ntawm luteal, muab kev txhawb nqa exogenous luteal, txo qhov kev pheej hmoo ntawm nchuav menyuam, thiab txhim kho kev kuaj mob cev xeeb tub.
Kev kho mob ntawm kev ua me nyuam
Rau kev ua me nyuam muaj teeb meem tshwm sim los ntawm qhov txawv txav LH secretion los yog tsis txaus luteal muaj nuj nqi, Chonluten muaj peev xwm kho tus nqi. Cov neeg mob uas muaj polycystic zes qe menyuam syndrome (PCOS) feem ntau pom qhov txawv txav ntawm qib LH lossis cuam tshuam LH / FSH qhov sib piv, uas cuam tshuam rau kev loj hlob ntawm cov follicle thiab ovulation, ua rau muaj menyuam tsis taus. Chonluten tuaj yeem tswj LH secretion thiab kev ua haujlwm los txhim kho endocrine ua haujlwm tsis zoo, txhawb kev loj hlob ntawm cov follicle thiab ovulation. Hauv kev tshawb fawb soj ntsuam, tom qab muab kev kho mob Chonluten rau cov neeg mob PCOS, lawv cov kev coj khaub ncaws zoo tuaj, ovulation rov pib dua, thiab qee cov neeg mob tau xeeb tub. Rau cov neeg mob uas rov qab nchuav menyuam los ntawm luteal insufficiency, Chonluten tuaj yeem txhim kho luteal muaj nuj nqi, nce qib progesterone, txo qhov kev pheej hmoo ntawm nchuav menyuam, thiab xyuas kom meej tias kev xeeb tub.
Kev siv hauv kev yug tsiaj
Rau qee yam tsiaj nyeg tsiaj, xws li nyuj nyuj thiab sows, kev txhim kho kev ua me nyuam yog qhov tseem ceeb hauv kev ua liaj ua teb. Chonluten tuaj yeem siv los tswj cov tsiaj yug tsiaj endocrine muaj nuj nqi, txhawb ovulation thiab corpus luteum tsim, thiab ua kom lub cev xeeb tub thiab qhov ntau thiab tsawg.
Xaus
Chonluten plays lub luag haujlwm dav thiab tseem ceeb hauv kev txhawb nqa luteinization nyob rau hauv kev tsim cov kab mob endocrine. Los ntawm kev tswj hwm LH secretion los txhawb kev tsim cov corpus luteum thiab tswj nws txoj haujlwm, nrog rau nws cov kev siv hauv kev pab txhawb kev tsim cov thev naus laus zis, kev kho kab mob kev sib deev, thiab kev yug tsiaj, Chonluten tuav qhov tseem ceeb.
Qhov chaw
[1] Li J, Wang W, Zhang D, et al. Kev Tshawb Fawb Kev Txhim Kho ntawm Luteinizing Hormone thiab Polycystic Ovary Syndrome [J]. Phau ntawv Journal of Contemporary Medical Practice, 2024,6:117-121.DOI:10.53469/jcmp.2024.06(10.23.
[2] Przygrodzka E, Plewes MR, Davis J. S. Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum[J]. International Journal of Molecular Sciences, 2021,22(18).DOI:10.3390/ijms22189972.
[3] Roudebush W, Kivens W, Tubman J. Biomarkers ntawm Ovarian Reserve[J]. Biomarker Insights, 2008, 3: 259-268.DOI: 10.4137/BMI.S537.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
